Found 285 hits with Last Name = 'dewnani' and Initial = 'sv' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon receptor
(Homo sapiens (Human)) | BDBM235136
(US9359339, 25)Show SMILES CCC[C@@H](C(c1csc2c(cc(Cl)cc12)C#N)c1ccc(OC(F)(F)F)cc1)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C31H26ClF3N2O4S/c1-2-3-24(18-4-6-20(7-5-18)30(40)37-13-12-27(38)39)28(19-8-10-23(11-9-19)41-31(33,34)35)26-17-42-29-21(16-36)14-22(32)15-25(26)29/h4-11,14-15,17,24,28H,2-3,12-13H2,1H3,(H,37,40)(H,38,39)/t24-,28?/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A stable CHO (Chinese hamster ovary) cell line expressing cloned human glucagon receptor was maintained as described (Chicchi, et. al. J Biol Chem 27... |
US Patent US9359339 (2016)
BindingDB Entry DOI: 10.7270/Q2FQ9VHC |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM235137
(US9359339, 27)Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)[C@@H](CCC(F)(F)F)C(c1csc2c(cc(Cl)cc12)C#N)c1ccc(Cl)cc1 Show InChI InChI=1S/C30H23Cl2F3N2O3S/c31-21-7-5-18(6-8-21)27(25-16-41-28-20(15-36)13-22(32)14-24(25)28)23(9-11-30(33,34)35)17-1-3-19(4-2-17)29(40)37-12-10-26(38)39/h1-8,13-14,16,23,27H,9-12H2,(H,37,40)(H,38,39)/t23-,27?/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A stable CHO (Chinese hamster ovary) cell line expressing cloned human glucagon receptor was maintained as described (Chicchi, et. al. J Biol Chem 27... |
US Patent US9359339 (2016)
BindingDB Entry DOI: 10.7270/Q2FQ9VHC |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM235135
(US9359339, 23)Show SMILES CCC[C@@H](C(c1csc2c(cc(C)cc12)C#N)c1ccc(OC(F)(F)F)cc1)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C32H29F3N2O4S/c1-3-4-25(20-5-7-22(8-6-20)31(40)37-14-13-28(38)39)29(21-9-11-24(12-10-21)41-32(33,34)35)27-18-42-30-23(17-36)15-19(2)16-26(27)30/h5-12,15-16,18,25,29H,3-4,13-14H2,1-2H3,(H,37,40)(H,38,39)/t25-,29?/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A stable CHO (Chinese hamster ovary) cell line expressing cloned human glucagon receptor was maintained as described (Chicchi, et. al. J Biol Chem 27... |
US Patent US9359339 (2016)
BindingDB Entry DOI: 10.7270/Q2FQ9VHC |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM235138
(US9359339, 29)Show SMILES CCCC[C@@H](C(c1csc2c(cc(Cl)cc12)C#N)c1ccc(Cl)cc1)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C31H28Cl2N2O3S/c1-2-3-4-25(19-5-7-21(8-6-19)31(38)35-14-13-28(36)37)29(20-9-11-23(32)12-10-20)27-18-39-30-22(17-34)15-24(33)16-26(27)30/h5-12,15-16,18,25,29H,2-4,13-14H2,1H3,(H,35,38)(H,36,37)/t25-,29?/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A stable CHO (Chinese hamster ovary) cell line expressing cloned human glucagon receptor was maintained as described (Chicchi, et. al. J Biol Chem 27... |
US Patent US9359339 (2016)
BindingDB Entry DOI: 10.7270/Q2FQ9VHC |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM406013
(US10351558, Example 188)Show SMILES Cc1ccc2n3C[C@@](CCc3c(C(O)=O)c2c1)(NC(=O)c1ccc(cc1Cl)-n1cnn(C)c1=O)c1cccc(F)c1 |r| Show InChI InChI=1S/C30H25ClFN5O4/c1-17-6-9-24-22(12-17)26(28(39)40)25-10-11-30(15-36(24)25,18-4-3-5-19(32)13-18)34-27(38)21-8-7-20(14-23(21)31)37-16-33-35(2)29(37)41/h3-9,12-14,16H,10-11,15H2,1-2H3,(H,34,38)(H,39,40)/t30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.509 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405953
(US10351558, Example 128)Show SMILES Cc1ccc2n3C[C@@](CCc3c(C(O)=O)c2c1)(NC(=O)c1ccc(cc1)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C29H25N5O3/c1-19-7-12-24-23(15-19)26(28(36)37)25-13-14-29(16-34(24)25,21-5-3-2-4-6-21)32-27(35)20-8-10-22(11-9-20)33-17-30-31-18-33/h2-12,15,17-18H,13-14,16H2,1H3,(H,32,35)(H,36,37)/t29-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.596 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405993
(US10351558, Example 168)Show SMILES COc1ncn(n1)-c1ccc(C(=O)N[C@@]2(CCc3c(C(O)=O)c4cc(C)ccc4n3C2)c2ccccc2)c(Cl)c1 |r| Show InChI InChI=1S/C30H26ClN5O4/c1-18-8-11-24-22(14-18)26(28(38)39)25-12-13-30(16-35(24)25,19-6-4-3-5-7-19)33-27(37)21-10-9-20(15-23(21)31)36-17-32-29(34-36)40-2/h3-11,14-15,17H,12-13,16H2,1-2H3,(H,33,37)(H,38,39)/t30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.636 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM235134
(US9359339, 21)Show SMILES CCC[C@@H](C(c1csc2c(cc(Cl)cc12)C#N)c1ccc(Cl)c(Cl)c1)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C30H25Cl3N2O3S/c1-2-3-22(17-4-6-18(7-5-17)30(38)35-11-10-27(36)37)28(19-8-9-25(32)26(33)13-19)24-16-39-29-20(15-34)12-21(31)14-23(24)29/h4-9,12-14,16,22,28H,2-3,10-11H2,1H3,(H,35,38)(H,36,37)/t22-,28?/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A stable CHO (Chinese hamster ovary) cell line expressing cloned human glucagon receptor was maintained as described (Chicchi, et. al. J Biol Chem 27... |
US Patent US9359339 (2016)
BindingDB Entry DOI: 10.7270/Q2FQ9VHC |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405996
(US10351558, Example 171)Show SMILES Cc1ncn(n1)-c1ccc(C(=O)N[C@@]2(CCc3c(C(O)=O)c4cc(C)ccc4n3C2)c2cccc(F)c2)c(Cl)c1 |r| Show InChI InChI=1S/C30H25ClFN5O3/c1-17-6-9-25-23(12-17)27(29(39)40)26-10-11-30(15-36(25)26,19-4-3-5-20(32)13-19)34-28(38)22-8-7-21(14-24(22)31)37-16-33-18(2)35-37/h3-9,12-14,16H,10-11,15H2,1-2H3,(H,34,38)(H,39,40)/t30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.791 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405985
(US10351558, Example 160)Show SMILES Cc1ccc2n3C[C@@](CCc3c(\C=C\C(O)=O)c2c1)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C31H26ClN5O3/c1-20-7-11-27-25(15-20)23(10-12-29(38)39)28-13-14-31(17-37(27)28,21-5-3-2-4-6-21)35-30(40)24-9-8-22(16-26(24)32)36-18-33-34-19-36/h2-12,15-16,18-19H,13-14,17H2,1H3,(H,35,40)(H,38,39)/b12-10+/t31-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.820 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM235139
(US9359339, 32)Show SMILES CC(C)C[C@@H](C(c1csc2c(cc(Cl)cc12)C#N)c1ccc(Cl)cc1)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C31H28Cl2N2O3S/c1-18(2)13-25(19-3-5-21(6-4-19)31(38)35-12-11-28(36)37)29(20-7-9-23(32)10-8-20)27-17-39-30-22(16-34)14-24(33)15-26(27)30/h3-10,14-15,17-18,25,29H,11-13H2,1-2H3,(H,35,38)(H,36,37)/t25-,29?/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A stable CHO (Chinese hamster ovary) cell line expressing cloned human glucagon receptor was maintained as described (Chicchi, et. al. J Biol Chem 27... |
US Patent US9359339 (2016)
BindingDB Entry DOI: 10.7270/Q2FQ9VHC |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405974
(US10351558, Example 149)Show SMILES Cc1ncn(n1)-c1ccc(C(=O)N[C@@]2(CCc3c(C(O)=O)c4cc(C)ccc4n3C2)c2ccccc2)c(Cl)c1 |r| Show InChI InChI=1S/C30H26ClN5O3/c1-18-8-11-25-23(14-18)27(29(38)39)26-12-13-30(16-35(25)26,20-6-4-3-5-7-20)33-28(37)22-10-9-21(15-24(22)31)36-17-32-19(2)34-36/h3-11,14-15,17H,12-13,16H2,1-2H3,(H,33,37)(H,38,39)/t30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.03 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM235130
(US9359339, 13)Show SMILES CCC[C@@H](C(c1csc2c(cc(F)cc12)C#N)c1ccc(Cl)cc1)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C30H26ClFN2O3S/c1-2-3-24(18-4-6-20(7-5-18)30(37)34-13-12-27(35)36)28(19-8-10-22(31)11-9-19)26-17-38-29-21(16-33)14-23(32)15-25(26)29/h4-11,14-15,17,24,28H,2-3,12-13H2,1H3,(H,34,37)(H,35,36)/t24-,28?/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A stable CHO (Chinese hamster ovary) cell line expressing cloned human glucagon receptor was maintained as described (Chicchi, et. al. J Biol Chem 27... |
US Patent US9359339 (2016)
BindingDB Entry DOI: 10.7270/Q2FQ9VHC |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405944
(US10351558, Example 119)Show SMILES OC(=O)Cn1c2CC[C@](Cc2c2ccc(Cl)cc12)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1cccc(F)c1 |r| Show InChI InChI=1S/C29H22Cl2FN5O3/c30-18-4-6-21-23-13-29(17-2-1-3-19(32)10-17,9-8-25(23)37(14-27(38)39)26(21)11-18)35-28(40)22-7-5-20(12-24(22)31)36-15-33-34-16-36/h1-7,10-12,15-16H,8-9,13-14H2,(H,35,40)(H,38,39)/t29-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.17 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM406007
(US10351558, Example 182)Show SMILES Cc1ncn(n1)-c1ccc(C(=O)N[C@@]2(CCc3c(\C=C\C(O)=O)c4cc(C)ccc4n3C2)c2ccccc2)c(Cl)c1 |r| Show InChI InChI=1S/C32H28ClN5O3/c1-20-8-12-28-26(16-20)24(11-13-30(39)40)29-14-15-32(18-37(28)29,22-6-4-3-5-7-22)35-31(41)25-10-9-23(17-27(25)33)38-19-34-21(2)36-38/h3-13,16-17,19H,14-15,18H2,1-2H3,(H,35,41)(H,39,40)/b13-11+/t32-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.18 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM50126915
(CHEMBL3629110 | US10351558, Example 138)Show SMILES Cc1ccc2n3C[C@@](CCc3c(C(N)=O)c2c1)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C29H25ClN6O2/c1-18-7-10-24-22(13-18)26(27(31)37)25-11-12-29(15-36(24)25,19-5-3-2-4-6-19)34-28(38)21-9-8-20(14-23(21)30)35-16-32-33-17-35/h2-10,13-14,16-17H,11-12,15H2,1H3,(H2,31,37)(H,34,38)/t29-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM235131
(US9359339, 14)Show SMILES CCC[C@@H](C(c1csc2c(cc(C)cc12)C#N)c1ccc(Cl)cc1)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C31H29ClN2O3S/c1-3-4-25(20-5-7-22(8-6-20)31(37)34-14-13-28(35)36)29(21-9-11-24(32)12-10-21)27-18-38-30-23(17-33)15-19(2)16-26(27)30/h5-12,15-16,18,25,29H,3-4,13-14H2,1-2H3,(H,34,37)(H,35,36)/t25-,29?/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A stable CHO (Chinese hamster ovary) cell line expressing cloned human glucagon receptor was maintained as described (Chicchi, et. al. J Biol Chem 27... |
US Patent US9359339 (2016)
BindingDB Entry DOI: 10.7270/Q2FQ9VHC |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405882
(US10351558, Example 57)Show SMILES Cc1ccc2n3C[C@@](CCc3nc2c1)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C27H23ClN6O/c1-18-7-10-24-23(13-18)31-25-11-12-27(15-34(24)25,19-5-3-2-4-6-19)32-26(35)21-9-8-20(14-22(21)28)33-16-29-30-17-33/h2-10,13-14,16-17H,11-12,15H2,1H3,(H,32,35)/t27-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.42 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM50126956
(CHEMBL3628961 | US10351558, Example 174)Show SMILES Cc1ccc2n3C[C@@](CCc3c(C(N)=O)c2c1)(NC(=O)c1c(Cl)cc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C29H24Cl2N6O2/c1-17-7-8-23-20(11-17)25(27(32)38)24-9-10-29(14-37(23)24,18-5-3-2-4-6-18)35-28(39)26-21(30)12-19(13-22(26)31)36-15-33-34-16-36/h2-8,11-13,15-16H,9-10,14H2,1H3,(H2,32,38)(H,35,39)/t29-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.45 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM406014
(US10351558, Example 189)Show SMILES Cc1ccc2n3C[C@@](CCc3c(-c3cncc(N)c3)c2c1)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C33H28ClN7O/c1-21-7-10-29-27(13-21)31(22-14-24(35)17-36-16-22)30-11-12-33(18-41(29)30,23-5-3-2-4-6-23)39-32(42)26-9-8-25(15-28(26)34)40-19-37-38-20-40/h2-10,13-17,19-20H,11-12,18,35H2,1H3,(H,39,42)/t33-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.58 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM406031
(US10351558, Example 206)Show SMILES Cc1ccc2n3C[C@@](CCc3c(-c3cnc(nc3)C3CC3)c2c1)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C35H30ClN7O/c1-22-7-12-30-28(15-22)32(24-17-37-33(38-18-24)23-8-9-23)31-13-14-35(19-43(30)31,25-5-3-2-4-6-25)41-34(44)27-11-10-26(16-29(27)36)42-20-39-40-21-42/h2-7,10-12,15-18,20-21,23H,8-9,13-14,19H2,1H3,(H,41,44)/t35-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.58 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
(Homo sapiens (Human)) | BDBM272063
(US10065945, Example 57)Show SMILES C[C@@H](N1CCc2ccc(cc2C1)S(=O)(=O)Nc1nc(no1)C(=O)N1CCCC1)c1cc(F)cc(F)c1 |r| Show InChI InChI=1S/C24H25F2N5O4S/c1-15(17-10-19(25)13-20(26)11-17)31-9-6-16-4-5-21(12-18(16)14-31)36(33,34)29-24-27-22(28-35-24)23(32)30-7-2-3-8-30/h4-5,10-13,15H,2-3,6-9,14H2,1H3,(H,27,28,29)/t15-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | 25 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A solution of 1 M LiHMDS in THF (51.7 ml, 51.7 mmol) was added dropwise to a mixture of Intermediate 3 (7.5 g, 17.2 mmol) and 5-(tert-butyl)-4-methyl... |
US Patent US10065945 (2018)
BindingDB Entry DOI: 10.7270/Q24X59TJ |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405975
(US10351558, Example 150)Show SMILES Cc1nncn1-c1ccc(C(=O)N[C@@]2(CCc3c(C(O)=O)c4cc(C)ccc4n3C2)c2ccccc2)c(Cl)c1 |r| Show InChI InChI=1S/C30H26ClN5O3/c1-18-8-11-25-23(14-18)27(29(38)39)26-12-13-30(16-35(25)26,20-6-4-3-5-7-20)33-28(37)22-10-9-21(15-24(22)31)36-17-32-34-19(36)2/h3-11,14-15,17H,12-13,16H2,1-2H3,(H,33,37)(H,38,39)/t30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405978
(US10351558, Example 153)Show SMILES Cc1ccc2n3C[C@@](CCc3c(C=O)c2c1)(NC(=O)c1c(Cl)cc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C29H23Cl2N5O2/c1-18-7-8-25-21(11-18)22(14-37)26-9-10-29(15-36(25)26,19-5-3-2-4-6-19)34-28(38)27-23(30)12-20(13-24(27)31)35-16-32-33-17-35/h2-8,11-14,16-17H,9-10,15H2,1H3,(H,34,38)/t29-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.61 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405994
(US10351558, Example 169)Show SMILES Cc1ccc2n3C[C@@](CCc3c(C(O)=O)c2c1)(NC(=O)c1ccc(cc1Cl)-n1cnn(C)c1=O)c1ccccc1 |r| Show InChI InChI=1S/C30H26ClN5O4/c1-18-8-11-24-22(14-18)26(28(38)39)25-12-13-30(16-35(24)25,19-6-4-3-5-7-19)33-27(37)21-10-9-20(15-23(21)31)36-17-32-34(2)29(36)40/h3-11,14-15,17H,12-13,16H2,1-2H3,(H,33,37)(H,38,39)/t30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.68 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM235132
(US9359339, 15)Show SMILES CCC[C@@H](C(c1csc2c(cc(cc12)C(F)(F)F)C#N)c1ccc(Cl)cc1)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C31H26ClF3N2O3S/c1-2-3-24(18-4-6-20(7-5-18)30(40)37-13-12-27(38)39)28(19-8-10-23(32)11-9-19)26-17-41-29-21(16-36)14-22(15-25(26)29)31(33,34)35/h4-11,14-15,17,24,28H,2-3,12-13H2,1H3,(H,37,40)(H,38,39)/t24-,28?/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A stable CHO (Chinese hamster ovary) cell line expressing cloned human glucagon receptor was maintained as described (Chicchi, et. al. J Biol Chem 27... |
US Patent US9359339 (2016)
BindingDB Entry DOI: 10.7270/Q2FQ9VHC |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM406028
(US10351558, Example 203)Show SMILES COc1ncc(cn1)-c1c2CC[C@](Cn2c2ccc(C)cc12)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C33H28ClN7O2/c1-21-8-11-28-26(14-21)30(22-16-35-32(43-2)36-17-22)29-12-13-33(18-41(28)29,23-6-4-3-5-7-23)39-31(42)25-10-9-24(15-27(25)34)40-19-37-38-20-40/h3-11,14-17,19-20H,12-13,18H2,1-2H3,(H,39,42)/t33-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.71 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM50126855
(CHEMBL3628962 | US10351558, Example 173)Show SMILES Cc1ccc2n3C[C@@](CCc3c(\C=N\O)c2c1)(NC(=O)c1c(Cl)cc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C29H24Cl2N6O2/c1-18-7-8-25-21(11-18)22(14-34-39)26-9-10-29(15-37(25)26,19-5-3-2-4-6-19)35-28(38)27-23(30)12-20(13-24(27)31)36-16-32-33-17-36/h2-8,11-14,16-17,39H,9-10,15H2,1H3,(H,35,38)/b34-14+/t29-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM235142
(US9359339, 45)Show SMILES CCC[C@@H](C(c1sc2ccccc2c1C)c1ccc(Cl)cc1)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C30H30ClNO3S/c1-3-6-25(20-9-11-22(12-10-20)30(35)32-18-17-27(33)34)28(21-13-15-23(31)16-14-21)29-19(2)24-7-4-5-8-26(24)36-29/h4-5,7-16,25,28H,3,6,17-18H2,1-2H3,(H,32,35)(H,33,34)/t25-,28?/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A stable CHO (Chinese hamster ovary) cell line expressing cloned human glucagon receptor was maintained as described (Chicchi, et. al. J Biol Chem 27... |
US Patent US9359339 (2016)
BindingDB Entry DOI: 10.7270/Q2FQ9VHC |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405862
(US10351558, Example 37)Show SMILES Cc1ncn(n1)-c1cc(Cl)c(C(=O)NC2(CCc3nn4cc(C)ccc4c3C2)c2cccc(C)c2)c(Cl)c1 Show InChI InChI=1S/C29H26Cl2N6O/c1-17-5-4-6-20(11-17)29(10-9-25-22(14-29)26-8-7-18(2)15-36(26)35-25)33-28(38)27-23(30)12-21(13-24(27)31)37-16-32-19(3)34-37/h4-8,11-13,15-16H,9-10,14H2,1-3H3,(H,33,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.84 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405969
(US10351558, Example 144)Show SMILES CC(=O)c1c2CC[C@](Cn2c2ccc(C)cc12)(NC(=O)c1ccc(cc1Cl)-n1cnc(C)n1)c1ccccc1 |r| Show InChI InChI=1S/C31H28ClN5O2/c1-19-9-12-27-25(15-19)29(20(2)38)28-13-14-31(17-36(27)28,22-7-5-4-6-8-22)34-30(39)24-11-10-23(16-26(24)32)37-18-33-21(3)35-37/h4-12,15-16,18H,13-14,17H2,1-3H3,(H,34,39)/t31-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.85 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM406022
(US10351558, Example 197)Show SMILES COC(=O)Cc1c2CC[C@](Cn2c2ccc(C)cc12)(NC(=O)c1c(Cl)cc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C31H27Cl2N5O3/c1-19-8-9-26-22(12-19)23(15-28(39)41-2)27-10-11-31(16-38(26)27,20-6-4-3-5-7-20)36-30(40)29-24(32)13-21(14-25(29)33)37-17-34-35-18-37/h3-9,12-14,17-18H,10-11,15-16H2,1-2H3,(H,36,40)/t31-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.87 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM406000
(US10351558, Example 175)Show SMILES Cc1ccc2n3C[C@@](CCc3c(C(=O)C(F)F)c2c1)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C30H24ClF2N5O2/c1-18-7-10-24-22(13-18)26(27(39)28(32)33)25-11-12-30(15-38(24)25,19-5-3-2-4-6-19)36-29(40)21-9-8-20(14-23(21)31)37-16-34-35-17-37/h2-10,13-14,16-17,28H,11-12,15H2,1H3,(H,36,40)/t30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.99 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405960
(& 146 | US10351558, Example 135)Show SMILES CC(=O)c1c2CC[C@](Cn2c2ccc(C)cc12)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C30H26ClN5O2/c1-19-8-11-26-24(14-19)28(20(2)37)27-12-13-30(16-36(26)27,21-6-4-3-5-7-21)34-29(38)23-10-9-22(15-25(23)31)35-17-32-33-18-35/h3-11,14-15,17-18H,12-13,16H2,1-2H3,(H,34,38)/t30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.01 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405982
(US10351558, Example 157)Show SMILES Cc1ccc2n3C[C@@](CCc3c(\C=C\C(N)=O)c2c1)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C31H27ClN6O2/c1-20-7-11-27-25(15-20)23(10-12-29(33)39)28-13-14-31(17-38(27)28,21-5-3-2-4-6-21)36-30(40)24-9-8-22(16-26(24)32)37-18-34-35-19-37/h2-12,15-16,18-19H,13-14,17H2,1H3,(H2,33,39)(H,36,40)/b12-10+/t31-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.03 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405972
(US10351558, Example 147)Show SMILES Cc1nncn1-c1ccc(C(=O)N[C@@]2(CCc3c(C(N)=O)c4cc(C)ccc4n3C2)c2ccccc2)c(Cl)c1 |r| Show InChI InChI=1S/C30H27ClN6O2/c1-18-8-11-25-23(14-18)27(28(32)38)26-12-13-30(16-36(25)26,20-6-4-3-5-7-20)34-29(39)22-10-9-21(15-24(22)31)37-17-33-35-19(37)2/h3-11,14-15,17H,12-13,16H2,1-2H3,(H2,32,38)(H,34,39)/t30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.05 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405838
(US10351558, Example 13)Show SMILES Cc1ncn(n1)-c1ccc(C(=O)NC2(CCc3nn4cc(C)ccc4c3C2)c2cccc(C)c2)c(Cl)c1 Show InChI InChI=1S/C29H27ClN6O/c1-18-5-4-6-21(13-18)29(12-11-26-24(15-29)27-10-7-19(2)16-35(27)34-26)32-28(37)23-9-8-22(14-25(23)30)36-17-31-20(3)33-36/h4-10,13-14,16-17H,11-12,15H2,1-3H3,(H,32,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.08 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM235129
(US9359339, 8)Show SMILES CCC[C@@H](C(c1c(C)sc2ccccc12)c1ccc(Cl)cc1)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C30H30ClNO3S/c1-3-6-24(20-9-11-22(12-10-20)30(35)32-18-17-27(33)34)29(21-13-15-23(31)16-14-21)28-19(2)36-26-8-5-4-7-25(26)28/h4-5,7-16,24,29H,3,6,17-18H2,1-2H3,(H,32,35)(H,33,34)/t24-,29?/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A stable CHO (Chinese hamster ovary) cell line expressing cloned human glucagon receptor was maintained as described (Chicchi, et. al. J Biol Chem 27... |
US Patent US9359339 (2016)
BindingDB Entry DOI: 10.7270/Q2FQ9VHC |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM235126
(US9359339, 3)Show SMILES CCC[C@@H](C(c1csc2c(Br)cc(C)cc12)c1ccc(Cl)cc1)c1ccc(cc1)C(=O)Nc1nnn[nH]1 |r| | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A stable CHO (Chinese hamster ovary) cell line expressing cloned human glucagon receptor was maintained as described (Chicchi, et. al. J Biol Chem 27... |
US Patent US9359339 (2016)
BindingDB Entry DOI: 10.7270/Q2FQ9VHC |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405981
(US10351558, Example 156)Show SMILES Cc1ccc2n3C[C@@](CCc3c(-c3nnn[nH]3)c2c1)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
US Patent
| n/a | n/a | 2.38 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405962
(US10351558, Example 137)Show SMILES Cc1ccc2n3C[C@@](CCc3c(\C=N\O)c2c1)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C29H25ClN6O2/c1-19-7-10-26-23(13-19)24(15-33-38)27-11-12-29(16-36(26)27,20-5-3-2-4-6-20)34-28(37)22-9-8-21(14-25(22)30)35-17-31-32-18-35/h2-10,13-15,17-18,38H,11-12,16H2,1H3,(H,34,37)/b33-15+/t29-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.38 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405847
(US10351558, Example 22)Show SMILES Cc1ccc(O)c2c3C[C@@](C)(CCc3nn12)NC(=O)c1ccc(cc1Cl)-n1cnc2ccc(cc12)C(N)=O |r| Show InChI InChI=1S/C28H25ClN6O3/c1-15-3-8-24(36)25-19-13-28(2,10-9-21(19)33-35(15)25)32-27(38)18-6-5-17(12-20(18)29)34-14-31-22-7-4-16(26(30)37)11-23(22)34/h3-8,11-12,14,36H,9-10,13H2,1-2H3,(H2,30,37)(H,32,38)/t28-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.38 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405848
(US10351558, Example 23)Show SMILES Cc1ccc(O)c2c3C[C@@](C)(CCc3nn12)NC(=O)c1ccc(cc1Cl)-n1cnc2cc(ccc12)C(N)=O |r| Show InChI InChI=1S/C28H25ClN6O3/c1-15-3-8-24(36)25-19-13-28(2,10-9-21(19)33-35(15)25)32-27(38)18-6-5-17(12-20(18)29)34-14-31-22-11-16(26(30)37)4-7-23(22)34/h3-8,11-12,14,36H,9-10,13H2,1-2H3,(H2,30,37)(H,32,38)/t28-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.44 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM235127
(US9359339, 4)Show SMILES CCC[C@@H](C(c1csc2c(Br)cc(C)cc12)c1ccc(Cl)cc1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r| | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
A stable CHO (Chinese hamster ovary) cell line expressing cloned human glucagon receptor was maintained as described (Chicchi, et. al. J Biol Chem 27... |
US Patent US9359339 (2016)
BindingDB Entry DOI: 10.7270/Q2FQ9VHC |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405955
(US10351558, Example 130)Show SMILES Cc1ccc2n3C[C@@](CCc3c(C(O)=O)c2c1)(NC(=O)c1ccc(cn1)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C28H24N6O3/c1-18-7-10-23-21(13-18)25(27(36)37)24-11-12-28(15-34(23)24,19-5-3-2-4-6-19)32-26(35)22-9-8-20(14-29-22)33-16-30-31-17-33/h2-10,13-14,16-17H,11-12,15H2,1H3,(H,32,35)(H,36,37)/t28-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.53 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405986
(US10351558, Example 161 | US10351558, Example 164)Show SMILES Cc1ccc2n3C[C@@](CCc3c(CCC(N)=O)c2c1)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C31H29ClN6O2/c1-20-7-11-27-25(15-20)23(10-12-29(33)39)28-13-14-31(17-38(27)28,21-5-3-2-4-6-21)36-30(40)24-9-8-22(16-26(24)32)37-18-34-35-19-37/h2-9,11,15-16,18-19H,10,12-14,17H2,1H3,(H2,33,39)(H,36,40)/t31-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.55 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405910
(US10351558, Example 85)Show SMILES Cc1ccc2n3CC(CC(F)(F)c3nc2c1)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 Show InChI InChI=1S/C27H21ClF2N6O/c1-17-7-10-23-22(11-17)33-25-27(29,30)13-26(14-36(23)25,18-5-3-2-4-6-18)34-24(37)20-9-8-19(12-21(20)28)35-15-31-32-16-35/h2-12,15-16H,13-14H2,1H3,(H,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.56 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM405988
(US10351558, Example 163)Show SMILES Cc1ncn(n1)-c1cc(C)c(C(=O)N[C@@]2(CCc3c(C(N)=O)c4cc(C)ccc4n3C2)c2ccccc2)c(Cl)c1 |r| Show InChI InChI=1S/C31H29ClN6O2/c1-18-9-10-25-23(13-18)28(29(33)39)26-11-12-31(16-37(25)26,21-7-5-4-6-8-21)35-30(40)27-19(2)14-22(15-24(27)32)38-17-34-20(3)36-38/h4-10,13-15,17H,11-12,16H2,1-3H3,(H2,33,39)(H,35,40)/t31-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.59 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM50126923
(CHEMBL3628832 | US10351558, Example 67)Show SMILES Cc1ncn(n1)-c1ccc(C(=O)N[C@@]2(CCc3nc4cc(C)ccc4n3C2)c2ccccc2)c(Cl)c1 |r| Show InChI InChI=1S/C28H25ClN6O/c1-18-8-11-25-24(14-18)31-26-12-13-28(16-34(25)26,20-6-4-3-5-7-20)32-27(36)22-10-9-21(15-23(22)29)35-17-30-19(2)33-35/h3-11,14-15,17H,12-13,16H2,1-2H3,(H,32,36)/t28-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.61 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM406025
(US10351558, Example 200)Show SMILES COc1ccc(cn1)-c1c2CC[C@](Cn2c2ccc(C)cc12)(NC(=O)c1ccc(cc1Cl)-n1cnnc1)c1ccccc1 |r| Show InChI InChI=1S/C34H29ClN6O2/c1-22-8-12-29-27(16-22)32(23-9-13-31(43-2)36-18-23)30-14-15-34(19-41(29)30,24-6-4-3-5-7-24)39-33(42)26-11-10-25(17-28(26)35)40-20-37-38-21-40/h3-13,16-18,20-21H,14-15,19H2,1-2H3,(H,39,42)/t34-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.63 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp
US Patent
| Assay Description
TBD |
US Patent US10351558 (2019)
BindingDB Entry DOI: 10.7270/Q2SX6GKR |
More data for this
Ligand-Target Pair | |
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