Compile Data Set for Download or QSAR

Found 61 hits with Last Name = 'bodendorf' and Initial = 'u'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546132 (CHEMBL4759048) Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N(C[C@H](O)[C@@H](N)c1ccc(OC(F)(F)F)cc1)C1CCC1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of SPPL2a in human U2OS cells cotransfected with EGFP-labeled TNFalpha (1 to 76 residues)-NTF incubated for 24 hrs by Hoechst staining bas...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Mus musculus)	BDBM50546132 (CHEMBL4759048) Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N(C[C@H](O)[C@@H](N)c1ccc(OC(F)(F)F)cc1)C1CCC1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of mouse SPPL2a cotransfected with EGFP-NLP-fused TNFalpha (1 to 77 residues)-NTF incubated for 24 hrs by Hoechst staining based Cellomics...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50262993 (CHEMBL4059711) Show SMILES C[C@H](CC(=O)Nc1cc(F)cc(F)c1)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r| Show InChI InChI=1S/C23H24F2N4O3/c1-14(9-20(30)26-18-11-16(24)10-17(25)12-18)22(31)27-21-19-6-3-2-5-15(19)13-28-7-4-8-29(28)23(21)32/h2-3,5-6,10-12,14,21H,4,7-9,13H2,1H3,(H,26,30)(H,27,31)/t14-,21+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50263008 (CHEMBL255473) Show SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 Show InChI InChI=1S/C43H64N6O9/c1-27(2)19-34(46-40(53)36(21-29(5)6)48-42(55)57-25-31-15-11-9-12-16-31)38(51)44-23-33(50)24-45-39(52)35(20-28(3)4)47-41(54)37(22-30(7)8)49-43(56)58-26-32-17-13-10-14-18-32/h9-18,27-30,34-37H,19-26H2,1-8H3,(H,44,51)(H,45,52)(H,46,53)(H,47,54)(H,48,55)(H,49,56)/t34-,35-,36-,37-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546130 (CHEMBL4762492) Show SMILES CC(C)(C)c1cccc(c1)S(=O)(=O)N(C[C@H](O)[C@@H](N)c1ccccc1)C1CCC1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546132 (CHEMBL4759048) Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N(C[C@H](O)[C@@H](N)c1ccc(OC(F)(F)F)cc1)C1CCC1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50241259 ((2S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetam...) Show SMILES C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@H]1c2ccccc2-c2ccccc2N(C)C1=O |r| Show InChI InChI=1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546128 (CHEMBL4753654) Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)S(=O)(=O)N(C[C@H](O)[C@@H](N)c1ccccc1)C1CCC1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546125 (CHEMBL4792187) Show SMILES N[C@H]([C@@H](O)CN(C1CCCCCC1)S(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546131 (CHEMBL4759943) Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N(C[C@H](O)[C@@H](N)c1ccccc1)C1CCC1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50262979 (CHEMBL4077007) Show SMILES C[C@H](CC(=O)Nc1ccccc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r| Show InChI InChI=1S/C24H28N4O3/c1-16-8-3-6-11-20(16)25-21(29)14-17(2)23(30)26-22-19-10-5-4-9-18(19)15-27-12-7-13-28(27)24(22)31/h3-6,8-11,17,22H,7,12-15H2,1-2H3,(H,25,29)(H,26,30)/t17-,22+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50263007 (CHEMBL4076827) Show SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r| Show InChI InChI=1S/C23H26FN5O3/c1-14(10-20(30)26-19-11-17(24)12-25-15(19)2)22(31)27-21-18-7-4-3-6-16(18)13-28-8-5-9-29(28)23(21)32/h3-4,6-7,11-12,14,21H,5,8-10,13H2,1-2H3,(H,26,30)(H,27,31)/t14-,21+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Mus musculus)	BDBM50263007 (CHEMBL4076827) Show SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r| Show InChI InChI=1S/C23H26FN5O3/c1-14(10-20(30)26-19-11-17(24)12-25-15(19)2)22(31)27-21-18-7-4-3-6-16(18)13-28-8-5-9-29(28)23(21)32/h3-4,6-7,11-12,14,21H,5,8-10,13H2,1-2H3,(H,26,30)(H,27,31)/t14-,21+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of SPPL2a in mouse whole blood assessed as increase in CD74/p8 accumulation after 5.5 hrs by Western bot method				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Similar to RIKEN cDNA 2010106G01 (Predicted) (Rattus norvegicus)	BDBM50263004 (CHEMBL4069936) Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r| Show InChI InChI=1S/C27H28FN5O4/c1-15-21(10-17(28)12-29-15)30-22(34)11-20(16-6-7-16)24(35)31-23-18-4-2-3-5-19(18)25(36)32-13-27(8-9-27)14-33(32)26(23)37/h2-5,10,12,16,20,23H,6-9,11,13-14H2,1H3,(H,30,34)(H,31,35)/t20-,23-/m0/s1	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of rat SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 77 residues) NLS as substrate after 24 hrs by Hoechst staini...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50262968 (CHEMBL4064631) Show SMILES C[C@H](CC(=O)Nc1cccc(C)c1)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r| Show InChI InChI=1S/C24H28N4O3/c1-16-7-5-9-19(13-16)25-21(29)14-17(2)23(30)26-22-20-10-4-3-8-18(20)15-27-11-6-12-28(27)24(22)31/h3-5,7-10,13,17,22H,6,11-12,14-15H2,1-2H3,(H,25,29)(H,26,30)/t17-,22+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50263010 (CHEMBL4100749) Show SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2cccc(F)c2CN2CCCN2C1=O |r| Show InChI InChI=1S/C23H25F2N5O3/c1-13(9-20(31)27-19-10-15(24)11-26-14(19)2)22(32)28-21-16-5-3-6-18(25)17(16)12-29-7-4-8-30(29)23(21)33/h3,5-6,10-11,13,21H,4,7-9,12H2,1-2H3,(H,27,31)(H,28,32)/t13-,21+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50263004 (CHEMBL4069936) Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r| Show InChI InChI=1S/C27H28FN5O4/c1-15-21(10-17(28)12-29-15)30-22(34)11-20(16-6-7-16)24(35)31-23-18-4-2-3-5-19(18)25(36)32-13-27(8-9-27)14-33(32)26(23)37/h2-5,10,12,16,20,23H,6-9,11,13-14H2,1H3,(H,30,34)(H,31,35)/t20-,23-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50263004 (CHEMBL4069936) Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r| Show InChI InChI=1S/C27H28FN5O4/c1-15-21(10-17(28)12-29-15)30-22(34)11-20(16-6-7-16)24(35)31-23-18-4-2-3-5-19(18)25(36)32-13-27(8-9-27)14-33(32)26(23)37/h2-5,10,12,16,20,23H,6-9,11,13-14H2,1H3,(H,30,34)(H,31,35)/t20-,23-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells using GAL4-VP16 fusedTNFalpha (1 to 76)-NTF as substrate after 24 hrs by Bright-Glo luciferase r...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546124 (CHEMBL4740837) Show SMILES N[C@H]([C@@H](O)CN(C1CCC1)S(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Mus musculus)	BDBM50263007 (CHEMBL4076827) Show SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r| Show InChI InChI=1S/C23H26FN5O3/c1-14(10-20(30)26-19-11-17(24)12-25-15(19)2)22(31)27-21-18-7-4-3-6-16(18)13-28-8-5-9-29(28)23(21)32/h3-4,6-7,11-12,14,21H,5,8-10,13H2,1-2H3,(H,26,30)(H,27,31)/t14-,21+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometry				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Mus musculus)	BDBM50263010 (CHEMBL4100749) Show SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2cccc(F)c2CN2CCCN2C1=O |r| Show InChI InChI=1S/C23H25F2N5O3/c1-13(9-20(31)27-19-10-15(24)11-26-14(19)2)22(32)28-21-16-5-3-6-18(25)17(16)12-29-7-4-8-30(29)23(21)33/h3,5-6,10-11,13,21H,4,7-9,12H2,1-2H3,(H,27,31)(H,28,32)/t13-,21+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	121	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometry				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Mus musculus)	BDBM50263004 (CHEMBL4069936) Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r| Show InChI InChI=1S/C27H28FN5O4/c1-15-21(10-17(28)12-29-15)30-22(34)11-20(16-6-7-16)24(35)31-23-18-4-2-3-5-19(18)25(36)32-13-27(8-9-27)14-33(32)26(23)37/h2-5,10,12,16,20,23H,6-9,11,13-14H2,1H3,(H,30,34)(H,31,35)/t20-,23-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometry				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Mus musculus)	BDBM50546132 (CHEMBL4759048) Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N(C[C@H](O)[C@@H](N)c1ccc(OC(F)(F)F)cc1)C1CCC1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of SPPL2a in Balb/c mouse A20 cells assessed as reduction in CD74/p8 NTF accumulation incubated for overnight by Western blot analysis				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Mus musculus)	BDBM50263004 (CHEMBL4069936) Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r| Show InChI InChI=1S/C27H28FN5O4/c1-15-21(10-17(28)12-29-15)30-22(34)11-20(16-6-7-16)24(35)31-23-18-4-2-3-5-19(18)25(36)32-13-27(8-9-27)14-33(32)26(23)37/h2-5,10,12,16,20,23H,6-9,11,13-14H2,1H3,(H,30,34)(H,31,35)/t20-,23-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of mouse SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 77 residues) NLS as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546118 (CHEMBL4762370) Show SMILES CC(C)CN(C[C@H](O)[C@@H](N)c1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50263005 (CHEMBL4077336) Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CCCN2C1=O |r| Show InChI InChI=1S/C25H26FN5O4/c1-14-20(11-16(26)13-27-14)28-21(32)12-19(15-7-8-15)23(33)29-22-17-5-2-3-6-18(17)24(34)30-9-4-10-31(30)25(22)35/h2-3,5-6,11,13,15,19,22H,4,7-10,12H2,1H3,(H,28,32)(H,29,33)/t19-,22-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	225	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2B (Homo sapiens)	BDBM50546132 (CHEMBL4759048) Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N(C[C@H](O)[C@@H](N)c1ccc(OC(F)(F)F)cc1)C1CCC1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of SPPL2b in human U2OS cells cotransfected with EGFP-labeled TNFalpha (1 to 76 residues)-NTF incubated for 24 hrs by Hoechst staining bas...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546122 (CHEMBL4747630) Show SMILES CC(C)ON(C[C@H](O)[C@@H](N)c1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Mus musculus)	BDBM50262979 (CHEMBL4077007) Show SMILES C[C@H](CC(=O)Nc1ccccc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r| Show InChI InChI=1S/C24H28N4O3/c1-16-8-3-6-11-20(16)25-21(29)14-17(2)23(30)26-22-19-10-5-4-9-18(19)15-27-12-7-13-28(27)24(22)31/h3-6,8-11,17,22H,7,12-15H2,1-2H3,(H,25,29)(H,26,30)/t17-,22+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometry				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2B (Homo sapiens)	BDBM50263004 (CHEMBL4069936) Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r| Show InChI InChI=1S/C27H28FN5O4/c1-15-21(10-17(28)12-29-15)30-22(34)11-20(16-6-7-16)24(35)31-23-18-4-2-3-5-19(18)25(36)32-13-27(8-9-27)14-33(32)26(23)37/h2-5,10,12,16,20,23H,6-9,11,13-14H2,1H3,(H,30,34)(H,31,35)/t20-,23-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2b expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Mus musculus)	BDBM50263005 (CHEMBL4077336) Show SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CCCN2C1=O |r| Show InChI InChI=1S/C25H26FN5O4/c1-14-20(11-16(26)13-27-14)28-21(32)12-19(15-7-8-15)23(33)29-22-17-5-2-3-6-18(17)24(34)30-9-4-10-31(30)25(22)35/h2-3,5-6,11,13,15,19,22H,4,7-10,12H2,1H3,(H,28,32)(H,29,33)/t19-,22-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	496	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometry				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Mus musculus)	BDBM50262979 (CHEMBL4077007) Show SMILES C[C@H](CC(=O)Nc1ccccc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r| Show InChI InChI=1S/C24H28N4O3/c1-16-8-3-6-11-20(16)25-21(29)14-17(2)23(30)26-22-19-10-5-4-9-18(19)15-27-12-7-13-28(27)24(22)31/h3-6,8-11,17,22H,7,12-15H2,1-2H3,(H,25,29)(H,26,30)/t17-,22+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of SPPL2a in mouse whole blood assessed as increase in CD74/p8 accumulation after 5.5 hrs by Western bot method				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546123 (CHEMBL4789381) Show SMILES N[C@H]([C@@H](O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546129 (CHEMBL4785324) Show SMILES N[C@H]([C@@H](O)CN(C1CCC1)S(=O)(=O)c1ccc2scnc2c1)c1ccccc1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546120 (CHEMBL4743609) Show SMILES CC(C)CN(C[C@H](O)[C@@H](N)Cc1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50263006 (CHEMBL4074838) Show SMILES C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2ccccc2C(=O)N2CCCN2C1=O |r| Show InChI InChI=1S/C23H24FN5O4/c1-13(10-19(30)26-18-11-15(24)12-25-14(18)2)21(31)27-20-16-6-3-4-7-17(16)22(32)28-8-5-9-29(28)23(20)33/h3-4,6-7,11-13,20H,5,8-10H2,1-2H3,(H,26,30)(H,27,31)/t13-,20+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546127 (CHEMBL4753079) Show SMILES CC1(CCC1)N(C[C@H](O)[C@@H](N)c1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546121 (CHEMBL4798232) Show SMILES CC(C)(O)CN(C[C@H](O)[C@@H](N)c1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50262965 (CHEMBL4105093) Show SMILES C[C@H](CC(=O)Nc1cccnc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r| Show InChI InChI=1S/C23H27N5O3/c1-15(13-20(29)25-19-9-5-10-24-16(19)2)22(30)26-21-18-8-4-3-7-17(18)14-27-11-6-12-28(27)23(21)31/h3-5,7-10,15,21H,6,11-14H2,1-2H3,(H,25,29)(H,26,30)/t15-,21+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50546132 (CHEMBL4759048) Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N(C[C@H](O)[C@@H](N)c1ccc(OC(F)(F)F)cc1)C1CCC1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50262967 (CHEMBL4075787) Show SMILES C[C@H](CC(=O)Nc1ccc(C)cc1)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r| Show InChI InChI=1S/C24H28N4O3/c1-16-8-10-19(11-9-16)25-21(29)14-17(2)23(30)26-22-20-7-4-3-6-18(20)15-27-12-5-13-28(27)24(22)31/h3-4,6-11,17,22H,5,12-15H2,1-2H3,(H,25,29)(H,26,30)/t17-,22+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546126 (CHEMBL4741014) Show SMILES N[C@H]([C@@H](O)CN(C1COC1)S(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50546128 (CHEMBL4753654) Show SMILES CC1(C)CCC(C)(C)c2cc(ccc12)S(=O)(=O)N(C[C@H](O)[C@@H](N)c1ccccc1)C1CCC1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50546125 (CHEMBL4792187) Show SMILES N[C@H]([C@@H](O)CN(C1CCCCCC1)S(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50262966 (CHEMBL4086098) Show SMILES C[C@H](CC(=O)Nc1ccccc1C(F)(F)F)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r| Show InChI InChI=1S/C24H25F3N4O3/c1-15(13-20(32)28-19-10-5-4-9-18(19)24(25,26)27)22(33)29-21-17-8-3-2-7-16(17)14-30-11-6-12-31(30)23(21)34/h2-5,7-10,15,21H,6,11-14H2,1H3,(H,28,32)(H,29,33)/t15-,21+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.85E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States. Curated by ChEMBL					Assay Description Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...				J Med Chem 61: 865-880 (2018) Article DOI: 10.1021/acs.jmedchem.7b01371 BindingDB Entry DOI: 10.7270/Q2JM2D49
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50546123 (CHEMBL4789381) Show SMILES N[C@H]([C@@H](O)CN(Cc1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50546131 (CHEMBL4759943) Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N(C[C@H](O)[C@@H](N)c1ccccc1)C1CCC1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50546130 (CHEMBL4762492) Show SMILES CC(C)(C)c1cccc(c1)S(=O)(=O)N(C[C@H](O)[C@@H](N)c1ccccc1)C1CCC1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Signal peptide peptidase-like 2A (Homo sapiens)	BDBM50546119 (CHEMBL4762488) Show SMILES CC(C)CN(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 |r| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human))	BDBM50546118 (CHEMBL4762370) Show SMILES CC(C)CN(C[C@H](O)[C@@H](N)c1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...				Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z
					More data for this Ligand-Target Pair

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