| Reaction Details |
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 | Report a problem with these data |
| Target | Signal peptide peptidase-like 2A |
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| Ligand | BDBM50263004 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1697373 (CHEMBL4048263) |
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| IC50 | 77±n/a nM |
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| Citation |  Velcicky, J; Bodendorf, U; Rigollier, P; Epple, R; Beisner, DR; Guerini, D; Smith, P; Liu, B; Feifel, R; Wipfli, P; Aichholz, R; Couttet, P; Dix, I; Widmer, T; Wen, B; Brandl, T Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo. J Med Chem61:865-880 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Signal peptide peptidase-like 2A |
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| Name: | Signal peptide peptidase-like 2A |
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| Synonyms: | 3.4.23.- | IMP-3 | IMP3 | Intramembrane protease 3 | PSL2 | Presenilin-like protein 2 | SPP-like 2A | SPP2A_HUMAN | SPPL2A | Signal peptide peptidase-like 2A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58152.61 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117438 |
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| Residue: | 520 |
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| Sequence: | MGPQRRLSPAGAALLWGFLLQLTAAQEAILHASGNGTTKDYCMLYNPYWTALPSTLENAT
SISLMNLTSTPLCNLSDIPPVGIKSKAVVVPWGSCHFLEKARIAQKGGAEAMLVVNNSVL
FPPSGNRSEFPDVKILIAFISYKDFRDMNQTLGDNITVKMYSPSWPNFDYTMVVIFVIAV
FTVALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTFSPLTVVIFVVICCVMMVLLYFF
YKWLVYVMIAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKNMEVRLIFLSGLCIAVA
VVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFKSCVILLGLLLLYDVFFVFITPF
ITKNGESIMVELAAGPFGNNEKLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLI
AYCRRFDVQTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASVVA
WRRKEMKKFWKGNSYQMMDHLDCATNEENPVISGEQIVQQ
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| BDBM50263004 |
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| n/a |
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| Name | BDBM50263004 |
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| Synonyms: | CHEMBL4069936 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H28FN5O4 |
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| Mol. Mass. | 505.5407 |
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| SMILES | Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O |r| |
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| Structure | 
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