Reaction Details |
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Target | Signal peptide peptidase-like 2A |
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Ligand | BDBM50263007 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1697375 |
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IC50 | 44±n/a nM |
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Citation | Velcicky, J; Bodendorf, U; Rigollier, P; Epple, R; Beisner, DR; Guerini, D; Smith, P; Liu, B; Feifel, R; Wipfli, P; Aichholz, R; Couttet, P; Dix, I; Widmer, T; Wen, B; Brandl, T Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo. J Med Chem61:865-880 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Signal peptide peptidase-like 2A |
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Name: | Signal peptide peptidase-like 2A |
Synonyms: | 3.4.23.- | IMP-3 | IMP3 | Intramembrane protease 3 | PSL2 | Presenilin-like protein 2 | SPP-like 2A | SPP2A_HUMAN | SPPL2A | Signal peptide peptidase-like 2A |
Type: | PROTEIN |
Mol. Mass.: | 58152.61 |
Organism: | Homo sapiens |
Description: | ChEMBL_117438 |
Residue: | 520 |
Sequence: | MGPQRRLSPAGAALLWGFLLQLTAAQEAILHASGNGTTKDYCMLYNPYWTALPSTLENAT
SISLMNLTSTPLCNLSDIPPVGIKSKAVVVPWGSCHFLEKARIAQKGGAEAMLVVNNSVL
FPPSGNRSEFPDVKILIAFISYKDFRDMNQTLGDNITVKMYSPSWPNFDYTMVVIFVIAV
FTVALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTFSPLTVVIFVVICCVMMVLLYFF
YKWLVYVMIAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKNMEVRLIFLSGLCIAVA
VVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFKSCVILLGLLLLYDVFFVFITPF
ITKNGESIMVELAAGPFGNNEKLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLI
AYCRRFDVQTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASVVA
WRRKEMKKFWKGNSYQMMDHLDCATNEENPVISGEQIVQQ
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BDBM50263007 |
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n/a |
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Name | BDBM50263007 |
Synonyms: | CHEMBL4076827 |
Type | Small organic molecule |
Emp. Form. | C23H26FN5O3 |
Mol. Mass. | 439.4826 |
SMILES | C[C@H](CC(=O)Nc1cc(F)cnc1C)C(=O)N[C@H]1c2ccccc2CN2CCCN2C1=O |r| |
Structure |
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