Found 292 hits with Last Name = 'ngo' and Initial = 'vth' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581458
(CHEMBL5092802)Show SMILES COc1cc(ccc1OCCN1CCOCC1)N(CC1CCCC1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581397
(CHEMBL5085353)Show SMILES COc1cc(NC(=S)N(CCCn2cncc2C)C(C)C)ccc1OCCCCc1ccnc(N)c1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581442
(CHEMBL5086776)Show SMILES COc1cc(ccc1OCCN1CCNCC1)N(CC1CCCC1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.460 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581399
(CHEMBL5085226)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(C1CCCC1)C(=S)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581400
(CHEMBL5075575)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(C1CCCCC1)C(=S)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581426
(CHEMBL5089771)Show SMILES COc1cc(ccc1OCCCCN(C)C)N(C1CCN(C)CC1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581398
(CHEMBL5083519)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(C1CCC1)C(=S)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581412
(CHEMBL5088732)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(Cc1ccccc1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581450
(CHEMBL5085670)Show SMILES COc1cc(ccc1OCCN1CCN(C)CC1)N(CC1CCCC1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50519290
(CHEMBL4525926)Show SMILES COc1ccc(cc1OC)N(Cc1ccc(F)cc1)C(=S)NCCCn1cncc1C Show InChI InChI=1S/C23H27FN4O2S/c1-17-14-25-16-27(17)12-4-11-26-23(31)28(15-18-5-7-19(24)8-6-18)20-9-10-21(29-2)22(13-20)30-3/h5-10,13-14,16H,4,11-12,15H2,1-3H3,(H,26,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751 BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581445
(CHEMBL5089285)Show SMILES COc1cc(ccc1OCCN1CCNCC1)N(Cc1ccc(F)cc1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581441
(CHEMBL5081653)Show SMILES COc1cc(ccc1OCCN1CCNCC1)N(C1CCCCC1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581443
(CHEMBL5083687)Show SMILES COc1cc(ccc1OCCN1CCNCC1)N(C1CCN(C)CC1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581436
(CHEMBL5081891)Show SMILES COc1cc(ccc1OCCc1ccnc(N)c1)N(Cc1ccc(F)cc1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50519285
(CHEMBL4445407)Show SMILES COc1ccc(cc1OC)N(CCCCc1ccnc(NCCN)c1)C(=O)NCCCn1cncc1C Show InChI InChI=1S/C27H39N7O3/c1-21-19-29-20-33(21)15-6-12-32-27(35)34(23-8-9-24(36-2)25(18-23)37-3)16-5-4-7-22-10-13-30-26(17-22)31-14-11-28/h8-10,13,17-20H,4-7,11-12,14-16,28H2,1-3H3,(H,30,31)(H,32,35) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751 BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581434
(CHEMBL5081537)Show SMILES COc1cc(ccc1OCCc1ccnc(N)c1)N(C1CCCCC1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581451
(CHEMBL5092925)Show SMILES COc1cc(ccc1OCCN1CCN(C)CC1)N(C1CCN(C)CC1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50454733
(CHEMBL4204093)Show SMILES COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCc1ccnc(NCCN)c1 Show InChI InChI=1S/C26H37N7O2S/c1-20-18-28-19-33(20)14-5-11-31-26(36)32-22-7-8-23(24(17-22)34-2)35-15-4-3-6-21-9-12-29-25(16-21)30-13-10-27/h7-9,12,16-19H,3-6,10-11,13-15,27H2,1-2H3,(H,29,30)(H2,31,32,36) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Inhibition of human glutaminyl cyclase using Gln-AMC as substrate by pGAPase coupled fluorescence assay |
Bioorg Med Chem 26: 1035-1049 (2018)
Article DOI: 10.1016/j.bmc.2018.01.015 BindingDB Entry DOI: 10.7270/Q2SN0CKG |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50612645
(CHEMBL5279792)Show SMILES Cc1cncn1CCCNC(=O)N(C1CCCCC1)c1ccc2[nH]nc(C)c2c1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50612631
(CHEMBL5266674)Show SMILES Cc1cncn1CCCNC(=O)N(Cc1ccc(F)cc1)c1ccc2c(C)nn(C)c2c1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581448
(CHEMBL5094369)Show SMILES COc1cc(ccc1OCCN1CCN(C)CC1)N(C(C)C)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581460
(CHEMBL5084485)Show SMILES COc1cc(ccc1OCCN1CCOCC1)N(Cc1ccc(F)cc1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581422
(CHEMBL5079181)Show SMILES COc1cc(ccc1OCCCN(C)C)N(C1CCCCC1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581410
(CHEMBL5081843)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(C1CCN(C)CC1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50519280
(CHEMBL4464130)Show InChI InChI=1S/C19H28N4O2S/c1-14(2)23(16-7-8-17(24-4)18(11-16)25-5)19(26)21-9-6-10-22-13-20-12-15(22)3/h7-8,11-14H,6,9-10H2,1-5H3,(H,21,26) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751 BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50612648
(CHEMBL5266206)Show SMILES Cc1cncn1CCCNC(=O)N(Cc1ccc(F)cc1)c1ccc2n(C)nc(C)c2c1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581453
(CHEMBL5076836)Show SMILES COc1cc(ccc1OCCN1CCN(C)CC1)N(Cc1cccnc1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50612627
(CHEMBL5282127)Show SMILES Cc1cncn1CCCNC(=O)N(C1CCCCC1)c1ccc2c(C)n[nH]c2c1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50519269
(CHEMBL4539841)Show SMILES COc1ccc(cc1OC)N(Cc1cccc(F)c1)C(=S)NCCCn1cncc1C Show InChI InChI=1S/C23H27FN4O2S/c1-17-14-25-16-27(17)11-5-10-26-23(31)28(15-18-6-4-7-19(24)12-18)20-8-9-21(29-2)22(13-20)30-3/h4,6-9,12-14,16H,5,10-11,15H2,1-3H3,(H,26,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751 BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581409
(CHEMBL5088413)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(CC1CCCC1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50612630
(CHEMBL5289328)Show SMILES Cc1cncn1CCCNC(=O)N(CC1CCCC1)c1ccc2c(C)nn(C)c2c1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581473
(CHEMBL5088100)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(Cc1ccc(F)cc1)C(=O)NCc1ccc2[nH]cnc2c1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581452
(CHEMBL5092800)Show SMILES COc1cc(ccc1OCCN1CCN(C)CC1)N(Cc1ccc(F)cc1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50519268
(CHEMBL4586501)Show SMILES COc1ccc(cc1OC)N(Cc1cccc(Cl)c1)C(=S)NCCCn1cncc1C Show InChI InChI=1S/C23H27ClN4O2S/c1-17-14-25-16-27(17)11-5-10-26-23(31)28(15-18-6-4-7-19(24)12-18)20-8-9-21(29-2)22(13-20)30-3/h4,6-9,12-14,16H,5,10-11,15H2,1-3H3,(H,26,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751 BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50454731
(CHEMBL4208618)Show SMILES COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCN1CCN(CCOCCN)CC1 Show InChI InChI=1S/C25H41N7O3S/c1-21-19-27-20-32(21)8-3-7-28-25(36)29-22-4-5-23(24(18-22)33-2)35-17-14-31-11-9-30(10-12-31)13-16-34-15-6-26/h4-5,18-20H,3,6-17,26H2,1-2H3,(H2,28,29,36) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Inhibition of human glutaminyl cyclase using Gln-AMC as substrate by pGAPase coupled fluorescence assay |
Bioorg Med Chem 26: 1035-1049 (2018)
Article DOI: 10.1016/j.bmc.2018.01.015 BindingDB Entry DOI: 10.7270/Q2SN0CKG |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50519240
(CHEMBL4547037)Show SMILES COc1ccc(cc1OC)N(CCCCc1ccnc(N)c1)C(=O)NCCCn1cncc1C Show InChI InChI=1S/C25H34N6O3/c1-19-17-27-18-30(19)13-6-11-29-25(32)31(21-8-9-22(33-2)23(16-21)34-3)14-5-4-7-20-10-12-28-24(26)15-20/h8-10,12,15-18H,4-7,11,13-14H2,1-3H3,(H2,26,28)(H,29,32) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751 BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581408
(CHEMBL5088872)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(C1CCCCC1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581435
(CHEMBL5089539)Show SMILES COc1cc(ccc1OCCc1ccnc(N)c1)N(C1CCN(C)CC1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50454751
(CHEMBL4212160)Show SMILES COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCN1CCN(CCN)CC1 Show InChI InChI=1S/C24H39N7O2S/c1-20-18-26-19-31(20)10-3-8-27-24(34)28-21-5-6-22(23(17-21)32-2)33-16-4-9-29-12-14-30(11-7-25)15-13-29/h5-6,17-19H,3-4,7-16,25H2,1-2H3,(H2,27,28,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Inhibition of human glutaminyl cyclase using Gln-AMC as substrate by pGAPase coupled fluorescence assay |
Bioorg Med Chem 26: 1035-1049 (2018)
Article DOI: 10.1016/j.bmc.2018.01.015 BindingDB Entry DOI: 10.7270/Q2SN0CKG |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581446
(CHEMBL5092266)Show SMILES COc1cc(ccc1OCCN1CCNCC1)N(Cc1cccnc1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581444
(CHEMBL5087075)Show SMILES COc1cc(ccc1OCCN1CCNCC1)N(C(=O)NCCCn1cncc1C)c1ccccc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50519259
(CHEMBL4448303)Show SMILES COc1ccc(cc1OC)N(Cc1ccc(F)cc1)C(=O)NCCCn1cncc1C Show InChI InChI=1S/C23H27FN4O3/c1-17-14-25-16-27(17)12-4-11-26-23(29)28(15-18-5-7-19(24)8-6-18)20-9-10-21(30-2)22(13-20)31-3/h5-10,13-14,16H,4,11-12,15H2,1-3H3,(H,26,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751 BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581468
(CHEMBL5076908)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(C1CCCCC1)C(=O)NCc1ccc2[nH]cnc2c1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50519272
(CHEMBL4445143)Show InChI InChI=1S/C22H32N4O2S/c1-17-14-23-16-25(17)12-6-11-24-22(29)26(15-18-7-4-5-8-18)19-9-10-20(27-2)21(13-19)28-3/h9-10,13-14,16,18H,4-8,11-12,15H2,1-3H3,(H,24,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751 BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581413
(CHEMBL5079213)Show SMILES COc1cc(ccc1OCCCCc1ccnc(N)c1)N(Cc1ccc(F)cc1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50612650
(CHEMBL5273104)Show SMILES Cc1cncn1CCCNC(=O)N(C1CCCCC1)c1ccc2n(C)nc(C)c2c1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50581461
(CHEMBL5079847)Show SMILES COc1cc(ccc1OCCN1CCOCC1)N(Cc1cccnc1)C(=O)NCCCn1cncc1C | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50237457
(CHEMBL4097599)Show SMILES COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCc1ccnc(N)c1 Show InChI InChI=1S/C24H32N6O2S/c1-18-16-26-17-30(18)12-5-10-28-24(33)29-20-7-8-21(22(15-20)31-2)32-13-4-3-6-19-9-11-27-23(25)14-19/h7-9,11,14-17H,3-6,10,12-13H2,1-2H3,(H2,25,27)(H2,28,29,33) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113819 BindingDB Entry DOI: 10.7270/Q2M61Q44 |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50237457
(CHEMBL4097599)Show SMILES COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCc1ccnc(N)c1 Show InChI InChI=1S/C24H32N6O2S/c1-18-16-26-17-30(18)12-5-10-28-24(33)29-20-7-8-21(22(15-20)31-2)32-13-4-3-6-19-9-11-27-23(25)14-19/h7-9,11,14-17H,3-6,10,12-13H2,1-2H3,(H2,25,27)(H2,28,29,33) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751 BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this Ligand-Target Pair | |
Glutaminyl-peptide cyclotransferase
(Homo sapiens (Human)) | BDBM50519261
(CHEMBL4549443)Show InChI InChI=1S/C22H32N4O3/c1-17-15-23-16-25(17)13-7-12-24-22(27)26(18-8-5-4-6-9-18)19-10-11-20(28-2)21(14-19)29-3/h10-11,14-16,18H,4-9,12-13H2,1-3H3,(H,24,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect ce... |
J Med Chem 62: 8011-8027 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00751 BindingDB Entry DOI: 10.7270/Q2W0999V |
More data for this Ligand-Target Pair | |