| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminyl-peptide cyclotransferase |
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| Ligand | BDBM50581450 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2151037 (CHEMBL5035499) |
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| IC50 | 1.000000±n/a nM |
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| Citation |  Van Manh, N; Hoang, VH; Ngo, VTH; Ann, J; Jang, TH; Ha, JH; Song, JY; Ha, HJ; Kim, H; Kim, YH; Lee, J; Lee, J Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design. Eur J Med Chem226:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutaminyl-peptide cyclotransferase |
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| Name: | Glutaminyl-peptide cyclotransferase |
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| Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 40877.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16769 |
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| Residue: | 361 |
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| Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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| BDBM50581450 |
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| n/a |
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| Name | BDBM50581450 |
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| Synonyms: | CHEMBL5085670 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H44N6O3 |
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| Mol. Mass. | 512.6874 |
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| SMILES | COc1cc(ccc1OCCN1CCN(C)CC1)N(CC1CCCC1)C(=O)NCCCn1cncc1C |
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| Structure | 
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