Compile Data Set for Download or QSAR

Found 120 hits with Last Name = 'adiey' and Initial = 'k'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(2) dopamine receptor (Homo sapiens (Human))	BDBM312156 (6-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butoxy)-2H...) Show SMILES COc1ccccc1N1CCN(CCCCOc2ccc3OCC(=O)Nc3c2)CC1 Show InChI InChI=1S/C23H29N3O4/c1-28-22-7-3-2-6-20(22)26-13-11-25(12-14-26)10-4-5-15-29-18-8-9-21-19(16-18)24-23(27)17-30-21/h2-3,6-9,16H,4-5,10-15,17H2,1H3,(H,24,27)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.300	n/a	0.980	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description Receptor Source: Human recombinant expressed in CHO cells Radioligand: [3H]Spiperone (20-60 Ci/mmol) Control Compound: Haloperidol Incubatio...				US Patent US9604944 (2017) BindingDB Entry DOI: 10.7270/Q2ZW1NZ2
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM312156 (6-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butoxy)-2H...) Show SMILES COc1ccccc1N1CCN(CCCCOc2ccc3OCC(=O)Nc3c2)CC1 Show InChI InChI=1S/C23H29N3O4/c1-28-22-7-3-2-6-20(22)26-13-11-25(12-14-26)10-4-5-15-29-18-8-9-21-19(16-18)24-23(27)17-30-21/h2-3,6-9,16H,4-5,10-15,17H2,1H3,(H,24,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kochi Medical School					Assay Description Dopamine, D2S: Materials and Methods: Receptor Source: Human recombinant expressed in CHO cells Radioligand: [3H]Spiperone (20-60 Ci/mmol) C...				J Med Chem 52: 2226-32 (2009) BindingDB Entry DOI: 10.7270/Q2QZ2D9J
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM312188 (6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...) Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4OCC(=O)Nc4c3)CC2)c1Cl Show InChI InChI=1S/C22H25Cl2N3O3/c23-17-4-3-5-19(22(17)24)27-11-9-26(10-12-27)8-1-2-13-29-16-6-7-20-18(14-16)25-21(28)15-30-20/h3-7,14H,1-2,8-13,15H2,(H,25,28)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	0.610	n/a	1.96	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description Receptor Source: Human recombinant expressed in CHO cells Radioligand: [3H]Spiperone (20-60 Ci/mmol) Control Compound: Haloperidol Incubatio...				US Patent US9604944 (2017) BindingDB Entry DOI: 10.7270/Q2ZW1NZ2
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM312188 (6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...) Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4OCC(=O)Nc4c3)CC2)c1Cl Show InChI InChI=1S/C22H25Cl2N3O3/c23-17-4-3-5-19(22(17)24)27-11-9-26(10-12-27)8-1-2-13-29-16-6-7-20-18(14-16)25-21(28)15-30-20/h3-7,14H,1-2,8-13,15H2,(H,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	0.610	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kochi Medical School					Assay Description Dopamine, D2S: Materials and Methods: Receptor Source: Human recombinant expressed in CHO cells Radioligand: [3H]Spiperone (20-60 Ci/mmol) C...				J Med Chem 52: 2226-32 (2009) BindingDB Entry DOI: 10.7270/Q2QZ2D9J
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM312156 (6-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butoxy)-2H...) Show SMILES COc1ccccc1N1CCN(CCCCOc2ccc3OCC(=O)Nc3c2)CC1 Show InChI InChI=1S/C23H29N3O4/c1-28-22-7-3-2-6-20(22)26-13-11-25(12-14-26)10-4-5-15-29-18-8-9-21-19(16-18)24-23(27)17-30-21/h2-3,6-9,16H,4-5,10-15,17H2,1H3,(H,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.650	n/a	0.970	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description Receptor Source: Human recombinant expressed in HEK-293 cells Radioligand: [3H]-8-OH-DPAT (221 Ci/mmol) Control Compound: 8-OH-DPAT Incubati...				US Patent US9604944 (2017) BindingDB Entry DOI: 10.7270/Q2ZW1NZ2
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM312156 (6-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butoxy)-2H...) Show SMILES COc1ccccc1N1CCN(CCCCOc2ccc3OCC(=O)Nc3c2)CC1 Show InChI InChI=1S/C23H29N3O4/c1-28-22-7-3-2-6-20(22)26-13-11-25(12-14-26)10-4-5-15-29-18-8-9-21-19(16-18)24-23(27)17-30-21/h2-3,6-9,16H,4-5,10-15,17H2,1H3,(H,24,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.650	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kochi Medical School					Assay Description Serotonin, 5HT1A:Receptor Source: Human recombinant expressed in HEK-293 cellsRadioligand: [3H]-8-OH-DPAT (221 Ci/mmol)Control Compound: 8-OH-DPATInc...				J Med Chem 52: 2226-32 (2009) BindingDB Entry DOI: 10.7270/Q2QZ2D9J
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202585 (US10035761, Compound 8j | US9238625, 8j) Show SMILES CCOCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C21H33Cl2NO/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3/t20-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Revivia Pharmaceuticals, Inc. US Patent					Assay Description The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...				US Patent US10035761 (2018) BindingDB Entry DOI: 10.7270/Q2D220N9
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202585 (US10035761, Compound 8j | US9238625, 8j) Show SMILES CCOCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C21H33Cl2NO/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3/t20-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...				US Patent US9238625 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GKK
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM172726 (US9096515, 33a -(R)-Isomer | US9296681, 33a-(R)-Is...) Show SMILES C[C@@H](CCNCCCC(N)=O)CC1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C19H28Cl2N2O/c1-14(7-11-23-10-2-4-18(22)24)13-19(8-3-9-19)15-5-6-16(20)17(21)12-15/h5-6,12,14,23H,2-4,7-11,13H2,1H3,(H2,22,24)/t14-/m0/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.910	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The monoamine transporters inhibitory activities of selected compounds cycloalkylmethylamine derivatives comprising Formula (I) are reported herein. ...				US Patent US9096515 (2015) BindingDB Entry DOI: 10.7270/Q2Z60MTK
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM172721 (US9096515, 21a | US9296681, 21a) Show SMILES CCOC(=O)NCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H30Cl2N2O2/c1-4-26-19(25)24-11-10-23-18(12-14(2)3)20(8-5-9-20)15-6-7-16(21)17(22)13-15/h6-7,13-14,18,23H,4-5,8-12H2,1-3H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The monoamine transporters inhibitory activities of selected compounds cycloalkylmethylamine derivatives comprising Formula (I) are reported herein. ...				US Patent US9096515 (2015) BindingDB Entry DOI: 10.7270/Q2Z60MTK
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM202585 (US10035761, Compound 8j | US9238625, 8j) Show SMILES CCOCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C21H33Cl2NO/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3/t20-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Revivia Pharmaceuticals, Inc. US Patent					Assay Description The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...				US Patent US10035761 (2018) BindingDB Entry DOI: 10.7270/Q2D220N9
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM202585 (US10035761, Compound 8j | US9238625, 8j) Show SMILES CCOCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C21H33Cl2NO/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3/t20-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...				US Patent US9238625 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GKK
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202584 (US10035761, Compound 8h | US9238625, 8h) Show SMILES COCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H31Cl2NO/c1-15(2)13-19(23-11-4-5-12-24-3)20(9-6-10-20)16-7-8-17(21)18(22)14-16/h7-8,14-15,19,23H,4-6,9-13H2,1-3H3/t19-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...				US Patent US9238625 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GKK
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202584 (US10035761, Compound 8h | US9238625, 8h) Show SMILES COCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H31Cl2NO/c1-15(2)13-19(23-11-4-5-12-24-3)20(9-6-10-20)16-7-8-17(21)18(22)14-16/h7-8,14-15,19,23H,4-6,9-13H2,1-3H3/t19-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Revivia Pharmaceuticals, Inc. US Patent					Assay Description The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...				US Patent US10035761 (2018) BindingDB Entry DOI: 10.7270/Q2D220N9
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202582 (US10035761, Compound 8a | US9238625, 8a) Show SMILES CCOCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C19H29Cl2NO/c1-4-23-11-10-22-18(12-14(2)3)19(8-5-9-19)15-6-7-16(20)17(21)13-15/h6-7,13-14,18,22H,4-5,8-12H2,1-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...				US Patent US9238625 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GKK
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202582 (US10035761, Compound 8a | US9238625, 8a) Show SMILES CCOCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C19H29Cl2NO/c1-4-23-11-10-22-18(12-14(2)3)19(8-5-9-19)15-6-7-16(20)17(21)13-15/h6-7,13-14,18,22H,4-5,8-12H2,1-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Revivia Pharmaceuticals, Inc. US Patent					Assay Description The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...				US Patent US10035761 (2018) BindingDB Entry DOI: 10.7270/Q2D220N9
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM312188 (6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...) Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4OCC(=O)Nc4c3)CC2)c1Cl Show InChI InChI=1S/C22H25Cl2N3O3/c23-17-4-3-5-19(22(17)24)27-11-9-26(10-12-27)8-1-2-13-29-16-6-7-20-18(14-16)25-21(28)15-30-20/h3-7,14H,1-2,8-13,15H2,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	1.5	n/a	2.25	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description Receptor Source: Human recombinant expressed in HEK-293 cells Radioligand: [3H]-8-OH-DPAT (221 Ci/mmol) Control Compound: 8-OH-DPAT Incubati...				US Patent US9604944 (2017) BindingDB Entry DOI: 10.7270/Q2ZW1NZ2
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM172725 (US9096515, 33a -Racemic) Show SMILES CC(CCNCCCC(N)=O)CC1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C19H28Cl2N2O/c1-14(7-11-23-10-2-4-18(22)24)13-19(8-3-9-19)15-5-6-16(20)17(21)12-15/h5-6,12,14,23H,2-4,7-11,13H2,1H3,(H2,22,24)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The monoamine transporters inhibitory activities of selected compounds cycloalkylmethylamine derivatives comprising Formula (I) are reported herein. ...				US Patent US9096515 (2015) BindingDB Entry DOI: 10.7270/Q2Z60MTK
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM312188 (6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)...) Show SMILES Clc1cccc(N2CCN(CCCCOc3ccc4OCC(=O)Nc4c3)CC2)c1Cl Show InChI InChI=1S/C22H25Cl2N3O3/c23-17-4-3-5-19(22(17)24)27-11-9-26(10-12-27)8-1-2-13-29-16-6-7-20-18(14-16)25-21(28)15-30-20/h3-7,14H,1-2,8-13,15H2,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kochi Medical School					Assay Description Serotonin, 5HT1A:Receptor Source: Human recombinant expressed in HEK-293 cellsRadioligand: [3H]-8-OH-DPAT (221 Ci/mmol)Control Compound: 8-OH-DPATInc...				J Med Chem 52: 2226-32 (2009) BindingDB Entry DOI: 10.7270/Q2QZ2D9J
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM172722 (US9096515, 21b | US9296681, 21b) Show SMILES CCOC(=O)NCCNC(CC(C)C)C1(CCC1)c1ccc(OCC)cc1 Show InChI InChI=1S/C22H36N2O3/c1-5-26-19-10-8-18(9-11-19)22(12-7-13-22)20(16-17(3)4)23-14-15-24-21(25)27-6-2/h8-11,17,20,23H,5-7,12-16H2,1-4H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The monoamine transporters inhibitory activities of selected compounds cycloalkylmethylamine derivatives comprising Formula (I) are reported herein. ...				US Patent US9096515 (2015) BindingDB Entry DOI: 10.7270/Q2Z60MTK
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM172726 (US9096515, 33a -(R)-Isomer | US9296681, 33a-(R)-Is...) Show SMILES C[C@@H](CCNCCCC(N)=O)CC1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C19H28Cl2N2O/c1-14(7-11-23-10-2-4-18(22)24)13-19(8-3-9-19)15-5-6-16(20)17(21)12-15/h5-6,12,14,23H,2-4,7-11,13H2,1H3,(H2,22,24)/t14-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The monoamine transporters inhibitory activities of selected compounds cycloalkylmethylamine derivatives comprising Formula (I) are reported herein. ...				US Patent US9096515 (2015) BindingDB Entry DOI: 10.7270/Q2Z60MTK
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM202582 (US10035761, Compound 8a | US9238625, 8a) Show SMILES CCOCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C19H29Cl2NO/c1-4-23-11-10-22-18(12-14(2)3)19(8-5-9-19)15-6-7-16(20)17(21)13-15/h6-7,13-14,18,22H,4-5,8-12H2,1-3H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...				US Patent US9238625 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GKK
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM202582 (US10035761, Compound 8a | US9238625, 8a) Show SMILES CCOCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C19H29Cl2NO/c1-4-23-11-10-22-18(12-14(2)3)19(8-5-9-19)15-6-7-16(20)17(21)13-15/h6-7,13-14,18,22H,4-5,8-12H2,1-3H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Revivia Pharmaceuticals, Inc. US Patent					Assay Description The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...				US Patent US10035761 (2018) BindingDB Entry DOI: 10.7270/Q2D220N9
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM202584 (US10035761, Compound 8h | US9238625, 8h) Show SMILES COCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H31Cl2NO/c1-15(2)13-19(23-11-4-5-12-24-3)20(9-6-10-20)16-7-8-17(21)18(22)14-16/h7-8,14-15,19,23H,4-6,9-13H2,1-3H3/t19-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.39	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Revivia Pharmaceuticals, Inc. US Patent					Assay Description The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...				US Patent US10035761 (2018) BindingDB Entry DOI: 10.7270/Q2D220N9
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM202584 (US10035761, Compound 8h | US9238625, 8h) Show SMILES COCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H31Cl2NO/c1-15(2)13-19(23-11-4-5-12-24-3)20(9-6-10-20)16-7-8-17(21)18(22)14-16/h7-8,14-15,19,23H,4-6,9-13H2,1-3H3/t19-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.39	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...				US Patent US9238625 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GKK
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM172729 (US9096515, 33b -(R)-Isomer | US9296681, 33b-(R)-Is...) Show SMILES CCOc1ccc(cc1)C1(C[C@@H](C)CCNCCCC(N)=O)CCC1 Show InChI InChI=1S/C21H34N2O2/c1-3-25-19-9-7-18(8-10-19)21(12-5-13-21)16-17(2)11-15-23-14-4-6-20(22)24/h7-10,17,23H,3-6,11-16H2,1-2H3,(H2,22,24)/t17-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The monoamine transporters inhibitory activities of selected compounds cycloalkylmethylamine derivatives comprising Formula (I) are reported herein. ...				US Patent US9096515 (2015) BindingDB Entry DOI: 10.7270/Q2Z60MTK
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202581 (US10035761, Compound 7g | US9238625, 7g) Show SMILES CCOCCCCNC(CC(C)C)C1(CCC1)c1ccc(SC)cc1 Show InChI InChI=1S/C22H37NOS/c1-5-24-16-7-6-15-23-21(17-18(2)3)22(13-8-14-22)19-9-11-20(25-4)12-10-19/h9-12,18,21,23H,5-8,13-17H2,1-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.99	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...				US Patent US9238625 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GKK
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202581 (US10035761, Compound 7g | US9238625, 7g) Show SMILES CCOCCCCNC(CC(C)C)C1(CCC1)c1ccc(SC)cc1 Show InChI InChI=1S/C22H37NOS/c1-5-24-16-7-6-15-23-21(17-18(2)3)22(13-8-14-22)19-9-11-20(25-4)12-10-19/h9-12,18,21,23H,5-8,13-17H2,1-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.99	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Revivia Pharmaceuticals, Inc. US Patent					Assay Description The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...				US Patent US10035761 (2018) BindingDB Entry DOI: 10.7270/Q2D220N9
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202587 (US10035761, Compound 12c | US9238625, 12c) Show SMILES CCOc1ccc(cc1)C1(CCC1)C(CC(C)C)NCCSCC Show InChI InChI=1S/C21H35NOS/c1-5-23-19-10-8-18(9-11-19)21(12-7-13-21)20(16-17(3)4)22-14-15-24-6-2/h8-11,17,20,22H,5-7,12-16H2,1-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Revivia Pharmaceuticals, Inc. US Patent					Assay Description The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...				US Patent US10035761 (2018) BindingDB Entry DOI: 10.7270/Q2D220N9
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202587 (US10035761, Compound 12c | US9238625, 12c) Show SMILES CCOc1ccc(cc1)C1(CCC1)C(CC(C)C)NCCSCC Show InChI InChI=1S/C21H35NOS/c1-5-23-19-10-8-18(9-11-19)21(12-7-13-21)20(16-17(3)4)22-14-15-24-6-2/h8-11,17,20,22H,5-7,12-16H2,1-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...				US Patent US9238625 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GKK
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202583 (US10035761, Compound 8d | US9238625, 8d) Show SMILES CCCOCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C21H33Cl2NO/c1-4-12-25-13-6-11-24-20(14-16(2)3)21(9-5-10-21)17-7-8-18(22)19(23)15-17/h7-8,15-16,20,24H,4-6,9-14H2,1-3H3/t20-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Revivia Pharmaceuticals, Inc. US Patent					Assay Description The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...				US Patent US10035761 (2018) BindingDB Entry DOI: 10.7270/Q2D220N9
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202583 (US10035761, Compound 8d | US9238625, 8d) Show SMILES CCCOCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C21H33Cl2NO/c1-4-12-25-13-6-11-24-20(14-16(2)3)21(9-5-10-21)17-7-8-18(22)19(23)15-17/h7-8,15-16,20,24H,4-6,9-14H2,1-3H3/t20-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...				US Patent US9238625 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GKK
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM202583 (US10035761, Compound 8d | US9238625, 8d) Show SMILES CCCOCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C21H33Cl2NO/c1-4-12-25-13-6-11-24-20(14-16(2)3)21(9-5-10-21)17-7-8-18(22)19(23)15-17/h7-8,15-16,20,24H,4-6,9-14H2,1-3H3/t20-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.45	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...				US Patent US9238625 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GKK
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM202583 (US10035761, Compound 8d | US9238625, 8d) Show SMILES CCCOCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C21H33Cl2NO/c1-4-12-25-13-6-11-24-20(14-16(2)3)21(9-5-10-21)17-7-8-18(22)19(23)15-17/h7-8,15-16,20,24H,4-6,9-14H2,1-3H3/t20-/m1/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.45	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Revivia Pharmaceuticals, Inc. US Patent					Assay Description The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...				US Patent US10035761 (2018) BindingDB Entry DOI: 10.7270/Q2D220N9
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM172728 (US9096515, 33b -Racemic | US9296681, 33b-Racemic) Show SMILES CCOc1ccc(cc1)C1(CC(C)CCNCCCC(N)=O)CCC1 Show InChI InChI=1S/C21H34N2O2/c1-3-25-19-9-7-18(8-10-19)21(12-5-13-21)16-17(2)11-15-23-14-4-6-20(22)24/h7-10,17,23H,3-6,11-16H2,1-2H3,(H2,22,24)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	5.49	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The monoamine transporters inhibitory activities of selected compounds cycloalkylmethylamine derivatives comprising Formula (I) are reported herein. ...				US Patent US9096515 (2015) BindingDB Entry DOI: 10.7270/Q2Z60MTK
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM172720 (US9096515, 12u | US9296681, 12u) Show SMILES CCOc1ccc(cc1)C1(CCC1)C(CC(C)C)NCCOC(=O)CC Show InChI InChI=1S/C22H35NO3/c1-5-21(24)26-15-14-23-20(16-17(3)4)22(12-7-13-22)18-8-10-19(11-9-18)25-6-2/h8-11,17,20,23H,5-7,12-16H2,1-4H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The monoamine transporters inhibitory activities of selected compounds cycloalkylmethylamine derivatives comprising Formula (I) are reported herein. ...				US Patent US9096515 (2015) BindingDB Entry DOI: 10.7270/Q2Z60MTK
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM172719 (US9096515, 12q | US9296681, 12q) Show SMILES CCC(=O)OCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H29Cl2NO2/c1-4-19(24)25-11-10-23-18(12-14(2)3)20(8-5-9-20)15-6-7-16(21)17(22)13-15/h6-7,13-14,18,23H,4-5,8-12H2,1-3H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The monoamine transporters inhibitory activities of selected compounds cycloalkylmethylamine derivatives comprising Formula (I) are reported herein. ...				US Patent US9096515 (2015) BindingDB Entry DOI: 10.7270/Q2Z60MTK
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM172725 (US9096515, 33a -Racemic) Show SMILES CC(CCNCCCC(N)=O)CC1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C19H28Cl2N2O/c1-14(7-11-23-10-2-4-18(22)24)13-19(8-3-9-19)15-5-6-16(20)17(21)12-15/h5-6,12,14,23H,2-4,7-11,13H2,1H3,(H2,22,24)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	8.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The monoamine transporters inhibitory activities of selected compounds cycloalkylmethylamine derivatives comprising Formula (I) are reported herein. ...				US Patent US9096515 (2015) BindingDB Entry DOI: 10.7270/Q2Z60MTK
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM172719 (US9096515, 12q | US9296681, 12q) Show SMILES CCC(=O)OCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H29Cl2NO2/c1-4-19(24)25-11-10-23-18(12-14(2)3)20(8-5-9-20)15-6-7-16(21)17(22)13-15/h6-7,13-14,18,23H,4-5,8-12H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	10.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The monoamine transporters inhibitory activities of selected compounds cycloalkylmethylamine derivatives comprising Formula (I) are reported herein. ...				US Patent US9096515 (2015) BindingDB Entry DOI: 10.7270/Q2Z60MTK
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM202585 (US10035761, Compound 8j | US9238625, 8j) Show SMILES CCOCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C21H33Cl2NO/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3/t20-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Revivia Pharmaceuticals, Inc. US Patent					Assay Description The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...				US Patent US10035761 (2018) BindingDB Entry DOI: 10.7270/Q2D220N9
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM202585 (US10035761, Compound 8j | US9238625, 8j) Show SMILES CCOCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C21H33Cl2NO/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3/t20-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	11.0	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...				US Patent US9238625 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GKK
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM202584 (US10035761, Compound 8h | US9238625, 8h) Show SMILES COCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H31Cl2NO/c1-15(2)13-19(23-11-4-5-12-24-3)20(9-6-10-20)16-7-8-17(21)18(22)14-16/h7-8,14-15,19,23H,4-6,9-13H2,1-3H3/t19-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...				US Patent US9238625 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GKK
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM202584 (US10035761, Compound 8h | US9238625, 8h) Show SMILES COCCCCN[C@H](CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H31Cl2NO/c1-15(2)13-19(23-11-4-5-12-24-3)20(9-6-10-20)16-7-8-17(21)18(22)14-16/h7-8,14-15,19,23H,4-6,9-13H2,1-3H3/t19-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Revivia Pharmaceuticals, Inc. US Patent					Assay Description The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...				US Patent US10035761 (2018) BindingDB Entry DOI: 10.7270/Q2D220N9
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM172721 (US9096515, 21a | US9296681, 21a) Show SMILES CCOC(=O)NCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H30Cl2N2O2/c1-4-26-19(25)24-11-10-23-18(12-14(2)3)20(8-5-9-20)15-6-7-16(21)17(22)13-15/h6-7,13-14,18,23H,4-5,8-12H2,1-3H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	13.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The monoamine transporters inhibitory activities of selected compounds cycloalkylmethylamine derivatives comprising Formula (I) are reported herein. ...				US Patent US9096515 (2015) BindingDB Entry DOI: 10.7270/Q2Z60MTK
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202588 (US10035761, Compound 13c | US9238625, 13c) Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C21H33Cl2NS/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	14.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Revivia Pharmaceuticals, Inc. US Patent					Assay Description The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...				US Patent US10035761 (2018) BindingDB Entry DOI: 10.7270/Q2D220N9
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202588 (US10035761, Compound 13c | US9238625, 13c) Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C21H33Cl2NS/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	14.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...				US Patent US9238625 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GKK
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM202588 (US10035761, Compound 13c | US9238625, 13c) Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C21H33Cl2NS/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	17.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...				US Patent US9238625 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GKK
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM202588 (US10035761, Compound 13c | US9238625, 13c) Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C21H33Cl2NS/c1-4-25-13-6-5-12-24-20(14-16(2)3)21(10-7-11-21)17-8-9-18(22)19(23)15-17/h8-9,15-16,20,24H,4-7,10-14H2,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	17.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Revivia Pharmaceuticals, Inc. US Patent					Assay Description The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...				US Patent US10035761 (2018) BindingDB Entry DOI: 10.7270/Q2D220N9
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202586 (US10035761, Compound 12b | US9238625, 12b) Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H34ClNS/c1-4-24-15-6-5-14-23-20(16-17(2)3)21(12-7-13-21)18-8-10-19(22)11-9-18/h8-11,17,20,23H,4-7,12-16H2,1-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	18.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
REVIVA PHARMACEUTICALS, INC. US Patent					Assay Description The compounds were evaluated using well established radioligand binding assays protocols (Galli, A. et al., J. Exp. Biol. 1995, 198, 2197-2212; Giros...				US Patent US9238625 (2016) BindingDB Entry DOI: 10.7270/Q2CV4GKK
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM202586 (US10035761, Compound 12b | US9238625, 12b) Show SMILES CCSCCCCNC(CC(C)C)C1(CCC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H34ClNS/c1-4-24-15-6-5-14-23-20(16-17(2)3)21(12-7-13-21)18-8-10-19(22)11-9-18/h8-11,17,20,23H,4-7,12-16H2,1-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	18.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Revivia Pharmaceuticals, Inc. US Patent					Assay Description The monoamine transporters inhibitory activities of selected cycloalkylmethylamines of Formula (I) are reported herein. The compounds were evaluated ...				US Patent US10035761 (2018) BindingDB Entry DOI: 10.7270/Q2D220N9
					More data for this Ligand-Target Pair

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