Found 39 hits with Last Name = 'behera' and Initial = 'db' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM31592
(PF-2545920 | US9138494, MP-10 | substituted pyraz...)Show SMILES Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1 Show InChI InChI=1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... |
Bioorg Med Chem Lett 24: 2073-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.054
BindingDB Entry DOI: 10.7270/Q22V2HNB |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50011502
(CHEMBL3261926)Show SMILES NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N |r| Show InChI InChI=1S/C22H22N4O2/c23-14-17-3-7-19(8-4-17)18-5-1-16(2-6-18)13-20(15-24)26-21(27)22(25)9-11-28-12-10-22/h1-8,20H,9-13,25H2,(H,26,27)/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM31596
(substituted pyrazole, 13)Show SMILES FC(F)(F)Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1 Show InChI InChI=1S/C26H19F3N4O/c27-26(28,29)17-33-15-23(18-11-13-30-14-12-18)25(32-33)20-6-9-22(10-7-20)34-16-21-8-5-19-3-1-2-4-24(19)31-21/h1-15H,16-17H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... |
Bioorg Med Chem Lett 24: 2073-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.054
BindingDB Entry DOI: 10.7270/Q22V2HNB |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568317
(CHEMBL4865824)Show SMILES [H][C@]12C[C@H](N[C@@]1([H])CCCC2)C(=O)N[C@@H](Cc1ccc(cc1)-c1cccc(c1)S(C)(=O)=O)C#N |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50011502
(CHEMBL3261926)Show SMILES NC1(CCOCC1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N |r| Show InChI InChI=1S/C22H22N4O2/c23-14-17-3-7-19(8-4-17)18-5-1-16(2-6-18)13-20(15-24)26-21(27)22(25)9-11-28-12-10-22/h1-8,20H,9-13,25H2,(H,26,27)/t20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of cellular cathepsin C (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568319
(CHEMBL4869673)Show SMILES [H][C@]12C[C@H](N[C@@]1([H])CCCC2)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(c(c1)C#N)S(C)(=O)=O)C#N |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568314
(CHEMBL4856217)Show SMILES [H][C@@]12CCC[C@]1([H])N[C@@H](C2)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50013146
(CHEMBL3262297)Show InChI InChI=1S/C24H20N4O/c1-28-22-7-3-2-5-20(22)21-15-17(16-27-23(21)28)10-14-29-24-19(6-4-11-26-24)18-8-12-25-13-9-18/h2-9,11-13,15-16H,10,14H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... |
Bioorg Med Chem Lett 24: 2073-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.054
BindingDB Entry DOI: 10.7270/Q22V2HNB |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568310
(CHEMBL4875554)Show SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CC2(CCCC2)CN1 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50013140
(CHEMBL3262293)Show InChI InChI=1S/C23H19N5O/c1-28-20-5-3-2-4-18(20)19-14-16(15-27-22(19)28)8-13-29-23-21(25-11-12-26-23)17-6-9-24-10-7-17/h2-7,9-12,14-15H,8,13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... |
Bioorg Med Chem Lett 24: 2073-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.054
BindingDB Entry DOI: 10.7270/Q22V2HNB |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568318
(CHEMBL4850769)Show SMILES [H][C@]12C[C@H](N[C@@]1([H])CCCC2)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(C#N)c(c1)S(C)(=O)=O)C#N |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50013148
(CHEMBL3262298)Show InChI InChI=1S/C23H19N5O/c1-28-21-7-3-2-5-19(21)20-11-16(12-27-22(20)28)8-10-29-23-18(6-4-9-26-23)17-13-24-15-25-14-17/h2-7,9,11-15H,8,10H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... |
Bioorg Med Chem Lett 24: 2073-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.054
BindingDB Entry DOI: 10.7270/Q22V2HNB |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568309
(CHEMBL4864151)Show SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CC2(CCC2)CN1 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50013152
(CHEMBL3262303)Show SMILES FC(F)n1c2ccccc2c2cc(CCOc3ncccc3-c3cncnc3)cnc12 Show InChI InChI=1S/C23H17F2N5O/c24-23(25)30-20-6-2-1-4-18(20)19-10-15(11-29-21(19)30)7-9-31-22-17(5-3-8-28-22)16-12-26-14-27-13-16/h1-6,8,10-14,23H,7,9H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... |
Bioorg Med Chem Lett 24: 2073-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.054
BindingDB Entry DOI: 10.7270/Q22V2HNB |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50013138
(CHEMBL3262291)Show SMILES Cn1c2ccccc2c2cc(CCOc3nccnc3-c3ccc(F)cc3)cnc12 Show InChI InChI=1S/C24H19FN4O/c1-29-21-5-3-2-4-19(21)20-14-16(15-28-23(20)29)10-13-30-24-22(26-11-12-27-24)17-6-8-18(25)9-7-17/h2-9,11-12,14-15H,10,13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... |
Bioorg Med Chem Lett 24: 2073-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.054
BindingDB Entry DOI: 10.7270/Q22V2HNB |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568316
(CHEMBL4869840)Show SMILES [H][C@]12C[C@H](N[C@@]1([H])CCCC2)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C#N |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50013142
(CHEMBL3262294)Show InChI InChI=1S/C22H18N6O/c1-28-19-5-3-2-4-17(19)18-10-15(11-27-21(18)28)6-9-29-22-20(25-7-8-26-22)16-12-23-14-24-13-16/h2-5,7-8,10-14H,6,9H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... |
Bioorg Med Chem Lett 24: 2073-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.054
BindingDB Entry DOI: 10.7270/Q22V2HNB |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568310
(CHEMBL4875554)Show SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CC2(CCCC2)CN1 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of cellular cathepsin C (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50013143
(CHEMBL3262295)Show SMILES Cn1c2ccccc2c2cc(CCOc3ncccc3-c3ccc(F)cc3)cnc12 Show InChI InChI=1S/C25H20FN3O/c1-29-23-7-3-2-5-21(23)22-15-17(16-28-24(22)29)12-14-30-25-20(6-4-13-27-25)18-8-10-19(26)11-9-18/h2-11,13,15-16H,12,14H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... |
Bioorg Med Chem Lett 24: 2073-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.054
BindingDB Entry DOI: 10.7270/Q22V2HNB |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568308
(CHEMBL4851884)Show SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CC2(CC2)CN1 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568313
(CHEMBL4854705)Show SMILES [H][C@]12CCC[C@@]1([H])N[C@@H](C2)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568313
(CHEMBL4854705)Show SMILES [H][C@]12CCC[C@@]1([H])N[C@@H](C2)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of cellular cathepsin C (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50502617
(CHEMBL4570759)Show SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CCCN1 |r| Show InChI InChI=1S/C21H20N4O/c22-13-16-5-9-18(10-6-16)17-7-3-15(4-8-17)12-19(14-23)25-21(26)20-2-1-11-24-20/h3-10,19-20,24H,1-2,11-12H2,(H,25,26)/t19-,20-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50013137
(CHEMBL3262290)Show InChI InChI=1S/C22H18N6O/c1-28-13-16(20-19(28)10-15-4-2-3-5-18(15)27-20)6-9-29-22-21(25-7-8-26-22)17-11-23-14-24-12-17/h2-5,7-8,10-14H,6,9H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 123 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... |
Bioorg Med Chem Lett 24: 2073-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.054
BindingDB Entry DOI: 10.7270/Q22V2HNB |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568309
(CHEMBL4864151)Show SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CC2(CCC2)CN1 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of cellular cathepsin C (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568315
(CHEMBL4876996)Show SMILES [H][C@]12C[C@H](N[C@@]1([H])CCCC2)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50013139
(CHEMBL3262292)Show SMILES Cn1c2ccccc2c2cc(CCOc3nccnc3-c3ccc(Cl)cc3)cnc12 Show InChI InChI=1S/C24H19ClN4O/c1-29-21-5-3-2-4-19(21)20-14-16(15-28-23(20)29)10-13-30-24-22(26-11-12-27-24)17-6-8-18(25)9-7-17/h2-9,11-12,14-15H,10,13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 188 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... |
Bioorg Med Chem Lett 24: 2073-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.054
BindingDB Entry DOI: 10.7270/Q22V2HNB |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568312
(CHEMBL4848266)Show SMILES [H][C@@]12C[C@]1([H])N[C@@H](C2)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 223 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568311
(CHEMBL4849657)Show SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1CC2(CN1)CCCCC2 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 228 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568306
(CHEMBL4846681)Show SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1COCCN1 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 308 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568307
(CHEMBL4847757)Show SMILES [H][C@@]12CCCN1C[C@@H](NC2)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 394 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50013145
(CHEMBL3262296)Show SMILES Cn1c2ccccc2c2cc(CCOc3ncccc3-c3ccc(Cl)cc3)cnc12 Show InChI InChI=1S/C25H20ClN3O/c1-29-23-7-3-2-5-21(23)22-15-17(16-28-24(22)29)12-14-30-25-20(6-4-13-27-25)18-8-10-19(26)11-9-18/h2-11,13,15-16H,12,14H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 592 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... |
Bioorg Med Chem Lett 24: 2073-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.054
BindingDB Entry DOI: 10.7270/Q22V2HNB |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568314
(CHEMBL4856217)Show SMILES [H][C@@]12CCC[C@]1([H])N[C@@H](C2)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 699 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of cellular cathepsin C (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50013151
(CHEMBL3262302)Show SMILES Cn1c2ccccc2c2cc(cnc12)C1(COc2ncccc2-c2cncnc2)CC1 Show InChI InChI=1S/C25H21N5O/c1-30-22-7-3-2-5-20(22)21-11-18(14-29-23(21)30)25(8-9-25)15-31-24-19(6-4-10-28-24)17-12-26-16-27-13-17/h2-7,10-14,16H,8-9,15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 971 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... |
Bioorg Med Chem Lett 24: 2073-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.054
BindingDB Entry DOI: 10.7270/Q22V2HNB |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568320
(CHEMBL4860749)Show SMILES [H][C@]12C[C@H](N[C@@]1([H])CCCC2)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc2oc(=O)n(C)c2c1)C#N |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human cathepsin C |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568315
(CHEMBL4876996)Show SMILES [H][C@]12C[C@H](N[C@@]1([H])CCCC2)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of cellular cathepsin C (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50013150
(CHEMBL3262300)Show SMILES Cn1c2ccccc2c2cc(CCCOc3ncccc3-c3cncnc3)cnc12 Show InChI InChI=1S/C24H21N5O/c1-29-22-9-3-2-7-20(22)21-12-17(13-28-23(21)29)6-5-11-30-24-19(8-4-10-27-24)18-14-25-16-26-15-18/h2-4,7-10,12-16H,5-6,11H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... |
Bioorg Med Chem Lett 24: 2073-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.054
BindingDB Entry DOI: 10.7270/Q22V2HNB |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50013149
(CHEMBL3262299)Show SMILES Cn1c2ccccc2c2cc(CCCOc3ncccc3-c3cccnc3F)cnc12 Show InChI InChI=1S/C25H21FN4O/c1-30-22-11-3-2-8-18(22)21-15-17(16-29-24(21)30)7-6-14-31-25-20(10-5-13-28-25)19-9-4-12-27-23(19)26/h2-5,8-13,15-16H,6-7,14H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Glenmark Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substrate hydrolysis using [3H]cAMP as substrate after 30 mins by two-step r... |
Bioorg Med Chem Lett 24: 2073-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.054
BindingDB Entry DOI: 10.7270/Q22V2HNB |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50568306
(CHEMBL4846681)Show SMILES O=C(N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C#N)[C@@H]1COCCN1 |r| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of cellular cathepsin C (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128202
BindingDB Entry DOI: 10.7270/Q2PR80R9 |
More data for this
Ligand-Target Pair | |
Search and Browse
