Compile Data Set for Download or QSAR

Found 998 hits with Last Name = 'berthelot' and Initial = 'dj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM17786 ((4S)-4-(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-...) Show SMILES CN(C1CCCCC1)C(=O)CC[C@@H](C1CCCCC1)N1Cc2cc(Oc3ccccc3)ccc2N=C1N |r,c:38| Show InChI InChI=1S/C31H42N4O2/c1-34(25-13-7-3-8-14-25)30(36)20-19-29(23-11-5-2-6-12-23)35-22-24-21-27(17-18-28(24)33-31(35)32)37-26-15-9-4-10-16-26/h4,9-10,15-18,21,23,25,29H,2-3,5-8,11-14,19-20,22H2,1H3,(H2,32,33)/t29-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	11	-45.0	n/a	n/a	n/a	n/a	n/a	5.0	22
Johnson & Johnson Pharmaceutical					Assay Description BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...				J Med Chem 50: 4261-4 (2007) Article DOI: 10.1021/jm0705408 BindingDB Entry DOI: 10.7270/Q24M92T2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Beta-secretase 1 (Homo sapiens (Human))	BDBM17785 (2-aminoquinazoline, 3 | 4-(2-amino-6-phenoxy-3,4-d...) Show SMILES CN(C1CCCCC1)C(=O)CCC(C1CCCCC1)N1Cc2cc(Oc3ccccc3)ccc2N=C1N |c:38| Show InChI InChI=1S/C31H42N4O2/c1-34(25-13-7-3-8-14-25)30(36)20-19-29(23-11-5-2-6-12-23)35-22-24-21-27(17-18-28(24)33-31(35)32)37-26-15-9-4-10-16-26/h4,9-10,15-18,21,23,25,29H,2-3,5-8,11-14,19-20,22H2,1H3,(H2,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	30	-42.5	n/a	n/a	n/a	n/a	n/a	5.0	22
Johnson & Johnson Pharmaceutical					Assay Description BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...				J Med Chem 50: 4261-4 (2007) Article DOI: 10.1021/jm0705408 BindingDB Entry DOI: 10.7270/Q24M92T2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Beta-secretase 1 (Homo sapiens (Human))	BDBM17784 (2-aminoquinazoline, 2 | 3-[(2-amino-6-phenoxy-3,4-...) Show SMILES CN(C1CCCCC1)C(=O)c1cccc(CN2Cc3cc(Oc4ccccc4)ccc3N=C2N)c1 |c:34| Show InChI InChI=1S/C29H32N4O2/c1-32(24-11-4-2-5-12-24)28(34)22-10-8-9-21(17-22)19-33-20-23-18-26(15-16-27(23)31-29(33)30)35-25-13-6-3-7-14-25/h3,6-10,13-18,24H,2,4-5,11-12,19-20H2,1H3,(H2,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	158	-38.4	n/a	n/a	n/a	n/a	n/a	5.0	22
Johnson & Johnson Pharmaceutical					Assay Description BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...				J Med Chem 50: 4261-4 (2007) Article DOI: 10.1021/jm0705408 BindingDB Entry DOI: 10.7270/Q24M92T2
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM17783 (2-aminoquinazoline, 1 | 3-(2-amino-6-benzoyl-3,4-d...) Show SMILES CN(C1CCCCC1)C(=O)CCN1Cc2cc(ccc2N=C1N)C(=O)c1ccccc1 |c:22| Show InChI InChI=1S/C25H30N4O2/c1-28(21-10-6-3-7-11-21)23(30)14-15-29-17-20-16-19(12-13-22(20)27-25(29)26)24(31)18-8-4-2-5-9-18/h2,4-5,8-9,12-13,16,21H,3,6-7,10-11,14-15,17H2,1H3,(H2,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Patents	MMDB PDB Article PubMed	900	-34.2	n/a	n/a	n/a	n/a	n/a	5.0	22
Johnson & Johnson Pharmaceutical					Assay Description BACE-1 activity was measured at pH 5 using the FS1 FRET substrate. Compounds were preincubated with recombinant BACE-1 for 20 min before adding subst...				J Med Chem 50: 4261-4 (2007) Article DOI: 10.1021/jm0705408 BindingDB Entry DOI: 10.7270/Q24M92T2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487969 (4-(4-((5-chloro-6-(2H-1,2,3- triazol-2-yl)pyridin-...) Show SMILES NC(=O)c1ncc(-n2ncc(C(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c2C(F)(F)F)c2ccsc12 Show InChI InChI=1S/C20H11ClF3N9O2S/c21-12-5-9(6-27-18(12)33-28-2-3-29-33)31-19(35)11-7-30-32(16(11)20(22,23)24)13-8-26-14(17(25)34)15-10(13)1-4-36-15/h1-8H,(H2,25,34)(H,31,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487728 (N-(5-cyano-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl)...) Show SMILES FC(F)(F)c1c(cnn1-c1ccnc2ccoc12)C(=O)Nc1cnc(c(c1)C#N)-n1nccn1 Show InChI InChI=1S/C20H10F3N9O2/c21-20(22,23)17-13(10-29-31(17)15-1-3-25-14-2-6-34-16(14)15)19(33)30-12-7-11(8-24)18(26-9-12)32-27-4-5-28-32/h1-7,9-10H,(H,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487612 (1-(benzofuran-4-yl)-N-(5-chloro- 6-(2H-1,2,3-triaz...) Show SMILES FC(F)(F)c1c(cnn1-c1cccc2occc12)C(=O)Nc1cnc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C20H11ClF3N7O2/c21-14-8-11(9-25-18(14)31-26-5-6-27-31)29-19(32)13-10-28-30(17(13)20(22,23)24)15-2-1-3-16-12(15)4-7-33-16/h1-10H,(H,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM488005 ((R)-N-(5-chloro-6-(2H-1,2,3- triazol-2-yl)pyridin-...) Show SMILES O[C@@H]1CCN(C1)c1ncc(-n2ncc(C(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c2C(F)(F)F)c2ccccc12 |r| Show InChI InChI=1S/C25H19ClF3N9O2/c26-19-9-14(10-30-23(19)38-32-6-7-33-38)35-24(40)18-11-34-37(21(18)25(27,28)29)20-12-31-22(36-8-5-15(39)13-36)17-4-2-1-3-16(17)20/h1-4,6-7,9-12,15,39H,5,8,13H2,(H,35,40)/t15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487998 (N-(5-chloro-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl...) Show SMILES COc1ccc2c(cccc2n1)-n1ncc(C(=O)Nc2cnc(c(Cl)c2)-n2nccn2)c1C(F)(F)F Show InChI InChI=1S/C22H14ClF3N8O2/c1-36-18-6-5-13-16(32-18)3-2-4-17(13)33-19(22(24,25)26)14(11-30-33)21(35)31-12-9-15(23)20(27-10-12)34-28-7-8-29-34/h2-11H,1H3,(H,31,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487687 (2-(3-chloro-5-(1-(quinolin-5-yl)- 5-(trifluorometh...) Show SMILES OC(=O)c1cnn(n1)-c1ncc(NC(=O)c2cnn(c2C(F)(F)F)-c2cccc3ncccc23)cc1Cl Show InChI InChI=1S/C22H12ClF3N8O3/c23-14-7-11(8-28-19(14)34-30-10-16(32-34)21(36)37)31-20(35)13-9-29-33(18(13)22(24,25)26)17-5-1-4-15-12(17)3-2-6-27-15/h1-10H,(H,31,35)(H,36,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487933 (US10954214, Compound 355 | methyl 3-chloro-5-(1-(1...) Show SMILES COC(=O)c1ncc(NC(=O)c2cnn(c2C(F)(F)F)-c2cccc3c2cc[nH]c3=O)cc1Cl Show InChI InChI=1S/C21H13ClF3N5O4/c1-34-20(33)16-14(22)7-10(8-27-16)29-19(32)13-9-28-30(17(13)21(23,24)25)15-4-2-3-12-11(15)5-6-26-18(12)31/h2-9H,1H3,(H,26,31)(H,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM488028 (N-(5-chloro-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl...) Show SMILES FC(F)(F)c1c(cnn1-c1ccnc2ccccc12)C(=O)Nc1cnc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C21H12ClF3N8O/c22-15-9-12(10-27-19(15)33-28-7-8-29-33)31-20(34)14-11-30-32(18(14)21(23,24)25)17-5-6-26-16-4-2-1-3-13(16)17/h1-11H,(H,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487689 (1-(1-amino-8-fluoroisoquinolin- 4-yl)-N-(5-cyano-6...) Show SMILES Nc1ncc(-n2ncc(C(=O)Nc3cnc(c(c3)C#N)-n3nccn3)c2C(F)(F)F)c2cccc(F)c12 Show InChI InChI=1S/C22H12F4N10O/c23-15-3-1-2-13-16(10-29-19(28)17(13)15)35-18(22(24,25)26)14(9-33-35)21(37)34-12-6-11(7-27)20(30-8-12)36-31-4-5-32-36/h1-6,8-10H,(H2,28,29)(H,34,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM488000 (N-(5-chloro-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl...) Show SMILES CCOc1ncc(-n2ncc(C(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c2C(F)(F)F)c2ccccc12 Show InChI InChI=1S/C23H16ClF3N8O2/c1-2-37-22-15-6-4-3-5-14(15)18(12-29-22)34-19(23(25,26)27)16(11-32-34)21(36)33-13-9-17(24)20(28-10-13)35-30-7-8-31-35/h3-12H,2H2,1H3,(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM488006 (N-(5-cyano-6-methoxypyridin-3- yl)-1-(1-oxo-1,2- d...) Show SMILES COc1ncc(NC(=O)C2=C(C(N=C2)c2cccc3c2cc[nH]c3=O)C(F)(F)F)cc1C#N |c:12,t:9| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487692 (1-(benzo[d]thiazol-7-yl)-N-(5- cyano-6-(2H-1,2,3-t...) Show SMILES FC(F)(F)c1c(cnn1-c1cccc2ncsc12)C(=O)Nc1cnc(c(c1)C#N)-n1nccn1 Show InChI InChI=1S/C20H10F3N9OS/c21-20(22,23)17-13(9-29-31(17)15-3-1-2-14-16(15)34-10-26-14)19(33)30-12-6-11(7-24)18(25-8-12)32-27-4-5-28-32/h1-6,8-10H,(H,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487625 (N-(5-cyano-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl)...) Show SMILES FC(F)(F)c1c(cnn1-c1cncc2ccccc12)C(=O)Nc1cnc(c(c1)C#N)-n1nccn1 Show InChI InChI=1S/C22H12F3N9O/c23-22(24,25)19-17(11-31-33(19)18-12-27-9-13-3-1-2-4-16(13)18)21(35)32-15-7-14(8-26)20(28-10-15)34-29-5-6-30-34/h1-7,9-12H,(H,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487691 (N-(5-cyano-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl)...) Show SMILES FC(F)(F)c1c(cnn1-c1cccc2c1cc[nH]c2=O)C(=O)Nc1cnc(c(c1)C#N)-n1nccn1 Show InChI InChI=1S/C22H12F3N9O2/c23-22(24,25)18-16(11-31-33(18)17-3-1-2-15-14(17)4-5-27-20(15)35)21(36)32-13-8-12(9-26)19(28-10-13)34-29-6-7-30-34/h1-8,10-11H,(H,27,35)(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487677 (N-(5-cyano-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl)...) Show SMILES FC(F)(F)c1c(cnn1-c1nccc2ccoc12)C(=O)Nc1cnc(c(c1)C#N)-n1nccn1 Show InChI InChI=1S/C20H10F3N9O2/c21-20(22,23)16-14(10-29-31(16)18-15-11(1-3-25-18)2-6-34-15)19(33)30-13-7-12(8-24)17(26-9-13)32-27-4-5-28-32/h1-7,9-10H,(H,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487581 (N-(5-chloro-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl...) Show SMILES FC(F)(F)c1c(cnn1-c1cccc2ccccc12)C(=O)Nc1cnc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C22H13ClF3N7O/c23-17-10-14(11-27-20(17)33-28-8-9-29-33)31-21(34)16-12-30-32(19(16)22(24,25)26)18-7-3-5-13-4-1-2-6-15(13)18/h1-12H,(H,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487971 (4-(4-((5-chloro-2-methyl-6-(2H- 1,2,3-triazol-2-yl...) Show SMILES Cc1nc(c(Cl)cc1NC(=O)c1cnn(c1C(F)(F)F)-c1cnc(C(N)=O)c2sccc12)-n1nccn1 Show InChI InChI=1S/C21H13ClF3N9O2S/c1-9-13(6-12(22)19(31-9)34-28-3-4-29-34)32-20(36)11-7-30-33(17(11)21(23,24)25)14-8-27-15(18(26)35)16-10(14)2-5-37-16/h2-8H,1H3,(H2,26,35)(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487731 (1-(benzo[d]thiazol-7-yl)-N-(5- chloro-6-(2H-1,2,3-...) Show SMILES FC(F)(F)c1c(cnn1-c1cccc2ncsc12)C(=O)Nc1cnc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C19H10ClF3N8OS/c20-12-6-10(7-24-17(12)31-26-4-5-27-31)29-18(32)11-8-28-30(16(11)19(21,22)23)14-3-1-2-13-15(14)33-9-25-13/h1-9H,(H,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487693 (N-(5-chloro-6-(4- (hydroxymethyl)-2H-1,2,3- triazo...) Show SMILES OCc1cnn(n1)-c1ncc(NC(=O)c2cnn(c2C(F)(F)F)-c2cccc3c2cc[nH]c3=O)cc1Cl Show InChI InChI=1S/C22H14ClF3N8O3/c23-16-6-11(7-28-19(16)34-30-8-12(10-35)32-34)31-21(37)15-9-29-33(18(15)22(24,25)26)17-3-1-2-14-13(17)4-5-27-20(14)36/h1-9,35H,10H2,(H,27,36)(H,31,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM488004 (N-(5-chloro-2-methyl-6-(2H- 1,2,3-triazol-2-yl)pyr...) Show SMILES Cc1nc(c(Cl)cc1NC(=O)c1cnn(c1C(F)(F)F)-c1cnc(Cl)c2sccc12)-n1nccn1 Show InChI InChI=1S/C20H11Cl2F3N8OS/c1-9-13(6-12(21)18(30-9)33-27-3-4-28-33)31-19(34)11-7-29-32(16(11)20(23,24)25)14-8-26-17(22)15-10(14)2-5-35-15/h2-8H,1H3,(H,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM488008 (N-(5-chloro-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl...) Show SMILES OC1CN(C1)c1ncc(-n2ncc(C(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c2C(F)(F)F)c2ccsc12 Show InChI InChI=1S/C22H15ClF3N9O2S/c23-15-5-11(6-27-19(15)35-29-2-3-30-35)32-21(37)14-7-31-34(18(14)22(24,25)26)16-8-28-20(33-9-12(36)10-33)17-13(16)1-4-38-17/h1-8,12,36H,9-10H2,(H,32,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM488021 ((*S)-N-(5-chloro-6-(2H-1,2,3- triazol-2-yl)pyridin...) Show SMILES C[C@H](O)c1ncc(-n2ncc(C(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c2C(F)(F)F)c2ccccc12 |r| Show InChI InChI=1S/C23H16ClF3N8O2/c1-12(36)19-15-5-3-2-4-14(15)18(11-28-19)34-20(23(25,26)27)16(10-32-34)22(37)33-13-8-17(24)21(29-9-13)35-30-6-7-31-35/h2-12,36H,1H3,(H,33,37)/t12-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487587 (N-(5-chloro-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl...) Show SMILES FC(F)(F)c1c(cnn1-c1cccc2ncccc12)C(=O)Nc1cnc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C21H12ClF3N8O/c22-15-9-12(10-27-19(15)33-28-7-8-29-33)31-20(34)14-11-30-32(18(14)21(23,24)25)17-5-1-4-16-13(17)3-2-6-26-16/h1-11H,(H,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487703 (N-(5-chloro-6-(4-methyl-2H- 1,2,3-triazol-2-yl)pyr...) Show SMILES Cc1cnn(n1)-c1ncc(NC(=O)c2cnn(c2C(F)(F)F)-c2cccc3ncccc23)cc1Cl Show InChI InChI=1S/C22H14ClF3N8O/c1-12-9-30-34(32-12)20-16(23)8-13(10-28-20)31-21(35)15-11-29-33(19(15)22(24,25)26)18-6-2-5-17-14(18)4-3-7-27-17/h2-11H,1H3,(H,31,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487697 (1-(benzo[d][1,2,3]thiadiazol-7- yl)-N-(5-cyano-6-(...) Show SMILES FC(F)(F)c1c(cnn1-c1cccc2nnsc12)C(=O)Nc1cnc(c(c1)C#N)-n1nccn1 Show InChI InChI=1S/C19H9F3N10OS/c20-19(21,22)16-12(9-27-31(16)14-3-1-2-13-15(14)34-30-29-13)18(33)28-11-6-10(7-23)17(24-8-11)32-25-4-5-26-32/h1-6,8-9H,(H,28,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487700 (N-(5-cyano-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl)...) Show SMILES Fc1cccc2c(cccc12)-n1ncc(C(=O)Nc2cnc(c(c2)C#N)-n2nccn2)c1C(F)(F)F Show InChI InChI=1S/C23H12F4N8O/c24-18-5-1-4-16-15(18)3-2-6-19(16)34-20(23(25,26)27)17(12-32-34)22(36)33-14-9-13(10-28)21(29-11-14)35-30-7-8-31-35/h1-9,11-12H,(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487701 (N-(5-chloro-2-methyl-6-(2H- 1,2,3-triazol-2-yl)pyr...) Show SMILES Cc1nc(c(Cl)cc1NC(=O)c1cnn(c1C(F)(F)F)-c1cncc2c(F)cccc12)-n1nccn1 Show InChI InChI=1S/C22H13ClF4N8O/c1-11-17(7-15(23)20(32-11)35-29-5-6-30-35)33-21(36)14-9-31-34(19(14)22(25,26)27)18-10-28-8-13-12(18)3-2-4-16(13)24/h2-10H,1H3,(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487695 (N-(5-chloro-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl...) Show SMILES Fc1cccc2c(cncc12)-n1ncc(C(=O)Nc2cnc(c(Cl)c2)-n2nccn2)c1C(F)(F)F Show InChI InChI=1S/C21H11ClF4N8O/c22-15-6-11(7-28-19(15)34-29-4-5-30-34)32-20(35)14-9-31-33(18(14)21(24,25)26)17-10-27-8-13-12(17)2-1-3-16(13)23/h1-10H,(H,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487997 (N-(5-chloro-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl...) Show SMILES Cn1c2ccccc2c(cc1=O)-n1ncc(C(=O)Nc2cnc(c(Cl)c2)-n2nccn2)c1C(F)(F)F Show InChI InChI=1S/C22H14ClF3N8O2/c1-32-16-5-3-2-4-13(16)17(9-18(32)35)33-19(22(24,25)26)14(11-30-33)21(36)31-12-8-15(23)20(27-10-12)34-28-6-7-29-34/h2-11H,1H3,(H,31,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487669 (N-(5-chloro-6-(oxazol-2- yl)pyridin-3-yl)-1-(quino...) Show SMILES FC(F)(F)c1c(cnn1-c1cccc2ncccc12)C(=O)Nc1cnc(-c2ncco2)c(Cl)c1 Show InChI InChI=1S/C22H12ClF3N6O2/c23-15-9-12(10-29-18(15)21-28-7-8-34-21)31-20(33)14-11-30-32(19(14)22(24,25)26)17-5-1-4-16-13(17)3-2-6-27-16/h1-11H,(H,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487775 (N-(5-chloro-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl...) Show SMILES FC(F)(F)c1c(cnn1-c1cccn2nccc12)C(=O)Nc1cnc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C19H11ClF3N9O/c20-13-8-11(9-24-17(13)32-26-5-6-27-32)29-18(33)12-10-28-31(16(12)19(21,22)23)15-2-1-7-30-14(15)3-4-25-30/h1-10H,(H,29,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487705 (N-(5-chloro-6-(oxazol-2- yl)pyridin-3-yl)-1-(1-oxo...) Show SMILES FC(F)(F)c1c(cnn1-c1cccc2c1cc[nH]c2=O)C(=O)Nc1cnc(-c2ncco2)c(Cl)c1 Show InChI InChI=1S/C22H12ClF3N6O3/c23-15-8-11(9-29-17(15)21-28-6-7-35-21)31-20(34)14-10-30-32(18(14)22(24,25)26)16-3-1-2-13-12(16)4-5-27-19(13)33/h1-10H,(H,27,33)(H,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487696 (N-(5-cyano-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl)...) Show SMILES Fc1cccc2c(cncc12)-n1ncc(C(=O)Nc2cnc(c(c2)C#N)-n2nccn2)c1C(F)(F)F Show InChI InChI=1S/C22H11F4N9O/c23-17-3-1-2-14-15(17)9-28-11-18(14)34-19(22(24,25)26)16(10-32-34)21(36)33-13-6-12(7-27)20(29-8-13)35-30-4-5-31-35/h1-6,8-11H,(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487704 (N-(5-cyano-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl)...) Show SMILES FC(F)(F)c1c(cnn1-c1ccnc2sccc12)C(=O)Nc1cnc(c(c1)C#N)-n1nccn1 Show InChI InChI=1S/C20H10F3N9OS/c21-20(22,23)16-14(10-29-31(16)15-1-3-25-19-13(15)2-6-34-19)18(33)30-12-7-11(8-24)17(26-9-12)32-27-4-5-28-32/h1-7,9-10H,(H,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487694 (N-(5-chloro-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl...) Show SMILES FC(F)(F)c1c(cnn1-c1cccc2c1cc[nH]c2=O)C(=O)Nc1cnc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C21H12ClF3N8O2/c22-15-8-11(9-27-18(15)33-28-6-7-29-33)31-20(35)14-10-30-32(17(14)21(23,24)25)16-3-1-2-13-12(16)4-5-26-19(13)34/h1-10H,(H,26,34)(H,31,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487707 (N-(3-chloro-4-(2H-1,2,3-triazol- 2-yl)phenyl)-1-(1...) Show SMILES FC(F)(F)c1c(cnn1-c1cccc2c1cc[nH]c2=O)C(=O)Nc1ccc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C22H13ClF3N7O2/c23-16-10-12(4-5-18(16)33-28-8-9-29-33)31-21(35)15-11-30-32(19(15)22(24,25)26)17-3-1-2-14-13(17)6-7-27-20(14)34/h1-11H,(H,27,34)(H,31,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487706 (N-(5-cyano-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl)...) Show SMILES FC(F)(F)c1c(cnn1-c1ccnc2ccsc12)C(=O)Nc1cnc(c(c1)C#N)-n1nccn1 Show InChI InChI=1S/C20H10F3N9OS/c21-20(22,23)17-13(10-29-31(17)15-1-3-25-14-2-6-34-16(14)15)19(33)30-12-7-11(8-24)18(26-9-12)32-27-4-5-28-32/h1-7,9-10H,(H,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM488009 ((S)-N-(5-chloro-6-(2H-1,2,3- triazol-2-yl)pyridin-...) Show SMILES O[C@H]1CCN(C1)c1ncc(-n2ncc(C(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c2C(F)(F)F)c2ccsc12 |r| Show InChI InChI=1S/C23H17ClF3N9O2S/c24-16-7-12(8-28-20(16)36-30-3-4-31-36)33-22(38)15-9-32-35(19(15)23(25,26)27)17-10-29-21(18-14(17)2-6-39-18)34-5-1-13(37)11-34/h2-4,6-10,13,37H,1,5,11H2,(H,33,38)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487587 (N-(5-chloro-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl...) Show SMILES FC(F)(F)c1c(cnn1-c1cccc2ncccc12)C(=O)Nc1cnc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C21H12ClF3N8O/c22-15-9-12(10-27-19(15)33-28-7-8-29-33)31-20(34)14-11-30-32(18(14)21(23,24)25)17-5-1-4-16-13(17)3-2-6-26-16/h1-11H,(H,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487661 (N-(5-cyano-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl)...) Show SMILES FC(F)(F)c1c(cnn1-c1cccc2ncccc12)C(=O)Nc1cnc(c(c1)C#N)-n1nccn1 Show InChI InChI=1S/C22H12F3N9O/c23-22(24,25)19-16(12-31-33(19)18-5-1-4-17-15(18)3-2-6-27-17)21(35)32-14-9-13(10-26)20(28-11-14)34-29-7-8-30-34/h1-9,11-12H,(H,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487690 (N-(5-chloro-2-methyl-6-(2H- 1,2,3-triazol-2-yl)pyr...) Show SMILES Cc1nc(c(Cl)cc1NC(=O)c1cnn(c1C(F)(F)F)-c1cccc2c1cc[nH]c2=O)-n1nccn1 Show InChI InChI=1S/C22H14ClF3N8O2/c1-11-16(9-15(23)19(31-11)34-28-7-8-29-34)32-21(36)14-10-30-33(18(14)22(24,25)26)17-4-2-3-13-12(17)5-6-27-20(13)35/h2-10H,1H3,(H,27,35)(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487763 (N-(5-bromo-2-methyl-6-(2H- 1,2,3-triazol-2-yl)pyri...) Show SMILES Cc1nc(c(Br)cc1NC(=O)c1cnn(c1C(F)(F)F)-c1cccc2c1cc[nH]c2=O)-n1nccn1 Show InChI InChI=1S/C22H14BrF3N8O2/c1-11-16(9-15(23)19(31-11)34-28-7-8-29-34)32-21(36)14-10-30-33(18(14)22(24,25)26)17-4-2-3-13-12(17)5-6-27-20(13)35/h2-10H,1H3,(H,27,35)(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487730 (N-(5-cyano-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl)...) Show SMILES FC(F)(F)c1c(cnn1-c1ccnc2ccccc12)C(=O)Nc1ccc(c(c1)C#N)-n1nccn1 Show InChI InChI=1S/C23H13F3N8O/c24-23(25,26)21-17(13-31-33(21)20-7-8-28-18-4-2-1-3-16(18)20)22(35)32-15-5-6-19(14(11-15)12-27)34-29-9-10-30-34/h1-11,13H,(H,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487992 (N-(5-chloro-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl...) Show SMILES FC(F)(F)c1c(cnn1-c1cnc(C#N)c2ccccc12)C(=O)Nc1cnc(c(Cl)c1)-n1nccn1 Show InChI InChI=1S/C22H11ClF3N9O/c23-16-7-12(9-29-20(16)35-30-5-6-31-35)33-21(36)15-10-32-34(19(15)22(24,25)26)18-11-28-17(8-27)13-3-1-2-4-14(13)18/h1-7,9-11H,(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487670 (N-(5-cyano-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl)...) Show SMILES Fc1cccc2c(ccnc12)-n1ncc(C(=O)Nc2cnc(c(c2)C#N)-n2nccn2)c1C(F)(F)F Show InChI InChI=1S/C22H11F4N9O/c23-16-3-1-2-14-17(4-5-28-18(14)16)34-19(22(24,25)26)15(11-32-34)21(36)33-13-8-12(9-27)20(29-10-13)35-30-6-7-31-35/h1-8,10-11H,(H,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM487672 (N-(5-cyano-6-(2H-1,2,3-triazol- 2-yl)pyridin-3-yl)...) Show SMILES FC(F)(F)c1c(cnn1-c1nccc2occc12)C(=O)Nc1cnc(c(c1)C#N)-n1nccn1 Show InChI InChI=1S/C20H10F3N9O2/c21-20(22,23)16-14(10-29-31(16)18-13-2-6-34-15(13)1-3-25-18)19(33)30-12-7-11(8-24)17(26-9-12)32-27-4-5-28-32/h1-7,9-10H,(H,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description MALT1 protease activity was assessed in an in vitro assay using a tetrapeptide as substrate and full-length MALT1 protein (Strep-MALT1(1-824)-His) pu...				US Patent US10954214 (2021) BindingDB Entry DOI: 10.7270/Q2SX6HB1
					More data for this Ligand-Target Pair

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