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Compile Data Set for Download or QSAR

Found 6 hits with Last Name = 'biondi' and Initial = 'a'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM35053
PNG
(K00486)
Show SMILES CCC(CO)Nc1ccc2ncc(-c3ccc(F)c(Cl)c3)n2n1
Show InChI InChI=1S/C16H16ClFN4O/c1-2-11(9-23)20-15-5-6-16-19-8-14(22(16)21-15)10-3-4-13(18)12(17)7-10/h3-8,11,23H,2,9H2,1H3,(H,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 40n/an/an/an/a7.525



University Hospital Basel



Assay Description
Phosphorylation reactions were monitored using a coupled-enzyme assay in which ADP production was coupled to NADH oxidation by pyruvate kinase and la...


Cancer Res 67: 6916-24 (2007)


Article DOI: 10.1158/0008-5472.CAN-07-0320
BindingDB Entry DOI: 10.7270/Q23X850Z
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM35052
PNG
(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Show SMILES Clc1cccc(c1)-c1cnc2ccc(NC3CCOCC3)nn12
Show InChI InChI=1S/C17H17ClN4O/c18-13-3-1-2-12(10-13)15-11-19-17-5-4-16(21-22(15)17)20-14-6-8-23-9-7-14/h1-5,10-11,14H,6-9H2,(H,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 50n/an/an/an/a7.525



University Hospital Basel



Assay Description
Phosphorylation reactions were monitored using a coupled-enzyme assay in which ADP production was coupled to NADH oxidation by pyruvate kinase and la...


Cancer Res 67: 6916-24 (2007)


Article DOI: 10.1158/0008-5472.CAN-07-0320
BindingDB Entry DOI: 10.7270/Q23X850Z
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM11835
PNG
(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)
Show SMILES CC(=O)c1cccc(c1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C18H18N4O/c1-12(23)14-3-2-4-15(9-14)16-11-20-18-8-7-17(21-22(16)18)19-10-13-5-6-13/h2-4,7-9,11,13H,5-6,10H2,1H3,(H,19,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 120n/an/an/an/a7.525



University Hospital Basel



Assay Description
Phosphorylation reactions were monitored using a coupled-enzyme assay in which ADP production was coupled to NADH oxidation by pyruvate kinase and la...


Cancer Res 67: 6916-24 (2007)


Article DOI: 10.1158/0008-5472.CAN-07-0320
BindingDB Entry DOI: 10.7270/Q23X850Z
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM11835
PNG
(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)
Show SMILES CC(=O)c1cccc(c1)-c1cnc2ccc(NCC3CC3)nn12
Show InChI InChI=1S/C18H18N4O/c1-12(23)14-3-2-4-15(9-14)16-11-20-18-8-7-17(21-22(16)18)19-10-13-5-6-13/h2-4,7-9,11,13H,5-6,10H2,1H3,(H,19,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.80E+3n/an/an/an/a7.525



University Hospital Basel



Assay Description
Phosphorylation reactions were monitored using a coupled-enzyme assay in which ADP production was coupled to NADH oxidation by pyruvate kinase and la...


Cancer Res 67: 6916-24 (2007)


Article DOI: 10.1158/0008-5472.CAN-07-0320
BindingDB Entry DOI: 10.7270/Q23X850Z
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM35053
PNG
(K00486)
Show SMILES CCC(CO)Nc1ccc2ncc(-c3ccc(F)c(Cl)c3)n2n1
Show InChI InChI=1S/C16H16ClFN4O/c1-2-11(9-23)20-15-5-6-16-19-8-14(22(16)21-15)10-3-4-13(18)12(17)7-10/h3-8,11,23H,2,9H2,1H3,(H,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/a7.525



University Hospital Basel



Assay Description
Phosphorylation reactions were monitored using a coupled-enzyme assay in which ADP production was coupled to NADH oxidation by pyruvate kinase and la...


Cancer Res 67: 6916-24 (2007)


Article DOI: 10.1158/0008-5472.CAN-07-0320
BindingDB Entry DOI: 10.7270/Q23X850Z
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM35052
PNG
(K00152 | US10047093, 8-39 | US10392392, Example 8-...)
Show SMILES Clc1cccc(c1)-c1cnc2ccc(NC3CCOCC3)nn12
Show InChI InChI=1S/C17H17ClN4O/c18-13-3-1-2-12(10-13)15-11-19-17-5-4-16(21-22(15)17)20-14-6-8-23-9-7-14/h1-5,10-11,14H,6-9H2,(H,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.10E+3n/an/an/an/a7.525



University Hospital Basel



Assay Description
Phosphorylation reactions were monitored using a coupled-enzyme assay in which ADP production was coupled to NADH oxidation by pyruvate kinase and la...


Cancer Res 67: 6916-24 (2007)


Article DOI: 10.1158/0008-5472.CAN-07-0320
BindingDB Entry DOI: 10.7270/Q23X850Z
More data for this
Ligand-Target Pair