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Compile Data Set for Download or QSAR

Found 743 hits with Last Name = 'blayo' and Initial = 'a'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546842
PNG
(CHEMBL4761419)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CC#N)cc1 |r|
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 0.450n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546842
PNG
(CHEMBL4761419)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CC#N)cc1 |r|
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 0.450n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546817
PNG
(CHEMBL4760409)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(OC)cc2)\C#N)cc1 |r|
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TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546817
PNG
(CHEMBL4760409)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(OC)cc2)\C#N)cc1 |r|
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TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546819
PNG
(CHEMBL4793824)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(F)cc2)\C#N)cc1 |r|
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 0.600n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546819
PNG
(CHEMBL4793824)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(F)cc2)\C#N)cc1 |r|
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 0.600n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM102978
PNG
(US8546435, 6)
Show SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2ccccc2)NC(C)=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1 |r|
Show InChI InChI=1S/C32H34N6O4/c1-21(40)34-28(16-22-8-4-3-5-9-22)31-36-37-32(38(31)19-23-12-14-25(42-2)15-13-23)29(35-30(41)20-39)17-24-18-33-27-11-7-6-10-26(24)27/h3-15,18,28-29,33,39H,16-17,19-20H2,1-2H3,(H,34,40)(H,35,41)/t28-,29-/m1/s1
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 0.800n/an/an/an/an/an/an/an/a



Universit£ de Montpellier

Curated by ChEMBL


Assay Description
Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method

Bioorg Med Chem Lett 26: 2408-12 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.003
BindingDB Entry DOI: 10.7270/Q2J9688V
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546815
PNG
(CHEMBL4744051)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(C)cc2)\C#N)cc1 |r|
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TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546815
PNG
(CHEMBL4744051)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(C)cc2)\C#N)cc1 |r|
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 1n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546828
PNG
(CHEMBL4753046)
Show SMILES COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(OC)cc2)\C#N)cc1 |r|
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 1.40n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546828
PNG
(CHEMBL4753046)
Show SMILES COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(OC)cc2)\C#N)cc1 |r|
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TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50165587
PNG
(CHEMBL3800298)
Show SMILES COc1ccc(Cn2c(nnc2C(Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)C(Cc2c[nH]c3ccccc23)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(C)=O)cc1
Show InChI InChI=1S/C50H64N10O5/c1-30(2)23-44(54-32(5)61)49(63)57-45(24-31(3)4)50(64)56-43(26-36-28-53-41-14-10-8-12-39(36)41)47-59-58-46(60(47)29-33-15-17-37(65-6)18-16-33)42(55-48(62)34-19-21-51-22-20-34)25-35-27-52-40-13-9-7-11-38(35)40/h7-18,27-28,30-31,34,42-45,51-53H,19-26,29H2,1-6H3,(H,54,61)(H,55,62)(H,56,64)(H,57,63)/t42-,43-,44+,45?/m1/s1
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 2 -49.7n/an/an/an/an/an/a25



Universit£ de Montpellier

Curated by ChEMBL


Assay Description
Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by...

Bioorg Med Chem Lett 26: 2408-12 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.003
BindingDB Entry DOI: 10.7270/Q2J9688V
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM102979
PNG
(US8546435, 7)
Show SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2ccccc2)NC(C)=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1 |r|
Show InChI InChI=1S/C35H39N7O4/c1-23(43)38-30(18-24-8-4-3-5-9-24)33-40-41-34(42(33)22-25-12-14-27(45-2)15-13-25)31(39-35(44)32-21-36-16-17-46-32)19-26-20-37-29-11-7-6-10-28(26)29/h3-15,20,30-32,36-37H,16-19,21-22H2,1-2H3,(H,38,43)(H,39,44)/t30-,31-,32+/m1/s1
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 2n/an/an/an/an/an/an/an/a



Universit£ de Montpellier

Curated by ChEMBL


Assay Description
Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method

Bioorg Med Chem Lett 26: 2408-12 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.003
BindingDB Entry DOI: 10.7270/Q2J9688V
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546818
PNG
(CHEMBL4745116)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(cc2)N(C)C)\C#N)cc1 |r|
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TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546818
PNG
(CHEMBL4745116)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(cc2)N(C)C)\C#N)cc1 |r|
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TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50165582
PNG
(CHEMBL3797225)
Show SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)[C@@H](Cc2c[nH]c3ccccc23)NC(C)=O)cc1 |r|
Show InChI InChI=1S/C38H45N9O3/c1-24(48)43-34(19-26-21-41-32-12-5-3-9-29(26)32)36-45-46-37(47(36)23-25-14-16-28(50-2)17-15-25)35(44-38(49)31(40)11-7-8-18-39)20-27-22-42-33-13-6-4-10-30(27)33/h3-6,9-10,12-17,21-22,31,34-35,41-42H,7-8,11,18-20,23,39-40H2,1-2H3,(H,43,48)(H,44,49)/t31-,34+,35+/m0/s1
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 2.5 -49.1n/an/an/an/an/an/a25



Universit£ de Montpellier

Curated by ChEMBL


Assay Description
Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by...

Bioorg Med Chem Lett 26: 2408-12 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.003
BindingDB Entry DOI: 10.7270/Q2J9688V
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546816
PNG
(CHEMBL4777792)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(O)cc2)\C#N)cc1 |r|
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TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50165588
PNG
(CHEMBL3800422)
Show SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1 |r|
Show InChI InChI=1S/C48H61N9O6/c1-28(2)21-41(51-30(5)58)45(59)53-42(22-29(3)4)46(60)52-39(23-32-25-49-37-15-11-9-13-35(32)37)43-55-56-44(57(43)27-31-17-19-34(63-8)20-18-31)40(54-47(61)48(6,7)62)24-33-26-50-38-16-12-10-14-36(33)38/h9-20,25-26,28-29,39-42,49-50,62H,21-24,27H2,1-8H3,(H,51,58)(H,52,60)(H,53,59)(H,54,61)/t39-,40-,41+,42+/m1/s1
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 3 -48.6n/an/an/an/an/an/a25



Universit£ de Montpellier

Curated by ChEMBL


Assay Description
Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by...

Bioorg Med Chem Lett 26: 2408-12 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.003
BindingDB Entry DOI: 10.7270/Q2J9688V
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50165589
PNG
(CHEMBL3798095)
Show SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1 |r|
Show InChI InChI=1S/C46H57N9O6/c1-27(2)19-40(49-29(5)57)45(59)52-41(20-28(3)4)46(60)51-39(22-32-24-48-37-14-10-8-12-35(32)37)44-54-53-43(55(44)25-30-15-17-33(61-6)18-16-30)38(50-42(58)26-56)21-31-23-47-36-13-9-7-11-34(31)36/h7-18,23-24,27-28,38-41,47-48,56H,19-22,25-26H2,1-6H3,(H,49,57)(H,50,58)(H,51,60)(H,52,59)/t38-,39-,40+,41+/m1/s1
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 3 -48.6n/an/an/an/an/an/a25



Universit£ de Montpellier

Curated by ChEMBL


Assay Description
Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by...

Bioorg Med Chem Lett 26: 2408-12 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.003
BindingDB Entry DOI: 10.7270/Q2J9688V
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546816
PNG
(CHEMBL4777792)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(O)cc2)\C#N)cc1 |r|
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TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546824
PNG
(CHEMBL4753794)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)C(=C\c2ccc(OC)cc2)\C#N)cc1 |r|
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TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546824
PNG
(CHEMBL4753794)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)C(=C\c2ccc(OC)cc2)\C#N)cc1 |r|
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 3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546831
PNG
(CHEMBL4781141)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C)(C)C#N)cc1 |r|
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 3.40n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546831
PNG
(CHEMBL4781141)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C)(C)C#N)cc1 |r|
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 3.40n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546843
PNG
(CHEMBL4780843)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C=C)cc1 |r|
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 4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546843
PNG
(CHEMBL4780843)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C=C)cc1 |r|
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 4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50165592
PNG
(CHEMBL3799776)
Show SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2ccccc2)NC(C)=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1 |r|
Show InChI InChI=1S/C36H34FN7O3/c1-23(45)40-31(19-24-9-4-3-5-10-24)34-42-43-35(44(34)22-25-14-16-27(47-2)17-15-25)32(41-36(46)33-29(37)12-8-18-38-33)20-26-21-39-30-13-7-6-11-28(26)30/h3-18,21,31-32,39H,19-20,22H2,1-2H3,(H,40,45)(H,41,46)/t31-,32-/m1/s1
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 4n/an/an/an/an/an/an/an/a



Universit£ de Montpellier

Curated by ChEMBL


Assay Description
Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method

Bioorg Med Chem Lett 26: 2408-12 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.003
BindingDB Entry DOI: 10.7270/Q2J9688V
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546839
PNG
(CHEMBL4784240)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccc(nc2)C#N)cc1 |r|
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 6.30n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546839
PNG
(CHEMBL4784240)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccc(nc2)C#N)cc1 |r|
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 6.30n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546822
PNG
(CHEMBL4746362)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2c[nH]c3ccccc23)\C#N)cc1 |r|
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 6.30n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546822
PNG
(CHEMBL4746362)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2c[nH]c3ccccc23)\C#N)cc1 |r|
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 6.30n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546827
PNG
(CHEMBL4797064)
Show SMILES COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(cc2)N(C)C)\C#N)cc1 |r|
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 6.30n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546827
PNG
(CHEMBL4797064)
Show SMILES COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(cc2)N(C)C)\C#N)cc1 |r|
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 6.30n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546810
PNG
(CHEMBL4747770)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(CC2)c2oc(C)nc2C#N)cc1 |r|
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 6.60n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546810
PNG
(CHEMBL4747770)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(CC2)c2oc(C)nc2C#N)cc1 |r|
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 6.60n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50165583
PNG
(CHEMBL3798645)
Show SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)[C@@H](Cc2c[nH]c3ccccc23)NC=O)cc1 |r|
Show InChI InChI=1S/C37H43N9O3/c1-49-27-15-13-24(14-16-27)22-46-35(33(42-23-47)18-25-20-40-31-11-4-2-8-28(25)31)44-45-36(46)34(43-37(48)30(39)10-6-7-17-38)19-26-21-41-32-12-5-3-9-29(26)32/h2-5,8-9,11-16,20-21,23,30,33-34,40-41H,6-7,10,17-19,22,38-39H2,1H3,(H,42,47)(H,43,48)/t30-,33+,34+/m0/s1
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 8 -46.2n/an/an/an/an/an/a25



Universit£ de Montpellier

Curated by ChEMBL


Assay Description
Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by...

Bioorg Med Chem Lett 26: 2408-12 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.003
BindingDB Entry DOI: 10.7270/Q2J9688V
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM102977
PNG
(US8546435, 5)
Show SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2ccccc2)NC=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 |r|
Show InChI InChI=1S/C35H33N7O3/c1-45-27-16-14-25(15-17-27)22-42-33(31(38-23-43)19-24-9-3-2-4-10-24)40-41-34(42)32(39-35(44)30-13-7-8-18-36-30)20-26-21-37-29-12-6-5-11-28(26)29/h2-18,21,23,31-32,37H,19-20,22H2,1H3,(H,38,43)(H,39,44)/t31-,32-/m1/s1
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 8n/an/an/an/an/an/an/an/a



Universit£ de Montpellier

Curated by ChEMBL


Assay Description
Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method

Bioorg Med Chem Lett 26: 2408-12 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.003
BindingDB Entry DOI: 10.7270/Q2J9688V
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546821
PNG
(CHEMBL4759418)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc[nH]2)\C#N)cc1 |r|
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 8.5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546821
PNG
(CHEMBL4759418)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc[nH]2)\C#N)cc1 |r|
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 8.5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546814
PNG
(CHEMBL4800459)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccccc2)\C#N)cc1 |r|
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 9n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546814
PNG
(CHEMBL4800459)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccccc2)\C#N)cc1 |r|
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 9n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM102975
PNG
(US8546435, 3)
Show SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)[C@@H](Cc2c[nH]c3ccccc23)NC(C)=O)cc1 |r|
Show InChI InChI=1S/C38H36N8O3/c1-24(47)42-34(19-26-21-40-31-11-5-3-9-29(26)31)36-44-45-37(46(36)23-25-14-16-28(49-2)17-15-25)35(43-38(48)33-13-7-8-18-39-33)20-27-22-41-32-12-6-4-10-30(27)32/h3-18,21-22,34-35,40-41H,19-20,23H2,1-2H3,(H,42,47)(H,43,48)/t34-,35-/m1/s1
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 9n/an/an/an/an/an/an/an/a



Universit£ de Montpellier

Curated by ChEMBL


Assay Description
Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method

Bioorg Med Chem Lett 26: 2408-12 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.003
BindingDB Entry DOI: 10.7270/Q2J9688V
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50165590
PNG
(CHEMBL3799225)
Show SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2ccccc2)NC(C)=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1 |r,t:42|
Show InChI InChI=1S/C36H38N6O4/c1-24(43)38-31(20-25-10-4-3-5-11-25)34-40-41-35(42(34)23-26-15-17-28(45-2)18-16-26)32(39-36(44)33-14-8-9-19-46-33)21-27-22-37-30-13-7-6-12-29(27)30/h3-7,10-18,22,31-32,37H,8-9,19-21,23H2,1-2H3,(H,38,43)(H,39,44)/t31-,32-/m1/s1
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 9n/an/an/an/an/an/an/an/a



Universit£ de Montpellier

Curated by ChEMBL


Assay Description
Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method

Bioorg Med Chem Lett 26: 2408-12 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.003
BindingDB Entry DOI: 10.7270/Q2J9688V
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546820
PNG
(CHEMBL4757313)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2cccs2)\C#N)cc1 |r|
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UniChem
Article
PubMed
 9.70n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546820
PNG
(CHEMBL4757313)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2cccs2)\C#N)cc1 |r|
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UniChem
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PubMed
 9.70n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM102976
PNG
(US8546435, 4)
Show SMILES COc1ccc(Cn2c(nnc2[C@@H](Cc2ccccc2)NC(C)=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1 |r|
Show InChI InChI=1S/C36H35N7O3/c1-24(44)39-32(20-25-10-4-3-5-11-25)34-41-42-35(43(34)23-26-15-17-28(46-2)18-16-26)33(40-36(45)31-14-8-9-19-37-31)21-27-22-38-30-13-7-6-12-29(27)30/h3-19,22,32-33,38H,20-21,23H2,1-2H3,(H,39,44)(H,40,45)/t32-,33-/m1/s1
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PubMed
 10n/an/an/an/an/an/an/an/a



Universit£ de Montpellier

Curated by ChEMBL


Assay Description
Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method

Bioorg Med Chem Lett 26: 2408-12 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.003
BindingDB Entry DOI: 10.7270/Q2J9688V
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546830
PNG
(CHEMBL4744139)
Show SMILES CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(OC)cc2)\C#N)n1Cc1ccc(OC)cc1 |r|
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UniChem
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 10n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546830
PNG
(CHEMBL4744139)
Show SMILES CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(=C\c2ccc(OC)cc2)\C#N)n1Cc1ccc(OC)cc1 |r|
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UniChem
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 10n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546846
PNG
(CHEMBL4782214)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(C)=O)cc1 |r|
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 10n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50546846
PNG
(CHEMBL4782214)
Show SMILES COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(C)=O)cc1 |r|
PDB

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UniChem
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PubMed
 10n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HT...

Citation and Details

Article DOI: 10.1021/acs.jmedchem.9b02122
BindingDB Entry DOI: 10.7270/Q28K7DN3
More data for this
Ligand-Target Pair
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