Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451038 (8-(4-((dimethylamino)methyl)phenyl)-N-(2-fluoro- |...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451065 (US10676479, Example 95 | ethyl 5-(((5-fluoro-2,3-d...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451070 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)- |...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451062 (US10676479, Example 92 | ethyl 5-(((5-fluoro-2,3-d...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291686 (8-(1,3-Dimethyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291686 (8-(1,3-Dimethyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291695 (3-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291695 (3-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291815 ((5-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291815 ((5-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methy...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291908 (8-(6-((dimethylamino)methyl)-2-methylpyridin-3-yl)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291925 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291908 (8-(6-((dimethylamino)methyl)-2-methylpyridin-3-yl)...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291925 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291909 (8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291909 (8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291824 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291824 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291824 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291824 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291814 ((5-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291909 (8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291909 (8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291814 ((5-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methy...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291823 (8-(4-chloro-6-methoxypyridin-3-yl)-N-((5-fluoro-2,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291823 (8-(4-chloro-6-methoxypyridin-3-yl)-N-((5-fluoro-2,...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291853 (8-(2-(difluoromethyl)pyridin-3-yl)-N-((5-fluoro-2,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291918 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451065 (US10676479, Example 95 | ethyl 5-(((5-fluoro-2,3-d...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291918 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM450978 (1-Chloro-8-(2,4-dimethylpyrimidin-5-yl)-N-((5-fluo...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291853 (8-(2-(difluoromethyl)pyridin-3-yl)-N-((5-fluoro-2,...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291689 (N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291689 (N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451074 (8-(2,4-dimethylpyrimidin-5-yl)-1-(ethylsulfonyl)- ...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291882 (8-(6-(difluoromethoxy)-4-methylpyridin-3-yl)-N-((5...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291909 (8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291909 (8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291882 (8-(6-(difluoromethoxy)-4-methylpyridin-3-yl)-N-((5...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451053 (8-(2-(3,5-dimethylpiperazin-1-yl)-4- | US10676479,...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM450981 (8-(2-(Difluoromethyl)pyridin-3-yl)-N-((5-fluoro-2,...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291873 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291873 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291879 (8-(2,5-dimethylpyridin-4-yl)-N-((5-fluoro-2,3-dihy...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291880 (8-(1,3-dimethyl-1H-pyrazol-4-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291830 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291879 (8-(2,5-dimethylpyridin-4-yl)-N-((5-fluoro-2,3-dihy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451072 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)- |...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451054 (5-(((5-fluoro-2,3-dihydrobenzofuran-4- | US1067647...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291880 (8-(1,3-dimethyl-1H-pyrazol-4-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair |
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