Found 8 hits with Last Name = 'fattorusso' and Initial = 'e' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Broad substrate specificity ATP-binding cassette transporter ABCG2
(Homo sapiens (Human)) | BDBM50370874
(CHEMBL221371)Show InChI InChI=1S/C18H14O7/c1-22-8-6-11(20)14-12(7-8)24-17-13(15(14)21)9-4-3-5-10(19)16(9)25-18(17)23-2/h3-7,18-20H,1-2H3 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
UMR 5086 CNRS/Universit£ Lyon 1
Curated by ChEMBL
| Assay Description Inhibition of BCRP expressed in human HEK293 cells assessed as maximal mitoxantrone accumulation |
J Med Chem 50: 1933-8 (2007)
Article DOI: 10.1021/jm061450q BindingDB Entry DOI: 10.7270/Q21V5FRP |
More data for this Ligand-Target Pair | |
Broad substrate specificity ATP-binding cassette transporter ABCG2
(Homo sapiens (Human)) | BDBM50370873
(CHEMBL222265)Show SMILES COC1Oc2c(O)cccc2-c2c1oc1cc(OC)c(C)c(O)c1c2=O Show InChI InChI=1S/C19H16O7/c1-8-11(23-2)7-12-14(15(8)21)16(22)13-9-5-4-6-10(20)17(9)26-19(24-3)18(13)25-12/h4-7,19-21H,1-3H3 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UMR 5086 CNRS/Universit£ Lyon 1
Curated by ChEMBL
| Assay Description Inhibition of BCRP expressed in human HEK293 cells assessed as maximal mitoxantrone accumulation |
J Med Chem 50: 1933-8 (2007)
Article DOI: 10.1021/jm061450q BindingDB Entry DOI: 10.7270/Q21V5FRP |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM50192696
(1-(4-(pyrrolidin-1-ylmethyl)benzylidene)-2-(7-chlo...)Show SMILES Clc1ccc2c(ccnc2c1)N=NCc1ccc(CN2CCCC2)cc1 |w:11.12| Show InChI InChI=1S/C21H21ClN4/c22-18-7-8-19-20(9-10-23-21(19)13-18)25-24-14-16-3-5-17(6-4-16)15-26-11-1-2-12-26/h3-10,13H,1-2,11-12,14-15H2 | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.30E+8 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description Inhibition of beta-hematin formation by BHIA assay |
Bioorg Med Chem Lett 16: 5384-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.060 BindingDB Entry DOI: 10.7270/Q2NP25NR |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM50041457
(4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)...)Show InChI InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23) | UniProtKB/SwissProt
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.90E+8 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description Inhibition of beta-hematin formation by BHIA assay |
Bioorg Med Chem Lett 16: 5384-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.060 BindingDB Entry DOI: 10.7270/Q2NP25NR |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)Show InChI InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21) | UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9.10E+8 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description Inhibition of beta-hematin formation by BHIA assay |
Bioorg Med Chem Lett 16: 5384-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.060 BindingDB Entry DOI: 10.7270/Q2NP25NR |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM22985
(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)Show InChI InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21) | UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.69E+9 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita' di Siena
Curated by ChEMBL
| Assay Description Inhibition of beta-hematin formation |
J Med Chem 50: 595-8 (2007)
Article DOI: 10.1021/jm061429p BindingDB Entry DOI: 10.7270/Q2RF5W85 |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM31774
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)Show InChI InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H | UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.50E+9 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita' di Siena
Curated by ChEMBL
| Assay Description Inhibition of beta-hematin formation |
J Med Chem 50: 595-8 (2007)
Article DOI: 10.1021/jm061429p BindingDB Entry DOI: 10.7270/Q2RF5W85 |
More data for this Ligand-Target Pair | |
Histidine-rich protein PFHRP-II
(Plasmodium falciparum) | BDBM50203749
((+/-)-1-((4-chlorophenyl)(phenyl)(4-(pyrrolidin-1-...)Show SMILES Clc1ccc(cc1)C(c1ccccc1)(c1ccc(CN2CCCC2)cc1)n1ccnc1 Show InChI InChI=1S/C27H26ClN3/c28-26-14-12-25(13-15-26)27(31-19-16-29-21-31,23-6-2-1-3-7-23)24-10-8-22(9-11-24)20-30-17-4-5-18-30/h1-3,6-16,19,21H,4-5,17-18,20H2 | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.53E+9 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita' di Siena
Curated by ChEMBL
| Assay Description Inhibition of beta-hematin formation |
J Med Chem 50: 595-8 (2007)
Article DOI: 10.1021/jm061429p BindingDB Entry DOI: 10.7270/Q2RF5W85 |
More data for this Ligand-Target Pair | |