Found 6 hits with Last Name = 'feilen' and Initial = 'pj' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
ATP-binding cassette sub-family C member 8
(Homo sapiens (Human)) | BDBM50153520
((S)-2-ethoxy-4-(2-(3-methyl-1-(2-(piperidin-1-yl)p...)Show SMILES CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(O)=O |r| Show InChI InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mainz
Curated by ChEMBL
| Assay Description In vitro displacement of [3H]-glibenclamide (IC50=0.61) from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1) |
Bioorg Med Chem Lett 14: 5205-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.059 BindingDB Entry DOI: 10.7270/Q2BG2NGF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
ATP-binding cassette sub-family C member 8
(Homo sapiens (Human)) | BDBM50153521
(2-Methoxy-4-{[(S)-3-methyl-1-(2-piperidin-1-yl-phe...)Show SMILES COc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(O)=O Show InChI InChI=1S/C26H34N2O4/c1-18(2)15-22(20-9-5-6-10-23(20)28-13-7-4-8-14-28)27-25(29)17-19-11-12-21(26(30)31)24(16-19)32-3/h5-6,9-12,16,18,22H,4,7-8,13-15,17H2,1-3H3,(H,27,29)(H,30,31)/t22-/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 163 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mainz
Curated by ChEMBL
| Assay Description In vitro displacement of [3H]-glibenclamide (IC50=0.61) from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1) |
Bioorg Med Chem Lett 14: 5205-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.059 BindingDB Entry DOI: 10.7270/Q2BG2NGF |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 8
(Homo sapiens (Human)) | BDBM50153522
(2-(2-Fluoro-ethoxy)-4-{[(S)-3-methyl-1-(2-piperidi...)Show SMILES CC(C)C[C@H](NC(=O)Cc1ccc(C(O)=O)c(OCCF)c1)c1ccccc1N1CCCCC1 Show InChI InChI=1S/C27H35FN2O4/c1-19(2)16-23(21-8-4-5-9-24(21)30-13-6-3-7-14-30)29-26(31)18-20-10-11-22(27(32)33)25(17-20)34-15-12-28/h4-5,8-11,17,19,23H,3,6-7,12-16,18H2,1-2H3,(H,29,31)(H,32,33)/t23-/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 281 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Mainz
Curated by ChEMBL
| Assay Description In vitro displacement of [3H]-glibenclamide (IC50=0.61) from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1) |
Bioorg Med Chem Lett 14: 5205-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.059 BindingDB Entry DOI: 10.7270/Q2BG2NGF |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 8
(Homo sapiens (Human)) | BDBM50153520
((S)-2-ethoxy-4-(2-(3-methyl-1-(2-(piperidin-1-yl)p...)Show SMILES CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(O)=O |r| Show InChI InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a |
University of Mainz
Curated by ChEMBL
| Assay Description Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1) |
Bioorg Med Chem Lett 14: 5205-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.059 BindingDB Entry DOI: 10.7270/Q2BG2NGF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
ATP-binding cassette sub-family C member 8
(Homo sapiens (Human)) | BDBM50153522
(2-(2-Fluoro-ethoxy)-4-{[(S)-3-methyl-1-(2-piperidi...)Show SMILES CC(C)C[C@H](NC(=O)Cc1ccc(C(O)=O)c(OCCF)c1)c1ccccc1N1CCCCC1 Show InChI InChI=1S/C27H35FN2O4/c1-19(2)16-23(21-8-4-5-9-24(21)30-13-6-3-7-14-30)29-26(31)18-20-10-11-22(27(32)33)25(17-20)34-15-12-28/h4-5,8-11,17,19,23H,3,6-7,12-16,18H2,1-2H3,(H,29,31)(H,32,33)/t23-/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 134 | n/a | n/a | n/a | n/a | n/a |
University of Mainz
Curated by ChEMBL
| Assay Description Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1) |
Bioorg Med Chem Lett 14: 5205-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.059 BindingDB Entry DOI: 10.7270/Q2BG2NGF |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family C member 8
(Homo sapiens (Human)) | BDBM50153521
(2-Methoxy-4-{[(S)-3-methyl-1-(2-piperidin-1-yl-phe...)Show SMILES COc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(O)=O Show InChI InChI=1S/C26H34N2O4/c1-18(2)15-22(20-9-5-6-10-23(20)28-13-7-4-8-14-28)27-25(29)17-19-11-12-21(26(30)31)24(16-19)32-3/h5-6,9-12,16,18,22H,4,7-8,13-15,17H2,1-3H3,(H,27,29)(H,30,31)/t22-/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a |
University of Mainz
Curated by ChEMBL
| Assay Description Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1) |
Bioorg Med Chem Lett 14: 5205-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.059 BindingDB Entry DOI: 10.7270/Q2BG2NGF |
More data for this Ligand-Target Pair | |