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Compile Data Set for Download or QSAR

Found 71 hits with Last Name = 'feledziak' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50425557
PNG
(CHEMBL2313948)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)OCC=C)C1=O |r|
Show InChI InChI=1S/C19H23NO5/c1-3-12-24-19(23)20-13-16(18(20)22)14(2)25-17(21)11-7-10-15-8-5-4-6-9-15/h3-6,8-9,14,16H,1,7,10-13H2,2H3/t14-,16+/m1/s1
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n/an/a 3.70n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assay


Eur J Med Chem 60: 101-11 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.035
BindingDB Entry DOI: 10.7270/Q28C9XJN
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM26739
PNG
(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
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n/an/a 4.60n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Irreversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting


J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM23120
PNG
(7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]hepta...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ccccn1
Show InChI InChI=1S/C21H22N2O2/c24-19(14-7-2-1-4-10-17-11-5-3-6-12-17)21-23-16-20(25-21)18-13-8-9-15-22-18/h3,5-6,8-9,11-13,15-16H,1-2,4,7,10,14H2
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n/an/a 4.70n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting


J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50393236
PNG
(CHEMBL2151432)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C20H25NO4/c1-3-4-12-18(22)21-14-17(20(21)24)15(2)25-19(23)13-8-11-16-9-6-5-7-10-16/h3,5-7,9-10,15,17H,1,4,8,11-14H2,2H3/t15-,17+/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting


J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299922
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(4-phenylbutanoyloxy...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)C1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C20H25NO4/c1-3-4-12-18(22)21-14-17(20(21)24)15(2)25-19(23)13-8-11-16-9-6-5-7-10-16/h3,5-7,9-10,15,17H,1,4,8,11-14H2,2H3/t15-,17?/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50393236
PNG
(CHEMBL2151432)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C20H25NO4/c1-3-4-12-18(22)21-14-17(20(21)24)15(2)25-19(23)13-8-11-16-9-6-5-7-10-16/h3,5-7,9-10,15,17H,1,4,8,11-14H2,2H3/t15-,17+/m1/s1
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n/an/a 5.30n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assay


Eur J Med Chem 60: 101-11 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.035
BindingDB Entry DOI: 10.7270/Q28C9XJN
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50393236
PNG
(CHEMBL2151432)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C20H25NO4/c1-3-4-12-18(22)21-14-17(20(21)24)15(2)25-19(23)13-8-11-16-9-6-5-7-10-16/h3,5-7,9-10,15,17H,1,4,8,11-14H2,2H3/t15-,17+/m1/s1
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n/an/a 5.37n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting


J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50425556
PNG
(CHEMBL2313949)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)NCC=C)C1=O |r|
Show InChI InChI=1S/C19H24N2O4/c1-3-12-20-19(24)21-13-16(18(21)23)14(2)25-17(22)11-7-10-15-8-5-4-6-9-15/h3-6,8-9,14,16H,1,7,10-13H2,2H3,(H,20,24)/t14-,16+/m1/s1
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n/an/a 5.60n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assay


Eur J Med Chem 60: 101-11 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.035
BindingDB Entry DOI: 10.7270/Q28C9XJN
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50393235
PNG
(CHEMBL2151436)
Show SMILES C[C@@H](OCCCCc1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C20H27NO3/c1-3-4-13-19(22)21-15-18(20(21)23)16(2)24-14-9-8-12-17-10-6-5-7-11-17/h3,5-7,10-11,16,18H,1,4,8-9,12-15H2,2H3/t16-,18+/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Irreversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting


J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50393235
PNG
(CHEMBL2151436)
Show SMILES C[C@@H](OCCCCc1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C20H27NO3/c1-3-4-13-19(22)21-15-18(20(21)23)16(2)24-14-9-8-12-17-10-6-5-7-11-17/h3,5-7,10-11,16,18H,1,4,8-9,12-15H2,2H3/t16-,18+/m1/s1
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n/an/a 8.13n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Irreversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting


J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299926
PNG
(1-(Hexa-5-enoyl)-(3S)-3-[1(R)-(4-phenylbutanoyloxy...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)CCCC=C)C1=O |r|
Show InChI InChI=1S/C21H27NO4/c1-3-4-6-13-19(23)22-15-18(21(22)25)16(2)26-20(24)14-9-12-17-10-7-5-8-11-17/h3,5,7-8,10-11,16,18H,1,4,6,9,12-15H2,2H3/t16-,18+/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50425564
PNG
(CHEMBL2313944)
Show SMILES C[C@@H](OC(=O)NCCc1ccccc1)[C@@H]1CN(C(=O)OCC=C)C1=O |r|
Show InChI InChI=1S/C18H22N2O5/c1-3-11-24-18(23)20-12-15(16(20)21)13(2)25-17(22)19-10-9-14-7-5-4-6-8-14/h3-8,13,15H,1,9-12H2,2H3,(H,19,22)/t13-,15+/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assay


Eur J Med Chem 60: 101-11 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.035
BindingDB Entry DOI: 10.7270/Q28C9XJN
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50425560
PNG
(CHEMBL2313951)
Show SMILES CCCSC(=O)N1C[C@@H]([C@@H](C)OC(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C19H25NO4S/c1-3-12-25-19(23)20-13-16(18(20)22)14(2)24-17(21)11-7-10-15-8-5-4-6-9-15/h4-6,8-9,14,16H,3,7,10-13H2,1-2H3/t14-,16+/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assay


Eur J Med Chem 60: 101-11 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.035
BindingDB Entry DOI: 10.7270/Q28C9XJN
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299923
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(biphenylacetyloxy)-...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C24H25NO4/c1-3-4-10-22(26)25-16-21(24(25)28)17(2)29-23(27)15-18-11-13-20(14-12-18)19-8-6-5-7-9-19/h3,5-9,11-14,17,21H,1,4,10,15-16H2,2H3/t17-,21+/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299927
PNG
(1-(Hexa-5-enoyl)-(3S)-3-[1(R)-(biphenylacetyloxy)-...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1CN(C(=O)CCCC=C)C1=O |r|
Show InChI InChI=1S/C25H27NO4/c1-3-4-6-11-23(27)26-17-22(25(26)29)18(2)30-24(28)16-19-12-14-21(15-13-19)20-9-7-5-8-10-20/h3,5,7-10,12-15,18,22H,1,4,6,11,16-17H2,2H3/t18-,22+/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50425563
PNG
(CHEMBL2313945)
Show SMILES C[C@@H](OC(=O)NCCc1ccccc1)[C@@H]1CN(C(=O)NCC=C)C1=O |r|
Show InChI InChI=1S/C18H23N3O4/c1-3-10-19-17(23)21-12-15(16(21)22)13(2)25-18(24)20-11-9-14-7-5-4-6-8-14/h3-8,13,15H,1,9-12H2,2H3,(H,19,23)(H,20,24)/t13-,15+/m1/s1
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n/an/a 29n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assay


Eur J Med Chem 60: 101-11 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.035
BindingDB Entry DOI: 10.7270/Q28C9XJN
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299917
PNG
(1-(4-Phenylbutanoyl)-(3S)-3-[1(R)-(4-phenylbutanoy...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C25H29NO4/c1-19(30-24(28)17-9-15-21-12-6-3-7-13-21)22-18-26(25(22)29)23(27)16-8-14-20-10-4-2-5-11-20/h2-7,10-13,19,22H,8-9,14-18H2,1H3/t19-,22+/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50425566
PNG
(CHEMBL2313940)
Show SMILES C[C@@H](OC(=O)COCc1ccccc1)[C@@H]1CN(C(=O)OCC=C)C1=O |r|
Show InChI InChI=1S/C18H21NO6/c1-3-9-24-18(22)19-10-15(17(19)21)13(2)25-16(20)12-23-11-14-7-5-4-6-8-14/h3-8,13,15H,1,9-12H2,2H3/t13-,15+/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assay


Eur J Med Chem 60: 101-11 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.035
BindingDB Entry DOI: 10.7270/Q28C9XJN
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50425567
PNG
(CHEMBL2313952)
Show SMILES C[C@@H](OC(=O)COCc1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C19H23NO5/c1-3-4-10-17(21)20-11-16(19(20)23)14(2)25-18(22)13-24-12-15-8-6-5-7-9-15/h3,5-9,14,16H,1,4,10-13H2,2H3/t14-,16+/m1/s1
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n/an/a 31n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assay


Eur J Med Chem 60: 101-11 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.035
BindingDB Entry DOI: 10.7270/Q28C9XJN
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299919
PNG
(1-(4-Phenylbutanoyl)-(3S)-3-[1(R)-(biphenylacetylo...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1CN(C(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C29H29NO4/c1-21(26-20-30(29(26)33)27(31)14-8-11-22-9-4-2-5-10-22)34-28(32)19-23-15-17-25(18-16-23)24-12-6-3-7-13-24/h2-7,9-10,12-13,15-18,21,26H,8,11,14,19-20H2,1H3/t21-,26+/m1/s1
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n/an/a 32n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299925
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(hexa-5-enoyloxy)-et...)
Show SMILES C[C@@H](OC(=O)CCCC=C)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C16H23NO4/c1-4-6-8-10-15(19)21-12(3)13-11-17(16(13)20)14(18)9-7-5-2/h4-5,12-13H,1-2,6-11H2,3H3/t12-,13+/m1/s1
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n/an/a 32n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM26740
PNG
(N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carbo...)
Show SMILES O=C(Nc1ccccc1)N1CCC(Cc2cnc3ccccc3c2)CC1
Show InChI InChI=1S/C22H23N3O/c26-22(24-20-7-2-1-3-8-20)25-12-10-17(11-13-25)14-18-15-19-6-4-5-9-21(19)23-16-18/h1-9,15-17H,10-14H2,(H,24,26)
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n/an/a 33n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting


J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50425565
PNG
(CHEMBL2313943)
Show SMILES C[C@@H](OC(=O)NCCc1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C19H24N2O4/c1-3-4-10-17(22)21-13-16(18(21)23)14(2)25-19(24)20-12-11-15-8-6-5-7-9-15/h3,5-9,14,16H,1,4,10-13H2,2H3,(H,20,24)/t14-,16+/m1/s1
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n/an/a 33n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assay


Eur J Med Chem 60: 101-11 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.035
BindingDB Entry DOI: 10.7270/Q28C9XJN
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299918
PNG
(1-(4-Phenylbutanoyl)-(3S)-3-[1(R)-(5-phenylpentano...)
Show SMILES C[C@@H](OC(=O)CCCCc1ccccc1)[C@@H]1CN(C(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C26H31NO4/c1-20(31-25(29)18-9-8-15-21-11-4-2-5-12-21)23-19-27(26(23)30)24(28)17-10-16-22-13-6-3-7-14-22/h2-7,11-14,20,23H,8-10,15-19H2,1H3/t20-,23+/m1/s1
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n/an/a 45n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299913
PNG
(1-(3-Phenylpropanoyl)-(3S)-3-[1(R)-(4-phenylbutano...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C24H27NO4/c1-18(29-23(27)14-8-13-19-9-4-2-5-10-19)21-17-25(24(21)28)22(26)16-15-20-11-6-3-7-12-20/h2-7,9-12,18,21H,8,13-17H2,1H3/t18-,21+/m1/s1
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n/an/a 49n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299915
PNG
(1-(3-Phenylpropanoyl)-(3S)-3-[1(R)-(biphenylacetyl...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1CN(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C28H27NO4/c1-20(25-19-29(28(25)32)26(30)17-14-21-8-4-2-5-9-21)33-27(31)18-22-12-15-24(16-13-22)23-10-6-3-7-11-23/h2-13,15-16,20,25H,14,17-19H2,1H3/t20-,25+/m1/s1
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n/an/a 50n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299916
PNG
(1-(4-Phenylbutanoyl)-(3S)-3-[1(R)-(3-phenylpropano...)
Show SMILES C[C@@H](OC(=O)CCc1ccccc1)[C@@H]1CN(C(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C24H27NO4/c1-18(29-23(27)16-15-20-11-6-3-7-12-20)21-17-25(24(21)28)22(26)14-8-13-19-9-4-2-5-10-19/h2-7,9-12,18,21H,8,13-17H2,1H3/t18-,21+/m1/s1
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n/an/a 57n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50425559
PNG
(CHEMBL2313941)
Show SMILES C[C@@H](OC(=O)COCc1ccccc1)[C@@H]1CN(C(=O)NCC=C)C1=O |r|
Show InChI InChI=1S/C18H22N2O5/c1-3-9-19-18(23)20-10-15(17(20)22)13(2)25-16(21)12-24-11-14-7-5-4-6-8-14/h3-8,13,15H,1,9-12H2,2H3,(H,19,23)/t13-,15+/m1/s1
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n/an/a 71n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assay


Eur J Med Chem 60: 101-11 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.035
BindingDB Entry DOI: 10.7270/Q28C9XJN
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299914
PNG
(1-(3-Phenylpropanoyl)-(3S)-3-[1(R)-(5-phenylpentan...)
Show SMILES C[C@@H](OC(=O)CCCCc1ccccc1)[C@@H]1CN(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C25H29NO4/c1-19(30-24(28)15-9-8-14-20-10-4-2-5-11-20)22-18-26(25(22)29)23(27)17-16-21-12-6-3-7-13-21/h2-7,10-13,19,22H,8-9,14-18H2,1H3/t19-,22+/m1/s1
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n/an/a 91n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299924
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(pent-4-enoyloxy)-et...)
Show SMILES C[C@@H](OC(=O)CCC=C)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C15H21NO4/c1-4-6-8-13(17)16-10-12(15(16)19)11(3)20-14(18)9-7-5-2/h4-5,11-12H,1-2,6-10H2,3H3/t11-,12+/m1/s1
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n/an/a 98n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50425568
PNG
(CHEMBL2313950)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=S)NCC=C)C1=O |r|
Show InChI InChI=1S/C19H24N2O3S/c1-3-12-20-19(25)21-13-16(18(21)23)14(2)24-17(22)11-7-10-15-8-5-4-6-9-15/h3-6,8-9,14,16H,1,7,10-13H2,2H3,(H,20,25)/t14-,16+/m1/s1
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n/an/a 146n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assay


Eur J Med Chem 60: 101-11 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.035
BindingDB Entry DOI: 10.7270/Q28C9XJN
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299912
PNG
(1-(3-Phenylpropanoyl)-(3S)-3-[1(R)-(3-phenylpropan...)
Show SMILES C[C@@H](OC(=O)CCc1ccccc1)[C@@H]1CN(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C23H25NO4/c1-17(28-22(26)15-13-19-10-6-3-7-11-19)20-16-24(23(20)27)21(25)14-12-18-8-4-2-5-9-18/h2-11,17,20H,12-16H2,1H3/t17-,20+/m1/s1
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n/an/a 157n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299921
PNG
(1-(5-Phenylpentanoyl)-(3S)-3-[1(R)-(biphenylacetyl...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1CN(C(=O)CCCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C30H31NO4/c1-22(35-29(33)20-24-16-18-26(19-17-24)25-13-6-3-7-14-25)27-21-31(30(27)34)28(32)15-9-8-12-23-10-4-2-5-11-23/h2-7,10-11,13-14,16-19,22,27H,8-9,12,15,20-21H2,1H3/t22-,27+/m1/s1
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n/an/a 236n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50425561
PNG
(CHEMBL2313947)
Show SMILES C[C@@H](OC(=O)CCCc1ccncc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C19H24N2O4/c1-3-4-7-17(22)21-13-16(19(21)24)14(2)25-18(23)8-5-6-15-9-11-20-12-10-15/h3,9-12,14,16H,1,4-8,13H2,2H3/t14-,16+/m1/s1
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n/an/a 310n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assay


Eur J Med Chem 60: 101-11 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.035
BindingDB Entry DOI: 10.7270/Q28C9XJN
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299920
PNG
(1-(5-Phenylpentanoyl)-(3S)-3-[1(R)-(4-phenylbutano...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)CCCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C26H31NO4/c1-20(31-25(29)18-10-16-22-13-6-3-7-14-22)23-19-27(26(23)30)24(28)17-9-8-15-21-11-4-2-5-12-21/h2-7,11-14,20,23H,8-10,15-19H2,1H3/t20-,23+/m1/s1
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n/an/a 449n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299938
PNG
(1-(4-Phenylbutanoyl)-(3R,4R)-3-[1(R)-(biphenylacet...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C31H31NO6/c1-21(37-28(35)20-24-16-18-26(19-17-24)25-13-7-4-8-14-25)29-30(36)32(31(29)38-22(2)33)27(34)15-9-12-23-10-5-3-6-11-23/h3-8,10-11,13-14,16-19,21,29,31H,9,12,15,20H2,1-2H3/t21-,29+,31-/m1/s1
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n/an/a 708n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299935
PNG
(1-(3-Phenylpropanoyl)-(3R,4R)-3-[1(R)-(biphenylace...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C30H29NO6/c1-20(36-27(34)19-23-13-16-25(17-14-23)24-11-7-4-8-12-24)28-29(35)31(30(28)37-21(2)32)26(33)18-15-22-9-5-3-6-10-22/h3-14,16-17,20,28,30H,15,18-19H2,1-2H3/t20-,28+,30-/m1/s1
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n/an/a 826n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50425562
PNG
(CHEMBL2313946)
Show SMILES C[C@@H](OC(=O)NCCc1ccccc1)[C@@H]1CN(C(=S)NCC=C)C1=O |r|
Show InChI InChI=1S/C18H23N3O3S/c1-3-10-19-17(25)21-12-15(16(21)22)13(2)24-18(23)20-11-9-14-7-5-4-6-8-14/h3-8,13,15H,1,9-12H2,2H3,(H,19,25)(H,20,23)/t13-,15+/m1/s1
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n/an/a 959n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assay


Eur J Med Chem 60: 101-11 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.035
BindingDB Entry DOI: 10.7270/Q28C9XJN
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299934
PNG
(1-(3-Phenylpropanoyl)-(3R,4R)-3-[1(R)-(4-phenylbut...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C26H29NO6/c1-18(32-23(30)15-9-14-20-10-5-3-6-11-20)24-25(31)27(26(24)33-19(2)28)22(29)17-16-21-12-7-4-8-13-21/h3-8,10-13,18,24,26H,9,14-17H2,1-2H3/t18-,24+,26-/m1/s1
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n/an/a 960n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50425558
PNG
(CHEMBL2313942)
Show SMILES C[C@@H](OC(=O)COCc1ccccc1)[C@@H]1CN(C(=S)NCC=C)C1=O |r|
Show InChI InChI=1S/C18H22N2O4S/c1-3-9-19-18(25)20-10-15(17(20)22)13(2)24-16(21)12-23-11-14-7-5-4-6-8-14/h3-8,13,15H,1,9-12H2,2H3,(H,19,25)/t13-,15+/m1/s1
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n/an/a 1.04E+3n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH-mediated [3H]AEA hydrolysis after 10 mins by liquid scintillation assay


Eur J Med Chem 60: 101-11 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.035
BindingDB Entry DOI: 10.7270/Q28C9XJN
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM50299923
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(biphenylacetyloxy)-...)
Show SMILES C[C@@H](OC(=O)Cc1ccc(cc1)-c1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C24H25NO4/c1-3-4-10-22(26)25-16-21(24(25)28)17(2)29-23(27)15-18-11-13-20(14-12-18)19-8-6-5-7-9-19/h3,5-9,11-14,17,21H,1,4,10,15-16H2,2H3/t17-,21+/m1/s1
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n/an/a 1.84E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MGL using 2-oleoylglycerol by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299929
PNG
(1-(Pent-4-enoyl)-(3R,4R)-3-[1(R)-(pent-4-enoyloxy)...)
Show SMILES C[C@@H](OC(=O)CCC=C)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C17H23NO6/c1-5-7-9-13(20)18-16(22)15(17(18)24-12(4)19)11(3)23-14(21)10-8-6-2/h5-6,11,15,17H,1-2,7-10H2,3-4H3/t11-,15+,17-/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299933
PNG
(1-(3-Phenylpropanoyl)-(3R,4R)-3-[1(R)-(3-phenylpro...)
Show SMILES C[C@@H](OC(=O)CCc1ccccc1)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C25H27NO6/c1-17(31-22(29)16-14-20-11-7-4-8-12-20)23-24(30)26(25(23)32-18(2)27)21(28)15-13-19-9-5-3-6-10-19/h3-12,17,23,25H,13-16H2,1-2H3/t17-,23+,25-/m1/s1
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n/an/a 2.19E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50393240
PNG
(CHEMBL2151435)
Show SMILES C[C@@H](OCCCCc1ccccc1)C1CN(C1)C(=O)CCC=C |r|
Show InChI InChI=1S/C20H29NO2/c1-3-4-13-20(22)21-15-19(16-21)17(2)23-14-9-8-12-18-10-6-5-7-11-18/h3,5-7,10-11,17,19H,1,4,8-9,12-16H2,2H3/t17-/m1/s1
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n/an/a 2.88E+3n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting


J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50393240
PNG
(CHEMBL2151435)
Show SMILES C[C@@H](OCCCCc1ccccc1)C1CN(C1)C(=O)CCC=C |r|
Show InChI InChI=1S/C20H29NO2/c1-3-4-13-20(22)21-15-19(16-21)17(2)23-14-9-8-12-18-10-6-5-7-11-18/h3,5-7,10-11,17,19H,1,4,8-9,12-16H2,2H3/t17-/m1/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Reversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation counting


J Med Chem 54: 6812-23 (2011)


Article DOI: 10.1021/jm200723m
BindingDB Entry DOI: 10.7270/Q2FB542J
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299937
PNG
(1-(4-Phenylbutanoyl)-(3R,4R)-3-[1(R)-(4-phenylbuta...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C27H31NO6/c1-19(33-24(31)18-10-16-22-13-7-4-8-14-22)25-26(32)28(27(25)34-20(2)29)23(30)17-9-15-21-11-5-3-6-12-21/h3-8,11-14,19,25,27H,9-10,15-18H2,1-2H3/t19-,25+,27-/m1/s1
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n/an/a 3.12E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM50299922
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(4-phenylbutanoyloxy...)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)C1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C20H25NO4/c1-3-4-12-18(22)21-14-17(20(21)24)15(2)25-19(23)13-8-11-16-9-6-5-7-10-16/h3,5-7,9-10,15,17H,1,4,8,11-14H2,2H3/t15-,17?/m1/s1
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n/an/a 4.06E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MGL using 2-oleoylglycerol by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM50393236
PNG
(CHEMBL2151432)
Show SMILES C[C@@H](OC(=O)CCCc1ccccc1)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C20H25NO4/c1-3-4-12-18(22)21-14-17(20(21)24)15(2)25-19(23)13-8-11-16-9-6-5-7-10-16/h3,5-7,9-10,15,17H,1,4,8,11-14H2,2H3/t15-,17+/m1/s1
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n/an/a 4.06E+3n/an/an/an/an/a25



Universit£ catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAGL using [3H]-2-OG as substrate incubated for 30 mins at room temperature followed by incubation at 37 degC for 10 ...


Eur J Med Chem 60: 101-11 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.035
BindingDB Entry DOI: 10.7270/Q28C9XJN
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM50299925
PNG
(1-(Pent-4-enoyl)-(3S)-3-[1(R)-(hexa-5-enoyloxy)-et...)
Show SMILES C[C@@H](OC(=O)CCCC=C)[C@@H]1CN(C(=O)CCC=C)C1=O |r|
Show InChI InChI=1S/C16H23NO4/c1-4-6-8-10-15(19)21-12(3)13-11-17(16(13)20)14(18)9-7-5-2/h4-5,12-13H,1-2,6-11H2,3H3/t12-,13+/m1/s1
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n/an/a 4.72E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MGL using 2-oleoylglycerol by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50299936
PNG
(1-(4-Phenylbutanoyl)-(3R,4R)-3-[1(R)-(3-phenylprop...)
Show SMILES C[C@@H](OC(=O)CCc1ccccc1)[C@@H]1[C@@H](OC(C)=O)N(C(=O)CCCc2ccccc2)C1=O |r|
Show InChI InChI=1S/C26H29NO6/c1-18(32-23(30)17-16-21-12-7-4-8-13-21)24-25(31)27(26(24)33-19(2)28)22(29)15-9-14-20-10-5-3-6-11-20/h3-8,10-13,18,24,26H,9,14-17H2,1-2H3/t18-,24+,26-/m1/s1
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n/an/a 4.90E+3n/an/an/an/an/an/a



Universite Catholique de Louvain

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH using [3H]anandamide by competitive hydrolysis assay


J Med Chem 52: 7054-68 (2009)


Article DOI: 10.1021/jm9008532
BindingDB Entry DOI: 10.7270/Q22B8Z3N
More data for this
Ligand-Target Pair
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