Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine--tRNA ligase (Staphylococcus aureus) | BDBM18131 (SB-243545 | butyl (2S)-2-[(2S)-2-amino-3-(4-hydrox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The concentration of inhibitor which results in 50% inhibition (IC50) of enzyme activity was determined by preincubating recombinant S. aureus TyrRS ... | Protein Sci 10: 2008-16 (2001) Article DOI: 10.1110/ps.18001 BindingDB Entry DOI: 10.7270/Q2NG4NXT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Tyrosine--tRNA ligase (Staphylococcus aureus) | BDBM18128 ((2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The concentration of inhibitor which results in 50% inhibition (IC50) of enzyme activity was determined by preincubating recombinant S. aureus TyrRS ... | Protein Sci 10: 2008-16 (2001) Article DOI: 10.1110/ps.18001 BindingDB Entry DOI: 10.7270/Q2NG4NXT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Methionine--tRNA ligase, cytoplasmic (Homo sapiens (Human)) | BDBM50112575 (2-[3-(6,8-Dibromo-1,2,3,4-tetrahydro-quinolin-4-yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibitory concentration against Methionyl-tRNA synthetase in a pyrophosphate exchange assay | J Med Chem 45: 1959-62 (2002) BindingDB Entry DOI: 10.7270/Q2HQ3Z6X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine--tRNA ligase (Staphylococcus aureus) | BDBM18130 ((2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | KEGG MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The concentration of inhibitor which results in 50% inhibition (IC50) of enzyme activity was determined by preincubating recombinant S. aureus TyrRS ... | Protein Sci 10: 2008-16 (2001) Article DOI: 10.1110/ps.18001 BindingDB Entry DOI: 10.7270/Q2NG4NXT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18116 (2-[2-({[(2R)-2-(4-bromothiophen-2-yl)-2-hydroxyeth...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine--tRNA ligase (Staphylococcus aureus) | BDBM18132 ((2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The concentration of inhibitor which results in 50% inhibition (IC50) of enzyme activity was determined by preincubating recombinant S. aureus TyrRS ... | Protein Sci 10: 2008-16 (2001) Article DOI: 10.1110/ps.18001 BindingDB Entry DOI: 10.7270/Q2NG4NXT | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18093 (2-[2-({[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]am...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18098 (2-({[2-(benzyloxy)phenyl]methyl}amino)-1-(4-bromot...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine--tRNA ligase, cytoplasmic (Homo sapiens (Human)) | BDBM50112577 (2-[3-(6-Ethyl-8-iodo-1,2,3,4-tetrahydro-quinolin-4...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibitory concentration against Staphylococcus aureus Methionyl-tRNA synthetase | J Med Chem 45: 1959-62 (2002) BindingDB Entry DOI: 10.7270/Q2HQ3Z6X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18102 (1-(4-bromothiophen-2-yl)-2-({[2-(pyridin-4-ylmetho...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18096 (1-(4-bromothiophen-2-yl)-2-[({2-[2-(morpholin-4-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18097 (1-(4-bromothiophen-2-yl)-2-({[2-(prop-2-en-1-yloxy...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18101 (1-(4-bromothiophen-2-yl)-2-({[2-(pyridin-3-ylmetho...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18114 (2-({[2-(4-aminobutoxy)phenyl]methyl}amino)-1-(4-br...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18110 (3-[2-({[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]am...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18099 (1-(4-bromothiophen-2-yl)-2-[({2-[(4-methanesulfony...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 26 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18103 (2-({[2-(1H-1,3-benzodiazol-2-ylmethoxy)phenyl]meth...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 26 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18113 (4-[2-({[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]am...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 26 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18112 (4-[2-({[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]am...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18085 (2-({[2-(benzyloxy)phenyl]methyl}amino)-1-(3-chloro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18105 (2-[2-({[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]am...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18086 (2-({[2-(benzyloxy)phenyl]methyl}amino)-1-(3-iodoph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18091 (1-(4-bromothiophen-2-yl)-2-({[2-(methoxymethoxy)ph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18109 (3-[2-({[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]am...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18104 (2-[2-({[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]am...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 42 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18111 (4-[2-({[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]am...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18100 (1-(4-bromothiophen-2-yl)-2-({[2-(pyridin-2-ylmetho...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18092 (2-[2-({[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]am...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 49 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18089 (1-(4-bromothiophen-2-yl)-2-{[(2-methoxyphenyl)meth...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18081 (2-({[2-(benzyloxy)phenyl]methyl}amino)-1-[3-(trifl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Haemophilus influenzae) | BDBM18116 (2-[2-({[(2R)-2-(4-bromothiophen-2-yl)-2-hydroxyeth...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 56 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18080 (2-({[2-(prop-2-en-1-yloxy)phenyl]methyl}amino)-1-[...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18108 (3-[2-({[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]am...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18115 (2-{4-[2-({[2-(4-bromothiophen-2-yl)-2-hydroxyethyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 69 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18087 (2-({[2-(benzyloxy)phenyl]methyl}amino)-1-(3-methox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 83 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18077 (2-[({2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethyl}...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18083 (2-{[(2-methoxyphenyl)methyl]amino}-1-(3-methylphen...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18082 (1-(3-bromophenyl)-2-{[(2-methoxyphenyl)methyl]amin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18107 (2-[2-({[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]am...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI (Staphylococcus aureus) | BDBM8767 (1,2,3,4-Tetrahydropyrido[3,4-b]indole 3 | 4-({9-[(...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | 6.5 | 30 |
GlaxoSmithKline | Assay Description Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e... | Bioorg Med Chem Lett 11: 2241-4 (2001) Article DOI: 10.1016/s0960-894x(01)00405-x BindingDB Entry DOI: 10.7270/Q24X5610 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18090 (1-(4-bromothiophen-2-yl)-2-{[(2-phenoxyphenyl)meth...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI (Staphylococcus aureus) | BDBM8786 (1,2,3,4-tetrahydro pyrido[3,4-b]indole 30 | 2-({9-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | 30 |
GlaxoSmithKline | Assay Description Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e... | Bioorg Med Chem Lett 11: 2241-4 (2001) Article DOI: 10.1016/s0960-894x(01)00405-x BindingDB Entry DOI: 10.7270/Q24X5610 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18106 (2-[2-({[2-(4-bromothiophen-2-yl)-2-hydroxyethyl]am...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Haemophilus influenzae) | BDBM18103 (2-({[2-(1H-1,3-benzodiazol-2-ylmethoxy)phenyl]meth...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | 2.0 | n/a |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptide deformylase (Haemophilus influenzae) | BDBM21683 (N-hydroxy-N-(3-phenylpropyl)formamide | SB-485345) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | 7.6 | 25 |
GSK | Assay Description Enzyme assay was carried out in 96-well microtiter plates with a SpectraMax plate reader (Molecular Devices Corp.). PDF activity was measured using a... | Protein Sci 12: 349-60 (2003) Article DOI: 10.1110/ps.0229303 BindingDB Entry DOI: 10.7270/Q2F18X1N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18072 (2-(benzylamino)-1-[3-(trifluoromethyl)phenyl]ethan...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI (Staphylococcus aureus) | BDBM8789 (1,2,3,4-tetrahydro pyrido[3,4-b]indole 33 | 2-chlo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | 30 |
GlaxoSmithKline | Assay Description Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e... | Bioorg Med Chem Lett 11: 2241-4 (2001) Article DOI: 10.1016/s0960-894x(01)00405-x BindingDB Entry DOI: 10.7270/Q24X5610 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylalanine--tRNA ligase alpha/beta subunit (Staphylococcus aureus) | BDBM18079 (2-{[(2-methoxyphenyl)methyl]amino}-1-[3-(trifluoro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | 7.9 | 37 |
GSK | Assay Description The reactions were performed in 96-well Packard 384-well Packard Optiplates. After 10 min of incubation, the reaction was stopped by addition of a co... | Bioorg Med Chem Lett 15: 2305-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.003 BindingDB Entry DOI: 10.7270/Q25D8Q3C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptide deformylase (Escherichia coli (strain K12)) | BDBM21683 (N-hydroxy-N-(3-phenylpropyl)formamide | SB-485345) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem | MMDB PDB Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | 7.6 | 25 |
GSK | Assay Description Enzyme assay was carried out in 96-well microtiter plates with a SpectraMax plate reader (Molecular Devices Corp.). PDF activity was measured using a... | Protein Sci 12: 349-60 (2003) Article DOI: 10.1110/ps.0229303 BindingDB Entry DOI: 10.7270/Q2F18X1N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI (Staphylococcus aureus) | BDBM8787 (1,2,3,4-tetrahydro pyrido[3,4-b]indole 31 | 5-chlo...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | 30 |
GlaxoSmithKline | Assay Description Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e... | Bioorg Med Chem Lett 11: 2241-4 (2001) Article DOI: 10.1016/s0960-894x(01)00405-x BindingDB Entry DOI: 10.7270/Q24X5610 | |||||||||||
More data for this Ligand-Target Pair |
Displayed 1 to 50 (of 178 total ) | Next | Last >> |