Found 2 hits with Last Name = 'frost' and Initial = 'hn' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50434377
(CHEMBL2387002)Show SMILES CC(C)n1cc(C(=O)c2cccc(NC(=O)Nc3ccc(Cl)cc3)c2)c2c(N)ncnc12 Show InChI InChI=1S/C23H21ClN6O2/c1-13(2)30-11-18(19-21(25)26-12-27-22(19)30)20(31)14-4-3-5-17(10-14)29-23(32)28-16-8-6-15(24)7-9-16/h3-13H,1-2H3,(H2,25,26,27)(H2,28,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDGFR (unknown origin) |
Bioorg Med Chem Lett 23: 3059-63 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.012 BindingDB Entry DOI: 10.7270/Q24J0GGF |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50434378
(CHEMBL2386994)Show SMILES Nc1ncnc2n(cc(C(=O)c3cccc(NC(=O)Nc4c(F)cccc4F)c3)c12)C1CCCC1 Show InChI InChI=1S/C25H22F2N6O2/c26-18-9-4-10-19(27)21(18)32-25(35)31-15-6-3-5-14(11-15)22(34)17-12-33(16-7-1-2-8-16)24-20(17)23(28)29-13-30-24/h3-6,9-13,16H,1-2,7-8H2,(H2,28,29,30)(H2,31,32,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDGFR (unknown origin) |
Bioorg Med Chem Lett 23: 3059-63 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.012 BindingDB Entry DOI: 10.7270/Q24J0GGF |
More data for this Ligand-Target Pair | |