| Reaction Details |
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 | Report a problem with these data |
| Target | Platelet-derived growth factor receptor beta |
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| Ligand | BDBM50434377 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_961757 (CHEMBL2389575) |
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| IC50 | 1400±n/a nM |
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| Citation |  Arcari, JT; Beebe, JS; Berliner, MA; Bernardo, V; Boehm, M; Borzillo, GV; Clark, T; Cohen, BD; Connell, RD; Frost, HN; Gordon, DA; Hungerford, WM; Kakar, SM; Kanter, A; Keene, NF; Knauth, EA; Lagreca, SD; Lu, Y; Martinez-Alsina, L; Marx, MA; Morris, J; Patel, NC; Savage, D; Soderstrom, CI; Thompson, C; Tkalcevic, G; Tom, NJ; Vajdos, FF; Valentine, JJ; Vincent, PW; Wessel, MD; Chen, JM Discovery and synthesis of novel 4-aminopyrrolopyrimidine Tie-2 kinase inhibitors for the treatment of solid tumors. Bioorg Med Chem Lett23:3059-63 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Platelet-derived growth factor receptor beta |
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| Name: | Platelet-derived growth factor receptor beta |
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| Synonyms: | Beta-type platelet-derived growth factor receptor | CD140 antigen-like family member B | CD140b antigen | CD_antigen=CD140b | PDGF Receptor Substrate | PDGF-R-beta | PDGFR | PDGFR substrate | PDGFR-1 | PDGFR1 | PDGFRB | PDGFRbeta | PGFRB_HUMAN | Platelet-Derived Growth Factor Receptor, beta | Platelet-derived growth factor receptor 1 | Platelet-derived growth factor receptor beta | Platelet-derived growth factor receptor beta (PDGFR-beta) | Platelet-derived growth factor receptor beta (PDGFRB) | Platelet-derived growth factor receptor beta (PDGFRbeta) | VHL/PDGFRB |
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| Type: | Enzyme |
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| Mol. Mass.: | 123922.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09619 |
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| Residue: | 1106 |
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| Sequence: | MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPV
VWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFV
PDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFS
GIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGN
EVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDH
QDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDS
SAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVL
ELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNV
TYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILA
LVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQL
VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGP
HLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNAL
PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVP
SAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLV
KICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLG
GTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLER
LLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDND
YIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQV
EPEPELEQLPDSGCPAPRAEAEDSFL
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| BDBM50434377 |
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| n/a |
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| Name | BDBM50434377 |
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| Synonyms: | CHEMBL2387002 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21ClN6O2 |
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| Mol. Mass. | 448.905 |
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| SMILES | CC(C)n1cc(C(=O)c2cccc(NC(=O)Nc3ccc(Cl)cc3)c2)c2c(N)ncnc12 |
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| Structure | 
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