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Compile Data Set for Download or QSAR

Found 183 hits with Last Name = 'imaoka' and Initial = 't'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase Fer


(Homo sapiens (Human))		BDBM50501949
PNG
(CHEMBL4461851)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(C#N)c3cn[nH]c(=O)c23)c1 |r|
Show InChI InChI=1S/C21H23N7O/c1-12-5-4-6-13(9-12)25-20-18-15(11-24-28-21(18)29)14(10-22)19(27-20)26-17-8-3-2-7-16(17)23/h4-6,9,11,16-17H,2-3,7-8,23H2,1H3,(H,28,29)(H2,25,26,27)/t16-,17+/m0/s1
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n/an/a 0.490n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide...

ACS Med Chem Lett 10: 737-742 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00631
BindingDB Entry DOI: 10.7270/Q2WS8XG3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50394470
PNG
(CHEMBL2160099)
Show SMILES OCCOc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 |r|
Show InChI InChI=1S/C24H26FN3O3/c25-20-8-7-18-13-17(5-6-19(18)14-20)15-28-10-9-21(16-28)26-24(30)27-22-3-1-2-4-23(22)31-12-11-29/h1-8,13-14,21,29H,9-12,15-16H2,(H2,26,27,30)/t21-/m1/s1
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n/an/a 0.870n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 receptor in human eosinophils assessed as inhibition of CCL11-induced degranulation after 4 hrs by ELISA

Bioorg Med Chem Lett 22: 6876-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.035
BindingDB Entry DOI: 10.7270/Q2QC04MN
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297172
PNG
(CHEMBL560275 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Show SMILES [#6]-c1ccc(-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]/[#6](=O)-[#7]-[#6@@H]-2-[#6]-[#6]-[#7](-[#6]-c3ccc4cc(F)ccc4c3)-[#6]-2)c(-[#8])c1 |r|
Show InChI InChI=1S/C30H32FN3O3/c1-20-2-7-27(28(35)14-20)30(37)34-12-8-21(9-13-34)16-29(36)32-26-10-11-33(19-26)18-22-3-4-24-17-25(31)6-5-23(24)15-22/h2-7,14-17,26,35H,8-13,18-19H2,1H3,(H,32,36)/t26-/m1/s1
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n/an/a 0.980n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297171
PNG
(CHEMBL551735 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Show SMILES [#8]-c1ccccc1-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/[#6](=O)-[#7]-[#6@@H]-1-[#6]-[#6]-[#7](-[#6]-c2ccc3cc(F)ccc3c2)-[#6]-1 |r|
Show InChI InChI=1S/C29H30FN3O3/c30-24-8-7-22-15-21(5-6-23(22)17-24)18-32-12-11-25(19-32)31-28(35)16-20-9-13-33(14-10-20)29(36)26-3-1-2-4-27(26)34/h1-8,15-17,25,34H,9-14,18-19H2,(H,31,35)/t25-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells by functional inhibition curve analysis

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297181
PNG
(2-[1-(1,3-Benzodioxol-5-ylcarbonyl)piperidin-4-yli...)
Show SMILES Fc1ccc2cc(-[#6]-[#7]-3-[#6]-[#6]-[#6@H](-[#6]-3)-[#7]-[#6](=O)\[#6]=[#6]-3/[#6]-[#6]-[#7](-[#6]-[#6]-3)-[#6](=O)-c3ccc4-[#8]-[#6]-[#8]-c4c3)ccc2c1 |r|
Show InChI InChI=1S/C30H30FN3O4/c31-25-5-3-22-13-21(1-2-23(22)15-25)17-33-10-9-26(18-33)32-29(35)14-20-7-11-34(12-8-20)30(36)24-4-6-27-28(16-24)38-19-37-27/h1-6,13-16,26H,7-12,17-19H2,(H,32,35)/t26-/m1/s1
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n/an/a 1.60n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50394470
PNG
(CHEMBL2160099)
Show SMILES OCCOc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 |r|
Show InChI InChI=1S/C24H26FN3O3/c25-20-8-7-18-13-17(5-6-19(18)14-20)15-28-10-9-21(16-28)26-24(30)27-22-3-1-2-4-23(22)31-12-11-29/h1-8,13-14,21,29H,9-12,15-16H2,(H2,26,27,30)/t21-/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 receptor

Bioorg Med Chem Lett 22: 6876-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.035
BindingDB Entry DOI: 10.7270/Q2QC04MN
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297183
PNG
(CHEMBL551738 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Show SMILES [#6]-[#8]-c1ccc(cc1)-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/[#6](=O)-[#7]-[#6@@H]-1-[#6]-[#6]-[#7](-[#6]-c2ccc3cc(F)ccc3c2)-[#6]-1 |r|
Show InChI InChI=1S/C30H32FN3O3/c1-37-28-8-5-23(6-9-28)30(36)34-14-10-21(11-15-34)17-29(35)32-27-12-13-33(20-27)19-22-2-3-25-18-26(31)7-4-24(25)16-22/h2-9,16-18,27H,10-15,19-20H2,1H3,(H,32,35)/t27-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50394487
PNG
(CHEMBL2160111)
Show SMILES Oc1ccccc1S(=O)(=O)N1CCC(CC1)NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 |r|
Show InChI InChI=1S/C27H31FN4O4S/c28-22-8-7-20-15-19(5-6-21(20)16-22)17-31-12-9-24(18-31)30-27(34)29-23-10-13-32(14-11-23)37(35,36)26-4-2-1-3-25(26)33/h1-8,15-16,23-24,33H,9-14,17-18H2,(H2,29,30,34)/t24-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 receptor

Bioorg Med Chem Lett 22: 6876-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.035
BindingDB Entry DOI: 10.7270/Q2QC04MN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fer


(Homo sapiens (Human))		BDBM50501965
PNG
(CHEMBL4457164)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(cc2C(N)=O)C#N)c1 |r|
Show InChI InChI=1S/C20H24N6O/c1-12-5-4-6-14(9-12)24-20-15(18(23)27)10-13(11-21)19(26-20)25-17-8-3-2-7-16(17)22/h4-6,9-10,16-17H,2-3,7-8,22H2,1H3,(H2,23,27)(H2,24,25,26)/t16-,17+/m0/s1
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n/an/a 2.60n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide...

ACS Med Chem Lett 10: 737-742 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00631
BindingDB Entry DOI: 10.7270/Q2WS8XG3
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fer


(Homo sapiens (Human))		BDBM50501961
PNG
(CHEMBL4456804)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(Br)c3cn[nH]c(=O)c23)c1 |r|
Show InChI InChI=1S/C20H23BrN6O/c1-11-5-4-6-12(9-11)24-18-16-13(10-23-27-20(16)28)17(21)19(26-18)25-15-8-3-2-7-14(15)22/h4-6,9-10,14-15H,2-3,7-8,22H2,1H3,(H,27,28)(H2,24,25,26)/t14-,15+/m0/s1
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n/an/a 2.70n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide...

ACS Med Chem Lett 10: 737-742 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00631
BindingDB Entry DOI: 10.7270/Q2WS8XG3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297177
PNG
(CHEMBL561535 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Show SMILES [#6]-[#8]-c1ccc(-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]/[#6](=O)-[#7]-[#6@@H]-2-[#6]-[#6]-[#7](-[#6]-c3ccc4cc(F)ccc4c3)-[#6]-2)c(-[#8])c1 |r|
Show InChI InChI=1S/C30H32FN3O4/c1-38-26-6-7-27(28(35)17-26)30(37)34-12-8-20(9-13-34)15-29(36)32-25-10-11-33(19-25)18-21-2-3-23-16-24(31)5-4-22(23)14-21/h2-7,14-17,25,35H,8-13,18-19H2,1H3,(H,32,36)/t25-/m1/s1
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n/an/a 3.30n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297182
PNG
(2-[1-(3,4-Dimethoxybenzoyl)piperidin-4-ylidene]-N-...)
Show SMILES [#6]-[#8]-c1ccc(cc1-[#8]-[#6])-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/[#6](=O)-[#7]-[#6@@H]-1-[#6]-[#6]-[#7](-[#6]-c2ccc3cc(F)ccc3c2)-[#6]-1 |r|
Show InChI InChI=1S/C31H34FN3O4/c1-38-28-8-6-25(18-29(28)39-2)31(37)35-13-9-21(10-14-35)16-30(36)33-27-11-12-34(20-27)19-22-3-4-24-17-26(32)7-5-23(24)15-22/h3-8,15-18,27H,9-14,19-20H2,1-2H3,(H,33,36)/t27-/m1/s1
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n/an/a 3.60n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297190
PNG
(2-(1-Benzoylpiperidin-4-ylidene)-N-{(3R)-1-[(6-flu...)
Show SMILES Fc1ccc2cc(-[#6]-[#7]-3-[#6]-[#6]-[#6@H](-[#6]-3)-[#7]-[#6](=O)\[#6]=[#6]-3/[#6]-[#6]-[#7](-[#6]-[#6]-3)-[#6](=O)-c3ccccc3)ccc2c1 |r|
Show InChI InChI=1S/C29H30FN3O2/c30-26-9-8-24-16-22(6-7-25(24)18-26)19-32-13-12-27(20-32)31-28(34)17-21-10-14-33(15-11-21)29(35)23-4-2-1-3-5-23/h1-9,16-18,27H,10-15,19-20H2,(H,31,34)/t27-/m1/s1
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n/an/a 4.40n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fer


(Homo sapiens (Human))		BDBM50501963
PNG
(CHEMBL4524587)
Show SMILES Cc1cccc(Nc2nc(NC3CCCCC3N)c(Cl)c3cn[nH]c(=O)c23)c1
Show InChI InChI=1S/C20H23ClN6O/c1-11-5-4-6-12(9-11)24-18-16-13(10-23-27-20(16)28)17(21)19(26-18)25-15-8-3-2-7-14(15)22/h4-6,9-10,14-15H,2-3,7-8,22H2,1H3,(H,27,28)(H2,24,25,26)
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n/an/a 4.70n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide...

ACS Med Chem Lett 10: 737-742 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00631
BindingDB Entry DOI: 10.7270/Q2WS8XG3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297188
PNG
(2-[1-(2-Fluorobenzoyl)piperidin-4-ylidene]-N-{(3R)...)
Show SMILES Fc1ccc2cc(-[#6]-[#7]-3-[#6]-[#6]-[#6@H](-[#6]-3)-[#7]-[#6](=O)\[#6]=[#6]-3/[#6]-[#6]-[#7](-[#6]-[#6]-3)-[#6](=O)-c3ccccc3F)ccc2c1 |r|
Show InChI InChI=1S/C29H29F2N3O2/c30-24-8-7-22-15-21(5-6-23(22)17-24)18-33-12-11-25(19-33)32-28(35)16-20-9-13-34(14-10-20)29(36)26-3-1-2-4-27(26)31/h1-8,15-17,25H,9-14,18-19H2,(H,32,35)/t25-/m1/s1
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n/an/a 4.80n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50387669
PNG
(CHEMBL2058071)
Show SMILES [O-][N+](=O)c1ccccc1NC(=O)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 |r,TLB:28:27:20.21.26:23.24,THB:19:20:27:23.24|
Show InChI InChI=1S/C30H32FN5O4/c31-22-10-9-20-14-19(7-8-21(20)15-22)18-35-24-11-12-25(35)17-23(16-24)32-30(38)34-13-3-6-28(34)29(37)33-26-4-1-2-5-27(26)36(39)40/h1-2,4-5,7-10,14-15,23-25,28H,3,6,11-13,16-18H2,(H,32,38)(H,33,37)/t24-,25-,28+/m1/s1
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n/an/a 4.90n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3

Bioorg Med Chem Lett 22: 4951-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.042
BindingDB Entry DOI: 10.7270/Q2057H06
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297180
PNG
(CHEMBL556916 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Show SMILES [#8]-c1cccc(c1)-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/[#6](=O)-[#7]-[#6@@H]-1-[#6]-[#6]-[#7](-[#6]-c2ccc3cc(F)ccc3c2)-[#6]-1 |r|
Show InChI InChI=1S/C29H30FN3O3/c30-25-7-6-22-14-21(4-5-23(22)16-25)18-32-11-10-26(19-32)31-28(35)15-20-8-12-33(13-9-20)29(36)24-2-1-3-27(34)17-24/h1-7,14-17,26,34H,8-13,18-19H2,(H,31,35)/t26-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297179
PNG
(CHEMBL562923 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Show SMILES [#8]-c1ccc(cc1)-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/[#6](=O)-[#7]-[#6@@H]-1-[#6]-[#6]-[#7](-[#6]-c2ccc3cc(F)ccc3c2)-[#6]-1 |r|
Show InChI InChI=1S/C29H30FN3O3/c30-25-6-3-23-15-21(1-2-24(23)17-25)18-32-12-11-26(19-32)31-28(35)16-20-9-13-33(14-10-20)29(36)22-4-7-27(34)8-5-22/h1-8,15-17,26,34H,9-14,18-19H2,(H,31,35)/t26-/m1/s1
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n/an/a 5.10n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297185
PNG
(CHEMBL556227 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Show SMILES [#6]-[#8]-c1ccccc1-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/[#6](=O)-[#7]-[#6@@H]-1-[#6]-[#6]-[#7](-[#6]-c2ccc3cc(F)ccc3c2)-[#6]-1 |r|
Show InChI InChI=1S/C30H32FN3O3/c1-37-28-5-3-2-4-27(28)30(36)34-14-10-21(11-15-34)17-29(35)32-26-12-13-33(20-26)19-22-6-7-24-18-25(31)9-8-23(24)16-22/h2-9,16-18,26H,10-15,19-20H2,1H3,(H,32,35)/t26-/m1/s1
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n/an/a 5.10n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297184
PNG
(CHEMBL557118 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Show SMILES [#6]-[#8]-c1cccc(c1)-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/[#6](=O)-[#7]-[#6@@H]-1-[#6]-[#6]-[#7](-[#6]-c2ccc3cc(F)ccc3c2)-[#6]-1 |r|
Show InChI InChI=1S/C30H32FN3O3/c1-37-28-4-2-3-25(18-28)30(36)34-13-9-21(10-14-34)16-29(35)32-27-11-12-33(20-27)19-22-5-6-24-17-26(31)8-7-23(24)15-22/h2-8,15-18,27H,9-14,19-20H2,1H3,(H,32,35)/t27-/m1/s1
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n/an/a 5.80n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297174
PNG
(2-[1-(4-Fluoro-2-hydroxybenzoyl)piperidin-4-yliden...)
Show SMILES [#8]-c1cc(F)ccc1-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/[#6](=O)-[#7]-[#6@@H]-1-[#6]-[#6]-[#7](-[#6]-c2ccc3cc(F)ccc3c2)-[#6]-1 |r|
Show InChI InChI=1S/C29H29F2N3O3/c30-23-4-3-21-13-20(1-2-22(21)15-23)17-33-10-9-25(18-33)32-28(36)14-19-7-11-34(12-8-19)29(37)26-6-5-24(31)16-27(26)35/h1-6,13-16,25,35H,7-12,17-18H2,(H,32,36)/t25-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297173
PNG
(2-[1-(4-Chloro-2-hydroxybenzoyl)piperidin-4-yliden...)
Show SMILES [#8]-c1cc(Cl)ccc1-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/[#6](=O)-[#7]-[#6@@H]-1-[#6]-[#6]-[#7](-[#6]-c2ccc3cc(F)ccc3c2)-[#6]-1 |r|
Show InChI InChI=1S/C29H29ClFN3O3/c30-23-4-6-26(27(35)16-23)29(37)34-11-7-19(8-12-34)14-28(36)32-25-9-10-33(18-25)17-20-1-2-22-15-24(31)5-3-21(22)13-20/h1-6,13-16,25,35H,7-12,17-18H2,(H,32,36)/t25-/m1/s1
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n/an/a 7.5n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50387649
PNG
(CHEMBL2057751)
Show SMILES Nc1ccc2n(C3CCN(CC3)C(=O)NC3C[C@H]4CC[C@H](C3)N4Cc3ccc4cc(F)ccc4c3)c(=O)[nH]c2c1 |r,TLB:23:22:15.16.21:18.19,THB:14:15:22:18.19|
Show InChI InChI=1S/C31H35FN6O2/c32-22-4-3-20-13-19(1-2-21(20)14-22)18-37-26-6-7-27(37)17-24(16-26)34-30(39)36-11-9-25(10-12-36)38-29-8-5-23(33)15-28(29)35-31(38)40/h1-5,8,13-15,24-27H,6-7,9-12,16-18,33H2,(H,34,39)(H,35,40)/t26-,27-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3

Bioorg Med Chem Lett 22: 4951-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.042
BindingDB Entry DOI: 10.7270/Q2057H06
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297171
PNG
(CHEMBL551735 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Show SMILES [#8]-c1ccccc1-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/[#6](=O)-[#7]-[#6@@H]-1-[#6]-[#6]-[#7](-[#6]-c2ccc3cc(F)ccc3c2)-[#6]-1 |r|
Show InChI InChI=1S/C29H30FN3O3/c30-24-8-7-22-15-21(5-6-23(22)17-24)18-32-12-11-25(19-32)31-28(35)16-20-9-13-33(14-10-20)29(36)26-3-1-2-4-27(26)34/h1-8,15-17,25,34H,9-14,18-19H2,(H,31,35)/t25-/m1/s1
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n/an/a 8.40n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50394482
PNG
(CHEMBL2159867)
Show SMILES OCCCCOc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 |r|
Show InChI InChI=1S/C26H30FN3O3/c27-22-10-9-20-15-19(7-8-21(20)16-22)17-30-12-11-23(18-30)28-26(32)29-24-5-1-2-6-25(24)33-14-4-3-13-31/h1-2,5-10,15-16,23,31H,3-4,11-14,17-18H2,(H2,28,29,32)/t23-/m1/s1
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n/an/a 9.90n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 receptor

Bioorg Med Chem Lett 22: 6876-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.035
BindingDB Entry DOI: 10.7270/Q2QC04MN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fer


(Homo sapiens (Human))		BDBM50501959
PNG
(CHEMBL4557212)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)cc3cn[nH]c(=O)c23)c1 |r|
Show InChI InChI=1S/C20H24N6O/c1-12-5-4-6-14(9-12)23-19-18-13(11-22-26-20(18)27)10-17(25-19)24-16-8-3-2-7-15(16)21/h4-6,9-11,15-16H,2-3,7-8,21H2,1H3,(H,26,27)(H2,23,24,25)/t15-,16+/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide...

ACS Med Chem Lett 10: 737-742 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00631
BindingDB Entry DOI: 10.7270/Q2WS8XG3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50264210
PNG
(2-(Azepan-1-ylcarbonyl)-N-{(3-exo)-8-[(6-fluoro-2-...)
Show SMILES Fc1ccc2cc(CN3[C@@H]4CC[C@@H]3CC(C4)NC(=O)c3ccccc3C(=O)N3CCCCCC3)ccc2c1 |r,TLB:7:8:14.15.13:10.11,THB:16:14:8:10.11|
Show InChI InChI=1S/C32H36FN3O2/c33-25-12-11-23-17-22(9-10-24(23)18-25)21-36-27-13-14-28(36)20-26(19-27)34-31(37)29-7-3-4-8-30(29)32(38)35-15-5-1-2-6-16-35/h3-4,7-12,17-18,26-28H,1-2,5-6,13-16,19-21H2,(H,34,37)/t27-,28-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Astellas Pharma. Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry

Bioorg Med Chem 16: 8607-18 (2008)


Article DOI: 10.1016/j.bmc.2008.08.006
BindingDB Entry DOI: 10.7270/Q21J9BPZ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50394481
PNG
(CHEMBL2159868)
Show SMILES OCCOc1ccc(NC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)cc1 |r|
Show InChI InChI=1S/C24H26FN3O3/c25-20-4-3-18-13-17(1-2-19(18)14-20)15-28-10-9-22(16-28)27-24(30)26-21-5-7-23(8-6-21)31-12-11-29/h1-8,13-14,22,29H,9-12,15-16H2,(H2,26,27,30)/t22-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 receptor

Bioorg Med Chem Lett 22: 6876-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.035
BindingDB Entry DOI: 10.7270/Q2QC04MN
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297187
PNG
((R)-2-(1-(3-fluorobenzoyl)piperidin-4-ylidene)-N-(...)
Show SMILES Fc1cccc(c1)-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/[#6](=O)-[#7]-[#6@@H]-1-[#6]-[#6]-[#7](-[#6]-c2ccc3cc(F)ccc3c2)-[#6]-1 |r|
Show InChI InChI=1S/C29H29F2N3O2/c30-25-3-1-2-24(17-25)29(36)34-12-8-20(9-13-34)15-28(35)32-27-10-11-33(19-27)18-21-4-5-23-16-26(31)7-6-22(23)14-21/h1-7,14-17,27H,8-13,18-19H2,(H,32,35)/t27-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50387661
PNG
(CHEMBL2057763)
Show SMILES Fc1ccc2cc(CN3[C@@H]4CC[C@@H]3CC(C4)NC(=O)N3CCC[C@H]3C(=O)Nc3ccccc3Br)ccc2c1 |r,TLB:7:8:14.15.13:10.11,16:14:8:10.11|
Show InChI InChI=1S/C30H32BrFN4O2/c31-26-4-1-2-5-27(26)34-29(37)28-6-3-13-35(28)30(38)33-23-16-24-11-12-25(17-23)36(24)18-19-7-8-21-15-22(32)10-9-20(21)14-19/h1-2,4-5,7-10,14-15,23-25,28H,3,6,11-13,16-18H2,(H,33,38)(H,34,37)/t24-,25-,28+/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3

Bioorg Med Chem Lett 22: 4951-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.042
BindingDB Entry DOI: 10.7270/Q2057H06
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50264161
PNG
(CHEMBL488929 | N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)...)
Show SMILES Fc1ccc2cc(CN3[C@@H]4CC[C@@H]3CC(C4)NC(=O)c3ccncc3C(=O)N3CCCCC3)ccc2c1 |r,TLB:7:8:14.15.13:10.11,THB:16:14:8:10.11|
Show InChI InChI=1S/C30H33FN4O2/c31-23-7-6-21-14-20(4-5-22(21)15-23)19-35-25-8-9-26(35)17-24(16-25)33-29(36)27-10-11-32-18-28(27)30(37)34-12-2-1-3-13-34/h4-7,10-11,14-15,18,24-26H,1-3,8-9,12-13,16-17,19H2,(H,33,36)/t25-,26-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Astellas Pharma. Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry

Bioorg Med Chem 16: 8607-18 (2008)


Article DOI: 10.1016/j.bmc.2008.08.006
BindingDB Entry DOI: 10.7270/Q21J9BPZ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50387664
PNG
(CHEMBL2057766)
Show SMILES Fc1ccc2cc(CN3[C@@H]4CC[C@@H]3CC(C4)NC(=O)N3CCC[C@H]3C(=O)Nc3ccccc3F)ccc2c1 |r,TLB:7:8:14.15.13:10.11,16:14:8:10.11|
Show InChI InChI=1S/C30H32F2N4O2/c31-22-10-9-20-14-19(7-8-21(20)15-22)18-36-24-11-12-25(36)17-23(16-24)33-30(38)35-13-3-6-28(35)29(37)34-27-5-2-1-4-26(27)32/h1-2,4-5,7-10,14-15,23-25,28H,3,6,11-13,16-18H2,(H,33,38)(H,34,37)/t24-,25-,28+/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3

Bioorg Med Chem Lett 22: 4951-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.042
BindingDB Entry DOI: 10.7270/Q2057H06
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297176
PNG
(CHEMBL562574 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Show SMILES [#6]-[#8]-c1ccc(-[#8])c(c1)-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/[#6](=O)-[#7]-[#6@@H]-1-[#6]-[#6]-[#7](-[#6]-c2ccc3cc(F)ccc3c2)-[#6]-1 |r|
Show InChI InChI=1S/C30H32FN3O4/c1-38-26-6-7-28(35)27(17-26)30(37)34-12-8-20(9-13-34)15-29(36)32-25-10-11-33(19-25)18-21-2-3-23-16-24(31)5-4-22(23)14-21/h2-7,14-17,25,35H,8-13,18-19H2,1H3,(H,32,36)/t25-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fer


(Homo sapiens (Human))		BDBM50501957
PNG
(CHEMBL4455220)
Show SMILES Cc1cccc(Nc2nc(NC3CCCCC3N)cc3cn[nH]c(=O)c23)c1
Show InChI InChI=1S/C20H24N6O/c1-12-5-4-6-14(9-12)23-19-18-13(11-22-26-20(18)27)10-17(25-19)24-16-8-3-2-7-15(16)21/h4-6,9-11,15-16H,2-3,7-8,21H2,1H3,(H,26,27)(H2,23,24,25)
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n/an/a 14n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide...

ACS Med Chem Lett 10: 737-742 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00631
BindingDB Entry DOI: 10.7270/Q2WS8XG3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50394486
PNG
(CHEMBL2159863)
Show SMILES CS(=O)(=O)N1CCC(CC1)NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 |r|
Show InChI InChI=1S/C22H29FN4O3S/c1-31(29,30)27-10-7-20(8-11-27)24-22(28)25-21-6-9-26(15-21)14-16-2-3-18-13-19(23)5-4-17(18)12-16/h2-5,12-13,20-21H,6-11,14-15H2,1H3,(H2,24,25,28)/t21-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 receptor

Bioorg Med Chem Lett 22: 6876-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.035
BindingDB Entry DOI: 10.7270/Q2QC04MN
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50387654
PNG
(CHEMBL2057756)
Show SMILES Fc1ccc2cc(CN3[C@@H]4CC[C@@H]3CC(C4)NC(=O)N3CCCN(Cc4c(Cl)cccc4Cl)CC3)ccc2c1 |r,TLB:7:8:14.15.13:10.11,16:14:8:10.11|
Show InChI InChI=1S/C31H35Cl2FN4O/c32-29-3-1-4-30(33)28(29)20-36-11-2-12-37(14-13-36)31(39)35-25-17-26-9-10-27(18-25)38(26)19-21-5-6-23-16-24(34)8-7-22(23)15-21/h1,3-8,15-16,25-27H,2,9-14,17-20H2,(H,35,39)/t26-,27-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3

Bioorg Med Chem Lett 22: 4951-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.042
BindingDB Entry DOI: 10.7270/Q2057H06
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50264142
PNG
(Biphenyl-2-carboxylic acid [(1R,5R)-8-(6-fluoro-na...)
Show SMILES Fc1ccc2cc(CN3C4CCC3CC(C4)NC(=O)c3ccccc3-c3ccccc3)ccc2c1 |TLB:7:8:14.15.13:10.11,16:14:8:10.11|
Show InChI InChI=1S/C31H29FN2O/c32-25-13-12-23-16-21(10-11-24(23)17-25)20-34-27-14-15-28(34)19-26(18-27)33-31(35)30-9-5-4-8-29(30)22-6-2-1-3-7-22/h1-13,16-17,26-28H,14-15,18-20H2,(H,33,35)
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n/an/a 20n/an/an/an/an/an/a



Astellas Pharma. Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry

Bioorg Med Chem 16: 8607-18 (2008)


Article DOI: 10.1016/j.bmc.2008.08.006
BindingDB Entry DOI: 10.7270/Q21J9BPZ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50375019
PNG
(CHEMBL258996)
Show SMILES Fc1ccc2cc(CN3[C@H]4CC[C@H]3CC(C4)NC(=O)c3ccccc3-c3ccccc3)ccc2c1 |THB:16:14:8:10.11|
Show InChI InChI=1S/C31H29FN2O/c32-25-13-12-23-16-21(10-11-24(23)17-25)20-34-27-14-15-28(34)19-26(18-27)33-31(35)30-9-5-4-8-29(30)22-6-2-1-3-7-22/h1-13,16-17,26-28H,14-15,18-20H2,(H,33,35)/t27-,28-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx

Bioorg Med Chem 16: 144-56 (2008)


Article DOI: 10.1016/j.bmc.2007.10.003
BindingDB Entry DOI: 10.7270/Q2445NBG
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50375019
PNG
(CHEMBL258996)
Show SMILES Fc1ccc2cc(CN3[C@H]4CC[C@H]3CC(C4)NC(=O)c3ccccc3-c3ccccc3)ccc2c1 |THB:16:14:8:10.11|
Show InChI InChI=1S/C31H29FN2O/c32-25-13-12-23-16-21(10-11-24(23)17-25)20-34-27-14-15-28(34)19-26(18-27)33-31(35)30-9-5-4-8-29(30)22-6-2-1-3-7-22/h1-13,16-17,26-28H,14-15,18-20H2,(H,33,35)/t27-,28-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx

Bioorg Med Chem 16: 144-56 (2008)


Article DOI: 10.1016/j.bmc.2007.10.003
BindingDB Entry DOI: 10.7270/Q2445NBG
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50264142
PNG
(Biphenyl-2-carboxylic acid [(1R,5R)-8-(6-fluoro-na...)
Show SMILES Fc1ccc2cc(CN3C4CCC3CC(C4)NC(=O)c3ccccc3-c3ccccc3)ccc2c1 |TLB:7:8:14.15.13:10.11,16:14:8:10.11|
Show InChI InChI=1S/C31H29FN2O/c32-25-13-12-23-16-21(10-11-24(23)17-25)20-34-27-14-15-28(34)19-26(18-27)33-31(35)30-9-5-4-8-29(30)22-6-2-1-3-7-22/h1-13,16-17,26-28H,14-15,18-20H2,(H,33,35)
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n/an/a 20n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))		BDBM50264142
PNG
(Biphenyl-2-carboxylic acid [(1R,5R)-8-(6-fluoro-na...)
Show SMILES Fc1ccc2cc(CN3C4CCC3CC(C4)NC(=O)c3ccccc3-c3ccccc3)ccc2c1 |TLB:7:8:14.15.13:10.11,16:14:8:10.11|
Show InChI InChI=1S/C31H29FN2O/c32-25-13-12-23-16-21(10-11-24(23)17-25)20-34-27-14-15-28(34)19-26(18-27)33-31(35)30-9-5-4-8-29(30)22-6-2-1-3-7-22/h1-13,16-17,26-28H,14-15,18-20H2,(H,33,35)
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n/an/a 20n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50387642
PNG
(CHEMBL2057491)
Show SMILES Fc1ccc2cc(CN3[C@@H]4CC[C@@H]3CC(C4)NC(=O)c3ccccc3-c3ccccc3)ccc2c1 |r,TLB:16:14:8:10.11|
Show InChI InChI=1S/C31H29FN2O/c32-25-13-12-23-16-21(10-11-24(23)17-25)20-34-27-14-15-28(34)19-26(18-27)33-31(35)30-9-5-4-8-29(30)22-6-2-1-3-7-22/h1-13,16-17,26-28H,14-15,18-20H2,(H,33,35)/t27-,28-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3

Bioorg Med Chem Lett 22: 4951-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.042
BindingDB Entry DOI: 10.7270/Q2057H06
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50264142
PNG
(Biphenyl-2-carboxylic acid [(1R,5R)-8-(6-fluoro-na...)
Show SMILES Fc1ccc2cc(CN3C4CCC3CC(C4)NC(=O)c3ccccc3-c3ccccc3)ccc2c1 |TLB:7:8:14.15.13:10.11,16:14:8:10.11|
Show InChI InChI=1S/C31H29FN2O/c32-25-13-12-23-16-21(10-11-24(23)17-25)20-34-27-14-15-28(34)19-26(18-27)33-31(35)30-9-5-4-8-29(30)22-6-2-1-3-7-22/h1-13,16-17,26-28H,14-15,18-20H2,(H,33,35)
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n/an/a 20n/an/an/an/an/an/a



Astellas Pharma. Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry

Bioorg Med Chem 16: 8607-18 (2008)


Article DOI: 10.1016/j.bmc.2008.08.006
BindingDB Entry DOI: 10.7270/Q21J9BPZ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50297186
PNG
(2-[1-(4-Fluorobenzoyl)piperidin-4-ylidene]-N-{(3R)...)
Show SMILES Fc1ccc(cc1)-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]/[#6](=O)-[#7]-[#6@@H]-1-[#6]-[#6]-[#7](-[#6]-c2ccc3cc(F)ccc3c2)-[#6]-1 |r|
Show InChI InChI=1S/C29H29F2N3O2/c30-25-6-3-22(4-7-25)29(36)34-13-9-20(10-14-34)16-28(35)32-27-11-12-33(19-27)18-21-1-2-24-17-26(31)8-5-23(24)15-21/h1-8,15-17,27H,9-14,18-19H2,(H,32,35)/t27-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50264212
PNG
(CHEMBL519042 | N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)...)
Show SMILES [O-][n+]1ccc(C(=O)NC2C[C@H]3CC[C@H](C2)N3Cc2ccc3cc(F)ccc3c2)c(c1)C(=O)N1CCCCC1 |r,TLB:16:15:8.9.14:11.12,7:8:15:11.12|
Show InChI InChI=1S/C30H33FN4O3/c31-23-7-6-21-14-20(4-5-22(21)15-23)18-35-25-8-9-26(35)17-24(16-25)32-29(36)27-10-13-34(38)19-28(27)30(37)33-11-2-1-3-12-33/h4-7,10,13-15,19,24-26H,1-3,8-9,11-12,16-18H2,(H,32,36)/t25-,26-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Astellas Pharma. Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry

Bioorg Med Chem 16: 8607-18 (2008)


Article DOI: 10.1016/j.bmc.2008.08.006
BindingDB Entry DOI: 10.7270/Q21J9BPZ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50394479
PNG
(CHEMBL2160097)
Show SMILES COCc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 |r|
Show InChI InChI=1S/C24H26FN3O2/c1-30-16-20-4-2-3-5-23(20)27-24(29)26-22-10-11-28(15-22)14-17-6-7-19-13-21(25)9-8-18(19)12-17/h2-9,12-13,22H,10-11,14-16H2,1H3,(H2,26,27,29)/t22-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 receptor

Bioorg Med Chem Lett 22: 6876-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.035
BindingDB Entry DOI: 10.7270/Q2QC04MN
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50264157
PNG
(CHEMBL519750 | N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)...)
Show SMILES Fc1ccc2cc(CN3[C@@H]4CC[C@@H]3CC(C4)NC(=O)c3ccccc3C(=O)N3CCCCC3)ccc2c1 |r,TLB:7:8:14.15.13:10.11,THB:16:14:8:10.11|
Show InChI InChI=1S/C31H34FN3O2/c32-24-11-10-22-16-21(8-9-23(22)17-24)20-35-26-12-13-27(35)19-25(18-26)33-30(36)28-6-2-3-7-29(28)31(37)34-14-4-1-5-15-34/h2-3,6-11,16-17,25-27H,1,4-5,12-15,18-20H2,(H,33,36)/t26-,27-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Astellas Pharma. Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry

Bioorg Med Chem 16: 8607-18 (2008)


Article DOI: 10.1016/j.bmc.2008.08.006
BindingDB Entry DOI: 10.7270/Q21J9BPZ
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50264212
PNG
(CHEMBL519042 | N-{(3-exo)-8-[(6-Fluoro-2-naphthyl)...)
Show SMILES [O-][n+]1ccc(C(=O)NC2C[C@H]3CC[C@H](C2)N3Cc2ccc3cc(F)ccc3c2)c(c1)C(=O)N1CCCCC1 |r,TLB:16:15:8.9.14:11.12,7:8:15:11.12|
Show InChI InChI=1S/C30H33FN4O3/c31-23-7-6-21-14-20(4-5-22(21)15-23)18-35-25-8-9-26(35)17-24(16-25)32-29(36)27-10-13-34(38)19-28(27)30(37)33-11-2-1-3-12-33/h4-7,10,13-15,19,24-26H,1-3,8-9,11-12,16-18H2,(H,32,36)/t25-,26-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Astellas Pharma Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux

Bioorg Med Chem 17: 5989-6002 (2009)


Article DOI: 10.1016/j.bmc.2009.06.066
BindingDB Entry DOI: 10.7270/Q2WD40NV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50394480
PNG
(CHEMBL2159869)
Show SMILES CN(C)C(=O)COc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 |r|
Show InChI InChI=1S/C26H29FN4O3/c1-30(2)25(32)17-34-24-6-4-3-5-23(24)29-26(33)28-22-11-12-31(16-22)15-18-7-8-20-14-21(27)10-9-19(20)13-18/h3-10,13-14,22H,11-12,15-17H2,1-2H3,(H2,28,29,33)/t22-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Toray Industries, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at CCR3 receptor

Bioorg Med Chem Lett 22: 6876-81 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.035
BindingDB Entry DOI: 10.7270/Q2QC04MN
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fer


(Homo sapiens (Human))		BDBM50501950
PNG
(CHEMBL4548027)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(Cl)cc2C(N)=O)c1 |r|
Show InChI InChI=1S/C19H24ClN5O/c1-11-5-4-6-12(9-11)23-18-13(17(22)26)10-14(20)19(25-18)24-16-8-3-2-7-15(16)21/h4-6,9-10,15-16H,2-3,7-8,21H2,1H3,(H2,22,26)(H2,23,24,25)/t15-,16+/m0/s1
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n/an/a 25n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide...

ACS Med Chem Lett 10: 737-742 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00631
BindingDB Entry DOI: 10.7270/Q2WS8XG3
More data for this
Ligand-Target Pair
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