Found 163 hits with Last Name = 'kerkman' and Initial = 'dj' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50226801
(CHEMBL7707)Show InChI InChI=1S/C13H16N2O2/c16-11-5-4-8-9(12(11)17)2-1-3-10(8)13-14-6-7-15-13/h4-5,10,16-17H,1-3,6-7H2,(H,14,15)/t10-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
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PC sid
UniChem
Similars
| PubMed
| 0.550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity for alpha-2 adrenergic receptor in rat cortex using [3H]rauwolscine. |
J Med Chem 30: 1011-7 (1987)
BindingDB Entry DOI: 10.7270/Q2T155VK |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor B
(RAT) | BDBM50003154
(2-{Propyl-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)Show SMILES CCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1ncccc1C(O)=O Show InChI InChI=1S/C23H22N6O2/c1-2-14-29(22-20(23(30)31)8-5-13-24-22)15-16-9-11-17(12-10-16)18-6-3-4-7-19(18)21-25-27-28-26-21/h3-13H,2,14-15H2,1H3,(H,30,31)(H,25,26,27,28) | PDB
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| 0.760 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver |
J Med Chem 35: 3714-7 (1992)
BindingDB Entry DOI: 10.7270/Q2H41QCN |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor B
(RAT) | BDBM50003158
(2-Methyl-4-{propyl-[2'-(1H-tetrazol-5-yl)-biphenyl...)Show SMILES CCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc(C)ncc1C(O)=O Show InChI InChI=1S/C23H23N7O2/c1-3-12-30(22-20(23(31)32)13-24-15(2)25-22)14-16-8-10-17(11-9-16)18-6-4-5-7-19(18)21-26-28-29-27-21/h4-11,13H,3,12,14H2,1-2H3,(H,31,32)(H,26,27,28,29) | PDB
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| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver |
J Med Chem 35: 3714-7 (1992)
BindingDB Entry DOI: 10.7270/Q2H41QCN |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor B
(RAT) | BDBM50003155
(4-{Butyl-[2''-(2H-tetrazol-5-yl)-biphenyl-4-ylmeth...)Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1ncncc1C(O)=O Show InChI InChI=1S/C23H23N7O2/c1-2-3-12-30(22-20(23(31)32)13-24-15-25-22)14-16-8-10-17(11-9-16)18-6-4-5-7-19(18)21-26-28-29-27-21/h4-11,13,15H,2-3,12,14H2,1H3,(H,31,32)(H,26,27,28,29) | PDB
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| 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver |
J Med Chem 35: 3714-7 (1992)
BindingDB Entry DOI: 10.7270/Q2H41QCN |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50226153
(CHEMBL545092)Show InChI InChI=1S/C12H14N2O2.BrH/c15-10-4-3-7-8(11(10)16)1-2-9(7)12-13-5-6-14-12;/h3-4,9,15-16H,1-2,5-6H2,(H,13,14);1H | PDB
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| 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
The compound was evaluated for the binding affinity towards alpha-2 adrenergic receptor from rat cortex |
J Med Chem 29: 463-7 (1986)
BindingDB Entry DOI: 10.7270/Q26D5W7D |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50226802
(CHEMBL7186)Show InChI InChI=1S/C13H16N2O2/c16-11-5-4-8-9(12(11)17)2-1-3-10(8)13-14-6-7-15-13/h4-5,10,16-17H,1-3,6-7H2,(H,14,15) | PDB
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| 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity for alpha-2 adrenergic receptor in rat cortex using [3H]rauwolscine. |
J Med Chem 30: 1011-7 (1987)
BindingDB Entry DOI: 10.7270/Q2T155VK |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50226155
(CHEMBL543684)Show InChI InChI=1S/C13H16N2O2.BrH/c16-11-5-4-8-9(12(11)17)2-1-3-10(8)13-14-6-7-15-13;/h4-5,10,16-17H,1-3,6-7H2,(H,14,15);1H | PDB
UniProtKB/SwissProt
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| CHEMBL
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PC sid
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| 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
The compound was evaluated for the binding affinity towards alpha-2 adrenergic receptor from rat cortex |
J Med Chem 29: 463-7 (1986)
BindingDB Entry DOI: 10.7270/Q26D5W7D |
More data for this
Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50225327
(CHEMBL31062)Show InChI InChI=1S/C11H15NO2/c1-12-6-7-2-3-9-8(7)4-5-10(13)11(9)14/h4-5,7,12-14H,2-3,6H2,1H3 | PDB
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha 2 adrenergic receptor |
J Med Chem 30: 178-84 (1987)
BindingDB Entry DOI: 10.7270/Q2891837 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225327
(CHEMBL31062)Show InChI InChI=1S/C11H15NO2/c1-12-6-7-2-3-9-8(7)4-5-10(13)11(9)14/h4-5,7,12-14H,2-3,6H2,1H3 | PDB
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50225302
(CHEMBL433083)Show InChI InChI=1S/C11H15NO3/c1-12(2)5-10-7-3-4-9(13)11(14)8(7)6-15-10/h3-4,10,13-14H,5-6H2,1-2H3 | PDB
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| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha 2 adrenergic receptor |
J Med Chem 30: 178-84 (1987)
BindingDB Entry DOI: 10.7270/Q2891837 |
More data for this
Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50225343
(CHEMBL31195)Show InChI InChI=1S/C10H13NO2/c11-5-6-1-2-8-7(6)3-4-9(12)10(8)13/h3-4,6,12-13H,1-2,5,11H2 | PDB
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha 2 adrenergic receptor |
J Med Chem 30: 178-84 (1987)
BindingDB Entry DOI: 10.7270/Q2891837 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225343
(CHEMBL31195)Show InChI InChI=1S/C10H13NO2/c11-5-6-1-2-8-7(6)3-4-9(12)10(8)13/h3-4,6,12-13H,1-2,5,11H2 | PDB
UniProtKB/SwissProt
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| CHEMBL
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor B
(RAT) | BDBM50003156
(4-{Butyl-[2''-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc(C)ncc1C(O)=O Show InChI InChI=1S/C24H25N7O2/c1-3-4-13-31(23-21(24(32)33)14-25-16(2)26-23)15-17-9-11-18(12-10-17)19-7-5-6-8-20(19)22-27-29-30-28-22/h5-12,14H,3-4,13,15H2,1-2H3,(H,32,33)(H,27,28,29,30) | PDB
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver |
J Med Chem 35: 3714-7 (1992)
BindingDB Entry DOI: 10.7270/Q2H41QCN |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor B
(RAT) | BDBM82258
(CAS_114798-26-4 | Losartan | NSC_3961)Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28) | PDB
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver |
J Med Chem 35: 3714-7 (1992)
BindingDB Entry DOI: 10.7270/Q2H41QCN |
More data for this
Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50225303
(CHEMBL52069)Show InChI InChI=1S/C10H13NO3/c1-11-4-9-6-2-3-8(12)10(13)7(6)5-14-9/h2-3,9,11-13H,4-5H2,1H3 | PDB
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| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha 2 adrenergic receptor |
J Med Chem 30: 178-84 (1987)
BindingDB Entry DOI: 10.7270/Q2891837 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225326
(CHEMBL31690)Show InChI InChI=1S/C11H15NO2/c1-12(2)6-7-5-9-8(7)3-4-10(13)11(9)14/h3-4,7,13-14H,5-6H2,1-2H3 | PDB
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| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225334
(CHEMBL281064)Show InChI InChI=1S/C12H17NO2/c1-13(2)7-8-3-4-10-9(8)5-6-11(14)12(10)15/h5-6,8,14-15H,3-4,7H2,1-2H3 | PDB
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| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50225334
(CHEMBL281064)Show InChI InChI=1S/C12H17NO2/c1-13(2)7-8-3-4-10-9(8)5-6-11(14)12(10)15/h5-6,8,14-15H,3-4,7H2,1-2H3 | PDB
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| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha 2 adrenergic receptor |
J Med Chem 30: 178-84 (1987)
BindingDB Entry DOI: 10.7270/Q2891837 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50019729
((S)-5-(4,5-Dihydro-1H-imidazol-2-yl)-5,6,7,8-tetra...)Show InChI InChI=1S/C13H16N2O2/c16-11-5-4-8-9(12(11)17)2-1-3-10(8)13-14-6-7-15-13/h4-5,10,16-17H,1-3,6-7H2,(H,14,15)/t10-/m0/s1 | PDB
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| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity for alpha-2 adrenergic receptor in rat cortex using [3H]rauwolscine. |
J Med Chem 30: 1011-7 (1987)
BindingDB Entry DOI: 10.7270/Q2T155VK |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM34572
(BRIMONIDINE | CHEMBL844 | MLS000069370 | SMR000058...)Show InChI InChI=1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17) | PDB
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| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225285
(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
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| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity for alpha-2 adrenergic receptor in rat cortex using [3H]rauwolscine. |
J Med Chem 30: 1011-7 (1987)
BindingDB Entry DOI: 10.7270/Q2T155VK |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225285
(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
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| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)Show InChI InChI=1S/C8H10FNO3/c9-5-2-7(12)6(11)1-4(5)8(13)3-10/h1-2,8,11-13H,3,10H2 | PDB
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| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50029051
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1 | PDB
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| 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
The compound was evaluated for the binding affinity towards alpha-2 adrenergic receptor from rat cortex |
J Med Chem 29: 463-7 (1986)
BindingDB Entry DOI: 10.7270/Q26D5W7D |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50029051
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1 | PDB
UniProtKB/SwissProt
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| 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity for alpha-2 adrenergic receptor in rat cortex using [3H]rauwolscine. |
J Med Chem 30: 1011-7 (1987)
BindingDB Entry DOI: 10.7270/Q2T155VK |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225342
(CHEMBL288787)Show InChI InChI=1S/C7H9NO3/c8-7(11)4-1-2-5(9)6(10)3-4/h1-3,7,9-11H,8H2 | PDB
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| 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225347
(CHEMBL31258)Show InChI InChI=1S/C12H17NO2/c1-13-7-8-3-2-4-10-9(8)5-6-11(14)12(10)15/h5-6,8,13-15H,2-4,7H2,1H3 | PDB
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| 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50226156
(CHEMBL544627)Show InChI InChI=1S/C11H12N2O2.BrH/c14-9-2-1-6-7(10(9)15)5-8(6)11-12-3-4-13-11;/h1-2,8,14-15H,3-5H2,(H,12,13);1H | PDB
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| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
The compound was evaluated for the binding affinity towards alpha-2 adrenergic receptor from rat cortex |
J Med Chem 29: 463-7 (1986)
BindingDB Entry DOI: 10.7270/Q26D5W7D |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225335
(CHEMBL281283)Show InChI InChI=1S/C11H15NO2/c12-6-7-2-1-3-9-8(7)4-5-10(13)11(9)14/h4-5,7,13-14H,1-3,6,12H2 | PDB
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| 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50225443
(CHEMBL299786)Show InChI InChI=1S/C9H11NO3/c10-3-8-5-1-2-7(11)9(12)6(5)4-13-8/h1-2,8,11-12H,3-4,10H2 | PDB
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| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha 2 adrenergic receptor |
J Med Chem 30: 178-84 (1987)
BindingDB Entry DOI: 10.7270/Q2891837 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor B
(RAT) | BDBM50003157
(2-{Butyl-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethy...)Show SMILES CCCCN(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)c1nc(C)ccc1C(O)=O Show InChI InChI=1S/C25H26N6O2/c1-3-4-15-31(24-22(25(32)33)14-9-17(2)26-24)16-18-10-12-19(13-11-18)20-7-5-6-8-21(20)23-27-29-30-28-23/h5-14H,3-4,15-16H2,1-2H3,(H,32,33)(H,27,28,29,30) | PDB
Reactome pathway
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| 122 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liver |
J Med Chem 35: 3714-7 (1992)
BindingDB Entry DOI: 10.7270/Q2H41QCN |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225350
(CHEMBL32683)Show InChI InChI=1S/C12H17NO2/c1-2-13-7-8-3-4-10-9(8)5-6-11(14)12(10)15/h5-6,8,13-15H,2-4,7H2,1H3 | PDB
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| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225339
(CHEMBL31789)Show InChI InChI=1S/C9H11NO2/c10-4-5-3-7-6(5)1-2-8(11)9(7)12/h1-2,5,11-12H,3-4,10H2 | PDB
UniProtKB/SwissProt
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| 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225345
(CHEMBL281712)Show InChI InChI=1S/C17H27NO2/c1-3-10-18(11-4-2)12-13-6-5-7-15-14(13)8-9-16(19)17(15)20/h8-9,13,19-20H,3-7,10-12H2,1-2H3 | PDB
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| 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor B
(RAT) | BDBM50003152
(2-Butyl-4-{[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)Show SMILES CCCCc1ncc(C(O)=O)c(NCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)n1 Show InChI InChI=1S/C23H23N7O2/c1-2-3-8-20-24-14-19(23(31)32)21(26-20)25-13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-27-29-30-28-22/h4-7,9-12,14H,2-3,8,13H2,1H3,(H,31,32)(H,24,25,26)(H,27,28,29,30) | PDB
Reactome pathway
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| 198 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Compound was evaluated for binding affinity against AT1 receptor in rat liver |
J Med Chem 35: 3714-7 (1992)
BindingDB Entry DOI: 10.7270/Q2H41QCN |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225341
(CHEMBL31458)Show InChI InChI=1S/C9H11NO2/c10-4-6-1-5-2-8(11)9(12)3-7(5)6/h2-3,6,11-12H,1,4,10H2 | PDB
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| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225351
(CHEMBL281759)Show InChI InChI=1S/C13H19NO2/c1-2-14-8-9-4-3-5-11-10(9)6-7-12(15)13(11)16/h6-7,9,14-16H,2-5,8H2,1H3 | PDB
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| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225354
(CHEMBL284484)Show InChI InChI=1S/C15H23NO2/c1-3-16(4-2)10-11-6-5-7-13-12(11)8-9-14(17)15(13)18/h8-9,11,17-18H,3-7,10H2,1-2H3 | PDB
UniProtKB/SwissProt
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| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225352
(CHEMBL285455)Show InChI InChI=1S/C14H21NO2/c1-3-15(4-2)9-10-5-6-12-11(10)7-8-13(16)14(12)17/h7-8,10,16-17H,3-6,9H2,1-2H3 | PDB
UniProtKB/SwissProt
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| 320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50226153
(CHEMBL545092)Show InChI InChI=1S/C12H14N2O2.BrH/c15-10-4-3-7-8(11(10)16)1-2-9(7)12-13-5-6-14-12;/h3-4,9,15-16H,1-2,5-6H2,(H,13,14);1H | PDB
Reactome pathway
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| 350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
The compound was evaluated for the inhibition of [3H]prazosin binding to alpha-1 adrenergic receptor from rat liver |
J Med Chem 29: 463-7 (1986)
BindingDB Entry DOI: 10.7270/Q26D5W7D |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50029051
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1 | PDB
Reactome pathway
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| 390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
The compound was evaluated for the inhibition of [3H]prazosin binding to alpha-1 adrenergic receptor from rat liver |
J Med Chem 29: 463-7 (1986)
BindingDB Entry DOI: 10.7270/Q26D5W7D |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50029051
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1 | PDB
Reactome pathway
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| PubMed
| 390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity for alpha-1 adrenergic receptor in rat liver using [3H]prazosin. |
J Med Chem 30: 1011-7 (1987)
BindingDB Entry DOI: 10.7270/Q2T155VK |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50225342
(CHEMBL288787)Show InChI InChI=1S/C7H9NO3/c8-7(11)4-1-2-5(9)6(10)3-4/h1-3,7,9-11H,8H2 | PDB
Reactome pathway
KEGG
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| CHEMBL
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Similars
| PubMed
| 390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity against alpha-1 adrenergic receptor in rat using [3H]prazosin as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50226155
(CHEMBL543684)Show InChI InChI=1S/C13H16N2O2.BrH/c16-11-5-4-8-9(12(11)17)2-1-3-10(8)13-14-6-7-15-13;/h4-5,10,16-17H,1-3,6-7H2,(H,14,15);1H | PDB
Reactome pathway
KEGG
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| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
The compound was evaluated for the inhibition of [3H]prazosin binding to alpha-1 adrenergic receptor from rat liver |
J Med Chem 29: 463-7 (1986)
BindingDB Entry DOI: 10.7270/Q26D5W7D |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50226802
(CHEMBL7186)Show InChI InChI=1S/C13H16N2O2/c16-11-5-4-8-9(12(11)17)2-1-3-10(8)13-14-6-7-15-13/h4-5,10,16-17H,1-3,6-7H2,(H,14,15) | PDB
Reactome pathway
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Similars
| PubMed
| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity for alpha-1 adrenergic receptor in rat liver using [3H]prazosin. |
J Med Chem 30: 1011-7 (1987)
BindingDB Entry DOI: 10.7270/Q2T155VK |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225332
(CHEMBL31332)Show InChI InChI=1S/C16H25NO2/c1-3-9-17(10-4-2)11-12-5-6-14-13(12)7-8-15(18)16(14)19/h7-8,12,18-19H,3-6,9-11H2,1-2H3 | PDB
UniProtKB/SwissProt
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| CHEMBL
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| PubMed
| 470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human)) | BDBM50225332
(CHEMBL31332)Show InChI InChI=1S/C16H25NO2/c1-3-9-17(10-4-2)11-12-5-6-14-13(12)7-8-15(18)16(14)19/h7-8,12,18-19H,3-6,9-11H2,1-2H3 | PDB
KEGG
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antibodypedia
antibodypedia
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| CHEMBL
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| PubMed
| 470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha 2 adrenergic receptor |
J Med Chem 30: 178-84 (1987)
BindingDB Entry DOI: 10.7270/Q2891837 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50225337
(CHEMBL442268)Show InChI InChI=1S/C10H13NO2/c11-5-7-2-1-6-3-9(12)10(13)4-8(6)7/h3-4,7,12-13H,1-2,5,11H2 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 520 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50225285
(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| PubMed
| 520 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity against alpha-1 adrenergic receptor in rat using [3H]prazosin as radioligand |
J Med Chem 28: 1398-404 (1985)
BindingDB Entry DOI: 10.7270/Q2H41TM1 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50225285
(CHEBI:3757 | Catapres | Catapres-Tts-1 | Catapres-...)Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| PubMed
| 520 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity for alpha-1 adrenergic receptor in rat liver using [3H]prazosin. |
J Med Chem 30: 1011-7 (1987)
BindingDB Entry DOI: 10.7270/Q2T155VK |
More data for this
Ligand-Target Pair | |
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