Found 83 hits with Last Name = 'lanthorn' and Initial = 't' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuronal acetylcholine receptor subunit alpha-7
(Mus musculus) | BDBM50096713
(1H-Indole-3-carboxylic acid 1-aza-bicyclo[2.2.2]oc...)Show SMILES O=C(OC1CN2CCC1CC2)c1c[nH]c2ccccc12 |THB:2:3:9.10:7.6,(10.78,-2.61,;10.78,-4.18,;12.1,-4.96,;13.37,-6.22,;12.58,-7.47,;14.26,-6.58,;15.87,-7.55,;16.69,-6.38,;15.12,-5.43,;15.11,-4.33,;14.26,-5.17,;9.44,-4.93,;9.44,-6.45,;8.09,-7.22,;6.74,-6.45,;5.4,-7.22,;4.07,-6.45,;4.07,-4.94,;5.4,-4.15,;6.74,-4.9,)| Show InChI InChI=1S/C16H18N2O2/c19-16(13-9-17-14-4-2-1-3-12(13)14)20-15-10-18-7-5-11(15)6-8-18/h1-4,9,11,15,17H,5-8,10H2 | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards alpha-7 nAChR was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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| PDB
PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards alpha-3 (PC12) nAChR was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Neuronal acetylcholine receptor subunit alpha-7
(Mus musculus) | BDBM50096712
(3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-...)Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12 |TLB:10:8:1:4.5| Show InChI InChI=1S/C18H22N2O2/c1-20(2)12-7-8-13(20)10-14(9-12)22-18(21)16-11-19-17-6-4-3-5-15(16)17/h3-6,11-14H,7-10H2,1-2H3/p+1 | PDB
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CHEMBL
PC cid
PC sid
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| 6.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards alpha-7 nAChR was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Mus musculus) | BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1c[nH]c2ccccc12 |r,THB:9:7:4.3:1| Show InChI InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13+ | PDB
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| PubMed
| 6.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards alpha-7 nAChR was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Mus musculus) | BDBM50096711
(CHEMBL320963 | Indole-1-carboxylic acid 1-aza-bicy...)Show SMILES O=C(OC1CN2CCC1CC2)n1ccc2ccccc12 |THB:2:3:9.10:7.6,(7.39,-10.08,;8.5,-8.89,;9.81,-9.66,;11.07,-10.94,;10.28,-12.18,;11.95,-11.29,;13.58,-12.25,;14.4,-11.1,;12.81,-10.15,;12.81,-9.03,;11.95,-9.89,;8.08,-7.22,;9.43,-6.44,;9.43,-4.92,;6.74,-4.9,;5.39,-4.15,;4.07,-4.93,;4.07,-6.44,;5.39,-7.22,;6.74,-6.44,)| Show InChI InChI=1S/C16H18N2O2/c19-16(18-10-7-12-3-1-2-4-14(12)18)20-15-11-17-8-5-13(15)6-9-17/h1-4,7,10,13,15H,5-6,8-9,11H2 | PDB
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UniChem
| PubMed
| 8.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards alpha-7 nAChR was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-3
(Homo sapiens (Human)) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB
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| 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards alpha-3 (PC12) nAChR was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Mus musculus) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB
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| PDB
PubMed
| 480 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards alpha-7 nAChR was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Neuronal acetylcholine receptor subunit alpha-3
(Homo sapiens (Human)) | BDBM50096712
(3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-...)Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12 |TLB:10:8:1:4.5| Show InChI InChI=1S/C18H22N2O2/c1-20(2)12-7-8-13(20)10-14(9-12)22-18(21)16-11-19-17-6-4-3-5-15(16)17/h3-6,11-14H,7-10H2,1-2H3/p+1 | PDB
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CHEMBL
PC cid
PC sid
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| 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards alpha-3 (PC12) nAChR was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50096713
(1H-Indole-3-carboxylic acid 1-aza-bicyclo[2.2.2]oc...)Show SMILES O=C(OC1CN2CCC1CC2)c1c[nH]c2ccccc12 |THB:2:3:9.10:7.6,(10.78,-2.61,;10.78,-4.18,;12.1,-4.96,;13.37,-6.22,;12.58,-7.47,;14.26,-6.58,;15.87,-7.55,;16.69,-6.38,;15.12,-5.43,;15.11,-4.33,;14.26,-5.17,;9.44,-4.93,;9.44,-6.45,;8.09,-7.22,;6.74,-6.45,;5.4,-7.22,;4.07,-6.45,;4.07,-4.94,;5.4,-4.15,;6.74,-4.9,)| Show InChI InChI=1S/C16H18N2O2/c19-16(13-9-17-14-4-2-1-3-12(13)14)20-15-10-18-7-5-11(15)6-8-18/h1-4,9,11,15,17H,5-8,10H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards alpha-1-beta-1-gamma-delta nAChR was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Mus musculus) | BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3 | PDB
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| >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards alpha-7 nAChR was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM50096712
(3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-...)Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12 |TLB:10:8:1:4.5| Show InChI InChI=1S/C18H22N2O2/c1-20(2)12-7-8-13(20)10-14(9-12)22-18(21)16-11-19-17-6-4-3-5-15(16)17/h3-6,11-14H,7-10H2,1-2H3/p+1 | PDB
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CHEMBL
PC cid
PC sid
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| 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB
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PC cid
PC sid
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| 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50096712
(3-(1H-Indole-3-carbonyloxy)-8,8-dimethyl-8-azonia-...)Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)c1c[nH]c2ccccc12 |TLB:10:8:1:4.5| Show InChI InChI=1S/C18H22N2O2/c1-20(2)12-7-8-13(20)10-14(9-12)22-18(21)16-11-19-17-6-4-3-5-15(16)17/h3-6,11-14H,7-10H2,1-2H3/p+1 | PDB
MMDB
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Reactome pathway
KEGG
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CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-7
(Mus musculus) | BDBM50000483
((BRL 43694)1-Methyl-1H-indazole-3-carboxylic acid ...)Show SMILES CN1C2CCCC1CC(C2)NC(=O)c1nn(C)c2ccccc12 |THB:10:8:1:3.5.4| Show InChI InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23) | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards alpha-7 nAChR was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50096711
(CHEMBL320963 | Indole-1-carboxylic acid 1-aza-bicy...)Show SMILES O=C(OC1CN2CCC1CC2)n1ccc2ccccc12 |THB:2:3:9.10:7.6,(7.39,-10.08,;8.5,-8.89,;9.81,-9.66,;11.07,-10.94,;10.28,-12.18,;11.95,-11.29,;13.58,-12.25,;14.4,-11.1,;12.81,-10.15,;12.81,-9.03,;11.95,-9.89,;8.08,-7.22,;9.43,-6.44,;9.43,-4.92,;6.74,-4.9,;5.39,-4.15,;4.07,-4.93,;4.07,-6.44,;5.39,-7.22,;6.74,-6.44,)| Show InChI InChI=1S/C16H18N2O2/c19-16(18-10-7-12-3-1-2-4-14(12)18)20-15-11-17-8-5-13(15)6-9-17/h1-4,7,10,13,15H,5-6,8-9,11H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards alpha-1-beta-1-gamma-delta nAChR was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-3
(Homo sapiens (Human)) | BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1c[nH]c2ccccc12 |r,THB:9:7:4.3:1| Show InChI InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13+ | PDB
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| PubMed
| 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards alpha-3 (PC12) nAChR was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human)) | BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1c[nH]c2ccccc12 |r,THB:9:7:4.3:1| Show InChI InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13+ | PDB
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| PubMed
| 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards alpha-1-beta-1-gamma delta nAChR was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50000483
((BRL 43694)1-Methyl-1H-indazole-3-carboxylic acid ...)Show SMILES CN1C2CCCC1CC(C2)NC(=O)c1nn(C)c2ccccc12 |THB:10:8:1:3.5.4| Show InChI InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23) | PDB
MMDB
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| PubMed
| 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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antibodypedia
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MCE
KEGG
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PC sid
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| 4.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50108392
((3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-I...)Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1c[nH]c2ccccc12 |r,THB:9:7:4.3:1| Show InChI InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12+,13+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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B.MOAD
DrugBank
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CHEMBL
MCE
KEGG
MMDB
PC cid
PC sid
PDB
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| PubMed
| 5.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards 5-hydroxytryptamine 3 receptor was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-3
(Homo sapiens (Human)) | BDBM50000483
((BRL 43694)1-Methyl-1H-indazole-3-carboxylic acid ...)Show SMILES CN1C2CCCC1CC(C2)NC(=O)c1nn(C)c2ccccc12 |THB:10:8:1:3.5.4| Show InChI InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23) | PDB
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| 6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
In vitro Binding affinity towards 5-hydroxytryptamine 3 receptor was determined |
Bioorg Med Chem Lett 11: 319-21 (2001)
BindingDB Entry DOI: 10.7270/Q2028S36 |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052641
(CHEMBL3318586)Show SMILES Clc1cccc(c1)-c1ccc(cc1)C(=O)N1C2CCC1CN(C2)c1ncccn1 |TLB:13:15:21.22.20:17.18,THB:23:21:15:17.18| Show InChI InChI=1S/C23H21ClN4O/c24-19-4-1-3-18(13-19)16-5-7-17(8-6-16)22(29)28-20-9-10-21(28)15-27(14-20)23-25-11-2-12-26-23/h1-8,11-13,20-21H,9-10,14-15H2 | UniProtKB/SwissProt
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052723
(CHEMBL3318579)Show SMILES C[C@H]1CN(CCN1C(=O)c1ccc(cc1)-c1ccc(Cl)cc1)c1ncccn1 |r| Show InChI InChI=1S/C22H21ClN4O/c1-16-15-26(22-24-11-2-12-25-22)13-14-27(16)21(28)19-5-3-17(4-6-19)18-7-9-20(23)10-8-18/h2-12,16H,13-15H2,1H3/t16-/m0/s1 | UniProtKB/SwissProt
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052718
(CHEMBL3318574)Show SMILES CC1CN(CC(C)N1C(=O)c1ccc(cc1)-c1cccc(Cl)c1)c1ncccn1 Show InChI InChI=1S/C23H23ClN4O/c1-16-14-27(23-25-11-4-12-26-23)15-17(2)28(16)22(29)19-9-7-18(8-10-19)20-5-3-6-21(24)13-20/h3-13,16-17H,14-15H2,1-2H3 | UniProtKB/SwissProt
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| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052729
(CHEMBL3318585)Show SMILES Clc1cccc(c1)-c1ccc(cc1)C(=O)N1CC2CCC(C1)N2c1ncccn1 |TLB:13:15:22:18.19| Show InChI InChI=1S/C23H21ClN4O/c24-19-4-1-3-18(13-19)16-5-7-17(8-6-16)22(29)27-14-20-9-10-21(15-27)28(20)23-25-11-2-12-26-23/h1-8,11-13,20-21H,9-10,14-15H2 | UniProtKB/SwissProt
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| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052660
(CHEMBL3318552)Show SMILES Cc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C22H22N4O/c1-17-3-5-18(6-4-17)19-7-9-20(10-8-19)21(27)25-13-15-26(16-14-25)22-23-11-2-12-24-22/h2-12H,13-16H2,1H3 | UniProtKB/SwissProt
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| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052648
(CHEMBL3318563)Show SMILES Cc1csc(c1)-c1ccc(cc1)C(=O)N1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C20H20N4OS/c1-15-13-18(26-14-15)16-3-5-17(6-4-16)19(25)23-9-11-24(12-10-23)20-21-7-2-8-22-20/h2-8,13-14H,9-12H2,1H3 | UniProtKB/SwissProt
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| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052728
(CHEMBL3318584)Show SMILES Clc1cccc(c1)-c1ccc(cc1)C(=O)N1CC2CN(CC2C1)c1ncccn1 Show InChI InChI=1S/C23H21ClN4O/c24-21-4-1-3-18(11-21)16-5-7-17(8-6-16)22(29)27-12-19-14-28(15-20(19)13-27)23-25-9-2-10-26-23/h1-11,19-20H,12-15H2 | UniProtKB/SwissProt
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| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052640
(CHEMBL3318548)Show SMILES Clc1cccc(c1)-c1ccc(cc1)C(=O)N1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C21H19ClN4O/c22-19-4-1-3-18(15-19)16-5-7-17(8-6-16)20(27)25-11-13-26(14-12-25)21-23-9-2-10-24-21/h1-10,15H,11-14H2 | UniProtKB/SwissProt
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| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052658
(CHEMBL3317462)Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C21H19ClN4O/c22-19-8-6-17(7-9-19)16-2-4-18(5-3-16)20(27)25-12-14-26(15-13-25)21-23-10-1-11-24-21/h1-11H,12-15H2 | UniProtKB/SwissProt
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| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052717
(CHEMBL3318573)Show SMILES CC1(C)CN(CCN1C(=O)c1ccc(cc1)-c1cccc(Cl)c1)c1ncccn1 Show InChI InChI=1S/C23H23ClN4O/c1-23(2)16-27(22-25-11-4-12-26-22)13-14-28(23)21(29)18-9-7-17(8-10-18)19-5-3-6-20(24)15-19/h3-12,15H,13-14,16H2,1-2H3 | UniProtKB/SwissProt
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| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052724
(CHEMBL3318580)Show SMILES C[C@@H]1CN(CCN1C(=O)c1ccc(cc1)-c1ccc(Cl)cc1)c1ncccn1 |r| Show InChI InChI=1S/C22H21ClN4O/c1-16-15-26(22-24-11-2-12-25-22)13-14-27(16)21(28)19-5-3-17(4-6-19)18-7-9-20(23)10-8-18/h2-12,16H,13-15H2,1H3/t16-/m1/s1 | UniProtKB/SwissProt
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| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052647
(CHEMBL3318564)Show SMILES Cc1ccc(s1)-c1ccc(cc1)C(=O)N1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C20H20N4OS/c1-15-3-8-18(26-15)16-4-6-17(7-5-16)19(25)23-11-13-24(14-12-23)20-21-9-2-10-22-20/h2-10H,11-14H2,1H3 | UniProtKB/SwissProt
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| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052663
(CHEMBL3318549)Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(cc1)C(=O)N1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C22H19F3N4O/c23-22(24,25)19-4-1-3-18(15-19)16-5-7-17(8-6-16)20(30)28-11-13-29(14-12-28)21-26-9-2-10-27-21/h1-10,15H,11-14H2 | UniProtKB/SwissProt
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| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052662
(CHEMBL3318550)Show SMILES FC(F)(F)Oc1cccc(c1)-c1ccc(cc1)C(=O)N1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C22H19F3N4O2/c23-22(24,25)31-19-4-1-3-18(15-19)16-5-7-17(8-6-16)20(30)28-11-13-29(14-12-28)21-26-9-2-10-27-21/h1-10,15H,11-14H2 | UniProtKB/SwissProt
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| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052720
(CHEMBL3318576)Show SMILES OCC1CN(CCN1C(=O)c1ccc(cc1)-c1cccc(Cl)c1)c1ncccn1 Show InChI InChI=1S/C22H21ClN4O2/c23-19-4-1-3-18(13-19)16-5-7-17(8-6-16)21(29)27-12-11-26(14-20(27)15-28)22-24-9-2-10-25-22/h1-10,13,20,28H,11-12,14-15H2 | UniProtKB/SwissProt
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| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052657
(CHEMBL3318554)Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(cc1)C(=O)N1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C22H19F3N4O/c23-22(24,25)19-8-6-17(7-9-19)16-2-4-18(5-3-16)20(30)28-12-14-29(15-13-28)21-26-10-1-11-27-21/h1-11H,12-15H2 | UniProtKB/SwissProt
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| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052659
(CHEMBL3318553)Show SMILES CCc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C23H24N4O/c1-2-18-4-6-19(7-5-18)20-8-10-21(11-9-20)22(28)26-14-16-27(17-15-26)23-24-12-3-13-25-23/h3-13H,2,14-17H2,1H3 | UniProtKB/SwissProt
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Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052725
(CHEMBL3318581)Show SMILES Clc1cccc(c1)-c1ccc(cc1)C(=O)N1CCCN(CC1)c1ncccn1 Show InChI InChI=1S/C22H21ClN4O/c23-20-5-1-4-19(16-20)17-6-8-18(9-7-17)21(28)26-12-3-13-27(15-14-26)22-24-10-2-11-25-22/h1-2,4-11,16H,3,12-15H2 | UniProtKB/SwissProt
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| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052721
(CHEMBL3318577)Show SMILES OC(=O)C1CN(CCN1C(=O)c1ccc(cc1)-c1cccc(Cl)c1)c1ncccn1 Show InChI InChI=1S/C22H19ClN4O3/c23-18-4-1-3-17(13-18)15-5-7-16(8-6-15)20(28)27-12-11-26(14-19(27)21(29)30)22-24-9-2-10-25-22/h1-10,13,19H,11-12,14H2,(H,29,30) | UniProtKB/SwissProt
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Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052708
(CHEMBL3318540)Show InChI InChI=1S/C20H19N3OS/c24-19(22-11-13-23(14-12-22)20-21-10-15-25-20)18-8-6-17(7-9-18)16-4-2-1-3-5-16/h1-10,15H,11-14H2 | UniProtKB/SwissProt
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Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052649
(CHEMBL3318562)Show SMILES Clc1ccc(s1)-c1ccc(cc1)C(=O)N1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C19H17ClN4OS/c20-17-7-6-16(26-17)14-2-4-15(5-3-14)18(25)23-10-12-24(13-11-23)19-21-8-1-9-22-19/h1-9H,10-13H2 | UniProtKB/SwissProt
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Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052713
(CHEMBL1543754)Show InChI InChI=1S/C22H21N3O/c26-22(20-11-9-19(10-12-20)18-6-2-1-3-7-18)25-16-14-24(15-17-25)21-8-4-5-13-23-21/h1-13H,14-17H2 | UniProtKB/SwissProt
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| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052656
(CHEMBL3318555)Show SMILES O=C(N1CCN(CC1)c1ncccn1)c1ccc(cc1)-c1ccc(cc1)C#N Show InChI InChI=1S/C22H19N5O/c23-16-17-2-4-18(5-3-17)19-6-8-20(9-7-19)21(28)26-12-14-27(15-13-26)22-24-10-1-11-25-22/h1-11H,12-15H2 | UniProtKB/SwissProt
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Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052661
(CHEMBL3318551)Show SMILES O=C(N1CCN(CC1)c1ncccn1)c1ccc(cc1)-c1cccc(c1)C#N Show InChI InChI=1S/C22H19N5O/c23-16-17-3-1-4-20(15-17)18-5-7-19(8-6-18)21(28)26-11-13-27(14-12-26)22-24-9-2-10-25-22/h1-10,15H,11-14H2 | UniProtKB/SwissProt
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Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052655
(CHEMBL3318556)Show SMILES COc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C22H22N4O2/c1-28-20-9-7-18(8-10-20)17-3-5-19(6-4-17)21(27)25-13-15-26(16-14-25)22-23-11-2-12-24-22/h2-12H,13-16H2,1H3 | UniProtKB/SwissProt
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Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052654
(CHEMBL3318557)Show SMILES Fc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C21H19FN4O/c22-19-8-6-17(7-9-19)16-2-4-18(5-3-16)20(27)25-12-14-26(15-13-25)21-23-10-1-11-24-21/h1-11H,12-15H2 | UniProtKB/SwissProt
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Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052644
(CHEMBL3318567)Show SMILES O=C(N1CCN(CC1)c1ncccn1)c1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C22H22N4O2/c27-21(25-13-15-26(16-14-25)22-23-11-4-12-24-22)19-7-9-20(10-8-19)28-17-18-5-2-1-3-6-18/h1-12H,13-17H2 | UniProtKB/SwissProt
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Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052704
(CHEMBL3318543)Show SMILES Cc1ccnc(n1)N1CCN(CC1)C(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C22H22N4O/c1-17-11-12-23-22(24-17)26-15-13-25(14-16-26)21(27)20-9-7-19(8-10-20)18-5-3-2-4-6-18/h2-12H,13-16H2,1H3 | UniProtKB/SwissProt
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Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
Sodium-dependent proline transporter
(Homo sapiens (Human)) | BDBM50052705
(CHEMBL1594803)Show InChI InChI=1S/C21H20N4O/c26-20(19-9-7-18(8-10-19)17-5-2-1-3-6-17)24-13-15-25(16-14-24)21-22-11-4-12-23-21/h1-12H,13-16H2 | UniProtKB/SwissProt
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Lexicon Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of human high-affinity L-proline transporter expressed in COS1 cells by [3H]proline uptake assay |
Bioorg Med Chem Lett 24: 3886-90 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.049
BindingDB Entry DOI: 10.7270/Q20C4XDG |
More data for this
Ligand-Target Pair | |
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