Found 18 hits with Last Name = 'lopchuk' and Initial = 'jm' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50266285
(CHEMBL4086276)Show SMILES Cc1cc2n(C)c(=O)n(C)c2cc1N1C(=O)c2cccc3c(CCCO)ccc(C1=O)c23 Show InChI InChI=1S/C25H23N3O4/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8-4-7-16-15(6-5-11-29)9-10-18(22(16)17)24(28)31/h4,7-10,12-13,29H,5-6,11H2,1-3H3 | PDB
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MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human TAF1 BD 1 (1373 to 1499 residues) transfected in Escherichia coli BL21 (DE3) by isothermal titration calorimetric analysis |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50503406
(CHEMBL4463538)Show SMILES Cn1cnc2c(cc(cc12)C(=O)N1CCOCC1)-c1cn(CCC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C24H25N5O3/c1-3-4-7-29-14-19(17-5-6-25-22(17)24(29)31)18-12-16(13-20-21(18)26-15-27(20)2)23(30)28-8-10-32-11-9-28/h3,5-6,12-15,25H,1,4,7-11H2,2H3 | PDB
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| PDB Article PubMed
| n/a | n/a | n/a | n/a | 920 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to TAF1 in HEK293T cells assessed as increase in TAF1 level by ITDR analysis |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50427326
(CHEMBL2325697)Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1cccc2[nH]ccc12)C1(CC1)S(C)(=O)=O |r| Show InChI InChI=1S/C21H24N4O3S/c1-14-13-28-11-10-25(14)19-12-18(21(7-8-21)29(2,26)27)23-20(24-19)16-4-3-5-17-15(16)6-9-22-17/h3-6,9,12,14,22H,7-8,10-11,13H2,1-2H3/t14-/m1/s1 | PDB
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Similars
| PDB Article PubMed
| n/a | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human TAF1 BD 2 (1501 to 1635 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant by isotherma... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50266285
(CHEMBL4086276)Show SMILES Cc1cc2n(C)c(=O)n(C)c2cc1N1C(=O)c2cccc3c(CCCO)ccc(C1=O)c23 Show InChI InChI=1S/C25H23N3O4/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8-4-7-16-15(6-5-11-29)9-10-18(22(16)17)24(28)31/h4,7-10,12-13,29H,5-6,11H2,1-3H3 | PDB
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MCE PC cid PC sid PDB UniChem
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| PDB Article PubMed
| n/a | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human TAF1 BD 2 (1501 to 1635 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant by isotherma... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50585017
(AZD6738 | Atr kinase inhibitor azd6738 | Azd 6738 ...)Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1cc[nH]c2nccc12)C1(CC1)[S@](C)(=N)=O |r| | PDB
KEGG
UniProtKB/SwissProt
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| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 1.67E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human TAF1 tandem bromodomain (1373 to 1499 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constan... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50427326
(CHEMBL2325697)Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1cccc2[nH]ccc12)C1(CC1)S(C)(=O)=O |r| Show InChI InChI=1S/C21H24N4O3S/c1-14-13-28-11-10-25(14)19-12-18(21(7-8-21)29(2,26)27)23-20(24-19)16-4-3-5-17-15(16)6-9-22-17/h3-6,9,12,14,22H,7-8,10-11,13H2,1-2H3/t14-/m1/s1 | PDB
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| PDB Article PubMed
| n/a | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human TAF1 tandem bromodomain (1373 to 1499 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constan... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50504160
(CHEMBL3133807 | US11773085, Compound B25)Show SMILES CCOC(=O)Nc1cc(nn2c(C)nnc12)-c1ccc(C)c(NS(C)(=O)=O)c1 Show InChI InChI=1S/C17H20N6O4S/c1-5-27-17(24)18-15-9-14(21-23-11(3)19-20-16(15)23)12-7-6-10(2)13(8-12)22-28(4,25)26/h6-9,22H,5H2,1-4H3,(H,18,24) | PDB
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MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | n/a | 147 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human TAF1 tandem bromodomain (1373 to 1499 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constan... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50503406
(CHEMBL4463538)Show SMILES Cn1cnc2c(cc(cc12)C(=O)N1CCOCC1)-c1cn(CCC=C)c(=O)c2[nH]ccc12 Show InChI InChI=1S/C24H25N5O3/c1-3-4-7-29-14-19(17-5-6-25-22(17)24(29)31)18-12-16(13-20-21(18)26-15-27(20)2)23(30)28-8-10-32-11-9-28/h3,5-6,12-15,25H,1,4,7-11H2,2H3 | PDB
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MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human TAF1 tandem bromodomain (1373 to 1499 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constan... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50585017
(AZD6738 | Atr kinase inhibitor azd6738 | Azd 6738 ...)Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1cc[nH]c2nccc12)C1(CC1)[S@](C)(=N)=O |r| | PDB
KEGG
UniProtKB/SwissProt
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| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 175 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human TAF1 BD 2 (1501 to 1635 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant by q-PCR bas... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50427326
(CHEMBL2325697)Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1cccc2[nH]ccc12)C1(CC1)S(C)(=O)=O |r| Show InChI InChI=1S/C21H24N4O3S/c1-14-13-28-11-10-25(14)19-12-18(21(7-8-21)29(2,26)27)23-20(24-19)16-4-3-5-17-15(16)6-9-22-17/h3-6,9,12,14,22H,7-8,10-11,13H2,1-2H3/t14-/m1/s1 | PDB
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CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 6.17E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human TAF1 BD 2 (1501 to 1635 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant by q-PCR bas... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50585017
(AZD6738 | Atr kinase inhibitor azd6738 | Azd 6738 ...)Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1cc[nH]c2nccc12)C1(CC1)[S@](C)(=N)=O |r| | PDB
KEGG
UniProtKB/SwissProt
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| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 427 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human TAF1 BD 2 (1501 to 1635 residues) transfected in Escherichia coli BL21 (DE3) by Alphascreen assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50427326
(CHEMBL2325697)Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1cccc2[nH]ccc12)C1(CC1)S(C)(=O)=O |r| Show InChI InChI=1S/C21H24N4O3S/c1-14-13-28-11-10-25(14)19-12-18(21(7-8-21)29(2,26)27)23-20(24-19)16-4-3-5-17-15(16)6-9-22-17/h3-6,9,12,14,22H,7-8,10-11,13H2,1-2H3/t14-/m1/s1 | PDB
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Similars
| PDB Article PubMed
| n/a | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human TAF1 BD 2 (1501 to 1635 residues) transfected in Escherichia coli BL21 (DE3) by Alphascreen assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50266285
(CHEMBL4086276)Show SMILES Cc1cc2n(C)c(=O)n(C)c2cc1N1C(=O)c2cccc3c(CCCO)ccc(C1=O)c23 Show InChI InChI=1S/C25H23N3O4/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8-4-7-16-15(6-5-11-29)9-10-18(22(16)17)24(28)31/h4,7-10,12-13,29H,5-6,11H2,1-3H3 | PDB
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MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human TAF1 tandem bromodomain (1373 to 1499 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constan... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50266285
(CHEMBL4086276)Show SMILES Cc1cc2n(C)c(=O)n(C)c2cc1N1C(=O)c2cccc3c(CCCO)ccc(C1=O)c23 Show InChI InChI=1S/C25H23N3O4/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8-4-7-16-15(6-5-11-29)9-10-18(22(16)17)24(28)31/h4,7-10,12-13,29H,5-6,11H2,1-3H3 | PDB
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MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human TAF1 tandem bromodomain (1373 to 1499 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constan... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50504160
(CHEMBL3133807 | US11773085, Compound B25)Show SMILES CCOC(=O)Nc1cc(nn2c(C)nnc12)-c1ccc(C)c(NS(C)(=O)=O)c1 Show InChI InChI=1S/C17H20N6O4S/c1-5-27-17(24)18-15-9-14(21-23-11(3)19-20-16(15)23)12-7-6-10(2)13(8-12)22-28(4,25)26/h6-9,22H,5H2,1-4H3,(H,18,24) | PDB
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MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to TAF1 BD 2 (unknown origin) assessed as dissociation constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50504160
(CHEMBL3133807 | US11773085, Compound B25)Show SMILES CCOC(=O)Nc1cc(nn2c(C)nnc12)-c1ccc(C)c(NS(C)(=O)=O)c1 Show InChI InChI=1S/C17H20N6O4S/c1-5-27-17(24)18-15-9-14(21-23-11(3)19-20-16(15)23)12-7-6-10(2)13(8-12)22-28(4,25)26/h6-9,22H,5H2,1-4H3,(H,18,24) | PDB
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MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to TAF1 BD 1 (unknown origin) assessed as dissociation constant |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50266285
(CHEMBL4086276)Show SMILES Cc1cc2n(C)c(=O)n(C)c2cc1N1C(=O)c2cccc3c(CCCO)ccc(C1=O)c23 Show InChI InChI=1S/C25H23N3O4/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8-4-7-16-15(6-5-11-29)9-10-18(22(16)17)24(28)31/h4,7-10,12-13,29H,5-6,11H2,1-3H3 | PDB
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MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 70 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to TAF1 in HEK293T cells assessed as increase in TAF1 level by ITDR analysis |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human)) | BDBM50585017
(AZD6738 | Atr kinase inhibitor azd6738 | Azd 6738 ...)Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1cc[nH]c2nccc12)C1(CC1)[S@](C)(=N)=O |r| | PDB
KEGG
UniProtKB/SwissProt
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| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 1.69E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to human TAF1 BD 2 (1501 to 1635 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant by isotherma... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 |
More data for this Ligand-Target Pair | |