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Compile Data Set for Download or QSAR

Found 199 hits with Last Name = 'maki' and Initial = 't'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bile acid receptor


(Homo sapiens (Human))		BDBM50286760
PNG
(CHEMBL4170032)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccc(C)cc3n2C)CC1 |r|
Show InChI InChI=1S/C35H39N5O4/c1-23(2)34(42)38-18-16-25(17-19-38)21-31(33-36-29-15-10-24(3)20-30(29)37(33)4)40-32(41)22-39(35(40)43)26-11-13-28(14-12-26)44-27-8-6-5-7-9-27/h5-15,20,23,25,31H,16-19,21-22H2,1-4H3/t31-/m0/s1
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n/an/a<0.00100n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...

ACS Med Chem Lett 9: 78-83 (2018)


Article DOI: 10.1021/acsmedchemlett.7b00363
BindingDB Entry DOI: 10.7270/Q2GQ7199
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50510491
PNG
(CHEMBL4552760)
Show SMILES COc1ccc(Oc2ccc(cc2)N2CC(=O)N([C@@H](CC3CCN(CC3)C(=O)C(C)C)c3nc4ccc(C)cc4n3C)C2=O)cc1 |r|
Show InChI InChI=1S/C36H41N5O5/c1-23(2)35(43)39-18-16-25(17-19-39)21-32(34-37-30-15-6-24(3)20-31(30)38(34)4)41-33(42)22-40(36(41)44)26-7-9-28(10-8-26)46-29-13-11-27(45-5)12-14-29/h6-15,20,23,25,32H,16-19,21-22H2,1-5H3/t32-/m0/s1
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n/an/a<0.00100n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50286734
PNG
(CHEMBL4172988)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccccc3n2C)CC1 |r|
Show InChI InChI=1S/C34H37N5O4/c1-23(2)33(41)37-19-17-24(18-20-37)21-30(32-35-28-11-7-8-12-29(28)36(32)3)39-31(40)22-38(34(39)42)25-13-15-27(16-14-25)43-26-9-5-4-6-10-26/h4-16,23-24,30H,17-22H2,1-3H3/t30-/m0/s1
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n/an/a<0.00100n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...

ACS Med Chem Lett 9: 78-83 (2018)


Article DOI: 10.1021/acsmedchemlett.7b00363
BindingDB Entry DOI: 10.7270/Q2GQ7199
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50286760
PNG
(CHEMBL4170032)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccc(C)cc3n2C)CC1 |r|
Show InChI InChI=1S/C35H39N5O4/c1-23(2)34(42)38-18-16-25(17-19-38)21-31(33-36-29-15-10-24(3)20-30(29)37(33)4)40-32(41)22-39(35(40)43)26-11-13-28(14-12-26)44-27-8-6-5-7-9-27/h5-15,20,23,25,31H,16-19,21-22H2,1-4H3/t31-/m0/s1
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n/an/a<0.00100n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50510487
PNG
(CHEMBL4569266)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3cc(C)ccc3n2C)CC1 |r|
Show InChI InChI=1S/C35H39N5O4/c1-23(2)34(42)38-18-16-25(17-19-38)21-31(33-36-29-20-24(3)10-15-30(29)37(33)4)40-32(41)22-39(35(40)43)26-11-13-28(14-12-26)44-27-8-6-5-7-9-27/h5-15,20,23,25,31H,16-19,21-22H2,1-4H3/t31-/m0/s1
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n/an/a<0.00100n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50286761
PNG
(CHEMBL4169187)
Show SMILES CC(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccccc3n2C)CC1 |r|
Show InChI InChI=1S/C32H33N5O4/c1-22(38)35-18-16-23(17-19-35)20-29(31-33-27-10-6-7-11-28(27)34(31)2)37-30(39)21-36(32(37)40)24-12-14-26(15-13-24)41-25-8-4-3-5-9-25/h3-15,23,29H,16-21H2,1-2H3/t29-/m0/s1
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n/an/a 0.00200n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...

ACS Med Chem Lett 9: 78-83 (2018)


Article DOI: 10.1021/acsmedchemlett.7b00363
BindingDB Entry DOI: 10.7270/Q2GQ7199
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50286736
PNG
(CHEMBL4161262)
Show SMILES Cc1ccc2nc([C@H](CC3CCN(CC3)C(=O)C3CCCC3)N3C(=O)CN(C3=O)c3ccc(Oc4ccccc4)cc3)n(C)c2c1 |r|
Show InChI InChI=1S/C37H41N5O4/c1-25-12-17-31-32(22-25)39(2)35(38-31)33(23-26-18-20-40(21-19-26)36(44)27-8-6-7-9-27)42-34(43)24-41(37(42)45)28-13-15-30(16-14-28)46-29-10-4-3-5-11-29/h3-5,10-17,22,26-27,33H,6-9,18-21,23-24H2,1-2H3/t33-/m0/s1
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n/an/a 0.00600n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...

ACS Med Chem Lett 9: 78-83 (2018)


Article DOI: 10.1021/acsmedchemlett.7b00363
BindingDB Entry DOI: 10.7270/Q2GQ7199
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50286763
PNG
(CHEMBL4169596)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccc(Cl)cc3n2C)CC1 |r|
Show InChI InChI=1S/C34H36ClN5O4/c1-22(2)33(42)38-17-15-23(16-18-38)19-30(32-36-28-14-9-24(35)20-29(28)37(32)3)40-31(41)21-39(34(40)43)25-10-12-27(13-11-25)44-26-7-5-4-6-8-26/h4-14,20,22-23,30H,15-19,21H2,1-3H3/t30-/m0/s1
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n/an/a 0.0500n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...

ACS Med Chem Lett 9: 78-83 (2018)


Article DOI: 10.1021/acsmedchemlett.7b00363
BindingDB Entry DOI: 10.7270/Q2GQ7199
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50510495
PNG
(CHEMBL4453417)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccc(F)cc3)cc2)c2nc3ccc(C)cc3n2C)CC1 |r|
Show InChI InChI=1S/C35H38FN5O4/c1-22(2)34(43)39-17-15-24(16-18-39)20-31(33-37-29-14-5-23(3)19-30(29)38(33)4)41-32(42)21-40(35(41)44)26-8-12-28(13-9-26)45-27-10-6-25(36)7-11-27/h5-14,19,22,24,31H,15-18,20-21H2,1-4H3/t31-/m0/s1
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Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50286733
PNG
(CHEMBL4162312)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3cc(F)ccc3n2C)CC1 |r|
Show InChI InChI=1S/C34H36FN5O4/c1-22(2)33(42)38-17-15-23(16-18-38)19-30(32-36-28-20-24(35)9-14-29(28)37(32)3)40-31(41)21-39(34(40)43)25-10-12-27(13-11-25)44-26-7-5-4-6-8-26/h4-14,20,22-23,30H,15-19,21H2,1-3H3/t30-/m0/s1
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n/an/a 0.0600n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...

ACS Med Chem Lett 9: 78-83 (2018)


Article DOI: 10.1021/acsmedchemlett.7b00363
BindingDB Entry DOI: 10.7270/Q2GQ7199
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50286762
PNG
(CHEMBL4159402)
Show SMILES CC(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccc(C)cc3n2C)CC1 |r|
Show InChI InChI=1S/C33H35N5O4/c1-22-9-14-28-29(19-22)35(3)32(34-28)30(20-24-15-17-36(18-16-24)23(2)39)38-31(40)21-37(33(38)41)25-10-12-27(13-11-25)42-26-7-5-4-6-8-26/h4-14,19,24,30H,15-18,20-21H2,1-3H3/t30-/m0/s1
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Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...

ACS Med Chem Lett 9: 78-83 (2018)


Article DOI: 10.1021/acsmedchemlett.7b00363
BindingDB Entry DOI: 10.7270/Q2GQ7199
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50286764
PNG
(CHEMBL4176369)
Show SMILES CC(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3cc(F)ccc3n2C)CC1 |r|
Show InChI InChI=1S/C32H32FN5O4/c1-21(39)36-16-14-22(15-17-36)18-29(31-34-27-19-23(33)8-13-28(27)35(31)2)38-30(40)20-37(32(38)41)24-9-11-26(12-10-24)42-25-6-4-3-5-7-25/h3-13,19,22,29H,14-18,20H2,1-2H3/t29-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...

ACS Med Chem Lett 9: 78-83 (2018)


Article DOI: 10.1021/acsmedchemlett.7b00363
BindingDB Entry DOI: 10.7270/Q2GQ7199
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090510
PNG
(CHEMBL3581716)
Show SMILES CC(=O)Nc1cc(cc2CCN(CCc3ccccc3)c12)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C24H23F2N3O3S/c1-16(30)27-23-15-20(33(31,32)28-22-8-7-19(25)14-21(22)26)13-18-10-12-29(24(18)23)11-9-17-5-3-2-4-6-17/h2-8,13-15,28H,9-12H2,1H3,(H,27,30)
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n/an/a 1n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090666
PNG
(CHEMBL3581717)
Show SMILES CC(=O)Nc1cc(cc2CCN(CCc3ccc(F)cc3)c12)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C24H22F3N3O3S/c1-15(31)28-23-14-20(34(32,33)29-22-7-6-19(26)13-21(22)27)12-17-9-11-30(24(17)23)10-8-16-2-4-18(25)5-3-16/h2-7,12-14,29H,8-11H2,1H3,(H,28,31)
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n/an/a 1.20n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090665
PNG
(CHEMBL3581718)
Show SMILES CC(=O)Nc1cc(cc2ccn(CCc3ccccc3)c12)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C24H21F2N3O3S/c1-16(30)27-23-15-20(33(31,32)28-22-8-7-19(25)14-21(22)26)13-18-10-12-29(24(18)23)11-9-17-5-3-2-4-6-17/h2-8,10,12-15,28H,9,11H2,1H3,(H,27,30)
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n/an/a 2.10n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090687
PNG
(CHEMBL3581715)
Show SMILES COc1ccc(NS(=O)(=O)c2cc3CCN(CCc4ccccc4)c3c(NC(C)=O)c2)cc1
Show InChI InChI=1S/C19H23N5O4/c1-10(2)11-5-3-4-6-12(11)23-17-14-18(21-8-20-17)24(9-22-14)19-16(27)15(26)13(7-25)28-19/h3-6,8-10,13,15-16,19,25-27H,7H2,1-2H3,(H,20,21,23)/t13?,15?,16?,19-/m1/s1
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n/an/a 2.20n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090648
PNG
(CHEMBL3581732)
Show SMILES Fc1ccc(NS(=O)(=O)c2cc3CCN(C(=O)OCc4ccccc4)c3c(c2)N2CCCNC2=O)c(F)c1
Show InChI InChI=1S/C26H24F2N4O5S/c27-19-7-8-22(21(28)14-19)30-38(35,36)20-13-18-9-12-32(26(34)37-16-17-5-2-1-3-6-17)24(18)23(15-20)31-11-4-10-29-25(31)33/h1-3,5-8,13-15,30H,4,9-12,16H2,(H,29,33)
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n/an/a 2.20n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50510488
PNG
(CHEMBL4519419)
Show SMILES CC(C)Cn1c(nc2ccc(C)cc12)[C@H](CC1CCN(CC1)C(=O)C(C)C)N1C(=O)CN(C1=O)c1ccc(Oc2ccccc2)cc1 |r|
Show InChI InChI=1S/C38H45N5O4/c1-25(2)23-42-33-21-27(5)11-16-32(33)39-36(42)34(22-28-17-19-40(20-18-28)37(45)26(3)4)43-35(44)24-41(38(43)46)29-12-14-31(15-13-29)47-30-9-7-6-8-10-30/h6-16,21,25-26,28,34H,17-20,22-24H2,1-5H3/t34-/m0/s1
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n/an/a 2.40n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090514
PNG
(CHEMBL3581736)
Show SMILES Fc1ccc(NS(=O)(=O)c2cc3CCN(C(=O)Nc4ccc(cc4)C(F)(F)F)c3c(c2)N2CCNC2=O)c(F)c1
Show InChI InChI=1S/C25H20F5N5O4S/c26-16-3-6-20(19(27)12-16)33-40(38,39)18-11-14-7-9-35(22(14)21(13-18)34-10-8-31-23(34)36)24(37)32-17-4-1-15(2-5-17)25(28,29)30/h1-6,11-13,33H,7-10H2,(H,31,36)(H,32,37)
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n/an/a 2.5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090617
PNG
(CHEMBL3581734)
Show SMILES Fc1ccc(NS(=O)(=O)c2cc3CCN(C(=O)Nc4ccc(cc4)C(F)(F)F)c3c(c2)N2CCCC2=O)c(F)c1
Show InChI InChI=1S/C26H21F5N4O4S/c27-17-5-8-21(20(28)13-17)33-40(38,39)19-12-15-9-11-35(24(15)22(14-19)34-10-1-2-23(34)36)25(37)32-18-6-3-16(4-7-18)26(29,30)31/h3-8,12-14,33H,1-2,9-11H2,(H,32,37)
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n/an/a 3.10n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090650
PNG
(CHEMBL3581730)
Show SMILES Fc1ccc(NS(=O)(=O)c2cc3CCN(C(=O)OCc4ccccc4)c3c(c2)N2CCNC2=O)c(F)c1
Show InChI InChI=1S/C25H22F2N4O5S/c26-18-6-7-21(20(27)13-18)29-37(34,35)19-12-17-8-10-31(25(33)36-15-16-4-2-1-3-5-16)23(17)22(14-19)30-11-9-28-24(30)32/h1-7,12-14,29H,8-11,15H2,(H,28,32)
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n/an/a 3.40n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090616
PNG
(CHEMBL3581735)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCc3cc(cc(N4CCCC4=O)c23)S(=O)(=O)Nc2ccc(F)cc2F)cc1
Show InChI InChI=1S/C29H30F2N4O4S/c1-29(2,3)19-6-9-21(10-7-19)32-28(37)35-14-12-18-15-22(17-25(27(18)35)34-13-4-5-26(34)36)40(38,39)33-24-11-8-20(30)16-23(24)31/h6-11,15-17,33H,4-5,12-14H2,1-3H3,(H,32,37)
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n/an/a 3.60n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090656
PNG
(CHEMBL3581724)
Show SMILES CC(=O)Nc1cc(cc2CCN(CCCc3ccccc3)c12)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C20H18O4/c1-20(22-2)12-15(13-8-4-3-5-9-13)17-18(24-20)14-10-6-7-11-16(14)23-19(17)21/h3-11,15H,12H2,1-2H3/t15?,20-/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090653
PNG
(CHEMBL3581727)
Show SMILES Fc1ccc(NS(=O)(=O)c2cc3CCN(CCc4ccccc4)c3c(c2)N2CCCC2=O)c(F)c1
Show InChI InChI=1S/C26H25F2N3O3S/c27-20-8-9-23(22(28)16-20)29-35(33,34)21-15-19-11-14-30(13-10-18-5-2-1-3-6-18)26(19)24(17-21)31-12-4-7-25(31)32/h1-3,5-6,8-9,15-17,29H,4,7,10-14H2
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n/an/a 6.70n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50510491
PNG
(CHEMBL4552760)
Show SMILES COc1ccc(Oc2ccc(cc2)N2CC(=O)N([C@@H](CC3CCN(CC3)C(=O)C(C)C)c3nc4ccc(C)cc4n3C)C2=O)cc1 |r|
Show InChI InChI=1S/C36H41N5O5/c1-23(2)35(43)39-18-16-25(17-19-39)21-32(34-37-30-15-6-24(3)20-31(30)38(34)4)41-33(42)22-40(36(41)44)26-7-9-28(10-8-26)46-29-13-11-27(45-5)12-14-29/h6-15,20,23,25,32H,16-19,21-22H2,1-5H3/t32-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090652
PNG
(CHEMBL3581728)
Show SMILES Fc1ccc(NS(=O)(=O)c2cc3CCN(CCc4ccccc4)c3c(c2)N2CCCCC2=O)c(F)c1
Show InChI InChI=1S/C27H27F2N3O3S/c28-21-9-10-24(23(29)17-21)30-36(34,35)22-16-20-12-15-31(14-11-19-6-2-1-3-7-19)27(20)25(18-22)32-13-5-4-8-26(32)33/h1-3,6-7,9-10,16-18,30H,4-5,8,11-15H2
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n/an/a 7.30n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50510490
PNG
(CHEMBL4556659)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccc(Cl)cc3)cc2)c2nc3ccc(C)cc3n2C)CC1 |r|
Show InChI InChI=1S/C35H38ClN5O4/c1-22(2)34(43)39-17-15-24(16-18-39)20-31(33-37-29-14-5-23(3)19-30(29)38(33)4)41-32(42)21-40(35(41)44)26-8-12-28(13-9-26)45-27-10-6-25(36)7-11-27/h5-14,19,22,24,31H,15-18,20-21H2,1-4H3/t31-/m0/s1
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n/an/a 9.30n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090649
PNG
(CHEMBL3581731)
Show SMILES Fc1ccc(NS(=O)(=O)c2cc3CCN(C(=O)OCc4ccccc4)c3c(c2)N2CCCCC2=O)c(F)c1
Show InChI InChI=1S/C27H25F2N3O5S/c28-20-9-10-23(22(29)15-20)30-38(35,36)21-14-19-11-13-32(27(34)37-17-18-6-2-1-3-7-18)26(19)24(16-21)31-12-5-4-8-25(31)33/h1-3,6-7,9-10,14-16,30H,4-5,8,11-13,17H2
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n/an/a 10n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090651
PNG
(CHEMBL3581729)
Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(NC(=O)OCc3ccccc3)c(c2)N2CCCC2=O)c(F)c1
Show InChI InChI=1S/C24H21F2N3O5S/c25-17-8-10-20(19(26)13-17)28-35(32,33)18-9-11-21(22(14-18)29-12-4-7-23(29)30)27-24(31)34-15-16-5-2-1-3-6-16/h1-3,5-6,8-11,13-14,28H,4,7,12,15H2,(H,27,31)
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n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50510492
PNG
(CHEMBL4472554)
Show SMILES CC(C)NC(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccc(C)cc3n2C)CC1 |r|
Show InChI InChI=1S/C35H40N6O4/c1-23(2)36-34(43)39-18-16-25(17-19-39)21-31(33-37-29-15-10-24(3)20-30(29)38(33)4)41-32(42)22-40(35(41)44)26-11-13-28(14-12-26)45-27-8-6-5-7-9-27/h5-15,20,23,25,31H,16-19,21-22H2,1-4H3,(H,36,43)/t31-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090657
PNG
(CHEMBL3581723)
Show SMILES CC(=O)Nc1cc(cc2CCN(Cc3ccccc3)c12)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C23H21F2N3O3S/c1-15(29)26-22-13-19(32(30,31)27-21-8-7-18(24)12-20(21)25)11-17-9-10-28(23(17)22)14-16-5-3-2-4-6-16/h2-8,11-13,27H,9-10,14H2,1H3,(H,26,29)
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n/an/a 23n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50510490
PNG
(CHEMBL4556659)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccc(Cl)cc3)cc2)c2nc3ccc(C)cc3n2C)CC1 |r|
Show InChI InChI=1S/C35H38ClN5O4/c1-22(2)34(43)39-17-15-24(16-18-39)20-31(33-37-29-14-5-23(3)19-30(29)38(33)4)41-32(42)21-40(35(41)44)26-8-12-28(13-9-26)45-27-10-6-25(36)7-11-27/h5-14,19,22,24,31H,15-18,20-21H2,1-4H3/t31-/m0/s1
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n/an/a 27n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090618
PNG
(CHEMBL3581733)
Show SMILES Fc1ccc(NC(=O)N2CCc3cc(cc(N4CCCC4=O)c23)S(=O)(=O)Nc2ccc(F)cc2F)cc1
Show InChI InChI=1S/C25H21F3N4O4S/c26-16-3-6-18(7-4-16)29-25(34)32-11-9-15-12-19(14-22(24(15)32)31-10-1-2-23(31)33)37(35,36)30-21-8-5-17(27)13-20(21)28/h3-8,12-14,30H,1-2,9-11H2,(H,29,34)
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n/an/a 28n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50286736
PNG
(CHEMBL4161262)
Show SMILES Cc1ccc2nc([C@H](CC3CCN(CC3)C(=O)C3CCCC3)N3C(=O)CN(C3=O)c3ccc(Oc4ccccc4)cc3)n(C)c2c1 |r|
Show InChI InChI=1S/C37H41N5O4/c1-25-12-17-31-32(22-25)39(2)35(38-31)33(23-26-18-20-40(21-19-26)36(44)27-8-6-7-9-27)42-34(43)24-41(37(42)45)28-13-15-30(16-14-28)46-29-10-4-3-5-11-29/h3-5,10-17,22,26-27,33H,6-9,18-21,23-24H2,1-2H3/t33-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...

ACS Med Chem Lett 9: 78-83 (2018)


Article DOI: 10.1021/acsmedchemlett.7b00363
BindingDB Entry DOI: 10.7270/Q2GQ7199
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50286760
PNG
(CHEMBL4170032)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccc(C)cc3n2C)CC1 |r|
Show InChI InChI=1S/C35H39N5O4/c1-23(2)34(42)38-18-16-25(17-19-38)21-31(33-36-29-15-10-24(3)20-30(29)37(33)4)40-32(41)22-39(35(40)43)26-11-13-28(14-12-26)44-27-8-6-5-7-9-27/h5-15,20,23,25,31H,16-19,21-22H2,1-4H3/t31-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...

ACS Med Chem Lett 9: 78-83 (2018)


Article DOI: 10.1021/acsmedchemlett.7b00363
BindingDB Entry DOI: 10.7270/Q2GQ7199
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50286760
PNG
(CHEMBL4170032)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccc(C)cc3n2C)CC1 |r|
Show InChI InChI=1S/C35H39N5O4/c1-23(2)34(42)38-18-16-25(17-19-38)21-31(33-36-29-15-10-24(3)20-30(29)37(33)4)40-32(41)22-39(35(40)43)26-11-13-28(14-12-26)44-27-8-6-5-7-9-27/h5-15,20,23,25,31H,16-19,21-22H2,1-4H3/t31-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50510495
PNG
(CHEMBL4453417)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccc(F)cc3)cc2)c2nc3ccc(C)cc3n2C)CC1 |r|
Show InChI InChI=1S/C35H38FN5O4/c1-22(2)34(43)39-17-15-24(16-18-39)20-31(33-37-29-14-5-23(3)19-30(29)38(33)4)41-32(42)21-40(35(41)44)26-8-12-28(13-9-26)45-27-10-6-25(36)7-11-27/h5-14,19,22,24,31H,15-18,20-21H2,1-4H3/t31-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50286734
PNG
(CHEMBL4172988)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccccc3n2C)CC1 |r|
Show InChI InChI=1S/C34H37N5O4/c1-23(2)33(41)37-19-17-24(18-20-37)21-30(32-35-28-11-7-8-12-29(28)36(32)3)39-31(40)22-38(34(39)42)25-13-15-27(16-14-25)43-26-9-5-4-6-10-26/h4-16,23-24,30H,17-22H2,1-3H3/t30-/m0/s1
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n/an/a 38n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...

ACS Med Chem Lett 9: 78-83 (2018)


Article DOI: 10.1021/acsmedchemlett.7b00363
BindingDB Entry DOI: 10.7270/Q2GQ7199
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50510482
PNG
(CHEMBL4463196)
Show SMILES CC(C)C(=O)N1CCC(C[C@@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccc(C)cc3n2C)CC1 |r|
Show InChI InChI=1S/C35H39N5O4/c1-23(2)34(42)38-18-16-25(17-19-38)21-31(33-36-29-15-10-24(3)20-30(29)37(33)4)40-32(41)22-39(35(40)43)26-11-13-28(14-12-26)44-27-8-6-5-7-9-27/h5-15,20,23,25,31H,16-19,21-22H2,1-4H3/t31-/m1/s1
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n/an/a 41n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090662
PNG
(CHEMBL3581719)
Show SMILES CC(=O)Nc1cc(cc2cnn(CCc3ccc(F)cc3)c12)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C23H19F3N4O3S/c1-14(31)28-22-12-19(34(32,33)29-21-7-6-18(25)11-20(21)26)10-16-13-27-30(23(16)22)9-8-15-2-4-17(24)5-3-15/h2-7,10-13,29H,8-9H2,1H3,(H,28,31)
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n/an/a 41n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090511
PNG
(CHEMBL3581739)
Show SMILES Fc1ccc(NS(=O)(=O)c2cc3CCN(C(=O)OCc4ccccc4)c3c(c2)N2CCOC2=O)c(F)c1
Show InChI InChI=1S/C25H21F2N3O6S/c26-18-6-7-21(20(27)13-18)28-37(33,34)19-12-17-8-9-30(25(32)36-15-16-4-2-1-3-5-16)23(17)22(14-19)29-10-11-35-24(29)31/h1-7,12-14,28H,8-11,15H2
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n/an/a 43n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50510487
PNG
(CHEMBL4569266)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3cc(C)ccc3n2C)CC1 |r|
Show InChI InChI=1S/C35H39N5O4/c1-23(2)34(42)38-18-16-25(17-19-38)21-31(33-36-29-20-24(3)10-15-30(29)37(33)4)40-32(41)22-39(35(40)43)26-11-13-28(14-12-26)44-27-8-6-5-7-9-27/h5-15,20,23,25,31H,16-19,21-22H2,1-4H3/t31-/m0/s1
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n/an/a 51n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50510479
PNG
(CHEMBL4592488)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(OC3CCCCC3)cc2)c2nc3ccc(C)cc3n2C)CC1 |r|
Show InChI InChI=1S/C35H45N5O4/c1-23(2)34(42)38-18-16-25(17-19-38)21-31(33-36-29-15-10-24(3)20-30(29)37(33)4)40-32(41)22-39(35(40)43)26-11-13-28(14-12-26)44-27-8-6-5-7-9-27/h10-15,20,23,25,27,31H,5-9,16-19,21-22H2,1-4H3/t31-/m0/s1
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n/an/a 53n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50510486
PNG
(CHEMBL4454185)
Show SMILES CC(C)S(=O)(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccc(C)cc3n2C)CC1 |r|
Show InChI InChI=1S/C34H39N5O5S/c1-23(2)45(42,43)37-18-16-25(17-19-37)21-31(33-35-29-15-10-24(3)20-30(29)36(33)4)39-32(40)22-38(34(39)41)26-11-13-28(14-12-26)44-27-8-6-5-7-9-27/h5-15,20,23,25,31H,16-19,21-22H2,1-4H3/t31-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50510497
PNG
(CHEMBL4461640)
Show SMILES Cc1ccc2nc([C@H](Cc3ccccc3)N3C(=O)CN(C3=O)c3ccc(Oc4ccccc4)cc3)n(C)c2c1 |r|
Show InChI InChI=1S/C32H28N4O3/c1-22-13-18-27-28(19-22)34(2)31(33-27)29(20-23-9-5-3-6-10-23)36-30(37)21-35(32(36)38)24-14-16-26(17-15-24)39-25-11-7-4-8-12-25/h3-19,29H,20-21H2,1-2H3/t29-/m0/s1
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n/an/a 81n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...

Bioorg Med Chem 27: 2220-2227 (2019)


Article DOI: 10.1016/j.bmc.2019.04.029
BindingDB Entry DOI: 10.7270/Q2R49V2G
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090512
PNG
(CHEMBL3581738)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(OCCc3ccccc3)c(NC(C)=O)c2)cc1
Show InChI InChI=1S/C23H24N2O5S/c1-17(26)24-22-16-21(31(27,28)25-19-8-10-20(29-2)11-9-19)12-13-23(22)30-15-14-18-6-4-3-5-7-18/h3-13,16,25H,14-15H2,1-2H3,(H,24,26)
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n/an/a 130n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090513
PNG
(CHEMBL3581737)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(C)c(NC(=O)COc3ccccc3)c2)cc1
Show InChI InChI=1S/C22H22N2O5S/c1-16-8-13-20(30(26,27)24-17-9-11-18(28-2)12-10-17)14-21(16)23-22(25)15-29-19-6-4-3-5-7-19/h3-14,24H,15H2,1-2H3,(H,23,25)
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n/an/a 130n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090654
PNG
(CHEMBL3581726)
Show SMILES CNc1cc(cc2CCN(CCc3ccccc3)c12)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C23H23F2N3O2S/c1-26-22-15-19(31(29,30)27-21-8-7-18(24)14-20(21)25)13-17-10-12-28(23(17)22)11-9-16-5-3-2-4-6-16/h2-8,13-15,26-27H,9-12H2,1H3
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n/an/a 130n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
Bile acid receptor


(Homo sapiens (Human))		BDBM50286763
PNG
(CHEMBL4169596)
Show SMILES CC(C)C(=O)N1CCC(C[C@H](N2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)c2nc3ccc(Cl)cc3n2C)CC1 |r|
Show InChI InChI=1S/C34H36ClN5O4/c1-22(2)33(42)38-17-15-23(16-18-38)19-30(32-36-28-14-9-24(35)20-29(28)37(32)3)40-31(41)21-39(34(40)43)25-10-12-27(13-11-25)44-26-7-5-4-6-8-26/h4-14,20,22-23,30H,15-19,21H2,1-3H3/t30-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...

ACS Med Chem Lett 9: 78-83 (2018)


Article DOI: 10.1021/acsmedchemlett.7b00363
BindingDB Entry DOI: 10.7270/Q2GQ7199
More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))		BDBM50090661
PNG
(CHEMBL3581720)
Show SMILES CC(=O)Nc1cc(cc2ncn(CCc3ccc(F)cc3)c12)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C19H18O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,12,15,20,22H,11H2,1H3/t12-,15?/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of full length human MGAT2 transfected in FreeStyle293 cells assessed as dioleoylglycerol by RapidFire/MS assay

J Med Chem 58: 3892-909 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00178
BindingDB Entry DOI: 10.7270/Q2XK8H94
More data for this
Ligand-Target Pair
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