Found 15 hits with Last Name = 'mcnulty' and Initial = 'ka' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50182369
(4-(2-(4-fluorophenyl)-7-(1-methylpiperidin-4-yl)H-...)Show SMILES CN1CCC(CC1)c1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1 Show InChI InChI=1S/C23H23FN6/c1-29-11-7-15(8-12-29)17-9-13-30-20(14-17)28-21(16-2-4-18(24)5-3-16)22(30)19-6-10-26-23(25)27-19/h2-6,9-10,13-15H,7-8,11-12H2,1H3,(H2,25,26,27) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against PKG |
Bioorg Med Chem Lett 16: 2479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50182367
(4-(2-(4-fluorophenyl)-7-(piperidin-4-yl)H-imidazo[...)Show SMILES Nc1nccc(n1)-c1c(nc2cc(ccn12)C1CCNCC1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H21FN6/c23-17-3-1-15(2-4-17)20-21(18-7-11-26-22(24)27-18)29-12-8-16(13-19(29)28-20)14-5-9-25-10-6-14/h1-4,7-8,11-14,25H,5-6,9-10H2,(H2,24,26,27) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against PKG |
Bioorg Med Chem Lett 16: 2479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50182359
(CHEMBL379059 | N-benzyl-4-(7-((dimethylamino)methy...)Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCc2ccccc2)n1 Show InChI InChI=1S/C27H25FN6/c1-33(2)18-20-13-15-34-24(16-20)32-25(21-8-10-22(28)11-9-21)26(34)23-12-14-29-27(31-23)30-17-19-6-4-3-5-7-19/h3-16H,17-18H2,1-2H3,(H,29,30,31) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0810 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against PKG |
Bioorg Med Chem Lett 16: 2479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50182362
(4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...)Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1 Show InChI InChI=1S/C20H19FN6/c1-26(2)12-13-8-10-27-17(11-13)25-18(14-3-5-15(21)6-4-14)19(27)16-7-9-23-20(22)24-16/h3-11H,12H2,1-2H3,(H2,22,23,24) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against PKG |
Bioorg Med Chem Lett 16: 2479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50182355
(4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...)Show SMILES CCCNc1nccc(n1)-c1c(nc2cc(CN(C)C)ccn12)-c1ccc(F)cc1 Show InChI InChI=1S/C23H25FN6/c1-4-11-25-23-26-12-9-19(27-23)22-21(17-5-7-18(24)8-6-17)28-20-14-16(15-29(2)3)10-13-30(20)22/h5-10,12-14H,4,11,15H2,1-3H3,(H,25,26,27) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against PKG |
Bioorg Med Chem Lett 16: 2479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50182358
(4-(2-(4-fluorophenyl)-7-((methylamino)methyl)H-imi...)Show SMILES CNCc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1 Show InChI InChI=1S/C19H17FN6/c1-22-11-12-7-9-26-16(10-12)25-17(13-2-4-14(20)5-3-13)18(26)15-6-8-23-19(21)24-15/h2-10,22H,11H2,1H3,(H2,21,23,24) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against PKG |
Bioorg Med Chem Lett 16: 2479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50182361
(4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...)Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCC(C)(C)C)n1 Show InChI InChI=1S/C25H29FN6/c1-25(2,3)16-28-24-27-12-10-20(29-24)23-22(18-6-8-19(26)9-7-18)30-21-14-17(15-31(4)5)11-13-32(21)23/h6-14H,15-16H2,1-5H3,(H,27,28,29) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against PKG |
Bioorg Med Chem Lett 16: 2479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50182356
(4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...)Show SMILES CNc1nccc(n1)-c1c(nc2cc(CN(C)C)ccn12)-c1ccc(F)cc1 Show InChI InChI=1S/C21H21FN6/c1-23-21-24-10-8-17(25-21)20-19(15-4-6-16(22)7-5-15)26-18-12-14(13-27(2)3)9-11-28(18)20/h4-12H,13H2,1-3H3,(H,23,24,25) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against PKG |
Bioorg Med Chem Lett 16: 2479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50182363
(4-(7-(aminomethyl)-2-(4-fluorophenyl)H-imidazo[1,2...)Show SMILES NCc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1 Show InChI InChI=1S/C18H15FN6/c19-13-3-1-12(2-4-13)16-17(14-5-7-22-18(21)23-14)25-8-6-11(10-20)9-15(25)24-16/h1-9H,10,20H2,(H2,21,22,23) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against PKG |
Bioorg Med Chem Lett 16: 2479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50182368
((2-(4-fluorophenyl)-3-(pyrimidin-4-yl)H-imidazo[1,...)Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccncn1 Show InChI InChI=1S/C20H18FN5/c1-25(2)12-14-8-10-26-18(11-14)24-19(15-3-5-16(21)6-4-15)20(26)17-7-9-22-13-23-17/h3-11,13H,12H2,1-2H3 | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against PKG |
Bioorg Med Chem Lett 16: 2479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50182360
(4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...)Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(n1)N(C)C Show InChI InChI=1S/C22H23FN6/c1-27(2)14-15-10-12-29-19(13-15)26-20(16-5-7-17(23)8-6-16)21(29)18-9-11-24-22(25-18)28(3)4/h5-13H,14H2,1-4H3 | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against PKG |
Bioorg Med Chem Lett 16: 2479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50182357
((2-(4-fluorophenyl)-3-(2-methoxypyrimidin-4-yl)H-i...)Show SMILES COc1nccc(n1)-c1c(nc2cc(CN(C)C)ccn12)-c1ccc(F)cc1 Show InChI InChI=1S/C21H20FN5O/c1-26(2)13-14-9-11-27-18(12-14)25-19(15-4-6-16(22)7-5-15)20(27)17-8-10-23-21(24-17)28-3/h4-12H,13H2,1-3H3 | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against PKG |
Bioorg Med Chem Lett 16: 2479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50182364
(4-(7-chloro-2-(4-fluorophenyl)H-imidazo[1,2-a]pyri...)Show SMILES Nc1nccc(n1)-c1c(nc2cc(Cl)ccn12)-c1ccc(F)cc1 Show InChI InChI=1S/C17H11ClFN5/c18-11-6-8-24-14(9-11)23-15(10-1-3-12(19)4-2-10)16(24)13-5-7-21-17(20)22-13/h1-9H,(H2,20,21,22) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against PKG |
Bioorg Med Chem Lett 16: 2479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50182366
((3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)H-imi...)Show SMILES Nc1nccc(n1)-c1c(nc2cc(CO)ccn12)-c1ccc(F)cc1 Show InChI InChI=1S/C18H14FN5O/c19-13-3-1-12(2-4-13)16-17(14-5-7-21-18(20)22-14)24-8-6-11(10-25)9-15(24)23-16/h1-9,25H,10H2,(H2,20,21,22) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against PKG |
Bioorg Med Chem Lett 16: 2479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
(Eimeria tenella) | BDBM50182365
(3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)H-imid...)Show SMILES Nc1nccc(n1)-c1c(nc2cc(ccn12)C#N)-c1ccc(F)cc1 Show InChI InChI=1S/C18H11FN6/c19-13-3-1-12(2-4-13)16-17(14-5-7-22-18(21)23-14)25-8-6-11(10-20)9-15(25)24-16/h1-9H,(H2,21,22,23) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibitory activity against PKG |
Bioorg Med Chem Lett 16: 2479-83 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.092 BindingDB Entry DOI: 10.7270/Q24X57CW |
More data for this Ligand-Target Pair | |