Compile Data Set for Download or QSAR

Found 223 hits with Last Name = 'merry' and Initial = 't'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50132351 (({4-[6-(2,6-Dichloro-phenyl)-8-(3-dimethylamino-pr...) Show SMILES CN(C)CCCn1c2nc(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(3.9,-7.22,;3.9,-5.68,;2.57,-4.91,;5.23,-4.91,;5.23,-3.37,;6.56,-2.59,;6.56,-1.05,;5.21,-.28,;3.88,-1.05,;2.55,-.29,;1.22,-1.06,;-.11,-.29,;-.11,1.25,;-1.44,2.01,;-2.78,1.23,;-2.77,-.31,;-1.44,-1.07,;-4.12,2,;-4.89,.67,;-3.35,3.34,;-5.45,2.77,;-5.45,4.31,;-6.99,4.32,;-5.86,5.8,;-4.12,5.09,;2.55,1.26,;3.88,2.03,;5.21,1.26,;6.54,2.03,;7.89,1.25,;9.22,2.02,;9.22,3.57,;7.89,4.33,;10.55,4.36,;11.88,3.57,;11.88,2.02,;10.55,1.25,;10.55,-.29,;7.89,-.28,;9.22,-1.05,)| Show InChI InChI=1S/C25H27Cl2N5O6P2/c1-31(2)11-4-12-32-23-16(13-19(24(32)33)22-20(26)5-3-6-21(22)27)14-28-25(30-23)29-17-7-9-18(10-8-17)39(34,35)15-40(36,37)38/h3,5-10,13-14H,4,11-12,15H2,1-2H3,(H,34,35)(H,28,29,30)(H2,36,37,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Src protein tryrosine kinase				Bioorg Med Chem Lett 13: 3071-4 (2003) BindingDB Entry DOI: 10.7270/Q21J995T
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50132348 (({4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-di...) Show SMILES Cn1c2nc(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(3.94,-2.74,;3.93,-1.2,;2.6,-.43,;1.27,-1.2,;-.06,-.43,;-1.39,-1.21,;-2.73,-.45,;-2.73,1.1,;-4.06,1.86,;-5.41,1.09,;-5.38,-.47,;-4.05,-1.22,;-6.74,1.86,;-7.53,.53,;-5.97,3.19,;-8.09,2.61,;-9.4,1.82,;-10.19,3.17,;-10.91,1.42,;-9.02,.34,;-.07,1.11,;1.27,1.88,;2.6,1.11,;3.93,1.88,;5.26,1.11,;6.59,1.88,;6.59,3.42,;5.26,4.19,;7.92,4.19,;9.26,3.42,;9.26,1.88,;7.92,1.11,;7.92,-.43,;5.26,-.43,;6.6,-1.2,)| Show InChI InChI=1S/C21H18Cl2N4O6P2/c1-27-19-12(9-15(20(27)28)18-16(22)3-2-4-17(18)23)10-24-21(26-19)25-13-5-7-14(8-6-13)34(29,30)11-35(31,32)33/h2-10H,11H2,1H3,(H,29,30)(H,24,25,26)(H2,31,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Src protein tryrosine kinase				Bioorg Med Chem Lett 13: 3071-4 (2003) BindingDB Entry DOI: 10.7270/Q21J995T
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM3071 (2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 38 | 2-ani...) Show SMILES Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(-2.82,-1.97,;-2.82,-.43,;-4.15,.34,;-5.48,-.43,;-6.82,.34,;-8.15,-.43,;-8.15,-1.97,;-6.81,-2.74,;-6.81,-4.28,;-8.14,-5.05,;-9.48,-4.29,;-9.48,-2.75,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,)| Show InChI InChI=1S/C20H14Cl2N4O/c1-26-18-12(11-23-20(25-18)24-13-6-3-2-4-7-13)10-14(19(26)27)17-15(21)8-5-9-16(17)22/h2-11H,1H3,(H,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Src protein tryrosine kinase				Bioorg Med Chem Lett 13: 3071-4 (2003) BindingDB Entry DOI: 10.7270/Q21J995T
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50132352 (({3-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-di...) Show SMILES Cn1c2nc(Nc3cccc(c3)P(O)(=O)CP(O)(O)=O)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(2.81,-5.78,;2.81,-4.24,;1.47,-3.47,;.14,-4.24,;-1.19,-3.48,;-2.53,-4.26,;-3.87,-3.49,;-5.19,-4.26,;-6.52,-3.52,;-6.54,-1.96,;-5.21,-1.18,;-3.87,-1.95,;-5.21,.37,;-6.75,.39,;-3.66,.37,;-5.21,1.91,;-6.55,2.68,;-5.78,4.01,;-7.64,3.78,;-7.66,1.61,;-1.21,-1.93,;.14,-1.15,;1.47,-1.93,;2.81,-1.15,;4.15,-1.94,;5.48,-1.17,;6.81,-1.94,;6.81,-3.48,;8.14,-1.17,;8.14,.39,;6.81,1.16,;5.48,.37,;4.15,1.15,;4.15,-3.47,;5.48,-4.24,)| Show InChI InChI=1S/C21H18Cl2N4O6P2/c1-27-19-12(8-15(20(27)28)18-16(22)6-3-7-17(18)23)10-24-21(26-19)25-13-4-2-5-14(9-13)34(29,30)11-35(31,32)33/h2-10H,11H2,1H3,(H,29,30)(H,24,25,26)(H2,31,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Src protein tryrosine kinase				Bioorg Med Chem Lett 13: 3071-4 (2003) BindingDB Entry DOI: 10.7270/Q21J995T
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50132353 (CHEMBL102801 | {4-[6-(2,6-Dichloro-phenyl)-8-methy...) Show SMILES Cn1c2nc(Nc3ccc(OCC(O)=O)c(c3)P(O)(O)=O)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(4.7,-3.27,;4.67,-1.73,;3.34,-.96,;2.01,-1.73,;.68,-.96,;-.65,-1.73,;-1.98,-.98,;-1.98,.58,;-3.31,1.33,;-4.64,.55,;-5.99,1.32,;-5.99,2.86,;-7.33,3.63,;-8.67,2.85,;-7.34,5.17,;-4.64,-.99,;-3.31,-1.75,;-5.97,-1.77,;-7.3,-2.57,;-7.46,-.86,;-5.3,-3.15,;.68,.58,;2.01,1.35,;3.34,.58,;4.67,1.35,;6.02,.58,;7.35,1.35,;7.35,2.89,;6.02,3.66,;8.68,3.66,;10.02,2.89,;10.02,1.35,;8.68,.58,;8.68,-.96,;6.02,-.96,;7.36,-1.73,)| Show InChI InChI=1S/C22H17Cl2N4O7P/c1-28-20-11(7-13(21(28)31)19-14(23)3-2-4-15(19)24)9-25-22(27-20)26-12-5-6-16(35-10-18(29)30)17(8-12)36(32,33)34/h2-9H,10H2,1H3,(H,29,30)(H,25,26,27)(H2,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Src protein tryrosine kinase				Bioorg Med Chem Lett 13: 3071-4 (2003) BindingDB Entry DOI: 10.7270/Q21J995T
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50097348 (CHEMBL348743 | [(4-{2-Acetylamino-2-[1-(3-carbamoy...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(cc1)C(P(O)(O)=O)P(O)(O)=O)NC(C)=O)c1ccc(OCC2CCCCC2)c(c1)C(N)=O Show InChI InChI=1S/C28H39N3O10P2/c1-17(22-12-13-25(23(15-22)26(29)33)41-16-20-6-4-3-5-7-20)30-27(34)24(31-18(2)32)14-19-8-10-21(11-9-19)28(42(35,36)37)43(38,39)40/h8-13,15,17,20,24,28H,3-7,14,16H2,1-2H3,(H2,29,33)(H,30,34)(H,31,32)(H2,35,36,37)(H2,38,39,40)/t17-,24-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of binding to Src SH2 domain				J Med Chem 44: 660-3 (2001) BindingDB Entry DOI: 10.7270/Q2DJ5DWC
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50132350 (({4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-di...) Show SMILES Cn1c2nc(Nc3ccc(CP(O)(=O)CP(O)(O)=O)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(5.26,-5.02,;5.25,-3.48,;3.9,-2.71,;2.57,-3.48,;1.24,-2.71,;-.09,-3.5,;-1.42,-2.74,;-1.42,-1.19,;-2.75,-.43,;-4.08,-1.2,;-5.43,-.43,;-5.43,1.11,;-6.97,1.16,;-3.89,1.09,;-5.41,2.64,;-6.74,3.42,;-5.94,4.76,;-7.81,4.54,;-7.86,2.37,;-4.08,-2.75,;-2.75,-3.51,;1.24,-1.17,;2.57,-.4,;3.9,-1.17,;5.23,-.4,;6.58,-1.17,;7.91,-.4,;9.24,-1.17,;9.24,-2.71,;10.58,-.4,;10.58,1.14,;9.24,1.91,;7.91,1.14,;6.58,1.91,;6.58,-2.71,;7.92,-3.48,)| Show InChI InChI=1S/C22H20Cl2N4O6P2/c1-28-20-14(9-16(21(28)29)19-17(23)3-2-4-18(19)24)10-25-22(27-20)26-15-7-5-13(6-8-15)11-35(30,31)12-36(32,33)34/h2-10H,11-12H2,1H3,(H,30,31)(H,25,26,27)(H2,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Src protein tryrosine kinase				Bioorg Med Chem Lett 13: 3071-4 (2003) BindingDB Entry DOI: 10.7270/Q21J995T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5106 (1,2,4-Oxadiazole Analogue 15c | 4-[(2S)-2-{[(1S)-2...) Show SMILES OC[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)Cc1ccccc1)c1nc(Cc2ccc3ccccc3c2)no1 |r| Show InChI InChI=1S/C32H31N4O8P/c37-20-28(32-35-29(36-43-32)18-23-10-13-24-8-4-5-9-25(24)16-23)34-31(39)27(33-30(38)19-21-6-2-1-3-7-21)17-22-11-14-26(15-12-22)44-45(40,41)42/h1-16,27-28,37H,17-20H2,(H,33,38)(H,34,39)(H2,40,41,42)/t27-,28-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50132349 (CHEMBL320374 | {5-[6-(2,6-Dichloro-phenyl)-8-methy...) Show SMILES Cn1c2nc(Nc3ccc(c(c3)P(O)(O)=O)P(O)(O)=O)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(3.82,-1.69,;3.82,-.15,;2.48,.62,;1.15,-.15,;-.19,.61,;-1.52,-.17,;-2.87,.6,;-2.87,2.14,;-4.2,2.91,;-5.53,2.13,;-5.52,.58,;-4.19,-.17,;-6.85,-.19,;-8.2,-.99,;-8.36,.72,;-6.19,-1.57,;-6.87,2.9,;-6.07,4.25,;-7.94,4.02,;-7.99,1.84,;-.2,2.17,;1.15,2.94,;2.48,2.17,;3.81,2.94,;5.15,2.15,;6.48,2.92,;6.48,4.48,;5.15,5.24,;7.82,5.25,;9.15,4.48,;9.15,2.92,;7.82,2.15,;7.82,.61,;5.15,.62,;6.48,-.15,)| Show InChI InChI=1S/C20H16Cl2N4O7P2/c1-26-18-10(7-12(19(26)27)17-13(21)3-2-4-14(17)22)9-23-20(25-18)24-11-5-6-15(34(28,29)30)16(8-11)35(31,32)33/h2-9H,1H3,(H,23,24,25)(H2,28,29,30)(H2,31,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of Src protein tryrosine kinase				Bioorg Med Chem Lett 13: 3071-4 (2003) BindingDB Entry DOI: 10.7270/Q21J995T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5103 (1,2,4-Oxadiazole Analogue 13c | 4-[(2S)-2-{[(1S)-1...) Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCc1ccccc1)c1nc(Cc2ccc(Cl)c(Cl)c2)no1 |r| Show InChI InChI=1S/C29H29Cl2N4O7P/c1-18(36)32-26(16-20-7-11-22(12-8-20)42-43(38,39)40)28(37)33-25(14-10-19-5-3-2-4-6-19)29-34-27(35-41-29)17-21-9-13-23(30)24(31)15-21/h2-9,11-13,15,25-26H,10,14,16-17H2,1H3,(H,32,36)(H,33,37)(H2,38,39,40)/t25-,26-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5105 (1,2,4-Oxadiazole Analogue 15b | 4-[(2S)-2-{[(1S)-1...) Show SMILES OC[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)Cc1ccccc1)c1nc(Cc2ccc(Cl)c(Cl)c2)no1 |r| Show InChI InChI=1S/C28H27Cl2N4O8P/c29-21-11-8-19(12-22(21)30)14-25-33-28(41-34-25)24(16-35)32-27(37)23(31-26(36)15-17-4-2-1-3-5-17)13-18-6-9-20(10-7-18)42-43(38,39)40/h1-12,23-24,35H,13-16H2,(H,31,36)(H,32,37)(H2,38,39,40)/t23-,24-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5099 (1,2,4-Oxadiazole Analogue 12c | 4-[(2S)-2-acetamid...) Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CO)c1nc(Cc2ccc3ccccc3c2)no1 |r| Show InChI InChI=1S/C26H27N4O8P/c1-16(32)27-22(13-17-7-10-21(11-8-17)38-39(34,35)36)25(33)28-23(15-31)26-29-24(30-37-26)14-18-6-9-19-4-2-3-5-20(19)12-18/h2-12,22-23,31H,13-15H2,1H3,(H,27,32)(H,28,33)(H2,34,35,36)/t22-,23-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50097347 (CHEMBL346499 | Phosphoric acid mono-(4-{2-acetylam...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)c1ccc(OCC2CCCCC2)c(c1)C(N)=O Show InChI InChI=1S/C27H36N3O8P/c1-17(21-10-13-25(23(15-21)26(28)32)37-16-20-6-4-3-5-7-20)29-27(33)24(30-18(2)31)14-19-8-11-22(12-9-19)38-39(34,35)36/h8-13,15,17,20,24H,3-7,14,16H2,1-2H3,(H2,28,32)(H,29,33)(H,30,31)(H2,34,35,36)/t17-,24-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of binding to Src SH2 domain				J Med Chem 44: 660-3 (2001) BindingDB Entry DOI: 10.7270/Q2DJ5DWC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Yes (Homo sapiens (Human))	BDBM50103784 (CHEMBL77638 | Phosphoric acid mono-(4-{2-acetylami...) Show SMILES C[C@H](NC(=O)C(Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)c1ccc(OCC2CCCCC2)c(c1)C(N)=O Show InChI InChI=1S/C27H36N3O8P/c1-17(21-10-13-25(23(15-21)26(28)32)37-16-20-6-4-3-5-7-20)29-27(33)24(30-18(2)31)14-19-8-11-22(12-9-19)38-39(34,35)36/h8-13,15,17,20,24H,3-7,14,16H2,1-2H3,(H2,28,32)(H,29,33)(H,30,31)(H2,34,35,36)/t17-,24?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of binding to Yes SH2 domain				Bioorg Med Chem Lett 11: 2319-23 (2001) BindingDB Entry DOI: 10.7270/Q2513XHJ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50103784 (CHEMBL77638 | Phosphoric acid mono-(4-{2-acetylami...) Show SMILES C[C@H](NC(=O)C(Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)c1ccc(OCC2CCCCC2)c(c1)C(N)=O Show InChI InChI=1S/C27H36N3O8P/c1-17(21-10-13-25(23(15-21)26(28)32)37-16-20-6-4-3-5-7-20)29-27(33)24(30-18(2)31)14-19-8-11-22(12-9-19)38-39(34,35)36/h8-13,15,17,20,24H,3-7,14,16H2,1-2H3,(H2,28,32)(H,29,33)(H,30,31)(H2,34,35,36)/t17-,24?/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of binding to Src SH2 domain				Bioorg Med Chem Lett 11: 2319-23 (2001) BindingDB Entry DOI: 10.7270/Q2513XHJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5104 (1,2,4-Oxadiazole Analogue 15a | 4-[(2S)-2-{[(1S)-2...) Show SMILES OC[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)Cc1ccccc1)c1nc(Cc2ccc(cc2)C(F)(F)F)no1 |r| Show InChI InChI=1S/C29H28F3N4O8P/c30-29(31,32)21-10-6-20(7-11-21)15-25-35-28(43-36-25)24(17-37)34-27(39)23(33-26(38)16-18-4-2-1-3-5-18)14-19-8-12-22(13-9-19)44-45(40,41)42/h1-13,23-24,37H,14-17H2,(H,33,38)(H,34,39)(H2,40,41,42)/t23-,24-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5102 (1,2,4-Oxadiazole Analogue 13b | 4-[(2S)-2-acetamid...) Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCc1ccccc1)c1nc(Cc2ccc3ccccc3c2)no1 |r| Show InChI InChI=1S/C33H33N4O7P/c1-22(38)34-30(20-24-12-16-28(17-13-24)44-45(40,41)42)32(39)35-29(18-14-23-7-3-2-4-8-23)33-36-31(37-43-33)21-25-11-15-26-9-5-6-10-27(26)19-25/h2-13,15-17,19,29-30H,14,18,20-21H2,1H3,(H,34,38)(H,35,39)(H2,40,41,42)/t29-,30-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5090 (1,2,4-Oxadiazole Analogue 14e | 4-[(2S)-2-[1-(naph...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)Cc1ccc2ccccc2c1)c1nc(Cc2ccc(cc2)C(F)(F)F)no1 |r| Show InChI InChI=1S/C33H30F3N4O7P/c1-20(32-39-29(40-46-32)18-22-7-12-26(13-8-22)33(34,35)36)37-31(42)28(17-21-9-14-27(15-10-21)47-48(43,44)45)38-30(41)19-23-6-11-24-4-2-3-5-25(24)16-23/h2-16,20,28H,17-19H2,1H3,(H,37,42)(H,38,41)(H2,43,44,45)/t20-,28-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5086 (1,2,4-Oxadiazole Analogue 14a | 4-[(2S)-2-(1-pheny...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)Cc1ccccc1)c1nc(Cc2ccc(cc2)C(F)(F)F)no1 |r| Show InChI InChI=1S/C29H28F3N4O7P/c1-18(28-35-25(36-42-28)16-21-7-11-22(12-8-21)29(30,31)32)33-27(38)24(34-26(37)17-19-5-3-2-4-6-19)15-20-9-13-23(14-10-20)43-44(39,40)41/h2-14,18,24H,15-17H2,1H3,(H,33,38)(H,34,37)(H2,39,40,41)/t18-,24-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5074 (1,2,4-Oxadiazole Analogue 5m | 4-[(2S)-2-{[(1S)-1-...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)c1nc(Cc2ccc(I)c(Cl)c2)no1 |r| Show InChI InChI=1S/C22H23ClIN4O7P/c1-12(22-27-20(28-34-22)11-15-5-8-18(24)17(23)9-15)25-21(30)19(26-13(2)29)10-14-3-6-16(7-4-14)35-36(31,32)33/h3-9,12,19H,10-11H2,1-2H3,(H,25,30)(H,26,29)(H2,31,32,33)/t12-,19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5075 (1,2,4-Oxadiazole Analogue 5n | 4-[(2S)-2-{[(1S)-1-...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)c1nc(Cc2ccc(I)c(Br)c2)no1 |r| Show InChI InChI=1S/C22H23BrIN4O7P/c1-12(22-27-20(28-34-22)11-15-5-8-18(24)17(23)9-15)25-21(30)19(26-13(2)29)10-14-3-6-16(7-4-14)35-36(31,32)33/h3-9,12,19H,10-11H2,1-2H3,(H,25,30)(H,26,29)(H2,31,32,33)/t12-,19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50103781 ((4-{2-Acetylamino-2-[1-(3-carbamoyl-4-cyclohexylme...) Show SMILES CC(=O)NC(Cc1ccc(OCC(O)=O)c(c1)P(O)(O)=O)C(=O)NC(C)(C)c1ccc(OCC2CCCCC2)c(c1)C(N)=O Show InChI InChI=1S/C30H40N3O10P/c1-18(34)32-23(13-20-9-11-25(43-17-27(35)36)26(14-20)44(39,40)41)29(38)33-30(2,3)21-10-12-24(22(15-21)28(31)37)42-16-19-7-5-4-6-8-19/h9-12,14-15,19,23H,4-8,13,16-17H2,1-3H3,(H2,31,37)(H,32,34)(H,33,38)(H,35,36)(H2,39,40,41)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of binding to Src SH2 domain				Bioorg Med Chem Lett 11: 2319-23 (2001) BindingDB Entry DOI: 10.7270/Q2513XHJ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50103782 ((4-{2-Acetylamino-2-[(S)-1-(3-carbamoyl-4-cyclohex...) Show SMILES C[C@H](NC(=O)C(Cc1ccc(OCC(O)=O)c(c1)P(O)(O)=O)NC(C)=O)c1ccc(OCC2CCCCC2)c(c1)C(N)=O Show InChI InChI=1S/C29H38N3O10P/c1-17(21-9-11-24(22(14-21)28(30)36)41-15-19-6-4-3-5-7-19)31-29(37)23(32-18(2)33)12-20-8-10-25(42-16-27(34)35)26(13-20)43(38,39)40/h8-11,13-14,17,19,23H,3-7,12,15-16H2,1-2H3,(H2,30,36)(H,31,37)(H,32,33)(H,34,35)(H2,38,39,40)/t17-,23?/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of binding to Src SH2 domain				Bioorg Med Chem Lett 11: 2319-23 (2001) BindingDB Entry DOI: 10.7270/Q2513XHJ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5072 (1,2,4-Oxadiazole Analogue 5k | 4-[(2S)-2-{[(1S)-1-...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)c1nc(Cc2ccc(Br)c(Br)c2)no1 |r| Show InChI InChI=1S/C22H23Br2N4O7P/c1-12(22-27-20(28-34-22)11-15-5-8-17(23)18(24)9-15)25-21(30)19(26-13(2)29)10-14-3-6-16(7-4-14)35-36(31,32)33/h3-9,12,19H,10-11H2,1-2H3,(H,25,30)(H,26,29)(H2,31,32,33)/t12-,19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5100 (1,2,4-Oxadiazole Analogue 12d | 4-[(2S)-2-acetamid...) Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CO)c1nc(Cc2ccc(cc2)C(F)(F)F)no1 |r| Show InChI InChI=1S/C23H24F3N4O8P/c1-13(32)27-18(10-14-4-8-17(9-5-14)38-39(34,35)36)21(33)28-19(12-31)22-29-20(30-37-22)11-15-2-6-16(7-3-15)23(24,25)26/h2-9,18-19,31H,10-12H2,1H3,(H,27,32)(H,28,33)(H2,34,35,36)/t18-,19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5098 (1,2,4-Oxadiazole Analogue 12b | 4-[(2S)-2-{[(1S)-1...) Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CO)c1nc(Cc2ccc(Cl)c(Cl)c2)no1 |r| Show InChI InChI=1S/C22H23Cl2N4O8P/c1-12(30)25-18(9-13-2-5-15(6-3-13)36-37(32,33)34)21(31)26-19(11-29)22-27-20(28-35-22)10-14-4-7-16(23)17(24)8-14/h2-8,18-19,29H,9-11H2,1H3,(H,25,30)(H,26,31)(H2,32,33,34)/t18-,19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5085 (1,2,4-Oxadiazole Analogue 12g | 4-[(2S)-2-acetamid...) Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CO)c1nc(Cc2ccc(I)cc2)no1 |r| Show InChI InChI=1S/C22H24IN4O8P/c1-13(29)24-18(10-14-4-8-17(9-5-14)35-36(31,32)33)21(30)25-19(12-28)22-26-20(27-34-22)11-15-2-6-16(23)7-3-15/h2-9,18-19,28H,10-12H2,1H3,(H,24,29)(H,25,30)(H2,31,32,33)/t18-,19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5087 (1,2,4-Oxadiazole Analogue 14b | 4-[(2S)-2-[1-(thio...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)Cc1cccs1)c1nc(Cc2ccc(cc2)C(F)(F)F)no1 |r| Show InChI InChI=1S/C27H26F3N4O7PS/c1-16(26-33-23(34-40-26)14-18-4-8-19(9-5-18)27(28,29)30)31-25(36)22(32-24(35)15-21-3-2-12-43-21)13-17-6-10-20(11-7-17)41-42(37,38)39/h2-12,16,22H,13-15H2,1H3,(H,31,36)(H,32,35)(H2,37,38,39)/t16-,22-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5091 (1,2,4-Oxadiazole Analogue 14f | 4-[(2S)-2-[1-(1H-i...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)Cc1c[nH]c2ccccc12)c1nc(Cc2ccc(cc2)C(F)(F)F)no1 |r| Show InChI InChI=1S/C31H29F3N5O7P/c1-18(30-38-27(39-45-30)15-20-6-10-22(11-7-20)31(32,33)34)36-29(41)26(14-19-8-12-23(13-9-19)46-47(42,43)44)37-28(40)16-21-17-35-25-5-3-2-4-24(21)25/h2-13,17-18,26,35H,14-16H2,1H3,(H,36,41)(H,37,40)(H2,42,43,44)/t18-,26-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5096 (1,2,4-Oxadiazole Analogue 5e | 4-[(2S)-2-acetamido...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)c1nc(Cc2ccc3ccccc3c2)no1 |r| Show InChI InChI=1S/C26H27N4O7P/c1-16(26-29-24(30-36-26)15-19-7-10-20-5-3-4-6-21(20)13-19)27-25(32)23(28-17(2)31)14-18-8-11-22(12-9-18)37-38(33,34)35/h3-13,16,23H,14-15H2,1-2H3,(H,27,32)(H,28,31)(H2,33,34,35)/t16-,23-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5101 (1,2,4-Oxadiazole Analogue 13a | 4-[(2S)-2-acetamid...) Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCc1ccccc1)c1nc(Cc2ccc(cc2)C(F)(F)F)no1 |r| Show InChI InChI=1S/C30H30F3N4O7P/c1-19(38)34-26(17-21-9-14-24(15-10-21)44-45(40,41)42)28(39)35-25(16-11-20-5-3-2-4-6-20)29-36-27(37-43-29)18-22-7-12-23(13-8-22)30(31,32)33/h2-10,12-15,25-26H,11,16-18H2,1H3,(H,34,38)(H,35,39)(H2,40,41,42)/t25-,26-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5071 (1,2,4-Oxadiazole Analogue 5j | 4-[(2S)-2-acetamido...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)c1nc(Cc2ccc(I)cc2)no1 |r| Show InChI InChI=1S/C22H24IN4O7P/c1-13(22-26-20(27-33-22)12-16-3-7-17(23)8-4-16)24-21(29)19(25-14(2)28)11-15-5-9-18(10-6-15)34-35(30,31)32/h3-10,13,19H,11-12H2,1-2H3,(H,24,29)(H,25,28)(H2,30,31,32)/t13-,19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5073 (1,2,4-Oxadiazole Analogue 5l | 4-[(2S)-2-{[(1S)-1-...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)c1nc(Cc2ccc(Cl)c(Br)c2)no1 |r| Show InChI InChI=1S/C22H23BrClN4O7P/c1-12(22-27-20(28-34-22)11-15-5-8-18(24)17(23)9-15)25-21(30)19(26-13(2)29)10-14-3-6-16(7-4-14)35-36(31,32)33/h3-9,12,19H,10-11H2,1-2H3,(H,25,30)(H,26,29)(H2,31,32,33)/t12-,19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50097350 (4-[2-Acetylamino-3-(4-phosphonooxy-phenyl)-propion...) Show SMILES CC(C)CC(NC(=O)C(CCC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(N)=O Show InChI InChI=1S/C27H40N5O13P/c1-14(2)12-20(24(28)38)32-26(40)19(9-11-23(36)37)30-25(39)18(8-10-22(34)35)31-27(41)21(29-15(3)33)13-16-4-6-17(7-5-16)45-46(42,43)44/h4-7,14,18-21H,8-13H2,1-3H3,(H2,28,38)(H,29,33)(H,30,39)(H,31,41)(H,32,40)(H,34,35)(H,36,37)(H2,42,43,44)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of binding to Src SH2 domain				J Med Chem 44: 660-3 (2001) BindingDB Entry DOI: 10.7270/Q2DJ5DWC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5095 (1,2,4-Oxadiazole Analogue 5d | 4-[(2S)-2-{[(1S)-1-...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)c1nc(Cc2ccc(Cl)c(Cl)c2)no1 |r| Show InChI InChI=1S/C22H23Cl2N4O7P/c1-12(22-27-20(28-34-22)11-15-5-8-17(23)18(24)9-15)25-21(30)19(26-13(2)29)10-14-3-6-16(7-4-14)35-36(31,32)33/h3-9,12,19H,10-11H2,1-2H3,(H,25,30)(H,26,29)(H2,31,32,33)/t12-,19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5088 (1,2,4-Oxadiazole Analogue 14c | 4-[(2S)-2-[1-(3,4-...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)Cc1ccc(F)c(F)c1)c1nc(Cc2ccc(cc2)C(F)(F)F)no1 |r| Show InChI InChI=1S/C29H26F5N4O7P/c1-16(28-37-25(38-44-28)14-18-2-7-20(8-3-18)29(32,33)34)35-27(40)24(13-17-4-9-21(10-5-17)45-46(41,42)43)36-26(39)15-19-6-11-22(30)23(31)12-19/h2-12,16,24H,13-15H2,1H3,(H,35,40)(H,36,39)(H2,41,42,43)/t16-,24-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5089 (1,2,4-Oxadiazole Analogue 14d | 4-[(2S)-2-[1-(4-me...) Show SMILES COc1ccc(CC(=O)N[C@@H](Cc2ccc(OP(O)(O)=O)cc2)C(=O)N[C@@H](C)c2nc(Cc3ccc(cc3)C(F)(F)F)no2)cc1 |r| Show InChI InChI=1S/C30H30F3N4O8P/c1-18(29-36-26(37-44-29)16-20-3-9-22(10-4-20)30(31,32)33)34-28(39)25(15-19-7-13-24(14-8-19)45-46(40,41)42)35-27(38)17-21-5-11-23(43-2)12-6-21/h3-14,18,25H,15-17H2,1-2H3,(H,34,39)(H,35,38)(H2,40,41,42)/t18-,25-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50080177 ((S)-4-{(S)-2-[(S)-2-Acetylamino-3-(4-phosphonooxy-...) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(N)=O Show InChI InChI=1S/C27H40N5O13P/c1-4-14(2)23(24(28)38)32-26(40)19(10-12-22(36)37)30-25(39)18(9-11-21(34)35)31-27(41)20(29-15(3)33)13-16-5-7-17(8-6-16)45-46(42,43)44/h5-8,14,18-20,23H,4,9-13H2,1-3H3,(H2,28,38)(H,29,33)(H,30,39)(H,31,41)(H,32,40)(H,34,35)(H,36,37)(H2,42,43,44)/t14-,18-,19-,20-,23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity against Src-homology 2 (SRC SH2).				Bioorg Med Chem Lett 9: 2359-64 (1999) BindingDB Entry DOI: 10.7270/Q2G73CX5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5084 (1,2,4-Oxadiazole Analogue 12f | 4-[(2S)-2-{[(1S)-1...) Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CO)c1nc(Cc2ccc(Br)cc2)no1 |r| Show InChI InChI=1S/C22H24BrN4O8P/c1-13(29)24-18(10-14-4-8-17(9-5-14)35-36(31,32)33)21(30)25-19(12-28)22-26-20(27-34-22)11-15-2-6-16(23)7-3-15/h2-9,18-19,28H,10-12H2,1H3,(H,24,29)(H,25,30)(H2,31,32,33)/t18-,19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5097 (1,2,4-Oxadiazole Analogue 5f | 4-[(2S)-2-acetamido...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)c1nc(Cc2ccc(cc2)C(F)(F)F)no1 |r| Show InChI InChI=1S/C23H24F3N4O7P/c1-13(22-29-20(30-36-22)12-16-3-7-17(8-4-16)23(24,25)26)27-21(32)19(28-14(2)31)11-15-5-9-18(10-6-15)37-38(33,34)35/h3-10,13,19H,11-12H2,1-2H3,(H,27,32)(H,28,31)(H2,33,34,35)/t13-,19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50080198 ((S)-4-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)...) Show SMILES CCCCCCCc1noc(n1)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O Show InChI InChI=1S/C24H35N4O9P/c1-3-4-5-6-7-8-21-27-24(36-28-21)19(13-14-22(30)31)26-23(32)20(25-16(2)29)15-17-9-11-18(12-10-17)37-38(33,34)35/h9-12,19-20H,3-8,13-15H2,1-2H3,(H,25,29)(H,26,32)(H,30,31)(H2,33,34,35)/t19-,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity against Src-homology 2 (SRC SH2).				Bioorg Med Chem Lett 9: 2359-64 (1999) BindingDB Entry DOI: 10.7270/Q2G73CX5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5069 (1,2,4-Oxadiazole Analogue 5i | 4-[(2S)-2-{[(1S)-1-...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)c1nc(Cc2ccc(Br)cc2)no1 |r| Show InChI InChI=1S/C22H24BrN4O7P/c1-13(22-26-20(27-33-22)12-16-3-7-17(23)8-4-16)24-21(29)19(25-14(2)28)11-15-5-9-18(10-6-15)34-35(30,31)32/h3-10,13,19H,11-12H2,1-2H3,(H,24,29)(H,25,28)(H2,30,31,32)/t13-,19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50103780 (CHEMBL308734 | [4-{2-Acetylamino-2-[(S)-1-(3-carba...) Show SMILES CCOP(O)(=O)c1cc(CC(NC(C)=O)C(=O)N[C@@H](C)c2ccc(OCC3CCCCC3)c(c2)C(N)=O)ccc1OCC(O)=O Show InChI InChI=1S/C31H42N3O10P/c1-4-44-45(40,41)28-15-22(10-12-27(28)43-18-29(36)37)14-25(34-20(3)35)31(39)33-19(2)23-11-13-26(24(16-23)30(32)38)42-17-21-8-6-5-7-9-21/h10-13,15-16,19,21,25H,4-9,14,17-18H2,1-3H3,(H2,32,38)(H,33,39)(H,34,35)(H,36,37)(H,40,41)/t19-,25?/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of binding to Src SH2 domain				Bioorg Med Chem Lett 11: 2319-23 (2001) BindingDB Entry DOI: 10.7270/Q2513XHJ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50097349 ((4-{2-Acetylamino-2-[1-(3-carbamoyl-4-cyclohexylme...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(CP(O)(O)=O)cc1)NC(C)=O)c1ccc(OCC2CCCCC2)c(c1)C(N)=O Show InChI InChI=1S/C28H38N3O7P/c1-18(23-12-13-26(24(15-23)27(29)33)38-16-21-6-4-3-5-7-21)30-28(34)25(31-19(2)32)14-20-8-10-22(11-9-20)17-39(35,36)37/h8-13,15,18,21,25H,3-7,14,16-17H2,1-2H3,(H2,29,33)(H,30,34)(H,31,32)(H2,35,36,37)/t18-,25-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of binding to Src SH2 domain				J Med Chem 44: 660-3 (2001) BindingDB Entry DOI: 10.7270/Q2DJ5DWC
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50080193 ((S)-4-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)...) Show SMILES CCCCCCc1noc(n1)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O Show InChI InChI=1S/C23H33N4O9P/c1-3-4-5-6-7-20-26-23(35-27-20)18(12-13-21(29)30)25-22(31)19(24-15(2)28)14-16-8-10-17(11-9-16)36-37(32,33)34/h8-11,18-19H,3-7,12-14H2,1-2H3,(H,24,28)(H,25,31)(H,29,30)(H2,32,33,34)/t18-,19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity against Src-homology 2 (SRC SH2).				Bioorg Med Chem Lett 9: 2359-64 (1999) BindingDB Entry DOI: 10.7270/Q2G73CX5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5094 (1,2,4-Oxadiazole Analogue 4j | 4-[(2S)-2-{[(1S)-3-...) Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)c1nc(Cc2ccc3ccccc3c2)no1 |r| Show InChI InChI=1S/C28H30N5O8P/c1-17(34)30-24(15-18-7-10-22(11-8-18)41-42(37,38)39)27(36)31-23(12-13-25(29)35)28-32-26(33-40-28)16-19-6-9-20-4-2-3-5-21(20)14-19/h2-11,14,23-24H,12-13,15-16H2,1H3,(H2,29,35)(H,30,34)(H,31,36)(H2,37,38,39)/t23-,24-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5082 (1,2,4-Oxadiazole Analogue 12a | 4-[(2S)-2-{[(1S)-1...) Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CO)c1nc(Cc2ccc(Cl)cc2)no1 |r| Show InChI InChI=1S/C22H24ClN4O8P/c1-13(29)24-18(10-14-4-8-17(9-5-14)35-36(31,32)33)21(30)25-19(12-28)22-26-20(27-34-22)11-15-2-6-16(23)7-3-15/h2-9,18-19,28H,10-12H2,1H3,(H,24,29)(H,25,30)(H2,31,32,33)/t18-,19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50080179 (CHEMBL80765 | Phosphoric acid mono-(4-{(S)-2-acety...) Show SMILES CCCCCCc1cnc(s1)[C@H](CC)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O Show InChI InChI=1S/C23H34N3O6PS/c1-4-6-7-8-9-19-15-24-23(34-19)20(5-2)26-22(28)21(25-16(3)27)14-17-10-12-18(13-11-17)32-33(29,30)31/h10-13,15,20-21H,4-9,14H2,1-3H3,(H,25,27)(H,26,28)(H2,29,30,31)/t20-,21-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity against Src-homology 2 (SRC SH2).				Bioorg Med Chem Lett 9: 2359-64 (1999) BindingDB Entry DOI: 10.7270/Q2G73CX5
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50080186 (CHEMBL77702 | Phosphoric acid mono-(4-{(S)-2-acety...) Show SMILES CCCCCCc1cnc(s1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O Show InChI InChI=1S/C30H37N4O6PS/c1-3-4-5-6-9-24-19-32-30(42-24)28(17-22-18-31-26-11-8-7-10-25(22)26)34-29(36)27(33-20(2)35)16-21-12-14-23(15-13-21)40-41(37,38)39/h7-8,10-15,18-19,27-28,31H,3-6,9,16-17H2,1-2H3,(H,33,35)(H,34,36)(H2,37,38,39)/t27-,28-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Binding affinity against Src-homology 2 (SRC SH2).				Bioorg Med Chem Lett 9: 2359-64 (1999) BindingDB Entry DOI: 10.7270/Q2G73CX5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM5066 (1,2,4-Oxadiazole Analogue 5b | 4-[(2S)-2-{[(1S)-1-...) Show SMILES C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)c1nc(Cc2ccc(Cl)cc2)no1 |r| Show InChI InChI=1S/C22H24ClN4O7P/c1-13(22-26-20(27-33-22)12-16-3-7-17(23)8-4-16)24-21(29)19(25-14(2)28)11-15-5-9-18(10-6-15)34-35(30,31)32/h3-10,13,19H,11-12H2,1-2H3,(H,24,29)(H,25,28)(H2,30,31,32)/t13-,19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
ARIAD Pharmaceuticals, Inc.					Assay Description Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...				J Med Chem 42: 4088-98 (1999) Article DOI: 10.1021/jm990229t BindingDB Entry DOI: 10.7270/Q27D2SBP
					More data for this Ligand-Target Pair

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