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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Proto-oncogene tyrosine-protein kinase Src | ||
| Ligand | BDBM50132348 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_202612 | ||
| IC50 | 2±n/a nM | ||
| Citation |  Vu, CB; Luke, GP; Kawahata, N; Shakespeare, WC; Wang, Y; Sundaramoorthi, R; Metcalf, CA; Keenan, TP; Pradeepan, S; Corpuz, E; Merry, T; Bohacek, RS; Dalgarno, DC; Narula, SS; van Schravendijk, MR; Ram, MK; Adams, S; Liou, S; Keats, JA; Violette, SM; Guan, W; Weigele, M; Sawyer, TK Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents. Bioorg Med Chem Lett13:3071-4 (2003) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Proto-oncogene tyrosine-protein kinase Src | |||
| Name: | Proto-oncogene tyrosine-protein kinase Src | ||
| Synonyms: | Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src | ||
| Type: | Protein | ||
| Mol. Mass.: | 59838.60 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P12931 | ||
| Residue: | 536 | ||
| Sequence: |
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| BDBM50132348 | |||
| n/a | |||
| Name | BDBM50132348 | ||
| Synonyms: | ({4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino]-phenyl}-hydroxy-phosphinoylmethyl)-phosphonic acid | CHEMBL419360 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H18Cl2N4O6P2 | ||
| Mol. Mass. | 555.244 | ||
| SMILES | Cn1c2nc(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(3.94,-2.74,;3.93,-1.2,;2.6,-.43,;1.27,-1.2,;-.06,-.43,;-1.39,-1.21,;-2.73,-.45,;-2.73,1.1,;-4.06,1.86,;-5.41,1.09,;-5.38,-.47,;-4.05,-1.22,;-6.74,1.86,;-7.53,.53,;-5.97,3.19,;-8.09,2.61,;-9.4,1.82,;-10.19,3.17,;-10.91,1.42,;-9.02,.34,;-.07,1.11,;1.27,1.88,;2.6,1.11,;3.93,1.88,;5.26,1.11,;6.59,1.88,;6.59,3.42,;5.26,4.19,;7.92,4.19,;9.26,3.42,;9.26,1.88,;7.92,1.11,;7.92,-.43,;5.26,-.43,;6.6,-1.2,)| | ||
| Structure | 
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