Compile Data Set for Download or QSAR

Found 549 hits with Last Name = 'mevellec' and Initial = 'la'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301927 (US9598396, Compound 4) Show SMILES CC(Cc1cccc(c1)C#N)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.933	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301928 (US9598396, Compound 5) Show SMILES CC(Cc1cccc(F)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.977	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301932 (US9598396, Compound 7) Show SMILES CC(Cc1cccc(n1)C#N)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.17	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301932 (US9598396, Compound 7) Show SMILES CC(Cc1cccc(n1)C#N)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.55	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301923 (US9598396, Compound 1) Show SMILES CC(Cc1ccccc1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.1	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301929 (US9598396, Compound 5a) Show SMILES C[C@](Cc1cccc(F)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.8	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301927 (US9598396, Compound 4) Show SMILES CC(Cc1cccc(c1)C#N)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.4	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301931 (US9598396, Compound 6) Show SMILES COc1cc(OC)nc(CC(C)(C#N)c2ccc3c4CCCCc4c(=O)[nH]c3c2)n1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19.1	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301928 (US9598396, Compound 5) Show SMILES CC(Cc1cccc(F)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19.5	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301940 (US9598396, Compound 15) Show SMILES CC(Cc1cccc(CO)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33.1	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301926 (US9598396, Compound 3) Show SMILES C[C@@](Cc1ccccc1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33.1	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301930 (US9598396, Compound 5b) Show SMILES C[C@@](Cc1cccc(F)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33.9	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301936 (US9598396, Compound 11) Show SMILES COc1cccc(CC(C)(C#N)c2ccc3c4CCCCc4c(=O)[nH]c3c2)c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35.5	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301923 (US9598396, Compound 1) Show SMILES CC(Cc1ccccc1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36.3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301930 (US9598396, Compound 5b) Show SMILES C[C@@](Cc1cccc(F)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36.3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301924 (US9598396, Compound 2) Show SMILES C[C@](Cc1ccccc1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	37.2	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301942 (US9598396, Compound 16) Show SMILES CC(Cc1cccc(CN)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301929 (US9598396, Compound 5a) Show SMILES C[C@](Cc1cccc(F)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39.8	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301940 (US9598396, Compound 15) Show SMILES CC(Cc1cccc(CO)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40.7	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301938 (BDBM301939 | US9598396, Compound 13) Show SMILES Cn1c(CC(C)(C#N)c2ccc3c4CCCCc4c(=O)[nH]c3c2)nc2ccccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41.7	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301938 (BDBM301939 | US9598396, Compound 13) Show SMILES Cn1c(CC(C)(C#N)c2ccc3c4CCCCc4c(=O)[nH]c3c2)nc2ccccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42.7	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301937 (US9598396, Compound 12) Show SMILES Cn1nc(CC(C)(C#N)c2ccc3c4CCCCc4c(=O)[nH]c3c2)c2ccccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42.7	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301945 (US9598396, Compound 17) Show SMILES CC(CCOc1ccc(cc1)C#N)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	44.7	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301937 (US9598396, Compound 12) Show SMILES Cn1nc(CC(C)(C#N)c2ccc3c4CCCCc4c(=O)[nH]c3c2)c2ccccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	45.7	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301924 (US9598396, Compound 2) Show SMILES C[C@](Cc1ccccc1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46.8	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301933 (US9598396, Compound 8) Show SMILES CC(Cc1cccc(Cl)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	52.5	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301945 (US9598396, Compound 17) Show SMILES CC(CCOc1ccc(cc1)C#N)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	52.5	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301931 (US9598396, Compound 6) Show SMILES COc1cc(OC)nc(CC(C)(C#N)c2ccc3c4CCCCc4c(=O)[nH]c3c2)n1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	53.7	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301926 (US9598396, Compound 3) Show SMILES C[C@@](Cc1ccccc1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 |r| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301935 (US9598396, Compound 10) Show SMILES CC(Cc1cccc(OC(F)(F)F)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	58.9	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301934 (US9598396, Compound 9) Show SMILES CC(Cc1cc(Cl)nc(Cl)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	63.1	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301938 (BDBM301939 | US9598396, Compound 13) Show SMILES Cn1c(CC(C)(C#N)c2ccc3c4CCCCc4c(=O)[nH]c3c2)nc2ccccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	63.1	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301946 (US9598396, Compound 19) Show SMILES CN(Cc1ccc(cc1)C#N)CC(C)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	64.6	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301933 (US9598396, Compound 8) Show SMILES CC(Cc1cccc(Cl)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	83.2	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301936 (US9598396, Compound 11) Show SMILES COc1cccc(CC(C)(C#N)c2ccc3c4CCCCc4c(=O)[nH]c3c2)c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	87.1	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301938 (BDBM301939 | US9598396, Compound 13) Show SMILES Cn1c(CC(C)(C#N)c2ccc3c4CCCCc4c(=O)[nH]c3c2)nc2ccccc12 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	97.7	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301935 (US9598396, Compound 10) Show SMILES CC(Cc1cccc(OC(F)(F)F)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	219	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM301934 (US9598396, Compound 9) Show SMILES CC(Cc1cc(Cl)nc(Cl)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	447	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description In principle, the assay relies upon the well established SPA technology for the detection of poly(ADP-ribosyl)ation of biotinylated target proteins, ...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM301942 (US9598396, Compound 16) Show SMILES CC(Cc1cccc(CN)c1)(C#N)c1ccc2c3CCCCc3c(=O)[nH]c2c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	794	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Compounds of the present invention were tested in an in vitro assay based on SPA technology with Ni Flash plates (96 or 384 well).In principle, the a...				US Patent US9598396 (2017) BindingDB Entry DOI: 10.7270/Q2M90BQV
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Homo sapiens (Human))	BDBM288386 (US10087187, Compound 81) Show SMILES CCC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C25H32F3N7O3/c1-4-14(2)21(30)24(36)38-13-19-23(31-18-7-5-6-16(15(18)3)25(26,27)28)35-22(32-19)17(29)12-20(33-35)34-8-10-37-11-9-34/h5-7,12,14,21,31H,4,8-11,13,29-30H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	2.69E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM288386 (US10087187, Compound 81) Show SMILES CCC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C25H32F3N7O3/c1-4-14(2)21(30)24(36)38-13-19-23(31-18-7-5-6-16(15(18)3)25(26,27)28)35-22(32-19)17(29)12-20(33-35)34-8-10-37-11-9-34/h5-7,12,14,21,31H,4,8-11,13,29-30H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	724	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM288386 (US10087187, Compound 81) Show SMILES CCC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C25H32F3N7O3/c1-4-14(2)21(30)24(36)38-13-19-23(31-18-7-5-6-16(15(18)3)25(26,27)28)35-22(32-19)17(29)12-20(33-35)34-8-10-37-11-9-34/h5-7,12,14,21,31H,4,8-11,13,29-30H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>3.02E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM288386 (US10087187, Compound 81) Show SMILES CCC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C25H32F3N7O3/c1-4-14(2)21(30)24(36)38-13-19-23(31-18-7-5-6-16(15(18)3)25(26,27)28)35-22(32-19)17(29)12-20(33-35)34-8-10-37-11-9-34/h5-7,12,14,21,31H,4,8-11,13,29-30H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>3.02E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Homo sapiens (Human))	BDBM288387 (US10087187, Compound 82) Show SMILES CC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C24H30F3N7O3/c1-13(2)20(29)23(35)37-12-18-22(30-17-6-4-5-15(14(17)3)24(25,26)27)34-21(31-18)16(28)11-19(32-34)33-7-9-36-10-8-33/h4-6,11,13,20,30H,7-10,12,28-29H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	3.24E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens (Human))	BDBM288387 (US10087187, Compound 82) Show SMILES CC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C24H30F3N7O3/c1-13(2)20(29)23(35)37-12-18-22(30-17-6-4-5-15(14(17)3)24(25,26)27)34-21(31-18)16(28)11-19(32-34)33-7-9-36-10-8-33/h4-6,11,13,20,30H,7-10,12,28-29H2,1-3H3	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM288387 (US10087187, Compound 82) Show SMILES CC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C24H30F3N7O3/c1-13(2)20(29)23(35)37-12-18-22(30-17-6-4-5-15(14(17)3)24(25,26)27)34-21(31-18)16(28)11-19(32-34)33-7-9-36-10-8-33/h4-6,11,13,20,30H,7-10,12,28-29H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	263	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM288387 (US10087187, Compound 82) Show SMILES CC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C24H30F3N7O3/c1-13(2)20(29)23(35)37-12-18-22(30-17-6-4-5-15(14(17)3)24(25,26)27)34-21(31-18)16(28)11-19(32-34)33-7-9-36-10-8-33/h4-6,11,13,20,30H,7-10,12,28-29H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	>3.02E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM288387 (US10087187, Compound 82) Show SMILES CC(C)C(N)C(=O)OCc1nc2c(N)cc(nn2c1Nc1cccc(c1C)C(F)(F)F)N1CCOCC1 Show InChI InChI=1S/C24H30F3N7O3/c1-13(2)20(29)23(35)37-12-18-22(30-17-6-4-5-15(14(17)3)24(25,26)27)34-21(31-18)16(28)11-19(32-34)33-7-9-36-10-8-33/h4-6,11,13,20,30H,7-10,12,28-29H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	2.51E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Homo sapiens (Human))	BDBM288388 (US10087187, Compound 83) Show SMILES Cc1c(Nc2c(COC(=O)C3(CC3)NC(=O)OC(C)(C)C)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C28H34F3N7O5/c1-16-17(28(29,30)31)6-5-7-19(16)33-23-20(15-42-24(39)27(8-9-27)35-25(40)43-26(2,3)4)34-22-18(32)14-21(36-38(22)23)37-10-12-41-13-11-37/h5-7,14,33H,8-13,15,32H2,1-4H3,(H,35,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	2.22E+4	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM288388 (US10087187, Compound 83) Show SMILES Cc1c(Nc2c(COC(=O)C3(CC3)NC(=O)OC(C)(C)C)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C28H34F3N7O5/c1-16-17(28(29,30)31)6-5-7-19(16)33-23-20(15-42-24(39)27(8-9-27)35-25(40)43-26(2,3)4)34-22-18(32)14-21(36-38(22)23)37-10-12-41-13-11-37/h5-7,14,33H,8-13,15,32H2,1-4H3,(H,35,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	309	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa...				US Patent US10087187 (2018) BindingDB Entry DOI: 10.7270/Q2M61N9J
					More data for this Ligand-Target Pair

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