BindingDB PrimarySearch

Found 19 hits with Last Name = 'mezei' and Initial = 'm'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Chromobox protein homolog 7 (Homo sapiens (Human))	BDBM50189696 (CHEMBL3827924) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...				ACS Med Chem Lett 7: 601-5 (2016) Article DOI: 10.1021/acsmedchemlett.6b00042 BindingDB Entry DOI: 10.7270/Q28054JT
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					More data for this Ligand-Target Pair
Chromobox protein homolog 7 (Homo sapiens (Human))	BDBM50189697 (CHEMBL3827733) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...				ACS Med Chem Lett 7: 601-5 (2016) Article DOI: 10.1021/acsmedchemlett.6b00042 BindingDB Entry DOI: 10.7270/Q28054JT
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					More data for this Ligand-Target Pair
Chromobox protein homolog 7 (Homo sapiens (Human))	BDBM50189699 (CHEMBL3827834) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...				ACS Med Chem Lett 7: 601-5 (2016) Article DOI: 10.1021/acsmedchemlett.6b00042 BindingDB Entry DOI: 10.7270/Q28054JT
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					More data for this Ligand-Target Pair
Chromobox protein homolog 7 (Homo sapiens (Human))	BDBM50189698 (CHEMBL3827336) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.69E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...				ACS Med Chem Lett 7: 601-5 (2016) Article DOI: 10.1021/acsmedchemlett.6b00042 BindingDB Entry DOI: 10.7270/Q28054JT
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					More data for this Ligand-Target Pair
Chromobox protein homolog 7 (Homo sapiens (Human))	BDBM50189711 (CHEMBL3827805) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...				ACS Med Chem Lett 7: 601-5 (2016) Article DOI: 10.1021/acsmedchemlett.6b00042 BindingDB Entry DOI: 10.7270/Q28054JT
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					More data for this Ligand-Target Pair
Chromobox protein homolog 7 (Homo sapiens (Human))	BDBM50189780 (CHEMBL3827954) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	3.31E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...				ACS Med Chem Lett 7: 601-5 (2016) Article DOI: 10.1021/acsmedchemlett.6b00042 BindingDB Entry DOI: 10.7270/Q28054JT
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Chromobox protein homolog 7 (Homo sapiens (Human))	BDBM50189762 (CHEMBL3827451) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.93E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...				ACS Med Chem Lett 7: 601-5 (2016) Article DOI: 10.1021/acsmedchemlett.6b00042 BindingDB Entry DOI: 10.7270/Q28054JT
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					More data for this Ligand-Target Pair
EEF1AKMT4-ECE2 readthrough transcript protein (Homo sapiens (Human))	BDBM50271179 (2-(2-(quinolin-2-yl)vinyl)phenol \| CHEMBL487942 \| ...) Show SMILES Oc1ccccc1\C=C/c1ccc2ccccc2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.63E+3	n/a	n/a	n/a	n/a	n/a	n/a
Mount Sinai School of Medicine Curated by ChEMBL					Assay Description Reduction of recombinant ECE2 (unknown origin) activity measured by McaBk2 fluorescent substrate hydrolysis				J Med Chem 51: 3378-87 (2008) Article DOI: 10.1021/jm7015478 BindingDB Entry DOI: 10.7270/Q2319VN5
Mount Sinai School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
EEF1AKMT4-ECE2 readthrough transcript protein (Homo sapiens (Human))	BDBM50271178 (1-(pyrrolidin-1-yl)-2-(quinoxalin-6-yl)ethanone \| ...) Show SMILES O=C(Cc1ccc2nccnc2c1)N1CCCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.83E+3	n/a	n/a	n/a	n/a	n/a	n/a
Mount Sinai School of Medicine Curated by ChEMBL					Assay Description Reduction of recombinant ECE2 (unknown origin) activity measured by McaBk2 fluorescent substrate hydrolysis				J Med Chem 51: 3378-87 (2008) Article DOI: 10.1021/jm7015478 BindingDB Entry DOI: 10.7270/Q2319VN5
Mount Sinai School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
EEF1AKMT4-ECE2 readthrough transcript protein (Homo sapiens (Human))	BDBM50001270 (2-(2-(quinolin-2-yl)vinyl)phenol \| 2-(2-Quinolin-2...) Show SMILES Oc1ccccc1\C=C\c1ccc2ccccc2n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.42E+3	n/a	n/a	n/a	n/a	n/a	n/a
Mount Sinai School of Medicine Curated by ChEMBL					Assay Description Reduction of recombinant ECE2 (unknown origin) activity measured by McaBk2 fluorescent substrate hydrolysis				J Med Chem 51: 3378-87 (2008) Article DOI: 10.1021/jm7015478 BindingDB Entry DOI: 10.7270/Q2319VN5
Mount Sinai School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
EEF1AKMT4-ECE2 readthrough transcript protein (Homo sapiens (Human))	BDBM50271180 (2-(2-hydroxy-3-methoxystyryl)quinolin-8-ol \| CHEMB...) Show SMILES COc1cccc(\C=C\c2ccc3cccc(O)c3n2)c1O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mount Sinai School of Medicine Curated by ChEMBL					Assay Description Reduction of recombinant ECE2 (unknown origin) activity measured by McaBk2 fluorescent substrate hydrolysis				J Med Chem 51: 3378-87 (2008) Article DOI: 10.1021/jm7015478 BindingDB Entry DOI: 10.7270/Q2319VN5
Mount Sinai School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
EEF1AKMT4-ECE2 readthrough transcript protein (Homo sapiens (Human))	BDBM50271181 (2-(3-methoxystyryl)quinolin-8-ol \| CHEMBL488140 \| ...) Show SMILES COc1cccc(\C=C\c2ccc3cccc(O)c3n2)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.57E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mount Sinai School of Medicine Curated by ChEMBL					Assay Description Reduction of recombinant ECE2 (unknown origin) activity measured by McaBk2 fluorescent substrate hydrolysis				J Med Chem 51: 3378-87 (2008) Article DOI: 10.1021/jm7015478 BindingDB Entry DOI: 10.7270/Q2319VN5
Mount Sinai School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50271178 (1-(pyrrolidin-1-yl)-2-(quinoxalin-6-yl)ethanone \| ...) Show SMILES O=C(Cc1ccc2nccnc2c1)N1CCCC1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Mount Sinai School of Medicine Curated by ChEMBL					Assay Description Inhibition of Neprilysin (unknown origin)				J Med Chem 51: 3378-87 (2008) Article DOI: 10.1021/jm7015478 BindingDB Entry DOI: 10.7270/Q2319VN5
Mount Sinai School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50001270 (2-(2-(quinolin-2-yl)vinyl)phenol \| 2-(2-Quinolin-2...) Show SMILES Oc1ccccc1\C=C\c1ccc2ccccc2n1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Mount Sinai School of Medicine Curated by ChEMBL					Assay Description Inhibition of Neprilysin (unknown origin)				J Med Chem 51: 3378-87 (2008) Article DOI: 10.1021/jm7015478 BindingDB Entry DOI: 10.7270/Q2319VN5
Mount Sinai School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Chromobox protein homolog 7 (Homo sapiens (Human))	BDBM50189695 (CHEMBL1198405) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	2.38E+4	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells assessed as compound/protein/F...				ACS Med Chem Lett 7: 601-5 (2016) Article DOI: 10.1021/acsmedchemlett.6b00042 BindingDB Entry DOI: 10.7270/Q28054JT
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Tat (Human immunodeficiency virus type 1 (isolate HXB2 ...)	BDBM50476285 (CHEMBL609729) Show SMILES CC(Cl)c1ccc(NCCCN)c(c1)[N+]([O-])=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Tat-mediated transcription of viral promoter in 293 T cells transfected with HIV1 tat by luciferase reporter gene assay				J Med Chem 50: 2285-8 (2007) Article DOI: 10.1021/jm070014g BindingDB Entry DOI: 10.7270/Q2WW7MG1
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Chromobox protein homolog 7 (Homo sapiens (Human))	BDBM50189780 (CHEMBL3827954) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.25E+5	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells assessed as compound/protein/F...				ACS Med Chem Lett 7: 601-5 (2016) Article DOI: 10.1021/acsmedchemlett.6b00042 BindingDB Entry DOI: 10.7270/Q28054JT
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Tat (Human immunodeficiency virus type 1 (isolate HXB2 ...)	BDBM50398244 (CHEMBL609728) Show SMILES Cc1ccc(NCCCN)c(c1)[N+]([O-])=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Tat-mediated transcription of viral promoter in 293 T cells transfected with HIV1 tat by luciferase reporter gene assay				J Med Chem 50: 2285-8 (2007) Article DOI: 10.1021/jm070014g BindingDB Entry DOI: 10.7270/Q2WW7MG1
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Chromobox protein homolog 7 (Homo sapiens (Human))	BDBM50189695 (CHEMBL1198405) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	5.00E+5	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Binding affinity to 15N-labeled CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells by HSQC/NMR titrat...				ACS Med Chem Lett 7: 601-5 (2016) Article DOI: 10.1021/acsmedchemlett.6b00042 BindingDB Entry DOI: 10.7270/Q28054JT
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)