Found 11 hits with Last Name = 'miwa' and Initial = 'h' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50184359
((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r,wU:21.75,50.52,12.11,4.4,39.41,wD:25.25,61.64,(19.68,-11.7,;18.32,-10.97,;18.27,-9.43,;16.91,-8.71,;16.86,-7.17,;18.17,-6.36,;18.11,-4.82,;19.42,-4,;16.76,-4.09,;15.5,-6.44,;15.45,-4.9,;14.19,-7.26,;12.83,-6.53,;11.53,-7.35,;11.58,-8.88,;12.94,-9.61,;10.27,-9.7,;8.91,-8.97,;7.6,-9.79,;6.25,-9.06,;4.94,-9.87,;3.58,-9.15,;3.53,-7.61,;2.17,-6.88,;.86,-7.7,;2.12,-5.35,;.76,-4.62,;.71,-3.08,;1.93,-2.14,;1.41,-.69,;-.14,-.74,;-1.21,.35,;-2.69,-.02,;-3.1,-1.51,;-2.03,-2.6,;-.56,-2.22,;3.43,-4.53,;4.79,-5.26,;4.84,-6.8,;6.98,-5.22,;8.76,-4.36,;10.12,-5.08,;10.17,-6.62,;8.86,-7.43,;7.5,-6.71,;6.19,-7.52,;8.83,-5.93,;6.09,-4.44,;6.04,-2.9,;4.68,-2.18,;7.35,-2.09,;7.3,-.55,;5.94,.17,;5.89,1.71,;4.53,2.44,;3.23,1.62,;3.28,.07,;4.64,-.64,;8.71,-2.82,;10.02,-2,;9.96,-.46,;11.37,-2.73,;12.68,-1.91,;12.64,-.37,;13.86,.56,;13.35,2.01,;11.81,1.97,;11.37,.5,;11.42,-4.27,;12.78,-4.99,;14.09,-4.18,;2.27,-9.96,;.91,-9.24,;2.32,-11.5,)| Show InChI InChI=1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1 | PDB
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| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
The concentration that inhibits 50% specific binding was determined against the Melanocortin 1 receptor |
J Med Chem 38: 4720-9 (1995)
BindingDB Entry DOI: 10.7270/Q2B56HRS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50029748
((2R,3R)-15-(2-Acetylamino-hexanoylamino)-9-benzyl-...)Show SMILES [H][C@]1(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O)[C@@H](C)c1c[nH]c2ccccc12 |wU:27.28,56.63,65.68,5.5,wD:37.55,46.52,16.16,1.0,(19.89,-7.11,;18.68,-8.53,;18.45,-7.02,;17.78,-5.61,;19.09,-4.78,;16.79,-4.45,;17.81,-3.3,;19.32,-3.62,;20.34,-2.47,;21.85,-2.76,;22.87,-1.63,;24.37,-1.93,;22.39,-.17,;15.51,-3.6,;14.03,-3.12,;13.68,-4.91,;12.5,-3.04,;12.37,-1.5,;13.62,-.62,;13.49,.92,;14.74,1.81,;16.15,1.17,;16.27,-.36,;15.03,-1.26,;11.02,-3.39,;9.65,-4.13,;10.31,-5.51,;8.56,-5.2,;7.34,-4.26,;7.57,-2.73,;8.91,-2,;8.62,-.49,;7.12,-.27,;6.45,-1.66,;7.79,-6.54,;7.41,-8.01,;5.87,-7.85,;7.44,-9.54,;7.89,-11.05,;8.72,-12.34,;7.57,-13.33,;9.87,-13.36,;11.25,-14.03,;12.78,-14.32,;14.29,-14.18,;15.73,-13.64,;16.98,-12.71,;17.94,-11.49,;18.52,-10.06,;19.99,-10.45,;18.07,-13.81,;17.65,-15.3,;19.54,-13.43,;5.93,-9.81,;5.36,-11.25,;6.35,-12.45,;3.85,-11.49,;2.89,-10.29,;3.44,-8.87,;2.44,-7.66,;2.99,-6.22,;3.31,-12.93,;1.8,-13.27,;1.32,-14.71,;.78,-12.11,;20.21,-8.52,;20.6,-7.02,;21.56,-9.26,;23,-8.75,;23.93,-9.99,;23.03,-11.25,;23.41,-12.75,;22.26,-13.81,;20.79,-13.36,;20.47,-11.86,;21.59,-10.8,)| Show InChI InChI=1S/C51H71N15O9/c1-4-5-17-37(60-30(3)67)45(70)65-41-25-42(68)56-21-12-11-19-36(44(52)69)61-50(75)43(29(2)34-27-58-35-18-10-9-16-33(34)35)66-46(71)38(20-13-22-57-51(53)54)62-47(72)39(23-31-14-7-6-8-15-31)63-48(73)40(64-49(41)74)24-32-26-55-28-59-32/h6-10,14-16,18,26-29,36-41,43,58H,4-5,11-13,17,19-25H2,1-3H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,75)(H,62,72)(H,63,73)(H,64,74)(H,65,70)(H,66,71)(H4,53,54,57)/t29-,36-,37-,38-,39+,40-,41-,43-/m0/s1 | PDB
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| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
The concentration that inhibits 50% specific binding was determined against the Melanocortin 1 receptor |
J Med Chem 38: 4720-9 (1995)
BindingDB Entry DOI: 10.7270/Q2B56HRS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50454019
(CHEMBL2370906)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]([C@H](C)c1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O |wU:12.11,30.30,67.70,4.3,wD:52.53,20.19,41.42,53.55,(-5.23,-3.6,;-3.9,-2.83,;-2.56,-3.6,;-1.23,-2.83,;.1,-3.6,;.1,-5.14,;-1.23,-5.91,;-2.56,-5.14,;-1.23,-7.45,;1.44,-2.83,;1.44,-1.29,;2.77,-3.6,;4.1,-2.83,;4.1,-1.29,;5.44,-.52,;6.77,-1.29,;5.44,1.02,;5.44,-3.6,;5.44,-5.14,;6.77,-2.83,;8.1,-3.6,;8.1,-5.14,;9.44,-5.91,;9.6,-7.44,;11.11,-7.76,;11.88,-6.42,;10.85,-5.28,;9.44,-2.83,;9.44,-1.29,;10.77,-3.6,;12.11,-2.83,;12.11,-1.29,;13.44,-.52,;14.77,-1.29,;16.11,-.52,;16.11,1.02,;14.77,1.79,;13.44,1.02,;13.44,-3.6,;13.44,-5.14,;14.77,-2.83,;16.11,-3.6,;16.11,-5.14,;14.77,-5.91,;14.77,-7.45,;13.44,-8.22,;13.44,-9.76,;12.11,-10.53,;14.77,-10.53,;17.44,-2.83,;17.44,-1.29,;18.77,-3.6,;20.11,-2.83,;20.11,-1.29,;18.77,-.52,;21.44,-.52,;22.85,-1.14,;23.88,0,;23.11,1.34,;23.58,2.8,;22.55,3.94,;21.05,3.62,;20.57,2.16,;21.6,1.02,;21.44,-3.6,;21.44,-5.14,;22.78,-2.83,;24.11,-3.6,;25.44,-2.83,;26.78,-3.6,;28.11,-2.83,;29.44,-3.6,;30.78,-2.83,;24.11,-5.14,;22.78,-5.91,;25.44,-5.91,)| Show InChI InChI=1S/C51H73N15O10/c1-4-5-17-37(60-30(3)67)45(71)65-41(25-42(68)69)49(75)64-40(24-32-26-56-28-59-32)48(74)63-39(23-31-14-7-6-8-15-31)47(73)62-38(20-13-22-57-51(54)55)46(72)66-43(50(76)61-36(44(53)70)19-11-12-21-52)29(2)34-27-58-35-18-10-9-16-33(34)35/h6-10,14-16,18,26-29,36-41,43,58H,4-5,11-13,17,19-25,52H2,1-3H3,(H2,53,70)(H,56,59)(H,60,67)(H,61,76)(H,62,73)(H,63,74)(H,64,75)(H,65,71)(H,66,72)(H,68,69)(H4,54,55,57)/t29-,36+,37+,38+,39+,40+,41+,43-/m1/s1 | PDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
The concentration that inhibits 50% specific binding was determined against the Melanocortin 1 receptor |
J Med Chem 38: 4720-9 (1995)
BindingDB Entry DOI: 10.7270/Q2B56HRS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50029748
((2R,3R)-15-(2-Acetylamino-hexanoylamino)-9-benzyl-...)Show SMILES [H][C@]1(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O)[C@@H](C)c1c[nH]c2ccccc12 |wU:27.28,56.63,65.68,5.5,wD:37.55,46.52,16.16,1.0,(19.89,-7.11,;18.68,-8.53,;18.45,-7.02,;17.78,-5.61,;19.09,-4.78,;16.79,-4.45,;17.81,-3.3,;19.32,-3.62,;20.34,-2.47,;21.85,-2.76,;22.87,-1.63,;24.37,-1.93,;22.39,-.17,;15.51,-3.6,;14.03,-3.12,;13.68,-4.91,;12.5,-3.04,;12.37,-1.5,;13.62,-.62,;13.49,.92,;14.74,1.81,;16.15,1.17,;16.27,-.36,;15.03,-1.26,;11.02,-3.39,;9.65,-4.13,;10.31,-5.51,;8.56,-5.2,;7.34,-4.26,;7.57,-2.73,;8.91,-2,;8.62,-.49,;7.12,-.27,;6.45,-1.66,;7.79,-6.54,;7.41,-8.01,;5.87,-7.85,;7.44,-9.54,;7.89,-11.05,;8.72,-12.34,;7.57,-13.33,;9.87,-13.36,;11.25,-14.03,;12.78,-14.32,;14.29,-14.18,;15.73,-13.64,;16.98,-12.71,;17.94,-11.49,;18.52,-10.06,;19.99,-10.45,;18.07,-13.81,;17.65,-15.3,;19.54,-13.43,;5.93,-9.81,;5.36,-11.25,;6.35,-12.45,;3.85,-11.49,;2.89,-10.29,;3.44,-8.87,;2.44,-7.66,;2.99,-6.22,;3.31,-12.93,;1.8,-13.27,;1.32,-14.71,;.78,-12.11,;20.21,-8.52,;20.6,-7.02,;21.56,-9.26,;23,-8.75,;23.93,-9.99,;23.03,-11.25,;23.41,-12.75,;22.26,-13.81,;20.79,-13.36,;20.47,-11.86,;21.59,-10.8,)| Show InChI InChI=1S/C51H71N15O9/c1-4-5-17-37(60-30(3)67)45(70)65-41-25-42(68)56-21-12-11-19-36(44(52)69)61-50(75)43(29(2)34-27-58-35-18-10-9-16-33(34)35)66-46(71)38(20-13-22-57-51(53)54)62-47(72)39(23-31-14-7-6-8-15-31)63-48(73)40(64-49(41)74)24-32-26-55-28-59-32/h6-10,14-16,18,26-29,36-41,43,58H,4-5,11-13,17,19-25H2,1-3H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,75)(H,62,72)(H,63,73)(H,64,74)(H,65,70)(H,66,71)(H4,53,54,57)/t29-,36-,37-,38-,39+,40-,41-,43-/m0/s1 | PDB
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PC cid
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| n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration against Melanocortin 1 receptor transfected into L-cells was determined by concentration of peptide for 50% maximal cAMP gene... |
J Med Chem 38: 4720-9 (1995)
BindingDB Entry DOI: 10.7270/Q2B56HRS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50454019
(CHEMBL2370906)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]([C@H](C)c1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O |wU:12.11,30.30,67.70,4.3,wD:52.53,20.19,41.42,53.55,(-5.23,-3.6,;-3.9,-2.83,;-2.56,-3.6,;-1.23,-2.83,;.1,-3.6,;.1,-5.14,;-1.23,-5.91,;-2.56,-5.14,;-1.23,-7.45,;1.44,-2.83,;1.44,-1.29,;2.77,-3.6,;4.1,-2.83,;4.1,-1.29,;5.44,-.52,;6.77,-1.29,;5.44,1.02,;5.44,-3.6,;5.44,-5.14,;6.77,-2.83,;8.1,-3.6,;8.1,-5.14,;9.44,-5.91,;9.6,-7.44,;11.11,-7.76,;11.88,-6.42,;10.85,-5.28,;9.44,-2.83,;9.44,-1.29,;10.77,-3.6,;12.11,-2.83,;12.11,-1.29,;13.44,-.52,;14.77,-1.29,;16.11,-.52,;16.11,1.02,;14.77,1.79,;13.44,1.02,;13.44,-3.6,;13.44,-5.14,;14.77,-2.83,;16.11,-3.6,;16.11,-5.14,;14.77,-5.91,;14.77,-7.45,;13.44,-8.22,;13.44,-9.76,;12.11,-10.53,;14.77,-10.53,;17.44,-2.83,;17.44,-1.29,;18.77,-3.6,;20.11,-2.83,;20.11,-1.29,;18.77,-.52,;21.44,-.52,;22.85,-1.14,;23.88,0,;23.11,1.34,;23.58,2.8,;22.55,3.94,;21.05,3.62,;20.57,2.16,;21.6,1.02,;21.44,-3.6,;21.44,-5.14,;22.78,-2.83,;24.11,-3.6,;25.44,-2.83,;26.78,-3.6,;28.11,-2.83,;29.44,-3.6,;30.78,-2.83,;24.11,-5.14,;22.78,-5.91,;25.44,-5.91,)| Show InChI InChI=1S/C51H73N15O10/c1-4-5-17-37(60-30(3)67)45(71)65-41(25-42(68)69)49(75)64-40(24-32-26-56-28-59-32)48(74)63-39(23-31-14-7-6-8-15-31)47(73)62-38(20-13-22-57-51(54)55)46(72)66-43(50(76)61-36(44(53)70)19-11-12-21-52)29(2)34-27-58-35-18-10-9-16-33(34)35/h6-10,14-16,18,26-29,36-41,43,58H,4-5,11-13,17,19-25,52H2,1-3H3,(H2,53,70)(H,56,59)(H,60,67)(H,61,76)(H,62,73)(H,63,74)(H,64,75)(H,65,71)(H,66,72)(H,68,69)(H4,54,55,57)/t29-,36+,37+,38+,39+,40+,41+,43-/m1/s1 | PDB
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KEGG
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| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration against Melanocortin 1 receptor transfected into L-cells was determined by concentration of peptide for 50% maximal cAMP gene... |
J Med Chem 38: 4720-9 (1995)
BindingDB Entry DOI: 10.7270/Q2B56HRS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50184359
((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r,wU:21.75,50.52,12.11,4.4,39.41,wD:25.25,61.64,(19.68,-11.7,;18.32,-10.97,;18.27,-9.43,;16.91,-8.71,;16.86,-7.17,;18.17,-6.36,;18.11,-4.82,;19.42,-4,;16.76,-4.09,;15.5,-6.44,;15.45,-4.9,;14.19,-7.26,;12.83,-6.53,;11.53,-7.35,;11.58,-8.88,;12.94,-9.61,;10.27,-9.7,;8.91,-8.97,;7.6,-9.79,;6.25,-9.06,;4.94,-9.87,;3.58,-9.15,;3.53,-7.61,;2.17,-6.88,;.86,-7.7,;2.12,-5.35,;.76,-4.62,;.71,-3.08,;1.93,-2.14,;1.41,-.69,;-.14,-.74,;-1.21,.35,;-2.69,-.02,;-3.1,-1.51,;-2.03,-2.6,;-.56,-2.22,;3.43,-4.53,;4.79,-5.26,;4.84,-6.8,;6.98,-5.22,;8.76,-4.36,;10.12,-5.08,;10.17,-6.62,;8.86,-7.43,;7.5,-6.71,;6.19,-7.52,;8.83,-5.93,;6.09,-4.44,;6.04,-2.9,;4.68,-2.18,;7.35,-2.09,;7.3,-.55,;5.94,.17,;5.89,1.71,;4.53,2.44,;3.23,1.62,;3.28,.07,;4.64,-.64,;8.71,-2.82,;10.02,-2,;9.96,-.46,;11.37,-2.73,;12.68,-1.91,;12.64,-.37,;13.86,.56,;13.35,2.01,;11.81,1.97,;11.37,.5,;11.42,-4.27,;12.78,-4.99,;14.09,-4.18,;2.27,-9.96,;.91,-9.24,;2.32,-11.5,)| Show InChI InChI=1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1 | PDB
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University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration for the effect of Melanocortin 1 receptor in the frog skin. |
J Med Chem 38: 4720-9 (1995)
BindingDB Entry DOI: 10.7270/Q2B56HRS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50184359
((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r,wU:21.75,50.52,12.11,4.4,39.41,wD:25.25,61.64,(19.68,-11.7,;18.32,-10.97,;18.27,-9.43,;16.91,-8.71,;16.86,-7.17,;18.17,-6.36,;18.11,-4.82,;19.42,-4,;16.76,-4.09,;15.5,-6.44,;15.45,-4.9,;14.19,-7.26,;12.83,-6.53,;11.53,-7.35,;11.58,-8.88,;12.94,-9.61,;10.27,-9.7,;8.91,-8.97,;7.6,-9.79,;6.25,-9.06,;4.94,-9.87,;3.58,-9.15,;3.53,-7.61,;2.17,-6.88,;.86,-7.7,;2.12,-5.35,;.76,-4.62,;.71,-3.08,;1.93,-2.14,;1.41,-.69,;-.14,-.74,;-1.21,.35,;-2.69,-.02,;-3.1,-1.51,;-2.03,-2.6,;-.56,-2.22,;3.43,-4.53,;4.79,-5.26,;4.84,-6.8,;6.98,-5.22,;8.76,-4.36,;10.12,-5.08,;10.17,-6.62,;8.86,-7.43,;7.5,-6.71,;6.19,-7.52,;8.83,-5.93,;6.09,-4.44,;6.04,-2.9,;4.68,-2.18,;7.35,-2.09,;7.3,-.55,;5.94,.17,;5.89,1.71,;4.53,2.44,;3.23,1.62,;3.28,.07,;4.64,-.64,;8.71,-2.82,;10.02,-2,;9.96,-.46,;11.37,-2.73,;12.68,-1.91,;12.64,-.37,;13.86,.56,;13.35,2.01,;11.81,1.97,;11.37,.5,;11.42,-4.27,;12.78,-4.99,;14.09,-4.18,;2.27,-9.96,;.91,-9.24,;2.32,-11.5,)| Show InChI InChI=1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1 | PDB
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| n/a | n/a | n/a | n/a | 0.150 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration against Melanocortin 1 receptor transfected into L-cells was determined by concentration of peptide for 50% maximal cAMP gene... |
J Med Chem 38: 4720-9 (1995)
BindingDB Entry DOI: 10.7270/Q2B56HRS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50454019
(CHEMBL2370906)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H]([C@H](C)c1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O |wU:12.11,30.30,67.70,4.3,wD:52.53,20.19,41.42,53.55,(-5.23,-3.6,;-3.9,-2.83,;-2.56,-3.6,;-1.23,-2.83,;.1,-3.6,;.1,-5.14,;-1.23,-5.91,;-2.56,-5.14,;-1.23,-7.45,;1.44,-2.83,;1.44,-1.29,;2.77,-3.6,;4.1,-2.83,;4.1,-1.29,;5.44,-.52,;6.77,-1.29,;5.44,1.02,;5.44,-3.6,;5.44,-5.14,;6.77,-2.83,;8.1,-3.6,;8.1,-5.14,;9.44,-5.91,;9.6,-7.44,;11.11,-7.76,;11.88,-6.42,;10.85,-5.28,;9.44,-2.83,;9.44,-1.29,;10.77,-3.6,;12.11,-2.83,;12.11,-1.29,;13.44,-.52,;14.77,-1.29,;16.11,-.52,;16.11,1.02,;14.77,1.79,;13.44,1.02,;13.44,-3.6,;13.44,-5.14,;14.77,-2.83,;16.11,-3.6,;16.11,-5.14,;14.77,-5.91,;14.77,-7.45,;13.44,-8.22,;13.44,-9.76,;12.11,-10.53,;14.77,-10.53,;17.44,-2.83,;17.44,-1.29,;18.77,-3.6,;20.11,-2.83,;20.11,-1.29,;18.77,-.52,;21.44,-.52,;22.85,-1.14,;23.88,0,;23.11,1.34,;23.58,2.8,;22.55,3.94,;21.05,3.62,;20.57,2.16,;21.6,1.02,;21.44,-3.6,;21.44,-5.14,;22.78,-2.83,;24.11,-3.6,;25.44,-2.83,;26.78,-3.6,;28.11,-2.83,;29.44,-3.6,;30.78,-2.83,;24.11,-5.14,;22.78,-5.91,;25.44,-5.91,)| Show InChI InChI=1S/C51H73N15O10/c1-4-5-17-37(60-30(3)67)45(71)65-41(25-42(68)69)49(75)64-40(24-32-26-56-28-59-32)48(74)63-39(23-31-14-7-6-8-15-31)47(73)62-38(20-13-22-57-51(54)55)46(72)66-43(50(76)61-36(44(53)70)19-11-12-21-52)29(2)34-27-58-35-18-10-9-16-33(34)35/h6-10,14-16,18,26-29,36-41,43,58H,4-5,11-13,17,19-25,52H2,1-3H3,(H2,53,70)(H,56,59)(H,60,67)(H,61,76)(H,62,73)(H,63,74)(H,64,75)(H,65,71)(H,66,72)(H,68,69)(H4,54,55,57)/t29-,36+,37+,38+,39+,40+,41+,43-/m1/s1 | PDB
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University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration for the effect of Melanocortin 1 receptor in the frog skin. |
J Med Chem 38: 4720-9 (1995)
BindingDB Entry DOI: 10.7270/Q2B56HRS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50029748
((2R,3R)-15-(2-Acetylamino-hexanoylamino)-9-benzyl-...)Show SMILES [H][C@]1(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O)[C@@H](C)c1c[nH]c2ccccc12 |wU:27.28,56.63,65.68,5.5,wD:37.55,46.52,16.16,1.0,(19.89,-7.11,;18.68,-8.53,;18.45,-7.02,;17.78,-5.61,;19.09,-4.78,;16.79,-4.45,;17.81,-3.3,;19.32,-3.62,;20.34,-2.47,;21.85,-2.76,;22.87,-1.63,;24.37,-1.93,;22.39,-.17,;15.51,-3.6,;14.03,-3.12,;13.68,-4.91,;12.5,-3.04,;12.37,-1.5,;13.62,-.62,;13.49,.92,;14.74,1.81,;16.15,1.17,;16.27,-.36,;15.03,-1.26,;11.02,-3.39,;9.65,-4.13,;10.31,-5.51,;8.56,-5.2,;7.34,-4.26,;7.57,-2.73,;8.91,-2,;8.62,-.49,;7.12,-.27,;6.45,-1.66,;7.79,-6.54,;7.41,-8.01,;5.87,-7.85,;7.44,-9.54,;7.89,-11.05,;8.72,-12.34,;7.57,-13.33,;9.87,-13.36,;11.25,-14.03,;12.78,-14.32,;14.29,-14.18,;15.73,-13.64,;16.98,-12.71,;17.94,-11.49,;18.52,-10.06,;19.99,-10.45,;18.07,-13.81,;17.65,-15.3,;19.54,-13.43,;5.93,-9.81,;5.36,-11.25,;6.35,-12.45,;3.85,-11.49,;2.89,-10.29,;3.44,-8.87,;2.44,-7.66,;2.99,-6.22,;3.31,-12.93,;1.8,-13.27,;1.32,-14.71,;.78,-12.11,;20.21,-8.52,;20.6,-7.02,;21.56,-9.26,;23,-8.75,;23.93,-9.99,;23.03,-11.25,;23.41,-12.75,;22.26,-13.81,;20.79,-13.36,;20.47,-11.86,;21.59,-10.8,)| Show InChI InChI=1S/C51H71N15O9/c1-4-5-17-37(60-30(3)67)45(70)65-41-25-42(68)56-21-12-11-19-36(44(52)69)61-50(75)43(29(2)34-27-58-35-18-10-9-16-33(34)35)66-46(71)38(20-13-22-57-51(53)54)62-47(72)39(23-31-14-7-6-8-15-31)63-48(73)40(64-49(41)74)24-32-26-55-28-59-32/h6-10,14-16,18,26-29,36-41,43,58H,4-5,11-13,17,19-25H2,1-3H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,75)(H,62,72)(H,63,73)(H,64,74)(H,65,70)(H,66,71)(H4,53,54,57)/t29-,36-,37-,38-,39+,40-,41-,43-/m0/s1 | PDB
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| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration against Melanocortin 1 receptor transfected into L-cells was determined by concentration of peptide for 50% maximal cAMP gene... |
J Med Chem 38: 4720-9 (1995)
BindingDB Entry DOI: 10.7270/Q2B56HRS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50029747
((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)Show SMILES CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O Show InChI InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 | PDB
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| n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration for the effect of Melanocortin 1 receptor in the frog skin. |
J Med Chem 38: 4720-9 (1995)
BindingDB Entry DOI: 10.7270/Q2B56HRS |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50029748
((2R,3R)-15-(2-Acetylamino-hexanoylamino)-9-benzyl-...)Show SMILES [H][C@]1(NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(=O)NCCCC[C@H](NC1=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O)[C@@H](C)c1c[nH]c2ccccc12 |wU:27.28,56.63,65.68,5.5,wD:37.55,46.52,16.16,1.0,(19.89,-7.11,;18.68,-8.53,;18.45,-7.02,;17.78,-5.61,;19.09,-4.78,;16.79,-4.45,;17.81,-3.3,;19.32,-3.62,;20.34,-2.47,;21.85,-2.76,;22.87,-1.63,;24.37,-1.93,;22.39,-.17,;15.51,-3.6,;14.03,-3.12,;13.68,-4.91,;12.5,-3.04,;12.37,-1.5,;13.62,-.62,;13.49,.92,;14.74,1.81,;16.15,1.17,;16.27,-.36,;15.03,-1.26,;11.02,-3.39,;9.65,-4.13,;10.31,-5.51,;8.56,-5.2,;7.34,-4.26,;7.57,-2.73,;8.91,-2,;8.62,-.49,;7.12,-.27,;6.45,-1.66,;7.79,-6.54,;7.41,-8.01,;5.87,-7.85,;7.44,-9.54,;7.89,-11.05,;8.72,-12.34,;7.57,-13.33,;9.87,-13.36,;11.25,-14.03,;12.78,-14.32,;14.29,-14.18,;15.73,-13.64,;16.98,-12.71,;17.94,-11.49,;18.52,-10.06,;19.99,-10.45,;18.07,-13.81,;17.65,-15.3,;19.54,-13.43,;5.93,-9.81,;5.36,-11.25,;6.35,-12.45,;3.85,-11.49,;2.89,-10.29,;3.44,-8.87,;2.44,-7.66,;2.99,-6.22,;3.31,-12.93,;1.8,-13.27,;1.32,-14.71,;.78,-12.11,;20.21,-8.52,;20.6,-7.02,;21.56,-9.26,;23,-8.75,;23.93,-9.99,;23.03,-11.25,;23.41,-12.75,;22.26,-13.81,;20.79,-13.36,;20.47,-11.86,;21.59,-10.8,)| Show InChI InChI=1S/C51H71N15O9/c1-4-5-17-37(60-30(3)67)45(70)65-41-25-42(68)56-21-12-11-19-36(44(52)69)61-50(75)43(29(2)34-27-58-35-18-10-9-16-33(34)35)66-46(71)38(20-13-22-57-51(53)54)62-47(72)39(23-31-14-7-6-8-15-31)63-48(73)40(64-49(41)74)24-32-26-55-28-59-32/h6-10,14-16,18,26-29,36-41,43,58H,4-5,11-13,17,19-25H2,1-3H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,75)(H,62,72)(H,63,73)(H,64,74)(H,65,70)(H,66,71)(H4,53,54,57)/t29-,36-,37-,38-,39+,40-,41-,43-/m0/s1 | PDB
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| n/a | n/a | n/a | n/a | 0.440 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Effective concentration for the effect of Melanocortin 1 receptor in the frog skin. |
J Med Chem 38: 4720-9 (1995)
BindingDB Entry DOI: 10.7270/Q2B56HRS |
More data for this
Ligand-Target Pair | |
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