Found 83 hits with Last Name = 'momose' and Initial = 'k' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 2
(RABBIT) | BDBM82279
(CAS_118997-30-1 | PYY, human)Show SMILES CCC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C193H294N54O59/c1-17-99(12)154(242-181(295)141-35-25-73-245(141)187(301)115(195)80-104-37-47-110(251)48-38-104)184(298)226-125(28-18-19-67-194)188(302)246-74-26-34-140(246)180(294)223-122(59-64-149(262)263)158(272)216-102(15)186(300)244-72-24-33-139(244)179(293)212-90-146(259)217-120(58-63-148(260)261)163(277)237-136(88-152(268)269)168(282)215-101(14)157(271)240-147(92-249)306(305)247-75-27-36-142(247)182(296)224-124(61-66-151(266)267)165(279)222-123(60-65-150(264)265)166(280)227-127(77-95(4)5)170(284)235-134(86-144(197)257)175(289)220-116(29-20-68-208-190(199)200)160(274)231-131(82-106-41-51-112(253)52-42-106)173(287)232-130(81-105-39-49-111(252)50-40-105)167(281)214-100(13)156(270)239-138(91-248)178(292)230-126(76-94(2)3)169(283)219-117(30-21-69-209-191(201)202)161(275)234-133(85-109-89-207-93-213-109)174(288)233-132(83-107-43-53-113(254)54-44-107)172(286)228-128(78-96(6)7)171(285)236-135(87-145(198)258)176(290)229-129(79-97(8)9)177(291)241-153(98(10)11)183(297)243-155(103(16)250)185(299)225-119(32-23-71-211-193(205)206)159(273)221-121(57-62-143(196)256)164(278)218-118(31-22-70-210-192(203)204)162(276)238-137(189(303)304)84-108-45-55-114(255)56-46-108/h37-56,89,93-103,115-142,147,153-155,248-255H,17-36,57-88,90-92,194-195H2,1-16H3,(H2,196,256)(H2,197,257)(H2,198,258)(H,207,213)(H,212,293)(H,214,281)(H,215,282)(H,216,272)(H,217,259)(H,218,278)(H,219,283)(H,220,289)(H,221,273)(H,222,279)(H,223,294)(H,224,296)(H,225,299)(H,226,298)(H,227,280)(H,228,286)(H,229,290)(H,230,292)(H,231,274)(H,232,287)(H,233,288)(H,234,275)(H,235,284)(H,236,285)(H,237,277)(H,238,276)(H,239,270)(H,240,271)(H,241,291)(H,242,295)(H,243,297)(H,260,261)(H,262,263)(H,264,265)(H,266,267)(H,268,269)(H,303,304)(H4,199,200,208)(H4,201,202,209)(H4,203,204,210)(H4,205,206,211)/t99?,100-,101-,102-,103+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,147+,153-,154-,155-/m0/s1 | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet 
| KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Co., Ltd.
Curated by PDSP Ki Database
| |
J Biol Chem 271: 27217-20 (1996)
Article DOI: 10.1074/jbc.271.44.27217
BindingDB Entry DOI: 10.7270/Q2K64GKW |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RABBIT) | BDBM82287
(NPY2-36 | NPY2-36, human | NPY2-36, porcine)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C181H278N54O55/c1-16-89(9)141(172(285)226-122(76-133(184)244)162(275)218-117(70-88(7)8)165(278)231-142(90(10)17-2)173(286)232-143(95(15)238)174(287)213-109(33-24-64-200-181(193)194)149(262)212-111(53-56-132(183)243)154(267)210-107(31-22-62-198-179(189)190)150(263)215-114(144(186)257)71-96-37-45-101(239)46-38-96)230-166(279)120(74-99-43-51-104(242)52-44-99)221-161(274)121(75-100-81-195-85-202-100)222-152(265)108(32-23-63-199-180(191)192)211-158(271)116(69-87(5)6)216-147(260)92(12)204-167(280)127(83-236)229-160(273)119(73-98-41-49-103(241)50-42-98)220-159(272)118(72-97-39-47-102(240)48-40-97)219-151(264)106(30-21-61-197-178(187)188)208-145(258)91(11)203-156(269)115(68-86(3)4)217-163(276)124(79-139(253)254)224-155(268)112(55-58-137(249)250)209-146(259)93(13)205-170(283)130-35-26-65-233(130)175(288)94(14)206-157(270)123(78-138(251)252)223-153(266)110(54-57-136(247)248)207-135(246)82-201-169(282)129-34-25-66-234(129)177(290)126(77-134(185)245)227-164(277)125(80-140(255)256)225-171(284)131-36-27-67-235(131)176(289)113(28-18-19-59-182)214-168(281)128(84-237)228-148(261)105-29-20-60-196-105/h37-52,81,85-95,105-131,141-143,196,236-242H,16-36,53-80,82-84,182H2,1-15H3,(H2,183,243)(H2,184,244)(H2,185,245)(H2,186,257)(H,195,202)(H,201,282)(H,203,269)(H,204,280)(H,205,283)(H,206,270)(H,207,246)(H,208,258)(H,209,259)(H,210,267)(H,211,271)(H,212,262)(H,213,287)(H,214,281)(H,215,263)(H,216,260)(H,217,276)(H,218,275)(H,219,264)(H,220,272)(H,221,274)(H,222,265)(H,223,266)(H,224,268)(H,225,284)(H,226,285)(H,227,277)(H,228,261)(H,229,273)(H,230,279)(H,231,278)(H,232,286)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,187,188,197)(H4,189,190,198)(H4,191,192,199)(H4,193,194,200)/t89-,90-,91-,92-,93-,94-,95+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,141-,142-,143-/m0/s1 | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Co., Ltd.
Curated by PDSP Ki Database
| |
J Biol Chem 271: 27217-20 (1996)
Article DOI: 10.1074/jbc.271.44.27217
BindingDB Entry DOI: 10.7270/Q2K64GKW |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RABBIT) | BDBM82282
(NPY13-36 | NPY13-36, porcine)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |wU:163.169,100.108,162.166,138.142,8.17,180.184,20.28,41.47,200.204,54.58,130.133,125.129,95.99,wD:116.125,108.116,154.158,146.150,84.95,4.4,169.173,72.84,30.39,189.193,60.71,155.160,2.2,49.51,(38.36,6.07,;37.02,5.3,;37.02,3.76,;38.36,2.99,;35.69,2.99,;35.69,1.45,;37.02,.68,;38.36,1.45,;37.02,-.86,;35.69,-1.63,;35.69,-3.17,;34.36,-3.94,;34.36,-5.48,;35.69,-6.25,;35.69,-7.79,;37.02,-5.48,;37.02,-3.94,;38.36,-1.63,;39.69,-.86,;39.69,.68,;41.02,-1.63,;41.02,-3.17,;42.36,-3.94,;43.76,-3.32,;44.8,-4.46,;44.03,-5.8,;42.52,-5.48,;42.36,-.86,;42.36,.68,;41.02,1.45,;43.13,2.01,;42.36,3.34,;43.13,4.68,;44.67,4.68,;45.44,6.01,;44.67,7.34,;45.44,8.68,;43.13,7.34,;44.67,2.01,;45.44,.68,;44.67,-.66,;46.98,.68,;47.75,-.66,;46.98,-1.99,;47.75,-3.32,;45.44,-1.99,;47.75,2.01,;49.29,2.01,;50.06,.68,;50.06,3.34,;49.29,4.68,;51.6,3.34,;52.37,4.68,;51.6,6.01,;53.91,4.68,;54.68,3.34,;56.22,3.34,;54.68,6.01,;56.22,6.01,;56.99,4.68,;56.99,7.34,;56.22,8.68,;56.99,10.01,;58.53,10.01,;59.3,11.35,;58.53,12.68,;59.3,14.01,;56.99,12.68,;56.22,11.35,;58.53,7.34,;59.3,6.01,;58.53,4.68,;60.84,6.01,;61.61,7.34,;63.15,7.34,;63.92,6.01,;65.46,6.01,;66.23,7.34,;67.77,7.34,;65.46,8.68,;63.92,8.68,;61.61,4.68,;60.84,3.34,;59.3,3.34,;61.61,2.01,;63.15,2.01,;63.92,.68,;65.46,.68,;66.23,-.66,;67.77,-.66,;68.54,-1.99,;68.54,.68,;60.84,.68,;61.61,-.66,;63.15,-.66,;60.84,-1.99,;59.3,-1.99,;61.61,-3.32,;60.84,-4.66,;59.3,-4.66,;61.61,-5.99,;60.84,-7.33,;59.3,-7.33,;58.53,-8.66,;58.53,-5.99,;63.15,-5.99,;63.92,-7.33,;63.15,-8.66,;65.46,-7.33,;66.23,-5.99,;67.77,-5.99,;68.54,-4.66,;68.54,-7.33,;66.23,-8.66,;65.46,-9.99,;63.92,-9.99,;66.23,-11.33,;67.77,-11.33,;68.54,-12.66,;70.08,-12.66,;70.85,-13.99,;70.85,-11.33,;65.46,-12.66,;66.23,-13.99,;67.77,-13.99,;65.46,-15.33,;63.92,-15.33,;66.23,-16.66,;65.46,-18,;63.92,-18,;66.23,-19.33,;65.6,-20.74,;66.75,-21.77,;68.08,-21,;67.76,-19.49,;34.36,3.76,;33.02,2.99,;34.36,5.3,;33.02,6.07,;32.03,4.89,;30.52,5.15,;29.53,3.97,;29.99,6.6,;33.02,7.61,;34.36,8.38,;32.03,8.79,;32.56,10.23,;34.08,10.5,;34.6,11.95,;36.12,12.22,;33.61,13.13,;31.57,11.41,;32.1,12.86,;30.05,11.15,;29.06,12.33,;29.59,13.77,;31.11,14.04,;28.6,14.95,;29.13,16.4,;27.55,12.06,;27.02,10.61,;26.56,13.24,;25.04,12.97,;24.51,11.52,;25.5,10.34,;23,11.26,;24.05,14.15,;24.58,15.6,;22.53,13.88,;21.54,15.06,;22.07,16.51,;21.08,17.69,;21.61,19.14,;20.62,20.32,;21.14,21.76,;20.15,22.94,;22.66,22.03,;20.03,14.8,;19.5,13.35,;19.04,15.97,;17.52,15.71,;16.99,14.26,;15.48,13.99,;14.95,12.55,;13.43,12.28,;15.94,11.37,;16.53,16.89,;17.06,18.33,;15.01,16.62,;14.02,17.8,;14.55,19.25,;13.56,20.43,;14.09,21.87,;13.1,23.05,;13.62,24.5,;12.63,25.68,;15.14,24.77,;12.51,17.53,;11.98,16.08,;11.52,18.71,;10,18.44,;9.47,17,;7.96,16.73,;6.97,17.91,;5.45,17.64,;4.92,16.19,;3.41,15.93,;5.91,15.02,;7.43,15.28,;9.01,19.62,;9.54,21.07,;7.49,19.36,)| Show InChI InChI=1S/C135H209N41O36/c1-15-68(9)105(129(210)172-98(60-102(137)184)124(205)166-93(54-67(7)8)126(207)175-106(69(10)16-2)130(211)176-107(73(14)178)131(212)162-87(26-21-51-152-135(145)146)113(194)161-88(43-45-101(136)183)117(198)159-85(24-19-49-150-133(141)142)114(195)163-90(108(138)189)55-74-27-35-79(179)36-28-74)174-127(208)96(58-77-33-41-82(182)42-34-77)169-123(204)97(59-78-62-147-64-153-78)170-116(197)86(25-20-50-151-134(143)144)160-120(201)92(53-66(5)6)164-111(192)72(13)156-128(209)100(63-177)173-122(203)95(57-76-31-39-81(181)40-32-76)168-121(202)94(56-75-29-37-80(180)38-30-75)167-115(196)84(23-18-48-149-132(139)140)157-109(190)71(12)155-119(200)91(52-65(3)4)165-125(206)99(61-104(187)188)171-118(199)89(44-46-103(185)186)158-110(191)70(11)154-112(193)83-22-17-47-148-83/h27-42,62,64-73,83-100,105-107,148,177-182H,15-26,43-61,63H2,1-14H3,(H2,136,183)(H2,137,184)(H2,138,189)(H,147,153)(H,154,193)(H,155,200)(H,156,209)(H,157,190)(H,158,191)(H,159,198)(H,160,201)(H,161,194)(H,162,212)(H,163,195)(H,164,192)(H,165,206)(H,166,205)(H,167,196)(H,168,202)(H,169,204)(H,170,197)(H,171,199)(H,172,210)(H,173,203)(H,174,208)(H,175,207)(H,176,211)(H,185,186)(H,187,188)(H4,139,140,149)(H4,141,142,150)(H4,143,144,151)(H4,145,146,152)/t68-,69-,70-,71-,72-,73+,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,105-,106-,107-/m0/s1 | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Co., Ltd.
Curated by PDSP Ki Database
| |
J Biol Chem 271: 27217-20 (1996)
Article DOI: 10.1074/jbc.271.44.27217
BindingDB Entry DOI: 10.7270/Q2K64GKW |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RABBIT) | BDBM82276
(L31,P34-NPY,human | NPY Leu31, Pro34, human, rat |...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C188H282N54O56S/c1-15-94(8)148(178(292)231-127(81-139(191)251)165(279)223-122(74-92(4)5)168(282)235-147(93(6)7)177(291)237-149(99(13)245)179(293)220-119(31-21-66-206-188(200)201)183(297)241-70-25-35-137(241)174(288)218-114(30-20-65-205-187(198)199)155(269)221-120(150(193)264)76-101-39-49-107(247)50-40-101)236-169(283)125(79-104-45-55-110(250)56-46-104)226-164(278)126(80-105-86-202-90-208-105)227-157(271)113(29-19-64-204-186(196)197)216-161(275)121(73-91(2)3)222-153(267)96(10)210-170(284)132(88-243)233-163(277)124(78-103-43-53-109(249)54-44-103)225-162(276)123(77-102-41-51-108(248)52-42-102)224-156(270)112(28-18-63-203-185(194)195)214-151(265)95(9)209-154(268)117(61-72-299-14)217-166(280)129(84-145(260)261)229-159(273)116(58-60-143(256)257)215-152(266)97(11)211-173(287)135-33-23-67-238(135)180(294)98(12)212-160(274)128(83-144(258)259)228-158(272)115(57-59-142(254)255)213-141(253)87-207-172(286)134-32-22-69-240(134)184(298)131(82-140(192)252)232-167(281)130(85-146(262)263)230-175(289)138-36-26-71-242(138)182(296)118(27-16-17-62-189)219-171(285)133(89-244)234-176(290)136-34-24-68-239(136)181(295)111(190)75-100-37-47-106(246)48-38-100/h37-56,86,90-99,111-138,147-149,243-250H,15-36,57-85,87-89,189-190H2,1-14H3,(H2,191,251)(H2,192,252)(H2,193,264)(H,202,208)(H,207,286)(H,209,268)(H,210,284)(H,211,287)(H,212,274)(H,213,253)(H,214,265)(H,215,266)(H,216,275)(H,217,280)(H,218,288)(H,219,285)(H,220,293)(H,221,269)(H,222,267)(H,223,279)(H,224,270)(H,225,276)(H,226,278)(H,227,271)(H,228,272)(H,229,273)(H,230,289)(H,231,292)(H,232,281)(H,233,277)(H,234,290)(H,235,282)(H,236,283)(H,237,291)(H,254,255)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H4,194,195,203)(H4,196,197,204)(H4,198,199,205)(H4,200,201,206)/t94-,95-,96-,97-,98-,99+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,147-,148-,149-/m0/s1 | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Co., Ltd.
Curated by PDSP Ki Database
| |
J Biol Chem 271: 27217-20 (1996)
Article DOI: 10.1074/jbc.271.44.27217
BindingDB Entry DOI: 10.7270/Q2K64GKW |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RABBIT) | BDBM82286
(CAS_59763-91-6 | PP, human | PP,SALMON)Show SMILES [#6]-[#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7+]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#7]-[#6](-[#7])=[#7+])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#16]-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6](-[#6])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#8])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6](-[#6])-[#7])-[#6](-[#6])-[#6])-[#6](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#16]-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](-[#7])=O Show InChI InChI=1S/C185H287N53O54S2/c1-21-91(10)143(175(286)228-125(84-137(190)248)164(275)213-114(63-74-294-20)158(269)221-120(77-89(6)7)167(278)232-144(98(17)239)176(287)217-115(34-25-67-203-185(198)199)178(289)235-69-28-37-131(235)170(281)214-110(33-24-66-202-184(196)197)154(265)218-117(146(191)257)78-100-40-48-104(241)49-41-100)231-168(279)122(80-102-44-52-106(243)53-45-102)224-155(266)109(32-23-65-201-183(194)195)210-153(264)108(31-22-64-200-182(192)193)211-161(272)118(75-87(2)3)222-165(276)126(85-140(253)254)219-149(260)94(13)204-147(258)93(12)206-159(270)121(79-101-42-50-105(242)51-43-101)223-156(267)111(56-59-134(187)245)209-148(259)95(14)205-152(263)113(62-73-293-19)212-163(274)124(83-136(189)247)225-157(268)112(57-60-138(249)250)215-171(282)132-38-30-72-238(132)181(292)145(99(18)240)233-151(262)97(16)207-160(271)123(82-135(188)246)226-166(277)127(86-141(255)256)220-150(261)96(15)208-169(280)129-35-27-71-237(129)180(291)128(81-103-46-54-107(244)55-47-103)229-174(285)142(90(8)9)230-173(284)133-39-29-70-236(133)179(290)116(58-61-139(251)252)216-162(273)119(76-88(4)5)227-172(283)130-36-26-68-234(130)177(288)92(11)186/h40-55,87-99,108-133,142-145,239-244H,21-39,56-86,186H2,1-20H3,(H2,187,245)(H2,188,246)(H2,189,247)(H2,190,248)(H2,191,257)(H,204,258)(H,205,263)(H,206,270)(H,207,271)(H,208,280)(H,209,259)(H,210,264)(H,211,272)(H,212,274)(H,213,275)(H,214,281)(H,215,282)(H,216,273)(H,217,287)(H,218,265)(H,219,260)(H,220,261)(H,221,269)(H,222,276)(H,223,267)(H,224,266)(H,225,268)(H,226,277)(H,227,283)(H,228,286)(H,229,285)(H,230,284)(H,231,279)(H,232,278)(H,233,262)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,192,193,200)(H4,194,195,201)(H4,196,197,202)(H4,198,199,203)/p+2/t91?,92?,93-,94-,95-,96?,97-,98+,99?,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,142-,143-,144-,145-/m0/s1 | PDB
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Co., Ltd.
Curated by PDSP Ki Database
| |
J Biol Chem 271: 27217-20 (1996)
Article DOI: 10.1074/jbc.271.44.27217
BindingDB Entry DOI: 10.7270/Q2K64GKW |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM50246785
((2E,2'E)-N,N'-(Thiodiethane-2,1-diyl)bis[3-(3,4-di...)Show SMILES Clc1ccc(\C=C\C(=O)NCCSCCNC(=O)\C=C\c2ccc(Cl)c(Cl)c2)cc1Cl Show InChI InChI=1S/C22H20Cl4N2O2S/c23-17-5-1-15(13-19(17)25)3-7-21(29)27-9-11-31-12-10-28-22(30)8-4-16-2-6-18(24)20(26)14-16/h1-8,13-14H,9-12H2,(H,27,29)(H,28,30)/b7-3+,8-4+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver glycogen phosphorylase a in presence of glucose |
Bioorg Med Chem 16: 8627-34 (2008)
Article DOI: 10.1016/j.bmc.2008.08.010
BindingDB Entry DOI: 10.7270/Q2T72H81 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35353
(indole-2-carboxamide derivative, 25e (R-isomer))Show SMILES O[C@@H]1c2cc(F)c(NC(=O)c3cc4cc(Cl)ccc4[nH]3)c(F)c2CCC1(F)F |r| Show InChI InChI=1S/C19H13ClF4N2O2/c20-9-1-2-13-8(5-9)6-14(25-13)18(28)26-16-12(21)7-11-10(15(16)22)3-4-19(23,24)17(11)27/h1-2,5-7,17,25,27H,3-4H2,(H,26,28)/t17-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 10001-12 (2008)
Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM50246632
((2E,2'E)-N,N'-Pentane-1,5-diylbis[3-(3,4-dichlorop...)Show SMILES Clc1ccc(\C=C\C(=O)NCCCCCNC(=O)\C=C\c2ccc(Cl)c(Cl)c2)cc1Cl Show InChI InChI=1S/C23H22Cl4N2O2/c24-18-8-4-16(14-20(18)26)6-10-22(30)28-12-2-1-3-13-29-23(31)11-7-17-5-9-19(25)21(27)15-17/h4-11,14-15H,1-3,12-13H2,(H,28,30)(H,29,31)/b10-6+,11-7+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver glycogen phosphorylase a in presence of glucose |
Bioorg Med Chem 16: 8627-34 (2008)
Article DOI: 10.1016/j.bmc.2008.08.010
BindingDB Entry DOI: 10.7270/Q2T72H81 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM50246786
((2E,2'E)-N,N'-(Sulfinyldiethane-2,1-diyl)bis[3-(3,...)Show SMILES Clc1ccc(\C=C\C(=O)NCCS(=O)CCNC(=O)\C=C\c2ccc(Cl)c(Cl)c2)cc1Cl Show InChI InChI=1S/C22H20Cl4N2O3S/c23-17-5-1-15(13-19(17)25)3-7-21(29)27-9-11-32(31)12-10-28-22(30)8-4-16-2-6-18(24)20(26)14-16/h1-8,13-14H,9-12H2,(H,27,29)(H,28,30)/b7-3+,8-4+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver glycogen phosphorylase a in presence of glucose |
Bioorg Med Chem 16: 8627-34 (2008)
Article DOI: 10.1016/j.bmc.2008.08.010
BindingDB Entry DOI: 10.7270/Q2T72H81 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM50246752
((2E,2'E)-N,N'-(Oxydiethane-2,1-diyl)bis[3-(3,4-dic...)Show SMILES Clc1ccc(\C=C\C(=O)NCCOCCNC(=O)\C=C\c2ccc(Cl)c(Cl)c2)cc1Cl Show InChI InChI=1S/C22H20Cl4N2O3/c23-17-5-1-15(13-19(17)25)3-7-21(29)27-9-11-31-12-10-28-22(30)8-4-16-2-6-18(24)20(26)14-16/h1-8,13-14H,9-12H2,(H,27,29)(H,28,30)/b7-3+,8-4+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver glycogen phosphorylase a in presence of glucose |
Bioorg Med Chem 16: 8627-34 (2008)
Article DOI: 10.1016/j.bmc.2008.08.010
BindingDB Entry DOI: 10.7270/Q2T72H81 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35351
(indole-2-carboxamide derivative, 25e)Show SMILES OC1c2cc(F)c(NC(=O)c3cc4cc(Cl)ccc4[nH]3)c(F)c2CCC1(F)F Show InChI InChI=1S/C19H13ClF4N2O2/c20-9-1-2-13-8(5-9)6-14(25-13)18(28)26-16-12(21)7-11-10(15(16)22)3-4-19(23,24)17(11)27/h1-2,5-7,17,25,27H,3-4H2,(H,26,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 10001-12 (2008)
Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM50246788
((2E,2'E)-N,N'-Butane-1,4-diylbis[3-(3,4-dichloroph...)Show SMILES Clc1ccc(\C=C\C(=O)NCCCCNC(=O)\C=C\c2ccc(Cl)c(Cl)c2)cc1Cl Show InChI InChI=1S/C22H20Cl4N2O2/c23-17-7-3-15(13-19(17)25)5-9-21(29)27-11-1-2-12-28-22(30)10-6-16-4-8-18(24)20(26)14-16/h3-10,13-14H,1-2,11-12H2,(H,27,29)(H,28,30)/b9-5+,10-6+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver glycogen phosphorylase a in presence of glucose |
Bioorg Med Chem 16: 8627-34 (2008)
Article DOI: 10.1016/j.bmc.2008.08.010
BindingDB Entry DOI: 10.7270/Q2T72H81 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35350
(indole-2-carboxamide derivative, 25d)Show SMILES OC1c2ccc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)c(F)c2CCC1(F)F Show InChI InChI=1S/C19H14ClF3N2O2/c20-10-1-3-13-9(7-10)8-15(24-13)18(27)25-14-4-2-12-11(16(14)21)5-6-19(22,23)17(12)26/h1-4,7-8,17,24,26H,5-6H2,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 10001-12 (2008)
Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35349
(indole-2-carboxamide derivative, 25c)Show SMILES OC1c2cc(F)c(NC(=O)c3cc4cc(Cl)ccc4[nH]3)cc2CCC1(F)F Show InChI InChI=1S/C19H14ClF3N2O2/c20-11-1-2-14-10(5-11)7-16(24-14)18(27)25-15-6-9-3-4-19(22,23)17(26)12(9)8-13(15)21/h1-2,5-8,17,24,26H,3-4H2,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 10001-12 (2008)
Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35345
(indole-2-carboxamide derivative, 15)Show SMILES OC1c2ccc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)cc2CCC1(F)F Show InChI InChI=1S/C19H15ClF2N2O2/c20-12-1-4-15-11(7-12)9-16(24-15)18(26)23-13-2-3-14-10(8-13)5-6-19(21,22)17(14)25/h1-4,7-9,17,24-25H,5-6H2,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 10001-12 (2008)
Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35352
(indole-2-carboxamide derivative, 25e (S-isomer))Show SMILES O[C@H]1c2cc(F)c(NC(=O)c3cc4cc(Cl)ccc4[nH]3)c(F)c2CCC1(F)F |r| Show InChI InChI=1S/C19H13ClF4N2O2/c20-9-1-2-13-8(5-9)6-14(25-13)18(28)26-16-12(21)7-11-10(15(16)22)3-4-19(23,24)17(11)27/h1-2,5-7,17,25,27H,3-4H2,(H,26,28)/t17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 10001-12 (2008)
Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35636
(5-chloroindolecarboxamide, 13a)Show InChI InChI=1S/C16H14ClN3O3/c17-11-2-3-12-10(5-11)6-13(19-12)16(23)20-15-4-1-9(7-18-15)14(22)8-21/h1-7,14,19,21-22H,8H2,(H,18,20,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 5452-64 (2008)
Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM50246632
((2E,2'E)-N,N'-Pentane-1,5-diylbis[3-(3,4-dichlorop...)Show SMILES Clc1ccc(\C=C\C(=O)NCCCCCNC(=O)\C=C\c2ccc(Cl)c(Cl)c2)cc1Cl Show InChI InChI=1S/C23H22Cl4N2O2/c24-18-8-4-16(14-20(18)26)6-10-22(30)28-12-2-1-3-13-29-23(31)11-7-17-5-9-19(25)21(27)15-17/h4-11,14-15H,1-3,12-13H2,(H,28,30)(H,29,31)/b10-6+,11-7+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver glycogen phosphorylase a in absence of glucose |
Bioorg Med Chem 16: 8627-34 (2008)
Article DOI: 10.1016/j.bmc.2008.08.010
BindingDB Entry DOI: 10.7270/Q2T72H81 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM50246786
((2E,2'E)-N,N'-(Sulfinyldiethane-2,1-diyl)bis[3-(3,...)Show SMILES Clc1ccc(\C=C\C(=O)NCCS(=O)CCNC(=O)\C=C\c2ccc(Cl)c(Cl)c2)cc1Cl Show InChI InChI=1S/C22H20Cl4N2O3S/c23-17-5-1-15(13-19(17)25)3-7-21(29)27-9-11-32(31)12-10-28-22(30)8-4-16-2-6-18(24)20(26)14-16/h1-8,13-14H,9-12H2,(H,27,29)(H,28,30)/b7-3+,8-4+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver glycogen phosphorylase a in absence of glucose |
Bioorg Med Chem 16: 8627-34 (2008)
Article DOI: 10.1016/j.bmc.2008.08.010
BindingDB Entry DOI: 10.7270/Q2T72H81 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35339
(indole-2-carboxamide derivative, 5b)Show SMILES OC1CCCc2cc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)ccc12 Show InChI InChI=1S/C19H17ClN2O2/c20-13-4-7-16-12(8-13)10-17(22-16)19(24)21-14-5-6-15-11(9-14)2-1-3-18(15)23/h4-10,18,22-23H,1-3H2,(H,21,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 10001-12 (2008)
Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35633
(5-chloroindolecarboxamide, 9h)Show SMILES OCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1C(F)(F)F Show InChI InChI=1S/C18H14ClF3N2O3/c19-10-1-4-14-9(5-10)6-15(24-14)17(27)23-11-2-3-12(16(26)8-25)13(7-11)18(20,21)22/h1-7,16,24-26H,8H2,(H,23,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 5452-64 (2008)
Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM50246788
((2E,2'E)-N,N'-Butane-1,4-diylbis[3-(3,4-dichloroph...)Show SMILES Clc1ccc(\C=C\C(=O)NCCCCNC(=O)\C=C\c2ccc(Cl)c(Cl)c2)cc1Cl Show InChI InChI=1S/C22H20Cl4N2O2/c23-17-7-3-15(13-19(17)25)5-9-21(29)27-11-1-2-12-28-22(30)10-6-16-4-8-18(24)20(26)14-16/h3-10,13-14H,1-2,11-12H2,(H,27,29)(H,28,30)/b9-5+,10-6+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver glycogen phosphorylase a in absence of glucose |
Bioorg Med Chem 16: 8627-34 (2008)
Article DOI: 10.1016/j.bmc.2008.08.010
BindingDB Entry DOI: 10.7270/Q2T72H81 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35628
(5-chloroindolecarboxamide, 9c)Show SMILES OCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)c(Cl)c1 Show InChI InChI=1S/C17H14Cl2N2O3/c18-11-2-4-13-10(5-11)7-15(20-13)17(24)21-14-3-1-9(6-12(14)19)16(23)8-22/h1-7,16,20,22-23H,8H2,(H,21,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 5452-64 (2008)
Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM50246752
((2E,2'E)-N,N'-(Oxydiethane-2,1-diyl)bis[3-(3,4-dic...)Show SMILES Clc1ccc(\C=C\C(=O)NCCOCCNC(=O)\C=C\c2ccc(Cl)c(Cl)c2)cc1Cl Show InChI InChI=1S/C22H20Cl4N2O3/c23-17-5-1-15(13-19(17)25)3-7-21(29)27-9-11-31-12-10-28-22(30)8-4-16-2-6-18(24)20(26)14-16/h1-8,13-14H,9-12H2,(H,27,29)(H,28,30)/b7-3+,8-4+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver glycogen phosphorylase a in absence of glucose |
Bioorg Med Chem 16: 8627-34 (2008)
Article DOI: 10.1016/j.bmc.2008.08.010
BindingDB Entry DOI: 10.7270/Q2T72H81 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35338
(indole-2-carboxamide derivative, 3)Show InChI InChI=1S/C18H15ClN2O2/c19-12-2-5-15-11(7-12)9-16(21-15)18(23)20-13-3-4-14-10(8-13)1-6-17(14)22/h2-5,7-9,17,21-22H,1,6H2,(H,20,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 10001-12 (2008)
Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35638
(5-chloroindolecarboxamide, 13c)Show InChI InChI=1S/C15H13ClN4O3/c16-9-1-2-10-8(3-9)4-11(19-10)15(23)20-14-6-17-12(5-18-14)13(22)7-21/h1-6,13,19,21-22H,7H2,(H,18,20,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 5452-64 (2008)
Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM50246785
((2E,2'E)-N,N'-(Thiodiethane-2,1-diyl)bis[3-(3,4-di...)Show SMILES Clc1ccc(\C=C\C(=O)NCCSCCNC(=O)\C=C\c2ccc(Cl)c(Cl)c2)cc1Cl Show InChI InChI=1S/C22H20Cl4N2O2S/c23-17-5-1-15(13-19(17)25)3-7-21(29)27-9-11-31-12-10-28-22(30)8-4-16-2-6-18(24)20(26)14-16/h1-8,13-14H,9-12H2,(H,27,29)(H,28,30)/b7-3+,8-4+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver glycogen phosphorylase a in absence of glucose |
Bioorg Med Chem 16: 8627-34 (2008)
Article DOI: 10.1016/j.bmc.2008.08.010
BindingDB Entry DOI: 10.7270/Q2T72H81 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35348
(indole-2-carboxamide derivative, 25b)Show SMILES COc1c(NC(=O)c2cc3cc(Cl)ccc3[nH]2)ccc2C(O)C(F)(F)CCc12 Show InChI InChI=1S/C20H17ClF2N2O3/c1-28-17-12-6-7-20(22,23)18(26)13(12)3-5-15(17)25-19(27)16-9-10-8-11(21)2-4-14(10)24-16/h2-5,8-9,18,24,26H,6-7H2,1H3,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 10001-12 (2008)
Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50356025
(CHEMBL1911522)Show InChI InChI=1S/C21H23NO3/c1-3-4-12-24-16-8-7-9-17(13-16)25-14-20-15(2)21(23)18-10-5-6-11-19(18)22-20/h5-11,13H,3-4,12,14H2,1-2H3,(H,22,23) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CYP2D6 |
Bioorg Med Chem Lett 21: 6861-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.015
BindingDB Entry DOI: 10.7270/Q2HH6KG1 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35343
(indole-2-carboxamide derivative, 9b | trans-isomer...)Show SMILES O[C@H]1CCc2cc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)ccc2[C@@H]1O |r| Show InChI InChI=1S/C19H17ClN2O3/c20-12-2-5-15-11(7-12)9-16(22-15)19(25)21-13-3-4-14-10(8-13)1-6-17(23)18(14)24/h2-5,7-9,17-18,22-24H,1,6H2,(H,21,25)/t17-,18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 10001-12 (2008)
Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35347
(indole-2-carboxamide derivative, 25a)Show SMILES COc1cc2C(O)C(F)(F)CCc2cc1NC(=O)c1cc2cc(Cl)ccc2[nH]1 Show InChI InChI=1S/C20H17ClF2N2O3/c1-28-17-9-13-10(4-5-20(22,23)18(13)26)7-15(17)25-19(27)16-8-11-6-12(21)2-3-14(11)24-16/h2-3,6-9,18,24,26H,4-5H2,1H3,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 810 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 10001-12 (2008)
Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35341
(indole-2-carboxamide derivative, 7)Show SMILES Oc1cccc2cc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)ccc12 Show InChI InChI=1S/C19H13ClN2O2/c20-13-4-7-16-12(8-13)10-17(22-16)19(24)21-14-5-6-15-11(9-14)2-1-3-18(15)23/h1-10,22-23H,(H,21,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 10001-12 (2008)
Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35622
(5-chloroindolecarboxamide, 2f)Show InChI InChI=1S/C17H15ClN2O3/c18-12-3-6-14-11(7-12)8-15(20-14)17(23)19-13-4-1-10(2-5-13)16(22)9-21/h1-8,16,20-22H,9H2,(H,19,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 5452-64 (2008)
Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35346
((S)-5-chloro-N-(3-(4-fluorophenyl)-1-(4-hydroxypip...)Show SMILES OC1CCN(CC1)C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1 |r| Show InChI InChI=1S/C23H23ClFN3O3/c24-16-3-6-19-15(12-16)13-20(26-19)22(30)27-21(11-14-1-4-17(25)5-2-14)23(31)28-9-7-18(29)8-10-28/h1-6,12-13,18,21,26,29H,7-11H2,(H,27,30)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| Purchase
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 920 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 5452-64 (2008)
Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35346
((S)-5-chloro-N-(3-(4-fluorophenyl)-1-(4-hydroxypip...)Show SMILES OC1CCN(CC1)C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1 |r| Show InChI InChI=1S/C23H23ClFN3O3/c24-16-3-6-19-15(12-16)13-20(26-19)22(30)27-21(11-14-1-4-17(25)5-2-14)23(31)28-9-7-18(29)8-10-28/h1-6,12-13,18,21,26,29H,7-11H2,(H,27,30)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
DrugBank
MMDB
PC cid
PC sid
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UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 920 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 10001-12 (2008)
Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35629
(5-chloroindolecarboxamide, 9d)Show SMILES OCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)c(c1)C(F)(F)F Show InChI InChI=1S/C18H14ClF3N2O3/c19-11-2-4-13-10(5-11)7-15(23-13)17(27)24-14-3-1-9(16(26)8-25)6-12(14)18(20,21)22/h1-7,16,23,25-26H,8H2,(H,24,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 5452-64 (2008)
Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50356029
(CHEMBL1911517)Show InChI InChI=1S/C19H25NO/c1-3-4-5-6-7-8-9-13-17-15(2)19(21)16-12-10-11-14-18(16)20-17/h8-12,14H,3-7,13H2,1-2H3,(H,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CYP2D6 |
Bioorg Med Chem Lett 21: 6861-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.015
BindingDB Entry DOI: 10.7270/Q2HH6KG1 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35340
(indole-2-carboxamide derivative, 5c)Show SMILES OC1CCCCc2cc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)ccc12 Show InChI InChI=1S/C20H19ClN2O2/c21-14-5-8-17-13(9-14)11-18(23-17)20(25)22-15-6-7-16-12(10-15)3-1-2-4-19(16)24/h5-11,19,23-24H,1-4H2,(H,22,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 10001-12 (2008)
Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35618
(5-chloroindolecarboxamide, 2b)Show InChI InChI=1S/C17H15ClN2O2/c18-13-3-6-15-12(9-13)10-16(20-15)17(22)19-14-4-1-11(2-5-14)7-8-21/h1-6,9-10,20-21H,7-8H2,(H,19,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 5452-64 (2008)
Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50356019
(CHEMBL1911523)Show InChI InChI=1S/C21H20F3NO3/c1-14-19(25-18-9-3-2-8-17(18)20(14)26)13-28-16-7-4-6-15(12-16)27-11-5-10-21(22,23)24/h2-4,6-9,12H,5,10-11,13H2,1H3,(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CYP2D6 |
Bioorg Med Chem Lett 21: 6861-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.015
BindingDB Entry DOI: 10.7270/Q2HH6KG1 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM50246787
((2E,2'E)-N,N'-(Sulfonyldiethane-2,1-diyl)bis[3-(3,...)Show SMILES Clc1ccc(\C=C\C(=O)NCCS(=O)(=O)CCNC(=O)\C=C\c2ccc(Cl)c(Cl)c2)cc1Cl Show InChI InChI=1S/C22H20Cl4N2O4S/c23-17-5-1-15(13-19(17)25)3-7-21(29)27-9-11-33(31,32)12-10-28-22(30)8-4-16-2-6-18(24)20(26)14-16/h1-8,13-14H,9-12H2,(H,27,29)(H,28,30)/b7-3+,8-4+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human liver glycogen phosphorylase a in absence of glucose |
Bioorg Med Chem 16: 8627-34 (2008)
Article DOI: 10.1016/j.bmc.2008.08.010
BindingDB Entry DOI: 10.7270/Q2T72H81 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35617
(5-chloroindolecarboxamide, 2a)Show InChI InChI=1S/C16H13ClN2O2/c17-12-3-6-14-11(7-12)8-15(19-14)16(21)18-13-4-1-10(9-20)2-5-13/h1-8,19-20H,9H2,(H,18,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 5452-64 (2008)
Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35635
(5-chloroindolecarboxamide, 9j)Show SMILES Nc1cc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)ccc1C(O)CO Show InChI InChI=1S/C17H16ClN3O3/c18-10-1-4-14-9(5-10)6-15(21-14)17(24)20-11-2-3-12(13(19)7-11)16(23)8-22/h1-7,16,21-23H,8,19H2,(H,20,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 5452-64 (2008)
Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50356031
(CHEMBL1911535)Show SMILES Cc1c(COc2cccc(OCC3CCOCC3)c2)nc2ccc(cc2c1O)-c1cccnc1 Show InChI InChI=1S/C28H28N2O4/c1-19-27(18-34-24-6-2-5-23(15-24)33-17-20-9-12-32-13-10-20)30-26-8-7-21(14-25(26)28(19)31)22-4-3-11-29-16-22/h2-8,11,14-16,20H,9-10,12-13,17-18H2,1H3,(H,30,31) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CYP2D6 |
Bioorg Med Chem Lett 21: 6861-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.015
BindingDB Entry DOI: 10.7270/Q2HH6KG1 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35634
(5-chloroindolecarboxamide, 9i)Show SMILES OCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1[N+]([O-])=O Show InChI InChI=1S/C17H14ClN3O5/c18-10-1-4-13-9(5-10)6-14(20-13)17(24)19-11-2-3-12(16(23)8-22)15(7-11)21(25)26/h1-7,16,20,22-23H,8H2,(H,19,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 5452-64 (2008)
Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35630
(5-chloroindolecarboxamide, 9e)Show SMILES COc1cc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)ccc1C(O)CO Show InChI InChI=1S/C18H17ClN2O4/c1-25-17-8-12(3-4-13(17)16(23)9-22)20-18(24)15-7-10-6-11(19)2-5-14(10)21-15/h2-8,16,21-23H,9H2,1H3,(H,20,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 5452-64 (2008)
Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35626
(5-chloroindolecarboxamide, 9a)Show SMILES Cc1cc(ccc1NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(O)CO Show InChI InChI=1S/C18H17ClN2O3/c1-10-6-11(17(23)9-22)2-4-14(10)21-18(24)16-8-12-7-13(19)3-5-15(12)20-16/h2-8,17,20,22-23H,9H2,1H3,(H,21,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 5452-64 (2008)
Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50356020
(CHEMBL1911524)Show InChI InChI=1S/C23H27NO4/c1-16-21(24-20-11-6-5-10-19(20)22(16)25)15-28-18-9-7-8-17(14-18)27-13-12-23(2,3)26-4/h5-11,14H,12-13,15H2,1-4H3,(H,24,25) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of CYP2D6 |
Bioorg Med Chem Lett 21: 6861-6 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.015
BindingDB Entry DOI: 10.7270/Q2HH6KG1 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35640
(5-chloroindolecarboxamide, 15b)Show InChI InChI=1S/C14H12ClN3O3S/c15-8-1-2-9-7(3-8)4-10(17-9)13(21)18-14-16-5-12(22-14)11(20)6-19/h1-5,11,17,19-20H,6H2,(H,16,18,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 5452-64 (2008)
Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2 |
More data for this
Ligand-Target Pair | |
Glycogen phosphorylase, liver form
(Homo sapiens (Human)) | BDBM35627
(5-chloroindolecarboxamide, 9b)Show SMILES OCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)c(F)c1 Show InChI InChI=1S/C17H14ClFN2O3/c18-11-2-4-13-10(5-11)7-15(20-13)17(24)21-14-3-1-9(6-12(14)19)16(23)8-22/h1-7,16,20,22-23H,8H2,(H,21,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | 6.8 | 22 |
Astellas Pharma Inc.
| Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed... |
Bioorg Med Chem 16: 5452-64 (2008)
Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2 |
More data for this
Ligand-Target Pair | |
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