Compile Data Set for Download or QSAR

Found 483 hits with Last Name = 'muramatsu' and Initial = 'y'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511546 (CHEMBL4553990) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(OC1CCN(C)CC1)cc2F Show InChI InChI=1S/C27H35FN6O3/c1-31-11-6-17(7-12-31)37-18-15-20(28)22-21(16-18)33(3)25(36)27(22)8-13-34(14-9-27)26-29-23-19(24(35)30-26)5-4-10-32(23)2/h15-17H,4-14H2,1-3H3,(H,29,30,35)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511565 (CHEMBL4539435) Show SMILES C[C@H]1CN(C[C@@H](C)N1)c1cc2N(C)C(=O)C3(CCN(CC3)c3nc4N(C)CCCc4c(=O)[nH]3)c2c(F)c1 |r| Show InChI InChI=1S/C27H36FN7O2/c1-16-14-35(15-17(2)29-16)18-12-20(28)22-21(13-18)33(4)25(37)27(22)7-10-34(11-8-27)26-30-23-19(24(36)31-26)6-5-9-32(23)3/h12-13,16-17,29H,5-11,14-15H2,1-4H3,(H,30,31,36)/t16-,17+	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511561 (CHEMBL4446044) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(cc2F)N1CCOCC1 Show InChI InChI=1S/C25H31FN6O3/c1-29-7-3-4-17-21(29)27-24(28-22(17)33)32-8-5-25(6-9-32)20-18(26)14-16(31-10-12-35-13-11-31)15-19(20)30(2)23(25)34/h14-15H,3-13H2,1-2H3,(H,27,28,33)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511570 (CHEMBL4442053) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCC2(CC1)C(=O)N(CS(C)(=O)=O)c1cc(F)cc(F)c21 Show InChI InChI=1S/C22H25F2N5O4S/c1-27-7-3-4-14-18(27)25-21(26-19(14)30)28-8-5-22(6-9-28)17-15(24)10-13(23)11-16(17)29(20(22)31)12-34(2,32)33/h10-11H,3-9,12H2,1-2H3,(H,25,26,30)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511541 (CHEMBL4572668) Show SMILES COCCOc1cc2N(C)C(=O)C3(CCN(CC3)c3nc4N(C)CCCc4c(=O)[nH]3)c2c(F)c1 Show InChI InChI=1S/C24H30FN5O4/c1-28-8-4-5-16-20(28)26-23(27-21(16)31)30-9-6-24(7-10-30)19-17(25)13-15(34-12-11-33-3)14-18(19)29(2)22(24)32/h13-14H,4-12H2,1-3H3,(H,26,27,31)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511568 (CHEMBL4470218) Show SMILES COc1cc2N(C)C(=O)C3(CCN(CC3)c3nc4N(C)CCCc4c(=O)[nH]3)c2c(F)c1 Show InChI InChI=1S/C22H26FN5O3/c1-26-8-4-5-14-18(26)24-21(25-19(14)29)28-9-6-22(7-10-28)17-15(23)11-13(31-3)12-16(17)27(2)20(22)30/h11-12H,4-10H2,1-3H3,(H,24,25,29)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511537 (CHEMBL4470270) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCC2(CC1)C(=O)N(CC(F)(F)F)c1cc(F)cc(F)c21 Show InChI InChI=1S/C22H22F5N5O2/c1-30-6-2-3-13-17(30)28-20(29-18(13)33)31-7-4-21(5-8-31)16-14(24)9-12(23)10-15(16)32(19(21)34)11-22(25,26)27/h9-10H,2-8,11H2,1H3,(H,28,29,33)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511536 (CHEMBL4585076) Show SMILES Cc1cccc2c1nc([nH]c2=O)N1CCC2(CC1)C(=O)N(CCO)c1cc(F)cc(F)c21 Show InChI InChI=1S/C23H22F2N4O3/c1-13-3-2-4-15-19(13)26-22(27-20(15)31)28-7-5-23(6-8-28)18-16(25)11-14(24)12-17(18)29(9-10-30)21(23)32/h2-4,11-12,30H,5-10H2,1H3,(H,26,27,31)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511553 (CHEMBL4532667) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCC2(CC1)C(=O)N(CC#N)c1cc(F)cc(F)c21 Show InChI InChI=1S/C22H22F2N6O2/c1-28-7-2-3-14-18(28)26-21(27-19(14)31)29-8-4-22(5-9-29)17-15(24)11-13(23)12-16(17)30(10-6-25)20(22)32/h11-12H,2-5,7-10H2,1H3,(H,26,27,31)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511539 (CHEMBL4457037) Show SMILES CN(C)CCOc1cc2N(C)C(=O)C3(CCN(CC3)c3nc4N(C)CCCc4c(=O)[nH]3)c2c(F)c1 Show InChI InChI=1S/C25H33FN6O3/c1-29(2)12-13-35-16-14-18(26)20-19(15-16)31(4)23(34)25(20)7-10-32(11-8-25)24-27-21-17(22(33)28-24)6-5-9-30(21)3/h14-15H,5-13H2,1-4H3,(H,27,28,33)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511545 (CHEMBL4581567) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCC2(CC1)C(=O)N(CC1COC1)c1cc(F)cc(F)c21 Show InChI InChI=1S/C24H27F2N5O3/c1-29-6-2-3-16-20(29)27-23(28-21(16)32)30-7-4-24(5-8-30)19-17(26)9-15(25)10-18(19)31(22(24)33)11-14-12-34-13-14/h9-10,14H,2-8,11-13H2,1H3,(H,27,28,32)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511538 (CHEMBL4466701) Show SMILES COCCN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(F)cc2F Show InChI InChI=1S/C23H27F2N5O3/c1-28-7-3-4-15-19(28)26-22(27-20(15)31)29-8-5-23(6-9-29)18-16(25)12-14(24)13-17(18)30(21(23)32)10-11-33-2/h12-13H,3-11H2,1-2H3,(H,26,27,31)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511557 (CHEMBL4544771) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(OCCN1CCOCC1)cc2F Show InChI InChI=1S/C27H35FN6O4/c1-31-7-3-4-19-23(31)29-26(30-24(19)35)34-8-5-27(6-9-34)22-20(28)16-18(17-21(22)32(2)25(27)36)38-15-12-33-10-13-37-14-11-33/h16-17H,3-15H2,1-2H3,(H,29,30,35)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511548 (CHEMBL4449082) Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1cc2N(C)C(=O)C3(CCN(CC3)c3nc4N(C)CCCc4c(=O)[nH]3)c2c(F)c1 |r| Show InChI InChI=1S/C27H35FN6O3/c1-16-14-34(15-17(2)37-16)18-12-20(28)22-21(13-18)32(4)25(36)27(22)7-10-33(11-8-27)26-29-23-19(24(35)30-26)6-5-9-31(23)3/h12-13,16-17H,5-11,14-15H2,1-4H3,(H,29,30,35)/t16-,17+	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511556 (CHEMBL4525942) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(OCCN1CCCC1)cc2F Show InChI InChI=1S/C27H35FN6O3/c1-31-9-5-6-19-23(31)29-26(30-24(19)35)34-12-7-27(8-13-34)22-20(28)16-18(17-21(22)32(2)25(27)36)37-15-14-33-10-3-4-11-33/h16-17H,3-15H2,1-2H3,(H,29,30,35)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511555 (CHEMBL4464007) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCC2(CC1)C(=O)N(CC(O)CO)c1cc(F)cc(F)c21 Show InChI InChI=1S/C23H27F2N5O4/c1-28-6-2-3-15-19(28)26-22(27-20(15)33)29-7-4-23(5-8-29)18-16(25)9-13(24)10-17(18)30(21(23)34)11-14(32)12-31/h9-10,14,31-32H,2-8,11-12H2,1H3,(H,26,27,33)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511542 (CHEMBL4467730) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(cc2F)N1CCCCC1 Show InChI InChI=1S/C26H33FN6O2/c1-30-10-6-7-18-22(30)28-25(29-23(18)34)33-13-8-26(9-14-33)21-19(27)15-17(32-11-4-3-5-12-32)16-20(21)31(2)24(26)35/h15-16H,3-14H2,1-2H3,(H,28,29,34)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511569 (CHEMBL4463639) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(OCCO)cc2F Show InChI InChI=1S/C23H28FN5O4/c1-27-7-3-4-15-19(27)25-22(26-20(15)31)29-8-5-23(6-9-29)18-16(24)12-14(33-11-10-30)13-17(18)28(2)21(23)32/h12-13,30H,3-11H2,1-2H3,(H,25,26,31)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511560 (CHEMBL4582280) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(cc2F)N1CCN(C)CC1 Show InChI InChI=1S/C26H34FN7O2/c1-30-11-13-33(14-12-30)17-15-19(27)21-20(16-17)32(3)24(36)26(21)6-9-34(10-7-26)25-28-22-18(23(35)29-25)5-4-8-31(22)2/h15-16H,4-14H2,1-3H3,(H,28,29,35)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511567 (CHEMBL4441063) Show SMILES Cn1ccc2c1nc([nH]c2=O)N1CCC2(CN(CCO)c3cc(F)cc(F)c23)CC1 Show InChI InChI=1S/C21H23F2N5O2/c1-26-5-2-14-18(26)24-20(25-19(14)30)27-6-3-21(4-7-27)12-28(8-9-29)16-11-13(22)10-15(23)17(16)21/h2,5,10-11,29H,3-4,6-9,12H2,1H3,(H,24,25,30)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511544 (CHEMBL4445363) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCC2(CC1)C(=O)N(CCO)c1cc(F)cc(F)c21 Show InChI InChI=1S/C22H25F2N5O3/c1-27-6-2-3-14-18(27)25-21(26-19(14)31)28-7-4-22(5-8-28)17-15(24)11-13(23)12-16(17)29(9-10-30)20(22)32/h11-12,30H,2-10H2,1H3,(H,25,26,31)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511558 (CHEMBL4441668) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(OCCN1CCN(C)CC1)cc2F Show InChI InChI=1S/C28H38FN7O3/c1-32-11-13-35(14-12-32)15-16-39-19-17-21(29)23-22(18-19)34(3)26(38)28(23)6-9-36(10-7-28)27-30-24-20(25(37)31-27)5-4-8-33(24)2/h17-18H,4-16H2,1-3H3,(H,30,31,37)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511541 (CHEMBL4572668) Show SMILES COCCOc1cc2N(C)C(=O)C3(CCN(CC3)c3nc4N(C)CCCc4c(=O)[nH]3)c2c(F)c1 Show InChI InChI=1S/C24H30FN5O4/c1-28-8-4-5-16-20(28)26-23(27-21(16)31)30-9-6-24(7-10-30)19-17(25)13-15(34-12-11-33-3)14-18(19)29(2)22(24)32/h13-14H,4-12H2,1-3H3,(H,26,27,31)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511550 (CHEMBL4460022) Show SMILES Cn1ccc2c1nc([nH]c2=O)N1CCC2(CC1)C(=O)N(CCO)c1cc(F)cc(F)c21 Show InChI InChI=1S/C21H21F2N5O3/c1-26-5-2-13-17(26)24-20(25-18(13)30)27-6-3-21(4-7-27)16-14(23)10-12(22)11-15(16)28(8-9-29)19(21)31/h2,5,10-11,29H,3-4,6-9H2,1H3,(H,24,25,30)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511553 (CHEMBL4532667) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCC2(CC1)C(=O)N(CC#N)c1cc(F)cc(F)c21 Show InChI InChI=1S/C22H22F2N6O2/c1-28-7-2-3-14-18(28)26-21(27-19(14)31)29-8-4-22(5-9-29)17-15(24)11-13(23)12-16(17)30(10-6-25)20(22)32/h11-12H,2-5,7-10H2,1H3,(H,26,27,31)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511561 (CHEMBL4446044) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(cc2F)N1CCOCC1 Show InChI InChI=1S/C25H31FN6O3/c1-29-7-3-4-17-21(29)27-24(28-22(17)33)32-8-5-25(6-9-32)20-18(26)14-16(31-10-12-35-13-11-31)15-19(20)30(2)23(25)34/h14-15H,3-13H2,1-2H3,(H,27,28,33)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511562 (CHEMBL4554146) Show SMILES OCCN1C(=O)C2(CCN(CC2)c2nc3CCCCc3c(=O)[nH]2)c2c1cc(F)cc2F Show InChI InChI=1S/C22H24F2N4O3/c23-13-11-15(24)18-17(12-13)28(9-10-29)20(31)22(18)5-7-27(8-6-22)21-25-16-4-2-1-3-14(16)19(30)26-21/h11-12,29H,1-10H2,(H,25,26,30)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511569 (CHEMBL4463639) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(OCCO)cc2F Show InChI InChI=1S/C23H28FN5O4/c1-27-7-3-4-15-19(27)25-22(26-20(15)31)29-8-5-23(6-9-29)18-16(24)12-14(33-11-10-30)13-17(18)28(2)21(23)32/h12-13,30H,3-11H2,1-2H3,(H,25,26,31)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50522329 (CHEMBL4452246) Show SMILES COc1ccccc1N1CCN(CC1)c1nc2CCSCc2c(=O)[nH]1 Show InChI InChI=1S/C18H22N4O2S/c1-24-16-5-3-2-4-15(16)21-7-9-22(10-8-21)18-19-14-6-11-25-12-13(14)17(23)20-18/h2-5H,6-12H2,1H3,(H,19,20,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
RIKEN Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...				J Med Chem 62: 3407-3427 (2019) Article DOI: 10.1021/acs.jmedchem.8b01888 BindingDB Entry DOI: 10.7270/Q2S46WC3
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511537 (CHEMBL4470270) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCC2(CC1)C(=O)N(CC(F)(F)F)c1cc(F)cc(F)c21 Show InChI InChI=1S/C22H22F5N5O2/c1-30-6-2-3-13-17(30)28-20(29-18(13)33)31-7-4-21(5-8-31)16-14(24)9-12(23)10-15(16)32(19(21)34)11-22(25,26)27/h9-10H,2-8,11H2,1H3,(H,28,29,33)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50522329 (CHEMBL4452246) Show SMILES COc1ccccc1N1CCN(CC1)c1nc2CCSCc2c(=O)[nH]1 Show InChI InChI=1S/C18H22N4O2S/c1-24-16-5-3-2-4-15(16)21-7-9-22(10-8-21)18-19-14-6-11-25-12-13(14)17(23)20-18/h2-5H,6-12H2,1H3,(H,19,20,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
RIKEN Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...				J Med Chem 62: 3407-3427 (2019) Article DOI: 10.1021/acs.jmedchem.8b01888 BindingDB Entry DOI: 10.7270/Q2S46WC3
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511563 (CHEMBL4471663) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(OCCN1CCCCC1)cc2F Show InChI InChI=1S/C28H37FN6O3/c1-32-10-6-7-20-24(32)30-27(31-25(20)36)35-13-8-28(9-14-35)23-21(29)17-19(18-22(23)33(2)26(28)37)38-16-15-34-11-4-3-5-12-34/h17-18H,3-16H2,1-2H3,(H,30,31,36)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50522343 (CHEMBL4453770) Show SMILES COc1ccc(cc1)N1CCN(CC1)c1nc2CCSCc2c(=O)[nH]1 Show InChI InChI=1S/C18H22N4O2S/c1-24-14-4-2-13(3-5-14)21-7-9-22(10-8-21)18-19-16-6-11-25-12-15(16)17(23)20-18/h2-5H,6-12H2,1H3,(H,19,20,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
RIKEN Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...				J Med Chem 62: 3407-3427 (2019) Article DOI: 10.1021/acs.jmedchem.8b01888 BindingDB Entry DOI: 10.7270/Q2S46WC3
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511546 (CHEMBL4553990) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(OC1CCN(C)CC1)cc2F Show InChI InChI=1S/C27H35FN6O3/c1-31-11-6-17(7-12-31)37-18-15-20(28)22-21(16-18)33(3)25(36)27(22)8-13-34(14-9-27)26-29-23-19(24(35)30-26)5-4-10-32(23)2/h15-17H,4-14H2,1-3H3,(H,29,30,35)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511549 (CHEMBL4518341) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCC2(CN(CCO)c3cc(F)cc(F)c23)CC1 Show InChI InChI=1S/C22H27F2N5O2/c1-27-6-2-3-15-19(27)25-21(26-20(15)31)28-7-4-22(5-8-28)13-29(9-10-30)17-12-14(23)11-16(24)18(17)22/h11-12,30H,2-10,13H2,1H3,(H,25,26,31)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511557 (CHEMBL4544771) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(OCCN1CCOCC1)cc2F Show InChI InChI=1S/C27H35FN6O4/c1-31-7-3-4-19-23(31)29-26(30-24(19)35)34-8-5-27(6-9-34)22-20(28)16-18(17-21(22)32(2)25(27)36)38-15-12-33-10-13-37-14-11-33/h16-17H,3-15H2,1-2H3,(H,29,30,35)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50522351 (CHEMBL4454164) Show SMILES Fc1cccc2NCC3(CCN(CC3)c3nc4CCCCc4c(=O)[nH]3)c12 Show InChI InChI=1S/C20H23FN4O/c21-14-5-3-7-16-17(14)20(12-22-16)8-10-25(11-9-20)19-23-15-6-2-1-4-13(15)18(26)24-19/h3,5,7,22H,1-2,4,6,8-12H2,(H,23,24,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
RIKEN Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...				J Med Chem 62: 3407-3427 (2019) Article DOI: 10.1021/acs.jmedchem.8b01888 BindingDB Entry DOI: 10.7270/Q2S46WC3
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511538 (CHEMBL4466701) Show SMILES COCCN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(F)cc2F Show InChI InChI=1S/C23H27F2N5O3/c1-28-7-3-4-15-19(28)26-22(27-20(15)31)29-8-5-23(6-9-29)18-16(25)12-14(24)13-17(18)30(21(23)32)10-11-33-2/h12-13H,3-11H2,1-2H3,(H,26,27,31)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511548 (CHEMBL4449082) Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1cc2N(C)C(=O)C3(CCN(CC3)c3nc4N(C)CCCc4c(=O)[nH]3)c2c(F)c1 |r| Show InChI InChI=1S/C27H35FN6O3/c1-16-14-34(15-17(2)37-16)18-12-20(28)22-21(13-18)32(4)25(36)27(22)7-10-33(11-8-27)26-29-23-19(24(35)30-26)6-5-9-31(23)3/h12-13,16-17H,5-11,14-15H2,1-4H3,(H,29,30,35)/t16-,17+	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511543 (CHEMBL4566625) Show SMILES Cc1cccc2c1nc([nH]c2=O)N1CCC2(CN(CCO)c3cc(F)cc(F)c23)CC1 Show InChI InChI=1S/C23H24F2N4O2/c1-14-3-2-4-16-20(14)26-22(27-21(16)31)28-7-5-23(6-8-28)13-29(9-10-30)18-12-15(24)11-17(25)19(18)23/h2-4,11-12,30H,5-10,13H2,1H3,(H,26,27,31)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511540 (CHEMBL4574717) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(cc2F)N1CCNCC1 Show InChI InChI=1S/C25H32FN7O2/c1-30-9-3-4-17-21(30)28-24(29-22(17)34)33-10-5-25(6-11-33)20-18(26)14-16(32-12-7-27-8-13-32)15-19(20)31(2)23(25)35/h14-15,27H,3-13H2,1-2H3,(H,28,29,34)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50522370 (CHEMBL4533577) Show SMILES Fc1cc2NCC3(CCN(CC3)c3nc4CCCCc4c(=O)[nH]3)c2c(F)c1 Show InChI InChI=1S/C20H22F2N4O/c21-12-9-14(22)17-16(10-12)23-11-20(17)5-7-26(8-6-20)19-24-15-4-2-1-3-13(15)18(27)25-19/h9-10,23H,1-8,11H2,(H,24,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
RIKEN Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...				J Med Chem 62: 3407-3427 (2019) Article DOI: 10.1021/acs.jmedchem.8b01888 BindingDB Entry DOI: 10.7270/Q2S46WC3
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50188594 (CHEBI:62878 | CHEMBL1086580) Show SMILES Oc1nc(nc2CCSCc12)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
RIKEN Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...				J Med Chem 62: 3407-3427 (2019) Article DOI: 10.1021/acs.jmedchem.8b01888 BindingDB Entry DOI: 10.7270/Q2S46WC3
					More data for this Ligand-Target Pair				3D Structure (crystal)
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50522343 (CHEMBL4453770) Show SMILES COc1ccc(cc1)N1CCN(CC1)c1nc2CCSCc2c(=O)[nH]1 Show InChI InChI=1S/C18H22N4O2S/c1-24-14-4-2-13(3-5-14)21-7-9-22(10-8-21)18-19-16-6-11-25-12-15(16)17(23)20-18/h2-5H,6-12H2,1H3,(H,19,20,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
RIKEN Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...				J Med Chem 62: 3407-3427 (2019) Article DOI: 10.1021/acs.jmedchem.8b01888 BindingDB Entry DOI: 10.7270/Q2S46WC3
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50511536 (CHEMBL4585076) Show SMILES Cc1cccc2c1nc([nH]c2=O)N1CCC2(CC1)C(=O)N(CCO)c1cc(F)cc(F)c21 Show InChI InChI=1S/C23H22F2N4O3/c1-13-3-2-4-15-19(13)26-22(27-20(15)31)28-7-5-23(6-8-28)18-16(25)11-14(24)12-17(18)29(9-10-30)21(23)32/h2-4,11-12,30H,5-10H2,1H3,(H,26,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 ARC5-SAM-PARP domain (613 to 1166 residues) expressed i...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50511569 (CHEMBL4463639) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(OCCO)cc2F Show InChI InChI=1S/C23H28FN5O4/c1-27-7-3-4-15-19(27)25-22(26-20(15)31)29-8-5-23(6-9-29)18-16(24)12-14(33-11-10-30)13-17(18)28(2)21(23)32/h12-13,30H,3-11H2,1-2H3,(H,25,26,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50511553 (CHEMBL4532667) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCC2(CC1)C(=O)N(CC#N)c1cc(F)cc(F)c21 Show InChI InChI=1S/C22H22F2N6O2/c1-28-7-2-3-14-18(28)26-21(27-19(14)31)29-8-4-22(5-9-29)17-15(24)11-13(23)12-16(17)30(10-6-25)20(22)32/h11-12H,2-5,7-10H2,1H3,(H,26,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50511567 (CHEMBL4441063) Show SMILES Cn1ccc2c1nc([nH]c2=O)N1CCC2(CN(CCO)c3cc(F)cc(F)c23)CC1 Show InChI InChI=1S/C21H23F2N5O2/c1-26-5-2-14-18(26)24-20(25-19(14)30)27-6-3-21(4-7-27)12-28(8-9-29)16-11-13(22)10-15(23)17(16)21/h2,5,10-11,29H,3-4,6-9,12H2,1H3,(H,24,25,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511544 (CHEMBL4445363) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCC2(CC1)C(=O)N(CCO)c1cc(F)cc(F)c21 Show InChI InChI=1S/C22H25F2N5O3/c1-27-6-2-3-14-18(27)25-21(26-19(14)31)28-7-4-22(5-8-28)17-15(24)11-13(23)12-16(17)29(9-10-30)20(22)32/h11-12,30H,2-10H2,1H3,(H,25,26,31)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 (Homo sapiens (Human))	BDBM50511552 (CHEMBL4439372) Show SMILES CN1C(=O)C2(CCN(CC2)c2nc3N(C)CCCc3c(=O)[nH]2)c2c1cc(F)cc2F Show InChI InChI=1S/C21H23F2N5O2/c1-26-7-3-4-13-17(26)24-20(25-18(13)29)28-8-5-21(6-9-28)16-14(23)10-12(22)11-15(16)27(2)19(21)30/h10-11H,3-9H2,1-2H3,(H,24,25,29)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Japanese Foundation for Cancer Research Curated by ChEMBL					Assay Description Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...				J Med Chem 63: 4183-4204 (2020) Article DOI: 10.1021/acs.jmedchem.0c00045 BindingDB Entry DOI: 10.7270/Q2XD150K
					More data for this Ligand-Target Pair

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