| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Poly [ADP-ribose] polymerase tankyrase-2 |
|---|
| Ligand | BDBM50522343 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1886446 (CHEMBL4388123) |
|---|
| IC50 | 2.6±n/a nM |
|---|
| Citation |  Shirai, F; Tsumura, T; Yashiroda, Y; Yuki, H; Niwa, H; Sato, S; Chikada, T; Koda, Y; Washizuka, K; Yoshimoto, N; Abe, M; Onuki, T; Mazaki, Y; Hirama, C; Fukami, T; Watanabe, H; Honma, T; Umehara, T; Shirouzu, M; Okue, M; Kano, Y; Watanabe, T; Kitamura, K; Shitara, E; Muramatsu, Y; Yoshida, H; Mizutani, A; Seimiya, H; Yoshida, M; Koyama, H Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors. J Med Chem62:3407-3427 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Poly [ADP-ribose] polymerase tankyrase-2 |
|---|
| Name: | Poly [ADP-ribose] polymerase tankyrase-2 |
|---|
| Synonyms: | (ARTD6 or PARP5b) | PARP5B | Poly [ADP-ribose] polymerase tankyrase-2 | TANK2 | TNKL | TNKS2 | TNKS2_HUMAN | TPoly [ADP-ribose] polymerase tankyrase-2 | Tankyrase 2 | Tankyrase II | Tankyrase-2 | Tankyrase-2 (TNKS-2) | Tankyrase-2 (TNKS2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 126937.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9H2K2 |
|---|
| Residue: | 1166 |
|---|
| Sequence: | MSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKST
PLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNAR
DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDE
LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK
DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG
ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH
PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV
KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQL
LQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVS
VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA
AKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLAR
VKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAA
SYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQT
PLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASS
LDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFEREQIT
LDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSP
DDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEEN
HNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTG
CPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYV
IYRGEQAYPEYLITYQIMRPEGMVDG
|
|
|
|---|
| BDBM50522343 |
|---|
| n/a |
|---|
| Name | BDBM50522343 |
|---|
| Synonyms: | CHEMBL4453770 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H22N4O2S |
|---|
| Mol. Mass. | 358.458 |
|---|
| SMILES | COc1ccc(cc1)N1CCN(CC1)c1nc2CCSCc2c(=O)[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
