Found 76 hits with Last Name = 'muraoka' and Initial = 't' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50186972
(CHEMBL3823127)Show SMILES CN1CCN(CC1)C(=O)c1ccc(NC(=O)c2csc3c2nc[nH]c3=O)c(c1)-c1ccccc1 Show InChI InChI=1S/C25H23N5O3S/c1-29-9-11-30(12-10-29)25(33)17-7-8-20(18(13-17)16-5-3-2-4-6-16)28-23(31)19-14-34-22-21(19)26-15-27-24(22)32/h2-8,13-15H,9-12H2,1H3,(H,28,31)(H,26,27,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187106
(CHEMBL3823992)Show SMILES CC(F)Oc1cc(ccc1NC(=O)c1csc2c1nc[nH]c2=O)C(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H22FN5O4S/c1-12(22)31-16-9-13(21(30)27-7-5-26(2)6-8-27)3-4-15(16)25-19(28)14-10-32-18-17(14)23-11-24-20(18)29/h3-4,9-12H,5-8H2,1-2H3,(H,25,28)(H,23,24,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50186971
(CHEMBL3823882)Show SMILES CC(C)c1cc(ccc1NC(=O)c1csc2c1nc[nH]c2=O)C(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H25N5O3S/c1-13(2)15-10-14(22(30)27-8-6-26(3)7-9-27)4-5-17(15)25-20(28)16-11-31-19-18(16)23-12-24-21(19)29/h4-5,10-13H,6-9H2,1-3H3,(H,25,28)(H,23,24,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187108
(CHEMBL3822845)Show SMILES CN(C)c1cc(ccc1NC(=O)c1csc2c1nc[nH]c2=O)C(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H24N6O3S/c1-25(2)16-10-13(21(30)27-8-6-26(3)7-9-27)4-5-15(16)24-19(28)14-11-31-18-17(14)22-12-23-20(18)29/h4-5,10-12H,6-9H2,1-3H3,(H,24,28)(H,22,23,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187107
(CHEMBL3822712)Show SMILES CN1CCN(CC1)C(=O)c1ccc(NC(=O)c2csc3c2nc[nH]c3=O)c(OC(C(F)(F)F)C(F)(F)F)c1 Show InChI InChI=1S/C22H19F6N5O4S/c1-32-4-6-33(7-5-32)19(36)11-2-3-13(14(8-11)37-20(21(23,24)25)22(26,27)28)31-17(34)12-9-38-16-15(12)29-10-30-18(16)35/h2-3,8-10,20H,4-7H2,1H3,(H,31,34)(H,29,30,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50186972
(CHEMBL3823127)Show SMILES CN1CCN(CC1)C(=O)c1ccc(NC(=O)c2csc3c2nc[nH]c3=O)c(c1)-c1ccccc1 Show InChI InChI=1S/C25H23N5O3S/c1-29-9-11-30(12-10-29)25(33)17-7-8-20(18(13-17)16-5-3-2-4-6-16)28-23(31)19-14-34-22-21(19)26-15-27-24(22)32/h2-8,13-15H,9-12H2,1H3,(H,28,31)(H,26,27,32) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 (unknown origin) |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187038
(CHEMBL3823000)Show SMILES CN1CCN(CC1)C(=O)c1ccc(NC(=O)c2csc3c2nc[nH]c3=O)c(Cl)c1 Show InChI InChI=1S/C19H18ClN5O3S/c1-24-4-6-25(7-5-24)19(28)11-2-3-14(13(20)8-11)23-17(26)12-9-29-16-15(12)21-10-22-18(16)27/h2-3,8-10H,4-7H2,1H3,(H,23,26)(H,21,22,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187032
(CHEMBL3822889)Show SMILES CN1CCN(CC1)C(=O)c1ccc(NC(=O)c2csc3c2nc[nH]c3=O)c(c1)C1CCCCC1 Show InChI InChI=1S/C25H29N5O3S/c1-29-9-11-30(12-10-29)25(33)17-7-8-20(18(13-17)16-5-3-2-4-6-16)28-23(31)19-14-34-22-21(19)26-15-27-24(22)32/h7-8,13-16H,2-6,9-12H2,1H3,(H,28,31)(H,26,27,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187058
(CHEMBL3823892)Show SMILES CN1CCN(CC1)C(=O)c1ccc(NC(=O)c2csc3c2nc[nH]c3=O)c(Br)c1 Show InChI InChI=1S/C19H18BrN5O3S/c1-24-4-6-25(7-5-24)19(28)11-2-3-14(13(20)8-11)23-17(26)12-9-29-16-15(12)21-10-22-18(16)27/h2-3,8-10H,4-7H2,1H3,(H,23,26)(H,21,22,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187114
(CHEMBL3823303)Show SMILES CCc1cc(Nc2ncc(F)c(n2)-c2cnc3cccnn23)cc(OCCN2CCC(O)CC2)c1 Show InChI InChI=1S/C25H28FN7O2/c1-2-17-12-18(14-20(13-17)35-11-10-32-8-5-19(34)6-9-32)30-25-28-15-21(26)24(31-25)22-16-27-23-4-3-7-29-33(22)23/h3-4,7,12-16,19,34H,2,5-6,8-11H2,1H3,(H,28,30,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of recombinant FLAG-tagged TAK1 kinase domain (unknown origin) expressed in baculovirus expression system coexpressing TAB using biotin-la... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)Show SMILES COc1cc(O)c2c(c1)\C=C\C[C@H](O)[C@H](O)C(=O)\C=C/C[C@H](C)OC2=O |r,c:19,t:10| Show InChI InChI=1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4+,7-3-/t11-,15-,18+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of full length TAK1 (unknown origin) fused with TAB1 using biotin-MKK6 as substrate by AlphaScreen assay |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187109
(CHEMBL3822535)Show SMILES CCN(C)c1cc(ccc1NC(=O)c1csc2c1nc[nH]c2=O)C(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H26N6O3S/c1-4-27(3)17-11-14(22(31)28-9-7-26(2)8-10-28)5-6-16(17)25-20(29)15-12-32-19-18(15)23-13-24-21(19)30/h5-6,11-13H,4,7-10H2,1-3H3,(H,25,29)(H,23,24,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187111
(CHEMBL3823738)Show SMILES CC(C)Oc1c(NC(=O)c2csc3c2nc[nH]c3=O)cccc1C(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H25N5O4S/c1-13(2)31-18-14(22(30)27-9-7-26(3)8-10-27)5-4-6-16(18)25-20(28)15-11-32-19-17(15)23-12-24-21(19)29/h4-6,11-13H,7-10H2,1-3H3,(H,25,28)(H,23,24,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187110
(CHEMBL3823335)Show SMILES COc1cc(ccc1NC(=O)c1csc2c1nc[nH]c2=O)C(=O)NCCCN1CCN(C)CC1 Show InChI InChI=1S/C23H28N6O4S/c1-28-8-10-29(11-9-28)7-3-6-24-21(30)15-4-5-17(18(12-15)33-2)27-22(31)16-13-34-20-19(16)25-14-26-23(20)32/h4-5,12-14H,3,6-11H2,1-2H3,(H,24,30)(H,27,31)(H,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187070
(CHEMBL3824212)Show SMILES COc1cc(ccc1NC(=O)c1csc2c1nc[nH]c2=O)C(=O)N1CCN(C)CC1 Show InChI InChI=1S/C20H21N5O4S/c1-24-5-7-25(8-6-24)20(28)12-3-4-14(15(9-12)29-2)23-18(26)13-10-30-17-16(13)21-11-22-19(17)27/h3-4,9-11H,5-8H2,1-2H3,(H,23,26)(H,21,22,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Sterol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50360307
(CHEMBL449307)Show SMILES CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1 |r| Show InChI InChI=1S/C33H45N3O5/c1-6-8-15-22(4)26-20-27(37)35-30(28(24-16-11-9-12-17-24)25-18-13-10-14-19-25)32(39)34-23(5)31(38)36-29(21(3)7-2)33(40)41-26/h9-14,16-19,21-23,26,28-30H,6-8,15,20H2,1-5H3,(H,34,39)(H,35,37)(H,36,38)/t21-,22-,23+,26-,29+,30-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku University
Curated by ChEMBL
| Assay Description
Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophages |
Bioorg Med Chem Lett 22: 696-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.045
BindingDB Entry DOI: 10.7270/Q2ZC839D |
More data for this
Ligand-Target Pair | |
Sterol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50360306
(CHEMBL505016)Show SMILES CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1 |r| Show InChI InChI=1S/C33H45N3O5/c1-6-8-15-22(4)26-20-27(37)35-30(28(24-16-11-9-12-17-24)25-18-13-10-14-19-25)32(39)34-23(5)31(38)36-29(21(3)7-2)33(40)41-26/h9-14,16-19,21-23,26,28-30H,6-8,15,20H2,1-5H3,(H,34,39)(H,35,37)(H,36,38)/t21-,22-,23-,26-,29+,30-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku University
Curated by ChEMBL
| Assay Description
Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophages |
Bioorg Med Chem Lett 22: 696-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.045
BindingDB Entry DOI: 10.7270/Q2ZC839D |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50186814
(CHEMBL3823018)Show SMILES CN1CCN(CC1)C(=O)c1ccc(NC(=O)c2csc3c2nc[nH]c3=O)c(C)c1 Show InChI InChI=1S/C20H21N5O3S/c1-12-9-13(20(28)25-7-5-24(2)6-8-25)3-4-15(12)23-18(26)14-10-29-17-16(14)21-11-22-19(17)27/h3-4,9-11H,5-8H2,1-2H3,(H,23,26)(H,21,22,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187113
(CHEMBL3824153)Show SMILES COCCN1CCN(Cc2ccc(cc2)-c2cc(NC(N)=O)c(s2)C(N)=O)CC1 Show InChI InChI=1S/C20H27N5O3S/c1-28-11-10-24-6-8-25(9-7-24)13-14-2-4-15(5-3-14)17-12-16(23-20(22)27)18(29-17)19(21)26/h2-5,12H,6-11,13H2,1H3,(H2,21,26)(H3,22,23,27) | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of TAK1 (unknown origin) |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal GST-tagged FLT3 cytoplasmic domain (564 to 993 residues) expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
Sterol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50360308
(CHEMBL1933478)Show SMILES CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1 |r| Show InChI InChI=1S/C33H45N3O6/c1-5-7-14-22(4)26-19-27(38)35-30(28(23-15-10-8-11-16-23)24-17-12-9-13-18-24)32(40)34-25(20-37)31(39)36-29(21(3)6-2)33(41)42-26/h8-13,15-18,21-22,25-26,28-30,37H,5-7,14,19-20H2,1-4H3,(H,34,40)(H,35,38)(H,36,39)/t21-,22-,25-,26-,29+,30-/m0/s1 | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku University
Curated by ChEMBL
| Assay Description
Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophages |
Bioorg Med Chem Lett 22: 696-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.045
BindingDB Entry DOI: 10.7270/Q2ZC839D |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187115
(CHEMBL3822835)Show SMILES Cc1cc(NC(=O)Nc2cc(nn2-c2cccc(c2)C#N)C(C)(C)C)ccc1Oc1ccncc1 Show InChI InChI=1S/C27H26N6O2/c1-18-14-20(8-9-23(18)35-22-10-12-29-13-11-22)30-26(34)31-25-16-24(27(2,3)4)32-33(25)21-7-5-6-19(15-21)17-28/h5-16H,1-4H3,(H2,30,31,34) | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
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CHEMBL
MCE
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 156 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of recombinant TAK1 (unknown origin) |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187036
(CHEMBL3823067)Show SMILES CN1CCN(CC1)C(=O)c1ccc(NC(=O)c2csc3c2nc[nH]c3=O)c(F)c1 Show InChI InChI=1S/C19H18FN5O3S/c1-24-4-6-25(7-5-24)19(28)11-2-3-14(13(20)8-11)23-17(26)12-9-29-16-15(12)21-10-22-18(16)27/h2-3,8-10H,4-7H2,1H3,(H,23,26)(H,21,22,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187118
(CHEMBL3822673)Show SMILES COc1cc(ccc1NC(=O)c1csc2cncnc12)C(=O)NCCCN1CCN(C)CC1 Show InChI InChI=1S/C23H28N6O3S/c1-28-8-10-29(11-9-28)7-3-6-25-22(30)16-4-5-18(19(12-16)32-2)27-23(31)17-14-33-20-13-24-15-26-21(17)20/h4-5,12-15H,3,6-11H2,1-2H3,(H,25,30)(H,27,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Sterol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50360310
(CHEMBL1933480)Show SMILES CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C2=N[C@H](CO2)C(=O)N[C@H](C2CCCCC2)C(=O)O1 |r,t:27| Show InChI InChI=1S/C35H45N3O5/c1-3-4-14-23(2)28-21-29(39)37-32(30(24-15-8-5-9-16-24)25-17-10-6-11-18-25)34-36-27(22-42-34)33(40)38-31(35(41)43-28)26-19-12-7-13-20-26/h5-6,8-11,15-18,23,26-28,30-32H,3-4,7,12-14,19-22H2,1-2H3,(H,37,39)(H,38,40)/t23-,27+,28-,31+,32-/m0/s1 | PDB
KEGG
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| Article
PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku University
Curated by ChEMBL
| Assay Description
Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophages |
Bioorg Med Chem Lett 22: 696-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.045
BindingDB Entry DOI: 10.7270/Q2ZC839D |
More data for this
Ligand-Target Pair | |
Sterol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50360309
(CHEMBL1933479)Show SMILES CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](CO)C(=O)N[C@H](C2CCCCC2)C(=O)O1 |r| Show InChI InChI=1S/C35H47N3O6/c1-3-4-14-23(2)28-21-29(40)37-32(30(24-15-8-5-9-16-24)25-17-10-6-11-18-25)34(42)36-27(22-39)33(41)38-31(35(43)44-28)26-19-12-7-13-20-26/h5-6,8-11,15-18,23,26-28,30-32,39H,3-4,7,12-14,19-22H2,1-2H3,(H,36,42)(H,37,40)(H,38,41)/t23-,27+,28-,31+,32-/m0/s1 | PDB
KEGG
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UniChem
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PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku University
Curated by ChEMBL
| Assay Description
Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophages |
Bioorg Med Chem Lett 22: 696-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.045
BindingDB Entry DOI: 10.7270/Q2ZC839D |
More data for this
Ligand-Target Pair | |
Sterol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50360305
(CHEMBL409855 | US9149492, Beauveriolide III)Show SMILES CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1 |r| Show InChI InChI=1S/C27H41N3O5/c1-6-8-12-18(4)22-16-23(31)29-21(15-20-13-10-9-11-14-20)26(33)28-19(5)25(32)30-24(17(3)7-2)27(34)35-22/h9-11,13-14,17-19,21-22,24H,6-8,12,15-16H2,1-5H3,(H,28,33)(H,29,31)(H,30,32)/t17-,18-,19-,21-,22-,24+/m0/s1 | PDB
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CHEMBL
MCE
PC cid
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UniChem
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| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku University
Curated by ChEMBL
| Assay Description
Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophages |
Bioorg Med Chem Lett 22: 696-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.045
BindingDB Entry DOI: 10.7270/Q2ZC839D |
More data for this
Ligand-Target Pair | |
Sterol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50360304
(CHEMBL516093 | US9149492, Beauveriolide I)Show SMILES CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H](CC(C)C)C(=O)O1 |r| Show InChI InChI=1S/C27H41N3O5/c1-6-7-11-18(4)23-16-24(31)29-21(15-20-12-9-8-10-13-20)26(33)28-19(5)25(32)30-22(14-17(2)3)27(34)35-23/h8-10,12-13,17-19,21-23H,6-7,11,14-16H2,1-5H3,(H,28,33)(H,29,31)(H,30,32)/t18-,19-,21-,22+,23-/m0/s1 | PDB
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CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku University
Curated by ChEMBL
| Assay Description
Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophages |
Bioorg Med Chem Lett 22: 696-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.045
BindingDB Entry DOI: 10.7270/Q2ZC839D |
More data for this
Ligand-Target Pair | |
Sterol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50360311
(CHEMBL1933481)Show SMILES CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](Cn2cc(CNC(=O)CCCCNC(=O)CCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)nn2)C(=O)N[C@H](C2CCCCC2)C(=O)O1 |r| Show InChI InChI=1S/C53H74N10O8S/c1-3-4-18-34(2)41-29-45(66)58-49(46(35-19-8-5-9-20-35)36-21-10-6-11-22-36)51(68)56-39(50(67)59-47(52(69)71-41)37-23-12-7-13-24-37)32-63-31-38(61-62-63)30-55-44(65)27-16-17-28-54-43(64)26-15-14-25-42-48-40(33-72-42)57-53(70)60-48/h5-6,8-11,19-22,31,34,37,39-42,46-49H,3-4,7,12-18,23-30,32-33H2,1-2H3,(H,54,64)(H,55,65)(H,56,68)(H,58,66)(H,59,67)(H2,57,60,70)/t34-,39+,40-,41-,42-,47+,48-,49-/m0/s1 | PDB
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| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku University
Curated by ChEMBL
| Assay Description
Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophages |
Bioorg Med Chem Lett 22: 696-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.045
BindingDB Entry DOI: 10.7270/Q2ZC839D |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187116
(CHEMBL3822538)Show InChI InChI=1S/C19H21N5O2S/c1-23-5-7-24(8-6-23)13-3-4-15(16(9-13)26-2)22-19(25)14-11-27-17-10-20-12-21-18(14)17/h3-4,9-12H,5-8H2,1-2H3,(H,22,25) | PDB
MMDB
Reactome pathway
KEGG
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187117
(CHEMBL3822610)Show SMILES COc1cc(ccc1NC(=O)c1csc2cncnc12)C(=O)N1CCN(C)CC1 Show InChI InChI=1S/C20H21N5O3S/c1-24-5-7-25(8-6-24)20(27)13-3-4-15(16(9-13)28-2)23-19(26)14-11-29-17-10-21-12-22-18(14)17/h3-4,9-12H,5-8H2,1-2H3,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged TAK1 (unknown origin) expressed in sf9 cells coexpressing His-tagged TAB1 using myelin basic protein as substrate incubated ... |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human)) | BDBM50187112
(CHEMBL3823800)Show SMILES [H][C@]12O[C@@]1([H])C(=O)C1=C([C@@H]2O)C2([H])O[C@H](C)C1([H])[C@]1([H])[C@@H](C)OC=C3[C@H](O)[C@@]4([H])O[C@@]4([H])C(=O)[C@@]213 |r,c:8,t:26,TLB:24:34:8.7:13.14,32:34:8.7:13.14,9:8:34.18:13.14,THB:20:18:8.7:13.14,5:7:34.18:13.14,15:14:34.18:8.7| Show InChI InChI=1S/C20H20O8/c1-4-7-8-9(13(23)16-15(27-16)12(8)22)19(26-4)20-6(3-25-5(2)10(7)20)11(21)14-17(28-14)18(20)24/h3-5,7,10-11,13-17,19,21,23H,1-2H3/t4-,5-,7?,10+,11+,13+,14-,15+,16-,17-,19?,20+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TAK1 fused with TAB1 using MKK6 as substrate in presence of gamma-[33P]ATP |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50187111
(CHEMBL3823738)Show SMILES CC(C)Oc1c(NC(=O)c2csc3c2nc[nH]c3=O)cccc1C(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H25N5O4S/c1-13(2)31-18-14(22(30)27-9-7-26(3)8-10-27)5-4-6-16(18)25-20(28)15-11-32-19-17(15)23-12-24-21(19)29/h4-6,11-13H,7-10H2,1-3H3,(H,25,28)(H,23,24,29) | PDB
NCI pathway
Reactome pathway
KEGG
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AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co,. Ltd
Curated by ChEMBL
| Assay Description
Inhibition of FLT3 (unknown origin) |
Bioorg Med Chem 24: 4206-4217 (2016)
Article DOI: 10.1016/j.bmc.2016.07.006
BindingDB Entry DOI: 10.7270/Q2JM2CKQ |
More data for this
Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human N-terminal GST-tagged Aurora kinase-A (1 to 403 residues) expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
Epithelial discoidin domain-containing receptor 1
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal GST-tagged DDR1 cytoplasmic domain (444 to 876 residues) expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal GST-tagged IGF1R cytoplasmic domain (959 to 1367 residues) expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal GST-tagged INSR cytoplasmic domain (1005 to 1310 residues) expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 2
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal GST-tagged EPHA2 cytoplasmic domain (572 to 976 residues) expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
Focal adhesion kinase 1
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal GST-tagged FAK cytoplasmic domain (376 to 1052 residues) expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Yes
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human N-terminal GST-tagged YES (1 to 543 residues) expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Fyn
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of FYN (unknown origin) |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lyn
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of LYN (unknown origin) |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
Protein-tyrosine kinase 6
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human N-terminal GST-tagged BRK (2 to 451 residues) expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human N-terminal GST-tagged ABL (2 to 1130 residues) expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal GST-tagged RAF1 catalytic domain (306 to 648 residues) expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal GST-tagged AKT1 catalytic domain (104 to 480 residues) expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 (unknown origin) |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human N-terminal GST-tagged PKCzeta (1 to 592 residues) expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha type
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human N-terminal GST-tagged PKCalpha (1 to 351 residues) expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
Protein kinase C beta type
(Homo sapiens (Human)) | BDBM206104
(US9255110, 17)Show InChI InChI=1S/C17H12N4O2S/c1-23-14-6-12-10(3-2-4-19-12)5-13(14)21-17(22)11-8-24-15-7-18-9-20-16(11)15/h2-9H,1H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human N-terminal GST-tagged PKCbeta2 (1 to 673 residues) expressed in baculovirus expression system |
Bioorg Med Chem Lett 27: 1031-1036 (2017)
Article DOI: 10.1016/j.bmcl.2016.12.064
BindingDB Entry DOI: 10.7270/Q22J6F3R |
More data for this
Ligand-Target Pair | |
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