Compile Data Set for Download or QSAR

Found 1336 hits with Last Name = 'okram' and Initial = 'b'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM103511 (US8546370, 17) Show SMILES NCCCc1cc2cc[nH]c(=O)c2c(Nc2ccc(cc2)N2CCOCC2)n1 Show InChI InChI=1S/C21H25N5O2/c22-8-1-2-17-14-15-7-9-23-21(27)19(15)20(25-17)24-16-3-5-18(6-4-16)26-10-12-28-13-11-26/h3-7,9,14H,1-2,8,10-13,22H2,(H,23,27)(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IRM LLC US Patent					Assay Description Homogenous time-resolved fluorescence assay using Syk enzyme.				US Patent US8546370 (2013) BindingDB Entry DOI: 10.7270/Q2GQ6WDM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM103519 (US8546370, 164) Show SMILES CN1CCC(CC1)c1ccc(Nc2nc(cc3cc[nH]c(=O)c23)-c2cncnc2)cc1 Show InChI InChI=1S/C24H24N6O/c1-30-10-7-17(8-11-30)16-2-4-20(5-3-16)28-23-22-18(6-9-27-24(22)31)12-21(29-23)19-13-25-15-26-14-19/h2-6,9,12-15,17H,7-8,10-11H2,1H3,(H,27,31)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
IRM LLC US Patent					Assay Description Homogenous time-resolved fluorescence assay using Syk enzyme.				US Patent US8546370 (2013) BindingDB Entry DOI: 10.7270/Q2GQ6WDM
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279275 (CHEMBL4176853) Show SMILES COc1cc2ncc(-c3cc(Cl)cc(NC(C)=O)c3)n2cc1S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C20H22ClN3O4S/c1-12(25)23-15-7-13(6-14(21)8-15)16-10-22-19-9-17(28-5)18(11-24(16)19)29(26,27)20(2,3)4/h6-11H,1-5H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279291 (CHEMBL4171924) Show SMILES CCOc1cc2ncc(-c3cc(N)nc(F)c3)n2cc1S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C18H21FN4O3S/c1-5-26-13-8-17-21-9-12(11-6-15(19)22-16(20)7-11)23(17)10-14(13)27(24,25)18(2,3)4/h6-10H,5H2,1-4H3,(H2,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM103512 (US8546370, 83) Show SMILES CCN1CCN(CC1)c1cc2cc[nH]c(=O)c2c(Nc2ccc(cc2)N2CCOCC2)n1 Show InChI InChI=1S/C24H30N6O2/c1-2-28-9-11-30(12-10-28)21-17-18-7-8-25-24(31)22(18)23(27-21)26-19-3-5-20(6-4-19)29-13-15-32-16-14-29/h3-8,17H,2,9-16H2,1H3,(H,25,31)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
IRM LLC US Patent					Assay Description Homogenous time-resolved fluorescence assay using Syk enzyme.				US Patent US8546370 (2013) BindingDB Entry DOI: 10.7270/Q2GQ6WDM
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279292 (CHEMBL4161327) Show SMILES CCOc1cc2ncc(-c3cc(N)nc(F)c3)n2cc1S(=O)(=O)C(C)C Show InChI InChI=1S/C17H19FN4O3S/c1-4-25-13-7-17-20-8-12(11-5-15(18)21-16(19)6-11)22(17)9-14(13)26(23,24)10(2)3/h5-10H,4H2,1-3H3,(H2,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM122149 (US8722692, 589) Show SMILES Cn1cnc2cc(nc(N[C@@H]3CC[C@H](N)CC3)c2c1=O)-c1ccc(cc1)N1CCOCC1 |r,wD:10.9,13.13,(7.34,-1.54,;6,-.77,;6,.77,;4.67,1.54,;3.33,.77,;2,1.54,;.67,.77,;.67,-.77,;2,-1.54,;2,-3.08,;.67,-3.85,;.67,-5.39,;-.67,-6.16,;-2,-5.39,;-3.33,-6.16,;-2,-3.85,;-.67,-3.08,;3.33,-.77,;4.67,-1.54,;4.67,-3.08,;-.67,1.54,;-.67,3.08,;-2,3.85,;-3.33,3.08,;-3.33,1.54,;-2,.77,;-4.67,3.85,;-4.67,5.39,;-6,6.16,;-7.34,5.39,;-7.34,3.85,;-6,3.08,)| Show InChI InChI=1S/C24H30N6O2/c1-29-15-26-21-14-20(16-2-8-19(9-3-16)30-10-12-32-13-11-30)28-23(22(21)24(29)31)27-18-6-4-17(25)5-7-18/h2-3,8-9,14-15,17-18H,4-7,10-13,25H2,1H3,(H,27,28)/t17-,18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.89	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...				US Patent US8722692 (2014) BindingDB Entry DOI: 10.7270/Q24Q7SNS
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279311 (CHEMBL4160817) Show SMILES COc1cc2ncc(-c3ccc(O)c(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C18H19ClN2O4S/c1-18(2,3)26(23,24)16-10-21-13(9-20-17(21)8-15(16)25-4)11-5-6-14(22)12(19)7-11/h5-10,22H,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Binding affinity towards nicotinic acetylcholine receptor alpha4-beta2 from rat brain homogenates				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279302 (CHEMBL4161723) Show SMILES CCOc1cc2ncc(-c3cc(N)nc(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C18H21ClN4O3S/c1-5-26-13-8-17-21-9-12(11-6-15(19)22-16(20)7-11)23(17)10-14(13)27(24,25)18(2,3)4/h6-10H,5H2,1-4H3,(H2,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human))	BDBM68208 (Type II inhibitor, 2) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1nccc(n1)-c1cccnc1 Show InChI InChI=1S/C24H18F3N5O/c1-15-7-8-19(30-22(33)16-4-2-6-18(12-16)24(25,26)27)13-21(15)32-23-29-11-9-20(31-23)17-5-3-10-28-14-17/h2-14H,1H3,(H,30,33)(H,29,31,32)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.5	n/a
The Scripps Research Institute					Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester...				Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279297 (CHEMBL4173493) Show SMILES COCCOc1cc2ncc(-c3cc(N)nc(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C19H23ClN4O4S/c1-19(2,3)29(25,26)15-11-24-13(12-7-16(20)23-17(21)8-12)10-22-18(24)9-14(15)28-6-5-27-4/h7-11H,5-6H2,1-4H3,(H2,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM122175 (US8722692, 615) Show SMILES Cn1cnc2cc(nc(O[C@@H]3CC[C@H](N)CC3)c2c1=O)-c1ccc(cc1)N1CCOCC1 |r,wU:10.9,13.13,(-7.34,1.54,;-6,.77,;-6,-.77,;-4.67,-1.54,;-3.33,-.77,;-2,-1.54,;-.67,-.77,;-.67,.77,;-2,1.54,;-2,3.08,;-.67,3.85,;.67,3.08,;2,3.85,;2,5.39,;3.33,6.16,;.67,6.16,;-.67,5.39,;-3.33,.77,;-4.67,1.54,;-4.67,3.08,;.67,-1.54,;.67,-3.08,;2,-3.85,;3.33,-3.08,;3.33,-1.54,;2,-.77,;4.67,-3.85,;4.67,-5.39,;6,-6.16,;7.34,-5.39,;7.34,-3.85,;6,-3.08,)| Show InChI InChI=1S/C24H29N5O3/c1-28-15-26-21-14-20(16-2-6-18(7-3-16)29-10-12-31-13-11-29)27-23(22(21)24(28)30)32-19-8-4-17(25)5-9-19/h2-3,6-7,14-15,17,19H,4-5,8-13,25H2,1H3/t17-,19+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.31	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...				US Patent US8722692 (2014) BindingDB Entry DOI: 10.7270/Q24Q7SNS
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM122148 (US8722692, 588) Show SMILES Cn1cnc2cc(nc(N[C@@H]3CC[C@H](N)CC3)c2c1=O)-c1ccc(cc1)N1CCC(C)(O)CC1 |r,wD:10.9,13.13,(8.11,-1.82,;6.77,-1.05,;6.77,.49,;5.44,1.26,;4.1,.49,;2.77,1.26,;1.44,.49,;1.44,-1.05,;2.77,-1.82,;2.77,-3.36,;1.44,-4.13,;1.44,-5.67,;.1,-6.44,;-1.23,-5.67,;-2.56,-6.44,;-1.23,-4.13,;.1,-3.36,;4.1,-1.05,;5.44,-1.82,;5.44,-3.36,;.1,1.26,;.1,2.8,;-1.23,3.57,;-2.56,2.8,;-2.56,1.26,;-1.23,.49,;-3.9,3.57,;-3.9,5.11,;-5.23,5.88,;-6.57,5.11,;-7.34,6.44,;-8.11,5.11,;-6.57,3.57,;-5.23,2.8,)| Show InChI InChI=1S/C26H34N6O2/c1-26(34)11-13-32(14-12-26)20-9-3-17(4-10-20)21-15-22-23(25(33)31(2)16-28-22)24(30-21)29-19-7-5-18(27)6-8-19/h3-4,9-10,15-16,18-19,34H,5-8,11-14,27H2,1-2H3,(H,29,30)/t18-,19+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.61	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...				US Patent US8722692 (2014) BindingDB Entry DOI: 10.7270/Q24Q7SNS
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human))	BDBM68217 (Type I progenitor, 11) Show SMILES CC(O)c1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 |(-1.06,-4.07,;-1.06,-2.53,;-2.39,-1.76,;.28,-1.76,;1.61,-2.53,;2.94,-1.76,;2.94,-.22,;1.61,.55,;1.61,2.09,;2.94,2.86,;2.94,4.4,;4.28,5.17,;5.61,4.4,;6.94,5.17,;8.28,4.4,;9.61,5.17,;9.61,6.71,;8.28,7.48,;10.94,7.48,;12.28,6.71,;12.28,5.17,;10.94,4.4,;10.94,2.86,;8.28,2.86,;9.61,2.09,;6.94,2.09,;6.94,.55,;5.61,2.86,;4.28,2.09,;.28,-.22,)| Show InChI InChI=1S/C22H18Cl2N4O2/c1-12(29)13-5-3-6-15(9-13)26-22-25-11-14-10-16(21(30)28(2)20(14)27-22)19-17(23)7-4-8-18(19)24/h3-12,29H,1-2H3,(H,25,26,27)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	7.5	n/a
The Scripps Research Institute					Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate.				Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human))	BDBM68217 (Type I progenitor, 11) Show SMILES CC(O)c1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 |(-1.06,-4.07,;-1.06,-2.53,;-2.39,-1.76,;.28,-1.76,;1.61,-2.53,;2.94,-1.76,;2.94,-.22,;1.61,.55,;1.61,2.09,;2.94,2.86,;2.94,4.4,;4.28,5.17,;5.61,4.4,;6.94,5.17,;8.28,4.4,;9.61,5.17,;9.61,6.71,;8.28,7.48,;10.94,7.48,;12.28,6.71,;12.28,5.17,;10.94,4.4,;10.94,2.86,;8.28,2.86,;9.61,2.09,;6.94,2.09,;6.94,.55,;5.61,2.86,;4.28,2.09,;.28,-.22,)| Show InChI InChI=1S/C22H18Cl2N4O2/c1-12(29)13-5-3-6-15(9-13)26-22-25-11-14-10-16(21(30)28(2)20(14)27-22)19-17(23)7-4-8-18(19)24/h3-12,29H,1-2H3,(H,25,26,27)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80	n/a	n/a	n/a	n/a	7.5	n/a
The Scripps Research Institute					Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester...				Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Mus musculus)	BDBM50279297 (CHEMBL4173493) Show SMILES COCCOc1cc2ncc(-c3cc(N)nc(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C19H23ClN4O4S/c1-19(2,3)29(25,26)15-11-24-13(12-7-16(20)23-17(21)8-12)10-22-18(24)9-14(15)28-6-5-27-4/h7-11H,5-6H2,1-4H3,(H2,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of RIPK2 in C57BL/6 mouse BMDM assessed as reduction in MDP/LPS-stimulated IL6 secretion pretreated for 30 mins followed by MDP/LPS stimul...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279317 (CHEMBL4166239) Show SMILES COc1cc2ncc(-c3cc(N)nc(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C17H19ClN4O3S/c1-17(2,3)26(23,24)13-9-22-11(8-20-16(22)7-12(13)25-4)10-5-14(18)21-15(19)6-10/h5-9H,1-4H3,(H2,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM121722 (US8722692, 161) Show SMILES Cn1cnc2cc(nc(NC3CC3)c2c1=O)-c1ccc(NCCN2CCOCC2)nc1 Show InChI InChI=1S/C22H27N7O2/c1-28-14-25-18-12-17(27-21(20(18)22(28)30)26-16-3-4-16)15-2-5-19(24-13-15)23-6-7-29-8-10-31-11-9-29/h2,5,12-14,16H,3-4,6-11H2,1H3,(H,23,24)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<6.86	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...				US Patent US8722692 (2014) BindingDB Entry DOI: 10.7270/Q24Q7SNS
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279303 (CHEMBL4170048) Show SMILES CC(C)Oc1cc2ncc(-c3cc(N)nc(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C19H23ClN4O3S/c1-11(2)27-14-8-18-22-9-13(12-6-16(20)23-17(21)7-12)24(18)10-15(14)28(25,26)19(3,4)5/h6-11H,1-5H3,(H2,21,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279325 (CHEMBL4159424) Show SMILES CC(C)(C)S(=O)(=O)c1cn2c(cnc2cc1OCC(F)(F)F)-c1cc(N)nc(Cl)c1 Show InChI InChI=1S/C18H18ClF3N4O3S/c1-17(2,3)30(27,28)13-8-26-11(10-4-14(19)25-15(23)5-10)7-24-16(26)6-12(13)29-9-18(20,21)22/h4-8H,9H2,1-3H3,(H2,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279296 (CHEMBL4162788) Show SMILES CN1CCN(CCOc2cc3ncc(-c4cc(N)nc(Cl)c4)n3cc2S(=O)(=O)C(C)(C)C)CC1 Show InChI InChI=1S/C23H31ClN6O3S/c1-23(2,3)34(31,32)19-15-30-17(16-11-20(24)27-21(25)12-16)14-26-22(30)13-18(19)33-10-9-29-7-5-28(4)6-8-29/h11-15H,5-10H2,1-4H3,(H2,25,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM103524 (US8546370, 304) Show SMILES COc1cncc(c1)-c1cc2cc[nH]c(=O)c2c(Nc2ccc(cc2)C2CCN(CCC(C)=O)CC2)n1 Show InChI InChI=1S/C29H31N5O3/c1-19(35)8-12-34-13-9-21(10-14-34)20-3-5-24(6-4-20)32-28-27-22(7-11-31-29(27)36)16-26(33-28)23-15-25(37-2)18-30-17-23/h3-7,11,15-18,21H,8-10,12-14H2,1-2H3,(H,31,36)(H,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
IRM LLC US Patent					Assay Description Homogenous time-resolved fluorescence assay using Syk enzyme.				US Patent US8546370 (2013) BindingDB Entry DOI: 10.7270/Q2GQ6WDM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM103522 (US8546370, 190) Show SMILES CNC(=O)C(C)(C)c1ccc(Nc2nc(cc3cc[nH]c(=O)c23)-c2cncnc2)cc1 Show InChI InChI=1S/C23H22N6O2/c1-23(2,22(31)24-3)16-4-6-17(7-5-16)28-20-19-14(8-9-27-21(19)30)10-18(29-20)15-11-25-13-26-12-15/h4-13H,1-3H3,(H,24,31)(H,27,30)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
IRM LLC US Patent					Assay Description Homogenous time-resolved fluorescence assay using Syk enzyme.				US Patent US8546370 (2013) BindingDB Entry DOI: 10.7270/Q2GQ6WDM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human))	BDBM50242740 (CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...) Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	n/a
The Scripps Research Institute					Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester...				Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279313 (CHEMBL4164217) Show SMILES COc1cc2ncc(-c3cc(O)cc(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C18H19ClN2O4S/c1-18(2,3)26(23,24)16-10-21-14(9-20-17(21)8-15(16)25-4)11-5-12(19)7-13(22)6-11/h5-10,22H,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279317 (CHEMBL4166239) Show SMILES COc1cc2ncc(-c3cc(N)nc(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C17H19ClN4O3S/c1-17(2,3)26(23,24)13-9-22-11(8-20-16(22)7-12(13)25-4)10-5-14(18)21-15(19)6-10/h5-9H,1-4H3,(H2,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of RIPK2 in human PBMCs assessed as reduction in MDP-stimulated IL8 secretion measured after 18 hrs				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM103512 (US8546370, 83) Show SMILES CCN1CCN(CC1)c1cc2cc[nH]c(=O)c2c(Nc2ccc(cc2)N2CCOCC2)n1 Show InChI InChI=1S/C24H30N6O2/c1-2-28-9-11-30(12-10-28)21-17-18-7-8-25-24(31)22(18)23(27-21)26-19-3-5-20(6-4-19)29-13-15-32-16-14-29/h3-8,17H,2,9-16H2,1H3,(H,25,31)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
IRM LLC US Patent					Assay Description Homogenous time-resolved fluorescence assay using Syk enzyme.				US Patent US8546370 (2013) BindingDB Entry DOI: 10.7270/Q2GQ6WDM
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279275 (CHEMBL4176853) Show SMILES COc1cc2ncc(-c3cc(Cl)cc(NC(C)=O)c3)n2cc1S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C20H22ClN3O4S/c1-12(25)23-15-7-13(6-14(21)8-15)16-10-22-19-9-17(28-5)18(11-24(16)19)29(26,27)20(2,3)4/h6-11H,1-5H3,(H,23,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of RIPK2 in human PBMCs assessed as reduction in MDP-stimulated IL8 secretion measured after 18 hrs				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human))	BDBM68219 (Type II inhibitor, 13) Show SMILES CC(O)c1cccc(Nc2ncc3cc(-c4cc(ccc4Cl)N(C)C(=O)c4cccc(c4)C(F)(F)F)c(=O)n(C)c3n2)c1 Show InChI InChI=1S/C31H25ClF3N5O3/c1-17(41)18-6-5-9-22(13-18)37-30-36-16-20-14-25(29(43)40(3)27(20)38-30)24-15-23(10-11-26(24)32)39(2)28(42)19-7-4-8-21(12-19)31(33,34)35/h4-17,41H,1-3H3,(H,36,37,38)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.10	n/a	n/a	n/a	n/a	7.5	n/a
The Scripps Research Institute					Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester...				Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM121563 (US8722692, 2) Show SMILES CC(C)Nc1nc(cc2ncn(C)c(=O)c12)-c1ccc(NCCN2CCCC2)c(c1)S(C)(=O)=O Show InChI InChI=1S/C24H32N6O3S/c1-16(2)27-23-22-20(26-15-29(3)24(22)31)14-19(28-23)17-7-8-18(21(13-17)34(4,32)33)25-9-12-30-10-5-6-11-30/h7-8,13-16,25H,5-6,9-12H2,1-4H3,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...				US Patent US8722692 (2014) BindingDB Entry DOI: 10.7270/Q24Q7SNS
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279323 (CHEMBL4168738) Show SMILES COc1cc(ccc1O)-c1cnc2cc(OC)c(cn12)S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C19H22N2O5S/c1-19(2,3)27(23,24)17-11-21-13(10-20-18(21)9-16(17)26-5)12-6-7-14(22)15(8-12)25-4/h6-11,22H,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM121648 (US8722692, 87) Show SMILES CN1CCC(CC1)Nc1ccc(cc1S(C)(=O)=O)-c1cc2ncn(C)c(=O)c2c(N[C@@H]2CCOC2)n1 |r| Show InChI InChI=1S/C25H32N6O4S/c1-30-9-6-17(7-10-30)27-19-5-4-16(12-22(19)36(3,33)34)20-13-21-23(25(32)31(2)15-26-21)24(29-20)28-18-8-11-35-14-18/h4-5,12-13,15,17-18,27H,6-11,14H2,1-3H3,(H,28,29)/t18-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...				US Patent US8722692 (2014) BindingDB Entry DOI: 10.7270/Q24Q7SNS
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human))	BDBM50242740 (CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...) Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.5	n/a
The Scripps Research Institute					Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate.				Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Mus musculus)	BDBM50279292 (CHEMBL4161327) Show SMILES CCOc1cc2ncc(-c3cc(N)nc(F)c3)n2cc1S(=O)(=O)C(C)C Show InChI InChI=1S/C17H19FN4O3S/c1-4-25-13-7-17-20-8-12(11-5-15(18)21-16(19)6-11)22(17)9-14(13)26(23,24)10(2)3/h5-10H,4H2,1-3H3,(H2,19,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of RIPK2 in C57BL/6 mouse BMDM assessed as reduction in MDP/LPS-stimulated IL6 secretion pretreated for 30 mins followed by MDP/LPS stimul...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM121562 (US8722692, 1) Show SMILES Cn1cnc2cc(nc(NC3CC3)c2c1=O)-c1ccc(NCCN2CCCC2)c(c1)S(C)(=O)=O Show InChI InChI=1S/C24H30N6O3S/c1-29-15-26-20-14-19(28-23(22(20)24(29)31)27-17-6-7-17)16-5-8-18(21(13-16)34(2,32)33)25-9-12-30-10-3-4-11-30/h5,8,13-15,17,25H,3-4,6-7,9-12H2,1-2H3,(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...				US Patent US8722692 (2014) BindingDB Entry DOI: 10.7270/Q24Q7SNS
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279320 (CHEMBL4163484) Show SMILES COc1cc2ncc(-c3ccc(O)cc3)n2cc1S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C18H20N2O4S/c1-18(2,3)25(22,23)16-11-20-14(12-5-7-13(21)8-6-12)10-19-17(20)9-15(16)24-4/h5-11,21H,1-4H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM122034 (US8722692, 473) Show SMILES Cn1cnc2cc(nc(N[C@@H]3CCOC3)c2c1=O)-c1ccc(cc1)N1CCNCC1 |r| Show InChI InChI=1S/C22H26N6O2/c1-27-14-24-19-12-18(15-2-4-17(5-3-15)28-9-7-23-8-10-28)26-21(20(19)22(27)29)25-16-6-11-30-13-16/h2-5,12,14,16,23H,6-11,13H2,1H3,(H,25,26)/t16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...				US Patent US8722692 (2014) BindingDB Entry DOI: 10.7270/Q24Q7SNS
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM122046 (US8722692, 485) Show SMILES C[C@H](CO)Nc1nc(cc2ncn(C)c(=O)c12)-c1ccc(cc1)N1CCNCC1 |r| Show InChI InChI=1S/C21H26N6O2/c1-14(12-28)24-20-19-18(23-13-26(2)21(19)29)11-17(25-20)15-3-5-16(6-4-15)27-9-7-22-8-10-27/h3-6,11,13-14,22,28H,7-10,12H2,1-2H3,(H,24,25)/t14-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...				US Patent US8722692 (2014) BindingDB Entry DOI: 10.7270/Q24Q7SNS
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human))	BDBM68218 (Type II inhibitor, 12) Show SMILES CC(O)c1cccc(Nc2ncc3cc(-c4cc(NC(=O)c5cccc(c5)C(F)(F)F)ccc4Cl)c(=O)n(C)c3n2)c1 Show InChI InChI=1S/C30H23ClF3N5O3/c1-16(40)17-5-4-8-21(12-17)37-29-35-15-19-13-24(28(42)39(2)26(19)38-29)23-14-22(9-10-25(23)31)36-27(41)18-6-3-7-20(11-18)30(32,33)34/h3-16,40H,1-2H3,(H,36,41)(H,35,37,38)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19.6	n/a	n/a	n/a	n/a	7.5	n/a
The Scripps Research Institute					Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate.				Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279316 (CHEMBL4167668) Show SMILES COc1cc2ncc(-c3ccc4[nH]ncc4c3)n2cc1S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C19H20N4O3S/c1-19(2,3)27(24,25)17-11-23-15(10-20-18(23)8-16(17)26-4)12-5-6-14-13(7-12)9-21-22-14/h5-11H,1-4H3,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM121641 (US8722692, 80) Show SMILES CNc1ccc(cc1S(C)(=O)=O)-c1cc2ncn(C)c(=O)c2c(N[C@@H]2CCOC2)n1 |r| Show InChI InChI=1S/C20H23N5O4S/c1-21-14-5-4-12(8-17(14)30(3,27)28)15-9-16-18(20(26)25(2)11-22-16)19(24-15)23-13-6-7-29-10-13/h4-5,8-9,11,13,21H,6-7,10H2,1-3H3,(H,23,24)/t13-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...				US Patent US8722692 (2014) BindingDB Entry DOI: 10.7270/Q24Q7SNS
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279290 (CHEMBL4171039) Show SMILES COc1cc2ncc(-c3cccc(NC(C)=O)c3)n2cc1S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C20H23N3O4S/c1-13(24)22-15-8-6-7-14(9-15)16-11-21-19-10-17(27-5)18(12-23(16)19)28(25,26)20(2,3)4/h6-12H,1-5H3,(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human))	BDBM6568 (6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfa...) Show SMILES CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 |(-12.18,1.86,;-10.84,1.09,;-9.51,1.86,;-9.51,3.4,;-8.18,4.17,;-6.84,3.4,;-6.84,1.86,;-5.51,1.08,;-4.18,1.85,;-4.18,3.39,;-2.84,4.16,;-1.51,3.4,;-.18,4.17,;1.16,3.4,;2.49,4.17,;2.49,5.71,;1.16,6.48,;3.83,6.48,;5.16,5.71,;5.16,4.17,;3.83,3.39,;3.83,1.85,;1.16,1.86,;2.49,1.09,;-.18,1.09,;-.18,-.45,;-1.51,1.86,;-2.84,1.08,;-8.18,1.08,)| Show InChI InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	7.5	n/a
The Scripps Research Institute					Assay Description An in vitro kinase assay using dephophorylated conformationally inactive Abl kinase was obtained by treating pure recombinant Abl with Yersinia ester...				Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM121951 (US8722692, 390) Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cc2ncn(C)c(=O)c2c(NCc2cnn[nH]2)n1 Show InChI InChI=1S/C22H25N9O/c1-29-7-9-31(10-8-29)17-5-3-15(4-6-17)18-11-19-20(22(32)30(2)14-24-19)21(26-18)23-12-16-13-25-28-27-16/h3-6,11,13-14H,7-10,12H2,1-2H3,(H,23,26)(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...				US Patent US8722692 (2014) BindingDB Entry DOI: 10.7270/Q24Q7SNS
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 [1-999,Q252H] (Homo sapiens (Human))	BDBM6568 (6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfa...) Show SMILES CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 |(-12.18,1.86,;-10.84,1.09,;-9.51,1.86,;-9.51,3.4,;-8.18,4.17,;-6.84,3.4,;-6.84,1.86,;-5.51,1.08,;-4.18,1.85,;-4.18,3.39,;-2.84,4.16,;-1.51,3.4,;-.18,4.17,;1.16,3.4,;2.49,4.17,;2.49,5.71,;1.16,6.48,;3.83,6.48,;5.16,5.71,;5.16,4.17,;3.83,3.39,;3.83,1.85,;1.16,1.86,;2.49,1.09,;-.18,1.09,;-.18,-.45,;-1.51,1.86,;-2.84,1.08,;-8.18,1.08,)| Show InChI InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	7.5	n/a
The Scripps Research Institute					Assay Description An in vitro kinase assay using phosphorylated recombinant human Abl kinase domains to phosphorylate a peptide substrate.				Chem Biol 13: 779-86 (2006) Article DOI: 10.1016/j.chembiol.2006.05.015 BindingDB Entry DOI: 10.7270/Q2JM2836
					More data for this Ligand-Target Pair				3D Structure (crystal)
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50279293 (CHEMBL4162913) Show SMILES COc1cc2ncc(C(=O)Nc3ccccc3C)n2cc1S(=O)(=O)C(C)(C)C Show InChI InChI=1S/C20H23N3O4S/c1-13-8-6-7-9-14(13)22-19(24)15-11-21-18-10-16(27-5)17(12-23(15)18)28(25,26)20(2,3)4/h6-12H,1-5H3,(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibition of full length RIPK2 (unknown origin) pretreated for 30 mins followed by ATP addition measured after 2 hrs by ADP-d2 tracer based fluoresc...				ACS Med Chem Lett 8: 1048-1053 (2017) Article DOI: 10.1021/acsmedchemlett.7b00258 BindingDB Entry DOI: 10.7270/Q2ST7SBP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM103521 (US8546370, 183) Show SMILES FC(F)(F)CNc1cc2cc[nH]c(=O)c2c(Nc2ccc(cc2)N2CCOCC2)n1 Show InChI InChI=1S/C20H20F3N5O2/c21-20(22,23)12-25-16-11-13-5-6-24-19(29)17(13)18(27-16)26-14-1-3-15(4-2-14)28-7-9-30-10-8-28/h1-6,11H,7-10,12H2,(H,24,29)(H2,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
IRM LLC US Patent					Assay Description Homogenous time-resolved fluorescence assay using Syk enzyme.				US Patent US8546370 (2013) BindingDB Entry DOI: 10.7270/Q2GQ6WDM
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM122061 (US8722692, 500) Show SMILES C[C@H](CO)Nc1nc(cc2ncn(C)c(=O)c12)-c1ccc(cc1)N1CCN(CC1)C(C)C |r| Show InChI InChI=1S/C24H32N6O2/c1-16(2)29-9-11-30(12-10-29)19-7-5-18(6-8-19)20-13-21-22(24(32)28(4)15-25-21)23(27-20)26-17(3)14-31/h5-8,13,15-17,31H,9-12,14H2,1-4H3,(H,26,27)/t17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...				US Patent US8722692 (2014) BindingDB Entry DOI: 10.7270/Q24Q7SNS
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM122181 (US8722692, 621) Show SMILES Cn1cnc2cc(nc(N[C@@H]3CCOC3)c2c1=O)-c1ccc(cc1)N1CCC(CC1)N1CCCC1 |r| Show InChI InChI=1S/C27H34N6O2/c1-31-18-28-24-16-23(30-26(25(24)27(31)34)29-20-10-15-35-17-20)19-4-6-21(7-5-19)33-13-8-22(9-14-33)32-11-2-3-12-32/h4-7,16,18,20,22H,2-3,8-15,17H2,1H3,(H,29,30)/t20-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...				US Patent US8722692 (2014) BindingDB Entry DOI: 10.7270/Q24Q7SNS
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM122178 (US8722692, 618) Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cc2ncn(C)c(=O)c2c(OCCc2cnn[nH]2)n1 Show InChI InChI=1S/C23H26N8O2/c1-29-8-10-31(11-9-29)18-5-3-16(4-6-18)19-13-20-21(23(32)30(2)15-24-20)22(26-19)33-12-7-17-14-25-28-27-17/h3-6,13-15H,7-12H2,1-2H3,(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	24.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Compounds of the examples provided herein were assessed for their ability to inhibit Syk kinase by utilizing Caliper Life Sciences' proprietary L...				US Patent US8722692 (2014) BindingDB Entry DOI: 10.7270/Q24Q7SNS
					More data for this Ligand-Target Pair

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