| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 2 |
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| Ligand | BDBM50279296 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1720584 (CHEMBL4135584) |
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| IC50 | 8.0±n/a nM |
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| Citation |  He, X; Da Ros, S; Nelson, J; Zhu, X; Jiang, T; Okram, B; Jiang, S; Michellys, PY; Iskandar, M; Espinola, S; Jia, Y; Bursulaya, B; Kreusch, A; Gao, MY; Spraggon, G; Baaten, J; Clemmer, L; Meeusen, S; Huang, D; Hill, R; Nguyen-Tran, V; Fathman, J; Liu, B; Tuntland, T; Gordon, P; Hollenbeck, T; Ng, K; Shi, J; Bordone, L; Liu, H Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases. ACS Med Chem Lett8:1048-1053 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 2 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 2 |
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| Synonyms: | CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2 |
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| Type: | Protein |
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| Mol. Mass.: | 61201.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 540 |
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| Sequence: | MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
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| BDBM50279296 |
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| n/a |
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| Name | BDBM50279296 |
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| Synonyms: | CHEMBL4162788 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H31ClN6O3S |
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| Mol. Mass. | 507.049 |
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| SMILES | CN1CCN(CCOc2cc3ncc(-c4cc(N)nc(Cl)c4)n3cc2S(=O)(=O)C(C)(C)C)CC1 |
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| Structure | 
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