Compile Data Set for Download or QSAR

Found 1379 hits with Last Name = 'potluri' and Initial = 'v'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50161957 (4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(p...) Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C Show InChI InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Sabila Biosciences LLC Curated by ChEMBL					Assay Description Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assay				Bioorg Med Chem Lett 29: 1435-1439 (2019) Article DOI: 10.1016/j.bmcl.2019.04.029 BindingDB Entry DOI: 10.7270/Q2R49V68
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5445 (CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...) Show SMILES CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 Show InChI InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Sabila Biosciences LLC Curated by ChEMBL					Assay Description Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assay				Bioorg Med Chem Lett 29: 1435-1439 (2019) Article DOI: 10.1016/j.bmcl.2019.04.029 BindingDB Entry DOI: 10.7270/Q2R49V68
					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50322823 ((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...) Show SMILES CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 |r| Show InChI InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Sabila Biosciences LLC Curated by ChEMBL					Assay Description Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assay				Bioorg Med Chem Lett 29: 1435-1439 (2019) Article DOI: 10.1016/j.bmcl.2019.04.029 BindingDB Entry DOI: 10.7270/Q2R49V68
					More data for this Ligand-Target Pair				3D Structure (crystal)
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4779 (CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...) Show SMILES Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl Show InChI InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Sabila Biosciences LLC Curated by ChEMBL					Assay Description Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assay				Bioorg Med Chem Lett 29: 1435-1439 (2019) Article DOI: 10.1016/j.bmcl.2019.04.029 BindingDB Entry DOI: 10.7270/Q2R49V68
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50522515 (CHEMBL4582933) Show SMILES COc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)CC1CCSS1 Show InChI InChI=1S/C27H24ClFN4O3S2/c1-35-25-13-22-20(12-23(25)33-26(34)11-19-7-8-37-38-19)27(31-15-30-22)32-18-5-6-24(21(28)10-18)36-14-16-3-2-4-17(29)9-16/h2-6,9-10,12-13,15,19H,7-8,11,14H2,1H3,(H,33,34)(H,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
Sabila Biosciences LLC Curated by ChEMBL					Assay Description Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assay				Bioorg Med Chem Lett 29: 1435-1439 (2019) Article DOI: 10.1016/j.bmcl.2019.04.029 BindingDB Entry DOI: 10.7270/Q2R49V68
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM373729 (US10246444, Example 110) Show SMILES COc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)C1CSSC1 Show InChI InChI=1S/C26H22ClFN4O3S2/c1-34-24-10-21-19(9-22(24)32-26(33)16-12-36-37-13-16)25(30-14-29-21)31-18-5-6-23(20(27)8-18)35-11-15-3-2-4-17(28)7-15/h2-10,14,16H,11-13H2,1H3,(H,32,33)(H,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Sabila Biosciences LLC Curated by ChEMBL					Assay Description Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assay				Bioorg Med Chem Lett 29: 1435-1439 (2019) Article DOI: 10.1016/j.bmcl.2019.04.029 BindingDB Entry DOI: 10.7270/Q2R49V68
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM373725 (US10246444, Example 98) Show SMILES OC[C@H](O)COc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)C1CSSC1 |r| Show InChI InChI=1S/C30H26ClFN4O5S2/c31-24-7-21(4-5-27(24)40-13-17-2-1-3-20(32)6-17)35-29-18(10-33)11-34-25-9-28(41-14-22(38)12-37)26(8-23(25)29)36-30(39)19-15-42-43-16-19/h1-9,11,19,22,37-38H,12-16H2,(H,34,35)(H,36,39)/t22-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Sabila Biosciences LLC Curated by ChEMBL					Assay Description Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assay				Bioorg Med Chem Lett 29: 1435-1439 (2019) Article DOI: 10.1016/j.bmcl.2019.04.029 BindingDB Entry DOI: 10.7270/Q2R49V68
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322883 (2-(1-(4-((6-(4-((2H-tetrazol-5-yl)methyl) piperidi...) Show SMILES NC(=O)c1c(Nc2ccc(nc2)N2CCC(CC(=N)N=N)CC2)nc(nc1C=N)N1CCC(CC#N)CC1 Show InChI InChI=1S/C25H32N12O/c26-8-3-16-4-11-37(12-5-16)25-33-19(14-27)22(23(29)38)24(34-25)32-18-1-2-21(31-15-18)36-9-6-17(7-10-36)13-20(28)35-30/h1-2,14-17,27-28,30H,3-7,9-13H2,(H2,29,38)(H,32,33,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322884 (2-(4-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...) Show SMILES OC(=O)CN1CCC(CC1)Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI InChI=1S/C25H31N7O4/c33-21(34)16-31-13-9-19(10-14-31)36-18-7-5-17(6-8-18)27-23-22-20(15-26-30-24(22)35)28-25(29-23)32-11-3-1-2-4-12-32/h5-8,15,19H,1-4,9-14,16H2,(H,30,35)(H,33,34)(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322885 (2-(azepan-1-yl)-4-((4-(4-(2-methoxyethyl) piperazi...) Show SMILES COCCN1CCN(CC1)c1ccc(Nc2nc(nc(C=N)c2C(N)=O)N2CCCCCC2)cc1 Show InChI InChI=1S/C25H36N8O2/c1-35-17-16-31-12-14-32(15-13-31)20-8-6-19(7-9-20)28-24-22(23(27)34)21(18-26)29-25(30-24)33-10-4-2-3-5-11-33/h6-9,18,26H,2-5,10-17H2,1H3,(H2,27,34)(H,28,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322886 (2-(1-(4-((4-(4-(2-methoxyethyl) piperazin-1-yl)phe...) Show SMILES COCCN1CCN(CC1)c1ccc(Nc2nc(nc(C=N)c2C(N)=O)N2CCC(CC#N)CC2)cc1 Show InChI InChI=1S/C26H35N9O2/c1-37-17-16-33-12-14-34(15-13-33)21-4-2-20(3-5-21)30-25-23(24(29)36)22(18-28)31-26(32-25)35-10-7-19(6-9-27)8-11-35/h2-5,18-19,28H,6-8,10-17H2,1H3,(H2,29,36)(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322887 (2-(1-(4-((4-(4-(2-aminoethyl)piperazin- 1-yl)pheny...) Show SMILES NCCN1CCN(CC1)c1ccc(Nc2nc(nc(C=N)c2C(N)=O)N2CCC(CC#N)CC2)cc1 Show InChI InChI=1S/C25H34N10O/c26-8-5-18-6-10-35(11-7-18)25-31-21(17-28)22(23(29)36)24(32-25)30-19-1-3-20(4-2-19)34-15-13-33(12-9-27)14-16-34/h1-4,17-18,28H,5-7,9-16,27H2,(H2,29,36)(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322891 (2-(1-(4-((4-(4-(3-hydroxypropyl) piperazin-1-yl)ph...) Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CCCO)CC2)nc(nc1C=N)N1CCC(CC#N)CC1 Show InChI InChI=1S/C26H35N9O2/c27-9-6-19-7-11-35(12-8-19)26-31-22(18-28)23(24(29)37)25(32-26)30-20-2-4-21(5-3-20)34-15-13-33(14-16-34)10-1-17-36/h2-5,18-19,28,36H,1,6-8,10-17H2,(H2,29,37)(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322892 (2-(4-(4-((2-(4-(cyanomethyl)piperidin-1- yl)-5-oxo...) Show SMILES OC(=O)CN1CCC(CC1)Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1 Show InChI InChI=1S/C26H30N8O4/c27-10-5-17-6-13-34(14-7-17)26-30-21-15-28-32-25(37)23(21)24(31-26)29-18-1-3-19(4-2-18)38-20-8-11-33(12-9-20)16-22(35)36/h1-4,15,17,20H,5-9,11-14,16H2,(H,32,37)(H,35,36)(H,29,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322893 (2-(azepan-1-yl)-4-((4-(4-(2-hydroxyethyl)- 1,4-dia...) Show SMILES OCCN1CCCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI InChI=1S/C25H34N8O2/c34-17-16-31-10-5-13-32(15-14-31)20-8-6-19(7-9-20)27-23-22-21(18-26-30-24(22)35)28-25(29-23)33-11-3-1-2-4-12-33/h6-9,18,34H,1-5,10-17H2,(H,30,35)(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322893 (2-(azepan-1-yl)-4-((4-(4-(2-hydroxyethyl)- 1,4-dia...) Show SMILES OCCN1CCCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI InChI=1S/C25H34N8O2/c34-17-16-31-10-5-13-32(15-14-31)20-8-6-19(7-9-20)27-23-22-21(18-26-30-24(22)35)28-25(29-23)33-11-3-1-2-4-12-33/h6-9,18,34H,1-5,10-17H2,(H,30,35)(H,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322894 (2-(1-(4-((4-(4-(2-hydroxyethyl)-1,4- diazepan-1-yl...) Show SMILES OCCN1CCCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1 Show InChI InChI=1S/C26H33N9O2/c27-9-6-19-7-12-35(13-8-19)26-30-22-18-28-32-25(37)23(22)24(31-26)29-20-2-4-21(5-3-20)34-11-1-10-33(14-15-34)16-17-36/h2-5,18-19,36H,1,6-8,10-17H2,(H,32,37)(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322894 (2-(1-(4-((4-(4-(2-hydroxyethyl)-1,4- diazepan-1-yl...) Show SMILES OCCN1CCCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1 Show InChI InChI=1S/C26H33N9O2/c27-9-6-19-7-12-35(13-8-19)26-30-22-18-28-32-25(37)23(22)24(31-26)29-20-2-4-21(5-3-20)34-11-1-10-33(14-15-34)16-17-36/h2-5,18-19,36H,1,6-8,10-17H2,(H,32,37)(H,29,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322895 (2-(azepan-1-yl)-4-((4-(4-(1-hydroxy-2- methylpropa...) Show SMILES CC(C)(CO)N1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI InChI=1S/C26H36N8O2/c1-26(2,18-35)34-15-13-32(14-16-34)20-9-7-19(8-10-20)28-23-22-21(17-27-31-24(22)36)29-25(30-23)33-11-5-3-4-6-12-33/h7-10,17,35H,3-6,11-16,18H2,1-2H3,(H,31,36)(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322895 (2-(azepan-1-yl)-4-((4-(4-(1-hydroxy-2- methylpropa...) Show SMILES CC(C)(CO)N1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI InChI=1S/C26H36N8O2/c1-26(2,18-35)34-15-13-32(14-16-34)20-9-7-19(8-10-20)28-23-22-21(17-27-31-24(22)36)29-25(30-23)33-11-5-3-4-6-12-33/h7-10,17,35H,3-6,11-16,18H2,1-2H3,(H,31,36)(H,28,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322896 (2-(1-(4-((4-(4-(1-hydroxy-2- methylpropan-2-yl)pip...) Show SMILES CC(C)(CO)N1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1 Show InChI InChI=1S/C27H35N9O2/c1-27(2,18-37)36-15-13-34(14-16-36)21-5-3-20(4-6-21)30-24-23-22(17-29-33-25(23)38)31-26(32-24)35-11-8-19(7-10-28)9-12-35/h3-6,17,19,37H,7-9,11-16,18H2,1-2H3,(H,33,38)(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322944 (2-(azepan-1-yl)-4-((4-((1-hydroxy-2- methylpropan-...) Show SMILES CC(C)(CO)Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI InChI=1S/C22H28N6O3/c1-22(2,14-29)31-16-9-7-15(8-10-16)24-19-18-17(13-23-27-20(18)30)25-21(26-19)28-11-5-3-4-6-12-28/h7-10,13,29H,3-6,11-12,14H2,1-2H3,(H,27,30)(H,24,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322946 (2-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimido[...) Show SMILES CC(C)(Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1)C(O)=O Show InChI InChI=1S/C22H26N6O4/c1-22(2,20(30)31)32-15-9-7-14(8-10-15)24-18-17-16(13-23-27-19(17)29)25-21(26-18)28-11-5-3-4-6-12-28/h7-10,13H,3-6,11-12H2,1-2H3,(H,27,29)(H,30,31)(H,24,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322952 (2-(azepan-1-yl)-4-((4-(2-hydroxyethyl) phenyl)amin...) Show SMILES OCCc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI InChI=1S/C20H24N6O2/c27-12-9-14-5-7-15(8-6-14)22-18-17-16(13-21-25-19(17)28)23-20(24-18)26-10-3-1-2-4-11-26/h5-8,13,27H,1-4,9-12H2,(H,25,28)(H,22,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322959 (2-(azepan-1-yl)-4-((4-((1-(2-hydroxyethyl) piperid...) Show SMILES OCCN1CCC(CC1)Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI InChI=1S/C25H33N7O3/c33-16-15-31-13-9-20(10-14-31)35-19-7-5-18(6-8-19)27-23-22-21(17-26-30-24(22)34)28-25(29-23)32-11-3-1-2-4-12-32/h5-8,17,20,33H,1-4,9-16H2,(H,30,34)(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322959 (2-(azepan-1-yl)-4-((4-((1-(2-hydroxyethyl) piperid...) Show SMILES OCCN1CCC(CC1)Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI InChI=1S/C25H33N7O3/c33-16-15-31-13-9-20(10-14-31)35-19-7-5-18(6-8-19)27-23-22-21(17-26-30-24(22)34)28-25(29-23)32-11-3-1-2-4-12-32/h5-8,17,20,33H,1-4,9-16H2,(H,30,34)(H,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322964 (2-(azepan-1-yl)-4-((4-(methylsulfonyl) phenyl)amin...) Show SMILES CS(=O)(=O)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI InChI=1S/C19H22N6O3S/c1-29(27,28)14-8-6-13(7-9-14)21-17-16-15(12-20-24-18(16)26)22-19(23-17)25-10-4-2-3-5-11-25/h6-9,12H,2-5,10-11H2,1H3,(H,24,26)(H,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322969 (4-((1H-benzo[d][1,2,3]triazol-5-yl) amino)-2-(azep...) Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc4[nH]nnc4c3)c12)N1CCCCCC1 Show InChI InChI=1S/C18H19N9O/c28-17-15-14(10-19-25-17)21-18(27-7-3-1-2-4-8-27)22-16(15)20-11-5-6-12-13(9-11)24-26-23-12/h5-6,9-10H,1-4,7-8H2,(H,25,28)(H,20,21,22)(H,23,24,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322668 (4-(4-(4-ethylpiperazin-1-yl)phenylamino)- 2-(thiop...) Show SMILES CCN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)-c2ccsc2)cc1 Show InChI InChI=1S/C22H23N7OS/c1-2-28-8-10-29(11-9-28)17-5-3-16(4-6-17)24-21-19-18(13-23-27-22(19)30)25-20(26-21)15-7-12-31-14-15/h3-7,12-14H,2,8-11H2,1H3,(H,27,30)(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322681 (2-ethoxy-4-((4-(piperazin-1-ylmethyl) phenyl)amino...) Show SMILES CCOc1nc(Nc2ccc(CN3CCNCC3)cc2)c2c(cn[nH]c2=O)n1 Show InChI InChI=1S/C19H23N7O2/c1-2-28-19-23-15-11-21-25-18(27)16(15)17(24-19)22-14-5-3-13(4-6-14)12-26-9-7-20-8-10-26/h3-6,11,20H,2,7-10,12H2,1H3,(H,25,27)(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322683 (2-(azepan-1-yl)-4-((4-(piperazin-1- ylmethyl)pheny...) Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(CN4CCNCC4)cc3)c12)N1CCCCCC1 Show InChI InChI=1S/C23H30N8O/c32-22-20-19(15-25-29-22)27-23(31-11-3-1-2-4-12-31)28-21(20)26-18-7-5-17(6-8-18)16-30-13-9-24-10-14-30/h5-8,15,24H,1-4,9-14,16H2,(H,29,32)(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322683 (2-(azepan-1-yl)-4-((4-(piperazin-1- ylmethyl)pheny...) Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(CN4CCNCC4)cc3)c12)N1CCCCCC1 Show InChI InChI=1S/C23H30N8O/c32-22-20-19(15-25-29-22)27-23(31-11-3-1-2-4-12-31)28-21(20)26-18-7-5-17(6-8-18)16-30-13-9-24-10-14-30/h5-8,15,24H,1-4,9-14,16H2,(H,29,32)(H,26,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322685 (2-(diisopropylamino)-4-((4-(piperazin-1- ylmethyl)...) Show SMILES CC(C)N(C(C)C)c1nc(Nc2ccc(CN3CCNCC3)cc2)c2c(cn[nH]c2=O)n1 Show InChI InChI=1S/C23H32N8O/c1-15(2)31(16(3)4)23-27-19-13-25-29-22(32)20(19)21(28-23)26-18-7-5-17(6-8-18)14-30-11-9-24-10-12-30/h5-8,13,15-16,24H,9-12,14H2,1-4H3,(H,29,32)(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322685 (2-(diisopropylamino)-4-((4-(piperazin-1- ylmethyl)...) Show SMILES CC(C)N(C(C)C)c1nc(Nc2ccc(CN3CCNCC3)cc2)c2c(cn[nH]c2=O)n1 Show InChI InChI=1S/C23H32N8O/c1-15(2)31(16(3)4)23-27-19-13-25-29-22(32)20(19)21(28-23)26-18-7-5-17(6-8-18)14-30-11-9-24-10-12-30/h5-8,13,15-16,24H,9-12,14H2,1-4H3,(H,29,32)(H,26,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322690 (2-(azepan-1-yl)-4-((4-morpholinophenyl) amino)pyri...) Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(cc3)N3CCOCC3)c12)N1CCCCCC1 Show InChI InChI=1S/C22H27N7O2/c30-21-19-18(15-23-27-21)25-22(29-9-3-1-2-4-10-29)26-20(19)24-16-5-7-17(8-6-16)28-11-13-31-14-12-28/h5-8,15H,1-4,9-14H2,(H,27,30)(H,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322690 (2-(azepan-1-yl)-4-((4-morpholinophenyl) amino)pyri...) Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(cc3)N3CCOCC3)c12)N1CCCCCC1 Show InChI InChI=1S/C22H27N7O2/c30-21-19-18(15-23-27-21)25-22(29-9-3-1-2-4-10-29)26-20(19)24-16-5-7-17(8-6-16)28-11-13-31-14-12-28/h5-8,15H,1-4,9-14H2,(H,27,30)(H,24,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322692 (6-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimido[...) Show SMILES OC(=O)C1CC11CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322692 (6-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimido[...) Show SMILES OC(=O)C1CC11CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322699 (2-(1-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...) Show SMILES OC(=O)CC1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI InChI=1S/C25H31N7O3/c33-21(34)15-17-9-13-31(14-10-17)19-7-5-18(6-8-19)27-23-22-20(16-26-30-24(22)35)28-25(29-23)32-11-3-1-2-4-12-32/h5-8,16-17H,1-4,9-15H2,(H,30,35)(H,33,34)(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322800 (6-(4-((2-(cyclohexyl(methyl)amino)-5- oxo-5,6-dihy...) Show SMILES CN(C1CCCCC1)c1nc(Nc2ccc(cc2)N2CCC3(CC3C(O)=O)CC2)c2c(cn[nH]c2=O)n1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322897 (2-(azepan-1-yl)-4-((4-(4-(2- (dimethylamino)ethyl)...) Show SMILES CN(C)CCN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI InChI=1S/C26H37N9O/c1-32(2)13-14-33-15-17-34(18-16-33)21-9-7-20(8-10-21)28-24-23-22(19-27-31-25(23)36)29-26(30-24)35-11-5-3-4-6-12-35/h7-10,19H,3-6,11-18H2,1-2H3,(H,31,36)(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322897 (2-(azepan-1-yl)-4-((4-(4-(2- (dimethylamino)ethyl)...) Show SMILES CN(C)CCN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI InChI=1S/C26H37N9O/c1-32(2)13-14-33-15-17-34(18-16-33)21-9-7-20(8-10-21)28-24-23-22(19-27-31-25(23)36)29-26(30-24)35-11-5-3-4-6-12-35/h7-10,19H,3-6,11-18H2,1-2H3,(H,31,36)(H,28,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322898 (2-(1-(4-((4-(4-(2-(dimethylamino)ethyl) piperazin-...) Show SMILES CN(C)CCN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1 Show InChI InChI=1S/C27H36N10O/c1-34(2)13-14-35-15-17-36(18-16-35)22-5-3-21(4-6-22)30-25-24-23(19-29-33-26(24)38)31-27(32-25)37-11-8-20(7-10-28)9-12-37/h3-6,19-20H,7-9,11-18H2,1-2H3,(H,33,38)(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322901 (2-(1-(4-((4-(2-(4-methylpiperazin-1-yl)-2- oxoetho...) Show SMILES CN1CCN(CC1)C(=O)COc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1 Show InChI InChI=1S/C26H31N9O3/c1-33-12-14-34(15-13-33)22(36)17-38-20-4-2-19(3-5-20)29-24-23-21(16-28-32-25(23)37)30-26(31-24)35-10-7-18(6-9-27)8-11-35/h2-5,16,18H,6-8,10-15,17H2,1H3,(H,32,37)(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322902 (2-(azepan-1-yl)-4-((4-(3-(2-hydroxyethyl) piperidi...) Show SMILES OCCC1CCCN(C1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322903 (2-(azepan-1-yl)-4-((4-(4-(2,3- dihydroxypropyl)pip...) Show SMILES OCC(O)CN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322903 (2-(azepan-1-yl)-4-((4-(4-(2,3- dihydroxypropyl)pip...) Show SMILES OCC(O)CN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322904 (2-(1-(4-((4-(4-(2,3-dihydroxypropyl) piperazin-1-y...) Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CC(O)CO)CC2)nc(nc1C=N)N1CCC(CC#N)CC1 Show InChI InChI=1S/C26H35N9O3/c27-8-5-18-6-9-35(10-7-18)26-31-22(15-28)23(24(29)38)25(32-26)30-19-1-3-20(4-2-19)34-13-11-33(12-14-34)16-21(37)17-36/h1-4,15,18,21,28,36-37H,5-7,9-14,16-17H2,(H2,29,38)(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM322904 (2-(1-(4-((4-(4-(2,3-dihydroxypropyl) piperazin-1-y...) Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CC(O)CO)CC2)nc(nc1C=N)N1CCC(CC#N)CC1 Show InChI InChI=1S/C26H35N9O3/c27-8-5-18-6-9-35(10-7-18)26-31-22(15-28)23(24(29)38)25(32-26)30-19-1-3-20(4-2-19)34-13-11-33(12-14-34)16-21(37)17-36/h1-4,15,18,21,28,36-37H,5-7,9-14,16-17H2,(H2,29,38)(H,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM322905 (2-(azepan-1-yl)-4-((4-(4-(2-fluoroethyl) piperazin...) Show SMILES FCCN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1 Show InChI InChI=1S/C24H31FN8O/c25-9-12-31-13-15-32(16-14-31)19-7-5-18(6-8-19)27-22-21-20(17-26-30-23(21)34)28-24(29-22)33-10-3-1-2-4-11-33/h5-8,17H,1-4,9-16H2,(H,30,34)(H,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Asan BioSciences, LLC US Patent					Assay Description 2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...				US Patent US10647720 (2020) BindingDB Entry DOI: 10.7270/Q2QJ7MB7
					More data for this Ligand-Target Pair

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