BindingDB PrimarySearch

Found 23 hits with Last Name = 'raines' and Initial = 'rt'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM50505279 (CHEMBL4436207) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In vitro inhibitory effect of histamine H3 antagonist on the electrically evoked contractile response of isolated guinea pig jejunum segments.				Citation and Details
TBA					More data for this Ligand-Target Pair
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM8125 ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In vitro inhibitory effect of histamine H3 antagonist on the electrically evoked contractile response of isolated guinea pig jejunum segments.				Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Gag-Pol polyprotein [489-587] (Human immunodeficiency virus type 1)	BDBM50406170 (CHEMBL5266997) Show SMILES Fc1ccccc1NC(=O)CCN1CCN(Cc2ccccc2)CC1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem		10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In vitro inhibitory effect of histamine H3 antagonist on the electrically evoked contractile response of isolated guinea pig jejunum segments.				Citation and Details
TBA					More data for this Ligand-Target Pair
Prolyl 4-hydroxylase subunit alpha-1 (Homo sapiens (Human))	BDBM50042876 (CHEMBL332005 \| [2,2']Bipyridinyl-5,5'-dicarboxylic...) Show SMILES OC(=O)c1ccc(nc1)-c1ccc(cn1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	140	n/a	n/a	n/a	n/a	n/a	n/a	7.8	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...				Bioorg Med Chem 23: 3081-90 (2015) Article DOI: 10.1016/j.bmc.2015.05.003 BindingDB Entry DOI: 10.7270/Q2N01897
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Prolyl 4-hydroxylase subunit alpha-1 (Homo sapiens (Human))	BDBM50092609 (CHEMBL3586252) Show SMILES OC(=O)c1ccc(nc1)-c1cc(ccn1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	7.8	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...				Bioorg Med Chem 23: 3081-90 (2015) Article DOI: 10.1016/j.bmc.2015.05.003 BindingDB Entry DOI: 10.7270/Q2N01897
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Prolyl 4-hydroxylase subunit alpha-1 (Homo sapiens (Human))	BDBM26114 (CHEMBL88972 \| pyridine carboxylate, 6b \| pyridine-...) Show SMILES OC(=O)c1ccc(nc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	Article PubMed	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.8	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...				Bioorg Med Chem 23: 3081-90 (2015) Article DOI: 10.1016/j.bmc.2015.05.003 BindingDB Entry DOI: 10.7270/Q2N01897
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Prolyl 4-hydroxylase subunit alpha-1 (Homo sapiens (Human))	BDBM50042876 (CHEMBL332005 \| [2,2']Bipyridinyl-5,5'-dicarboxylic...) Show SMILES OC(=O)c1ccc(nc1)-c1ccc(cn1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	840	n/a	n/a	n/a	n/a	7.8	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...				Bioorg Med Chem 23: 3081-90 (2015) Article DOI: 10.1016/j.bmc.2015.05.003 BindingDB Entry DOI: 10.7270/Q2N01897
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Prolyl 4-hydroxylase subunit alpha-1 (Homo sapiens (Human))	BDBM50092609 (CHEMBL3586252) Show SMILES OC(=O)c1ccc(nc1)-c1cc(ccn1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	7.8	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...				Bioorg Med Chem 23: 3081-90 (2015) Article DOI: 10.1016/j.bmc.2015.05.003 BindingDB Entry DOI: 10.7270/Q2N01897
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Prolyl 4-hydroxylase subunit alpha-1 (Homo sapiens (Human))	BDBM26114 (CHEMBL88972 \| pyridine carboxylate, 6b \| pyridine-...) Show SMILES OC(=O)c1ccc(nc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	7.8	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Inhibition of human human recombinant CP4H1 expressed in Escherichia coli Origami B(DE3) pre-incubated for 2 mins followed by alpha-ketoglutarate add...				Bioorg Med Chem 23: 3081-90 (2015) Article DOI: 10.1016/j.bmc.2015.05.003 BindingDB Entry DOI: 10.7270/Q2N01897
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50241603 (CHEMBL4072121) Show SMILES OB(O)c1ccc(\C=C\c2cc(O)cc(O)c2)c(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site ...				J Med Chem 60: 7820-7834 (2017) Article DOI: 10.1021/acs.jmedchem.7b00952 BindingDB Entry DOI: 10.7270/Q26W9D7Z
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50241604 (CHEMBL4060726) Show SMILES OC(=O)c1cccc(\C=C\c2ccc(O)cc2)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site ...				J Med Chem 60: 7820-7834 (2017) Article DOI: 10.1021/acs.jmedchem.7b00952 BindingDB Entry DOI: 10.7270/Q26W9D7Z
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50241605 (CHEMBL4082603) Show SMILES OB(O)c1ccc(\C=C\c2cccc(c2)C(O)=O)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	990	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site ...				J Med Chem 60: 7820-7834 (2017) Article DOI: 10.1021/acs.jmedchem.7b00952 BindingDB Entry DOI: 10.7270/Q26W9D7Z
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50197883 (CHEBI:78538 \| FX-1006 \| Tafamidis \| US10377729, Co...) Show SMILES OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	278	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Binding affinity to wild type TTR (unknown origin) assessed as equilibrium dissociation constant of second site by isothermal titration calorimetry				J Med Chem 60: 7820-7834 (2017) Article DOI: 10.1021/acs.jmedchem.7b00952 BindingDB Entry DOI: 10.7270/Q26W9D7Z
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50241609 (CHEMBL4102478) Show SMILES Oc1ccc(\C=C\c2ccc(O)cc2Cl)c(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site ...				J Med Chem 60: 7820-7834 (2017) Article DOI: 10.1021/acs.jmedchem.7b00952 BindingDB Entry DOI: 10.7270/Q26W9D7Z
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50241612 (CHEMBL4078202) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site ...				J Med Chem 60: 7820-7834 (2017) Article DOI: 10.1021/acs.jmedchem.7b00952 BindingDB Entry DOI: 10.7270/Q26W9D7Z
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50197883 (CHEBI:78538 \| FX-1006 \| Tafamidis \| US10377729, Co...) Show SMILES OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site ...				J Med Chem 60: 7820-7834 (2017) Article DOI: 10.1021/acs.jmedchem.7b00952 BindingDB Entry DOI: 10.7270/Q26W9D7Z
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50241613 (CHEMBL4090439) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site ...				J Med Chem 60: 7820-7834 (2017) Article DOI: 10.1021/acs.jmedchem.7b00952 BindingDB Entry DOI: 10.7270/Q26W9D7Z
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50241614 (CHEMBL4069407) Show SMILES OC(=O)c1cccc(\C=C\c2ccc(O)cc2Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site ...				J Med Chem 60: 7820-7834 (2017) Article DOI: 10.1021/acs.jmedchem.7b00952 BindingDB Entry DOI: 10.7270/Q26W9D7Z
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50241615 (CHEMBL4065175) Show SMILES OB(O)c1cccc(\C=C\c2ccc(cc2Cl)B(O)O)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	790	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site ...				J Med Chem 60: 7820-7834 (2017) Article DOI: 10.1021/acs.jmedchem.7b00952 BindingDB Entry DOI: 10.7270/Q26W9D7Z
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM23926 ((E)-resveratrol \| 5-[(E)-2-(4-hydroxyphenyl)etheny...) Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site ...				J Med Chem 60: 7820-7834 (2017) Article DOI: 10.1021/acs.jmedchem.7b00952 BindingDB Entry DOI: 10.7270/Q26W9D7Z
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Ribonuclease pancreatic (Bison bison (American bison))	BDBM50391853 (CHEMBL2147156) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Inhibition of bovine RNase A interaction to ribonuclease inhibitor protein after 30 mins by competition assay				Bioorg Med Chem Lett 21: 2756-8 (2011) Article DOI: 10.1016/j.bmcl.2010.11.028 BindingDB Entry DOI: 10.7270/Q2QC04K6
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50241598 (CHEMBL4063503) Show SMILES OB(O)c1ccc(\C=C\c2cc(O)cc(O)c2)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site ...				J Med Chem 60: 7820-7834 (2017) Article DOI: 10.1021/acs.jmedchem.7b00952 BindingDB Entry DOI: 10.7270/Q26W9D7Z
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50241602 (CHEMBL4099088) Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)c(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site ...				J Med Chem 60: 7820-7834 (2017) Article DOI: 10.1021/acs.jmedchem.7b00952 BindingDB Entry DOI: 10.7270/Q26W9D7Z
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)