Found 43 hits with Last Name = 'reymundo' and Initial = 'i' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50326432
(CHEMBL1242995 | N-ethyl-4-methyl-5-(2-(4-(piperazi...)Show SMILES CCNc1nc(C)c(s1)-c1ccnc(Nc2ccc(cc2)N2CCNCC2)n1 Show InChI InChI=1S/C20H25N7S/c1-3-22-20-24-14(2)18(28-20)17-8-9-23-19(26-17)25-15-4-6-16(7-5-15)27-12-10-21-11-13-27/h4-9,21H,3,10-13H2,1-2H3,(H,22,24)(H,23,25,26) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of FLT3 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326421
(2,6-Dibromo-4-(6,7-dimethoxy-quinazolin-4-ylamino)...)Show InChI InChI=1S/C16H13Br2N3O3/c1-23-13-5-9-12(6-14(13)24-2)19-7-20-16(9)21-8-3-10(17)15(22)11(18)4-8/h3-7,22H,1-2H3,(H,19,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326413
(4-(9H-purin-6-ylamino)benzamide | CHEMBL1241463)Show InChI InChI=1S/C12H10N6O/c13-10(19)7-1-3-8(4-2-7)18-12-9-11(15-5-14-9)16-6-17-12/h1-6H,(H2,13,19)(H2,14,15,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM27344
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16) | PDB MMDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 171 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK2 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human)) | BDBM16314
(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)Show InChI InChI=1S/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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Patents
Similars
| PDB Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Biomar, S.A.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined |
J Med Chem 46: 5208-21 (2003)
Article DOI: 10.1021/jm030957n BindingDB Entry DOI: 10.7270/Q20Z72PQ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM3532
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50326412
(4-(3-(piperidin-4-yl)-1H-pyrazol-5-yl)pyridine | C...)Show InChI InChI=1S/C13H16N4/c1-5-14-6-2-10(1)12-9-13(17-16-12)11-3-7-15-8-4-11/h1-2,5-6,9,11,15H,3-4,7-8H2,(H,16,17) | PDB MMDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 575 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK2 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326429
(CHEMBL1240786 | N-(4-chlorophenyl)-1H-pyrazolo[3,4...)Show InChI InChI=1S/C11H8ClN5/c12-7-1-3-8(4-2-7)16-10-9-5-15-17-11(9)14-6-13-10/h1-6H,(H2,13,14,15,16,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM3032
(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)Show InChI InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326412
(4-(3-(piperidin-4-yl)-1H-pyrazol-5-yl)pyridine | C...)Show InChI InChI=1S/C13H16N4/c1-5-14-6-2-10(1)12-9-13(17-16-12)11-3-7-15-8-4-11/h1-2,5-6,9,11,15H,3-4,7-8H2,(H,16,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 646 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326428
(4-(9H-Purin-6-ylamino)-benzoic acid methyl ester |...)Show InChI InChI=1S/C13H11N5O2/c1-20-13(19)8-2-4-9(5-3-8)18-12-10-11(15-6-14-10)16-7-17-12/h2-7H,1H3,(H2,14,15,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50298223
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
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| Article PubMed
| n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326427
((4-Fluoro-phenyl)-(9H-purin-6-yl)-amine | CHEMBL36...)Show InChI InChI=1S/C11H8FN5/c12-7-1-3-8(4-2-7)17-11-9-10(14-5-13-9)15-6-16-11/h1-6H,(H2,13,14,15,16,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50321929
(3-((1-Cyclohexyl-3-hydroxypropan-2-ylamino)methyl)...)Show SMILES OCC(CC1CCCCC1)NCc1coc2cccc(OCC3CCCCC3)c2c1=O Show InChI InChI=1S/C26H37NO4/c28-16-22(14-19-8-3-1-4-9-19)27-15-21-18-31-24-13-7-12-23(25(24)26(21)29)30-17-20-10-5-2-6-11-20/h7,12-13,18-20,22,27-28H,1-6,8-11,14-17H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326430
(CHEMBL1240884 | N-(naphthalen-2-yl)-1H-pyrazolo[3,...)Show InChI InChI=1S/C15H11N5/c1-2-4-11-7-12(6-5-10(11)3-1)19-14-13-8-18-20-15(13)17-9-16-14/h1-9H,(H2,16,17,18,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326422
(3-(6-(methylamino)imidazo[1,2-b]pyridazin-3-yl)phe...)Show InChI InChI=1S/C13H12N4O/c1-14-12-5-6-13-15-8-11(17(13)16-12)9-3-2-4-10(18)7-9/h2-8,18H,1H3,(H,14,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM53334
(2-methoxy-N-[2-[1-(1-methylsulfanylpropan-2-yl)pip...)Show InChI InChI=1S/C20H28N4O2S/c1-15(14-27-3)23-12-9-16(10-13-23)24-19(8-11-21-24)22-20(25)17-6-4-5-7-18(17)26-2/h4-8,11,15-16H,9-10,12-14H2,1-3H3,(H,22,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50298223
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) | PDB MMDB
KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK2 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326416
(3-(4-chlorophenyl)-N-(2-methoxyethyl)imidazo[1,2-b...)Show InChI InChI=1S/C15H15ClN4O/c1-21-9-8-17-14-6-7-15-18-10-13(20(15)19-14)11-2-4-12(16)5-3-11/h2-7,10H,8-9H2,1H3,(H,17,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM3603
(4-N-(3-bromophenyl)-6-N-methylpyrido[3,4-d]pyrimid...)Show InChI InChI=1S/C14H12BrN5/c1-16-13-6-11-12(7-17-13)18-8-19-14(11)20-10-4-2-3-9(15)5-10/h2-8H,1H3,(H,16,17)(H,18,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326425
(CHEMBL1240674 | N-(cyclopropylmethyl)-5-(pyridin-4...)Show InChI InChI=1S/C13H13N5S/c1-2-9(1)7-15-12-17-18-11(8-16-13(18)19-12)10-3-5-14-6-4-10/h3-6,8-9H,1-2,7H2,(H,15,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326418
(3-(3-(4-fluorophenyl)imidazo[1,2-b]pyridazin-6-yla...)Show InChI InChI=1S/C15H15FN4O/c16-12-4-2-11(3-5-12)13-10-18-15-7-6-14(19-20(13)15)17-8-1-9-21/h2-7,10,21H,1,8-9H2,(H,17,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM27344
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50298223
(CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fl...)Show InChI InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of SGK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM3570
(8-[(3-Bromophenyl)amino]-1H-imidazo[4,5-g]quinazol...)Show InChI InChI=1S/C15H10BrN5/c16-9-2-1-3-10(4-9)21-15-11-5-13-14(19-7-18-13)6-12(11)17-8-20-15/h1-8H,(H,18,19)(H,17,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
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| Article PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326415
(2-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yla...)Show InChI InChI=1S/C14H13ClN4O/c15-11-3-1-10(2-4-11)12-9-17-14-6-5-13(16-7-8-20)18-19(12)14/h1-6,9,20H,7-8H2,(H,16,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human)) | BDBM50135849
(2,3,4-trichloro-6-(3,4,5-trichloro-2-hydroxyphenox...)Show SMILES Oc1c(Oc2cc(Cl)c(Cl)c(Cl)c2O)cc(Cl)c(Cl)c1Cl Show InChI InChI=1S/C12H4Cl6O3/c13-3-1-5(11(19)9(17)7(3)15)21-6-2-4(14)8(16)10(18)12(6)20/h1-2,19-20H | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Biomar, S.A.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined |
J Med Chem 46: 5208-21 (2003)
Article DOI: 10.1021/jm030957n BindingDB Entry DOI: 10.7270/Q20Z72PQ |
More data for this Ligand-Target Pair | |
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human)) | BDBM50135852
(2,3,4-tribromo-6-(3,4-dibromo-5-fluoro-2-hydroxyph...)Show InChI InChI=1S/C12H4Br5FO3/c13-3-1-5(11(19)9(16)7(3)14)21-6-2-4(18)8(15)10(17)12(6)20/h1-2,19-20H | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Biomar, S.A.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined |
J Med Chem 46: 5208-21 (2003)
Article DOI: 10.1021/jm030957n BindingDB Entry DOI: 10.7270/Q20Z72PQ |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326419
(3-(3-(2-fluorophenyl)imidazo[1,2-b]pyridazin-6-yla...)Show InChI InChI=1S/C15H15FN4O/c16-12-5-2-1-4-11(12)13-10-18-15-7-6-14(19-20(13)15)17-8-3-9-21/h1-2,4-7,10,21H,3,8-9H2,(H,17,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human)) | BDBM16312
((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)Show InChI InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Biomar, S.A.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined |
J Med Chem 46: 5208-21 (2003)
Article DOI: 10.1021/jm030957n BindingDB Entry DOI: 10.7270/Q20Z72PQ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326424
(3-(pyridin-4-yl)imidazo[1,2-b]pyridazine | CHEMBL1...)Show InChI InChI=1S/C11H8N4/c1-2-11-13-8-10(15(11)14-5-1)9-3-6-12-7-4-9/h1-8H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326423
(3-(4-fluorophenyl)-N-methylimidazo[1,2-b]pyridazin...)Show InChI InChI=1S/C13H11FN4/c1-15-12-6-7-13-16-8-11(18(13)17-12)9-2-4-10(14)5-3-9/h2-8H,1H3,(H,15,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326417
(3-(4-fluorophenyl)-N-(2-methoxyethyl)imidazo[1,2-b...)Show InChI InChI=1S/C15H15FN4O/c1-21-9-8-17-14-6-7-15-18-10-13(20(15)19-14)11-2-4-12(16)5-3-11/h2-7,10H,8-9H2,1H3,(H,17,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326420
(3-phenyl-N-(2-(pyridin-2-yl)ethyl)imidazo[1,2-b]py...)Show InChI InChI=1S/C19H17N5/c1-2-6-15(7-3-1)17-14-22-19-10-9-18(23-24(17)19)21-13-11-16-8-4-5-12-20-16/h1-10,12,14H,11,13H2,(H,21,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 4.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human)) | BDBM50135854
(2,4-Dibromo-6-(3,4,5-tribromo-2-hydroxy-phenoxy)-b...)Show InChI InChI=1S/C12H5Br5O4/c13-3-1-5(11(19)8(16)7(3)15)21-6-2-4(14)10(18)9(17)12(6)20/h1-2,18-20H | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Biomar, S.A.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined |
J Med Chem 46: 5208-21 (2003)
Article DOI: 10.1021/jm030957n BindingDB Entry DOI: 10.7270/Q20Z72PQ |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50309189
(4-(2-amino-5-phenylpyridin-3-yl)benzamide | CHEMBL...)Show InChI InChI=1S/C18H15N3O/c19-17-16(13-6-8-14(9-7-13)18(20)22)10-15(11-21-17)12-4-2-1-3-5-12/h1-11H,(H2,19,21)(H2,20,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human)) | BDBM50135850
(2,3,4,5-Tetrabromo-6-(3,4,5-tribromo-2-hydroxy-phe...)Show SMILES Oc1c(Oc2c(O)c(Br)c(Br)c(Br)c2Br)cc(Br)c(Br)c1Br Show InChI InChI=1S/C12H3Br7O3/c13-2-1-3(10(20)7(17)4(2)14)22-12-9(19)6(16)5(15)8(18)11(12)21/h1,20-21H | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Biomar, S.A.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined |
J Med Chem 46: 5208-21 (2003)
Article DOI: 10.1021/jm030957n BindingDB Entry DOI: 10.7270/Q20Z72PQ |
More data for this Ligand-Target Pair | |
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human)) | BDBM50135853
(2,3,4-tribromo-6-(3,4,5-tribromo-2-hydroxyphenoxy)...)Show SMILES Oc1c(Oc2cc(Br)c(Br)c(Br)c2O)cc(Br)c(Br)c1Br Show InChI InChI=1S/C12H4Br6O3/c13-3-1-5(11(19)9(17)7(3)15)21-6-2-4(14)8(16)10(18)12(6)20/h1-2,19-20H | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Biomar, S.A.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined |
J Med Chem 46: 5208-21 (2003)
Article DOI: 10.1021/jm030957n BindingDB Entry DOI: 10.7270/Q20Z72PQ |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326426
(CHEMBL1240675 | N-isobutyl-5-(pyridin-4-yl)imidazo...)Show InChI InChI=1S/C13H15N5S/c1-9(2)7-15-12-17-18-11(8-16-13(18)19-12)10-3-5-14-6-4-10/h3-6,8-9H,7H2,1-2H3,(H,15,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human)) | BDBM50135851
(2,3,4,5-tetrabromo-6-(3,5-dibromo-2-hydroxy-phenox...)Show SMILES Oc1c(Br)cc(Br)cc1Oc1c(O)c(Br)c(Br)c(Br)c1Br Show InChI InChI=1S/C12H4Br6O3/c13-3-1-4(14)10(19)5(2-3)21-12-9(18)7(16)6(15)8(17)11(12)20/h1-2,19-20H | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Biomar, S.A.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined |
J Med Chem 46: 5208-21 (2003)
Article DOI: 10.1021/jm030957n BindingDB Entry DOI: 10.7270/Q20Z72PQ |
More data for this Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50326414
(1H-pyrazolo[4,3-g]quinazolin-5(6H)-one | CHEMBL124...)Show InChI InChI=1S/C9H6N4O/c14-9-6-1-5-3-12-13-7(5)2-8(6)10-4-11-9/h1-4H,(H,12,13)(H,10,11,14) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 8.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
| Assay Description Inhibition of MNK1 |
J Med Chem 53: 6618-28 (2010)
Article DOI: 10.1021/jm1005513 BindingDB Entry DOI: 10.7270/Q2Z038CP |
More data for this Ligand-Target Pair | |
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human)) | BDBM50135856
(6-(2-Amino-3,4,5-tribromo-phenoxy)-2,3,4-tribromo-...)Show SMILES Nc1c(Br)c(Br)c(Br)cc1Oc1cc(Br)c(Br)c(Br)c1O Show InChI InChI=1S/C12H5Br6NO2/c13-3-1-5(11(19)9(17)7(3)15)21-6-2-4(14)8(16)10(18)12(6)20/h1-2,20H,19H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Biomar, S.A.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined |
J Med Chem 46: 5208-21 (2003)
Article DOI: 10.1021/jm030957n BindingDB Entry DOI: 10.7270/Q20Z72PQ |
More data for this Ligand-Target Pair | |
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human)) | BDBM50135855
(CHEMBL358713 | [2,3,4,5-Tetrabromo-6-(3,5-dibromo-...)Show SMILES OC(=O)COc1c(Br)cc(Br)cc1Oc1c(Br)c(Br)c(Br)c(Br)c1CC(O)=O Show InChI InChI=1S/C16H8Br6O6/c17-5-1-7(18)16(27-4-10(25)26)8(2-5)28-15-6(3-9(23)24)11(19)12(20)13(21)14(15)22/h1-2H,3-4H2,(H,23,24)(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Instituto Biomar, S.A.
Curated by ChEMBL
| Assay Description In vitro inhibitory activity against recombinant human aldose reductase (ALR2) was determined |
J Med Chem 46: 5208-21 (2003)
Article DOI: 10.1021/jm030957n BindingDB Entry DOI: 10.7270/Q20Z72PQ |
More data for this Ligand-Target Pair | |