Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Enoyl-acyl-carrier protein reductase (Plasmodium falciparum) | BDBM8726 (5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 0.00190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Immunology Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum ENR in presence of EGCG by dilution assay | J Med Chem 50: 765-75 (2007) Article DOI: 10.1021/jm061154d BindingDB Entry DOI: 10.7270/Q2QJ7J4Q | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase MRCK alpha (Homo sapiens (Human)) | BDBM572232 (3-[4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- py...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.00500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM106870 (US8592455, 70) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | 0.00600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of PIM1 kinase (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by alphascreen assay | J Med Chem 58: 8373-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01275 BindingDB Entry DOI: 10.7270/Q2H41VGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50500526 (CHEMBL3747517) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.00600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of PDE10A (unknown origin) by IMAP assay | Bioorg Med Chem Lett 26: 126-32 (2016) Article DOI: 10.1016/j.bmcl.2015.11.013 BindingDB Entry DOI: 10.7270/Q2NP27FW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM126826 (US8785467, 1-29) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 0.00820 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assay | J Med Chem 58: 7888-94 (2015) Article DOI: 10.1021/acs.jmedchem.5b00983 BindingDB Entry DOI: 10.7270/Q26Q202C | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human)) | BDBM106870 (US8592455, 70) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | 0.00900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of PIM3 kinase (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by alphascreen assay | J Med Chem 58: 8373-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01275 BindingDB Entry DOI: 10.7270/Q2H41VGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50500520 (CHEMBL3746993) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of PDE10A (unknown origin) by IMAP assay | Bioorg Med Chem Lett 26: 126-32 (2016) Article DOI: 10.1016/j.bmcl.2015.11.013 BindingDB Entry DOI: 10.7270/Q2NP27FW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50500521 (CHEMBL3746277) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of PDE10A (unknown origin) by IMAP assay | Bioorg Med Chem Lett 26: 126-32 (2016) Article DOI: 10.1016/j.bmcl.2015.11.013 BindingDB Entry DOI: 10.7270/Q2NP27FW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50500538 (CHEMBL3745790) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of PDE10A (unknown origin) by IMAP assay | Bioorg Med Chem Lett 26: 126-32 (2016) Article DOI: 10.1016/j.bmcl.2015.11.013 BindingDB Entry DOI: 10.7270/Q2NP27FW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK beta (Homo sapiens (Human)) | BDBM572231 (3-[4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- py...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK alpha (Homo sapiens (Human)) | BDBM572231 (3-[4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- py...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK alpha (Homo sapiens (Human)) | BDBM572233 ((6S)-8-(3-pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridin-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | US Patent | 0.0140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK beta (Homo sapiens (Human)) | BDBM572232 (3-[4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- py...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK alpha (Homo sapiens (Human)) | BDBM572237 (2-[4-[(5S)-2,6-diazaspiro[4.5]decan-2-yl]-1H- pyrr...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM50387298 (CHEMBL2048872) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of PIM1 kinase (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by alphascreen assay | J Med Chem 58: 8373-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01275 BindingDB Entry DOI: 10.7270/Q2H41VGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human)) | BDBM106870 (US8592455, 70) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | 0.0180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of PIM2 kinase (unknown origin) using Biotin-AGAGRSRHSSYPAGT-OH as substrate after 2 hrs by alphascreen assay | J Med Chem 58: 8373-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01275 BindingDB Entry DOI: 10.7270/Q2H41VGN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK alpha (Homo sapiens (Human)) | BDBM572236 ((6S)-1-methyl-8-(3-pyrimidin-4-yl-1H-pyrrolo[2,3- ...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM126825 (US8785467, 1-27) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assay | J Med Chem 58: 7888-94 (2015) Article DOI: 10.1021/acs.jmedchem.5b00983 BindingDB Entry DOI: 10.7270/Q26Q202C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-P receptor (Homo sapiens (Human)) | BDBM50186527 ((R)-3-((1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)m...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute Curated by ChEMBL | Assay Description Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cells | Bioorg Med Chem Lett 16: 3859-63 (2006) Article DOI: 10.1016/j.bmcl.2006.04.031 BindingDB Entry DOI: 10.7270/Q2QV3M44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50500519 (CHEMBL3746917) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of PDE10A (unknown origin) by IMAP assay | Bioorg Med Chem Lett 26: 126-32 (2016) Article DOI: 10.1016/j.bmcl.2015.11.013 BindingDB Entry DOI: 10.7270/Q2NP27FW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM50500535 (CHEMBL3747450) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of PDE10A (unknown origin) by IMAP assay | Bioorg Med Chem Lett 26: 126-32 (2016) Article DOI: 10.1016/j.bmcl.2015.11.013 BindingDB Entry DOI: 10.7270/Q2NP27FW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK alpha (Homo sapiens (Human)) | BDBM572244 (2-[4-[(5S)-2,6-diazaspiro[4.5]decan-2-yl]-1H- pyrr...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human)) | BDBM50315401 ((R)-1-((2'-oxo-1',2',6,8-tetrahydrospiro[cyclopent...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck& Co. Curated by ChEMBL | Assay Description Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1 | Bioorg Med Chem Lett 20: 2572-6 (2010) Article DOI: 10.1016/j.bmcl.2010.02.086 BindingDB Entry DOI: 10.7270/Q2765FFZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK beta (Homo sapiens (Human)) | BDBM572233 ((6S)-8-(3-pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridin-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB US Patent | 0.0230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase MRCK beta (Homo sapiens (Human)) | BDBM572234 (2-[4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- py...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK beta (Homo sapiens (Human)) | BDBM572235 ((6S)-8-(3-pyridazin-4-yl-1H-pyrrolo[2,3-b]pyridin-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK beta (Homo sapiens (Human)) | BDBM572236 ((6S)-1-methyl-8-(3-pyrimidin-4-yl-1H-pyrrolo[2,3- ...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK alpha (Homo sapiens (Human)) | BDBM572282 ((6S)-8-(3-pyrimidin-5-yl-1H-pyrrolo[2,3-b]pyridin-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK alpha (Homo sapiens (Human)) | BDBM572240 ((6S)-1-ethyl-8-(3-pyrimidin-4-yl-1H-pyrrolo[2,3- b...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK beta (Homo sapiens (Human)) | BDBM572237 (2-[4-[(5S)-2,6-diazaspiro[4.5]decan-2-yl]-1H- pyrr...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50521464 (CHEMBL4469869 | US11596639, Example 78) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine Curated by ChEMBL | Assay Description Inhibition of FITC-labeled Bak peptide binding to MBP-fused Mcl-1 (unknown origin) measured after 3 hrs by TR-FRET assay | J Med Chem 62: 3971-3988 (2019) Article DOI: 10.1021/acs.jmedchem.8b01991 BindingDB Entry DOI: 10.7270/Q2V69P04 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50521464 (CHEMBL4469869 | US11596639, Example 78) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine Curated by ChEMBL | Assay Description Inhibition of FITC-labeled Bak peptide binding to MBP-fused Mcl-1 (unknown origin) measured after 3 hrs by TR-FRET assay | J Med Chem 62: 3971-3988 (2019) Article DOI: 10.1021/acs.jmedchem.8b01991 BindingDB Entry DOI: 10.7270/Q2V69P04 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM126823 (US8785467, 1-20) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of PDE10A (unknown origin) by IMAP assay | Bioorg Med Chem Lett 26: 126-32 (2016) Article DOI: 10.1016/j.bmcl.2015.11.013 BindingDB Entry DOI: 10.7270/Q2NP27FW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM126823 (US8785467, 1-20) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of PDE10A (unknown origin) by IMAP assay | Bioorg Med Chem Lett 26: 126-32 (2016) Article DOI: 10.1016/j.bmcl.2015.11.013 BindingDB Entry DOI: 10.7270/Q2NP27FW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM50521464 (CHEMBL4469869 | US11596639, Example 78) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine Curated by ChEMBL | Assay Description Inhibition of FITC-labeled Bak peptide binding to MBP-fused Mcl-1 (unknown origin) measured after 3 hrs by TR-FRET assay | J Med Chem 62: 3971-3988 (2019) Article DOI: 10.1021/acs.jmedchem.8b01991 BindingDB Entry DOI: 10.7270/Q2V69P04 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human)) | BDBM50442922 (CHEMBL3086984) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.0310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Curated by ChEMBL | Assay Description Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assay | J Med Chem 56: 8404-21 (2013) Article DOI: 10.1021/jm4008455 BindingDB Entry DOI: 10.7270/Q2JW8GBV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK alpha (Homo sapiens (Human)) | BDBM572249 ((5S)-2-(3-pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridin-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human)) | BDBM50442927 (CHEMBL3086994) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Curated by ChEMBL | Assay Description Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assay | J Med Chem 56: 8404-21 (2013) Article DOI: 10.1021/jm4008455 BindingDB Entry DOI: 10.7270/Q2JW8GBV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK alpha (Homo sapiens (Human)) | BDBM572234 (2-[4-[(6S)-1,8-diazaspiro[5.5]undecan-8-yl]-1H- py...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK beta (Homo sapiens (Human)) | BDBM572239 ((6S)-8-[3-(2-pyridyl)-1H-pyrrolo[2,3-b]pyridin-4-y...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK beta (Homo sapiens (Human)) | BDBM572238 (2-[4-(1-ethyl-1,8-diazaspiro[5.5]undecan-8-yl)-1H-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50007377 (2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2-pyr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Adolor Corporation Curated by ChEMBL | Assay Description Binding affinity for human Kappa opioid receptor | Bioorg Med Chem Lett 14: 5693-7 (2004) Article DOI: 10.1016/j.bmcl.2004.08.041 BindingDB Entry DOI: 10.7270/Q27D2TMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM126827 (US8785467, 1-32) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of human PDE10A2 transfected in AD293 cells by IMAP FP assay | J Med Chem 58: 7888-94 (2015) Article DOI: 10.1021/acs.jmedchem.5b00983 BindingDB Entry DOI: 10.7270/Q26Q202C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcitonin gene-related peptide type 1 receptor (Homo sapiens (Human)) | BDBM50254445 ((S)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck& Co. Curated by ChEMBL | Assay Description Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1 | Bioorg Med Chem Lett 20: 2572-6 (2010) Article DOI: 10.1016/j.bmcl.2010.02.086 BindingDB Entry DOI: 10.7270/Q2765FFZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK beta (Homo sapiens (Human)) | BDBM572240 ((6S)-1-ethyl-8-(3-pyrimidin-4-yl-1H-pyrrolo[2,3- b...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK alpha (Homo sapiens (Human)) | BDBM572243 ((5S)-2-(3-pyrimidin-5-yl-1H-pyrrolo[2,3-b]pyridin-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Electrophorus electricus (Electric eel)) | BDBM50560609 (CHEMBL4749763) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0417 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Mixed type inhibition of electric eel AChE assessed as inhibition constant using varying levels of acetylthiocholine as substrate by reciprocal Linew... | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127477 BindingDB Entry DOI: 10.7270/Q2W099MW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase MRCK alpha (Homo sapiens (Human)) | BDBM572239 ((6S)-8-[3-(2-pyridyl)-1H-pyrrolo[2,3-b]pyridin-4-y...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2VD72PZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human)) | BDBM50442921 (CHEMBL3086985) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Curated by ChEMBL | Assay Description Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assay | J Med Chem 56: 8404-21 (2013) Article DOI: 10.1021/jm4008455 BindingDB Entry DOI: 10.7270/Q2JW8GBV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human)) | BDBM50442924 (CHEMBL3086982) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0460 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University Curated by ChEMBL | Assay Description Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assay | J Med Chem 56: 8404-21 (2013) Article DOI: 10.1021/jm4008455 BindingDB Entry DOI: 10.7270/Q2JW8GBV | |||||||||||
More data for this Ligand-Target Pair |
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