Compile Data Set for Download or QSAR

Found 740 hits with Last Name = 'sherman' and Initial = 'b'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156774 (CHEMBL3792888) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(CO)cc1 Show InChI InChI=1S/C19H19N3O2/c20-10-18(14-3-1-13(12-23)2-4-14)19(24)22-17-6-5-16-11-21-8-7-15(16)9-17/h1-9,11,18,23H,10,12,20H2,(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156799 (CHEMBL3793004) Show SMILES NC[C@@H](C(=O)Nc1ccc2cnccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C18H17N3O/c19-11-17(13-4-2-1-3-5-13)18(22)21-16-7-6-15-12-20-9-8-14(15)10-16/h1-10,12,17H,11,19H2,(H,21,22)/t17-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156788 (CHEMBL3794104) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(Cl)cc1 Show InChI InChI=1S/C18H16ClN3O/c19-15-4-1-12(2-5-15)17(10-20)18(23)22-16-6-3-14-11-21-8-7-13(14)9-16/h1-9,11,17H,10,20H2,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156784 (CHEMBL3792673) Show SMILES Cc1ccc(cc1)C(CN)C(=O)Nc1ccc2cnccc2c1 Show InChI InChI=1S/C19H19N3O/c1-13-2-4-14(5-3-13)18(11-20)19(23)22-17-7-6-16-12-21-9-8-15(16)10-17/h2-10,12,18H,11,20H2,1H3,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156782 (CHEMBL3792663) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(O)cc1 Show InChI InChI=1S/C18H17N3O2/c19-10-17(12-2-5-16(22)6-3-12)18(23)21-15-4-1-14-11-20-8-7-13(14)9-15/h1-9,11,17,22H,10,19H2,(H,21,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156683 (CHEMBL3793788) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(COC(=O)c2cccnc2)cc1 Show InChI InChI=1S/C25H22N4O3/c26-13-23(24(30)29-22-8-7-20-14-28-11-9-19(20)12-22)18-5-3-17(4-6-18)16-32-25(31)21-2-1-10-27-15-21/h1-12,14-15,23H,13,16,26H2,(H,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156732 (CHEMBL3793497) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc2ccccc2c1 Show InChI InChI=1S/C22H19N3O/c23-13-21(18-6-5-15-3-1-2-4-16(15)11-18)22(26)25-20-8-7-19-14-24-10-9-17(19)12-20/h1-12,14,21H,13,23H2,(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50148579 (CHEMBL3770836) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccccc1 Show InChI InChI=1S/C18H17N3O/c19-11-17(13-4-2-1-3-5-13)18(22)21-16-7-6-15-12-20-9-8-14(15)10-16/h1-10,12,17H,11,19H2,(H,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156687 (CHEMBL3793029) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(COC(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C27H25N3O3/c28-16-25(27(32)30-24-11-10-23-17-29-13-12-22(23)15-24)21-8-6-20(7-9-21)18-33-26(31)14-19-4-2-1-3-5-19/h1-13,15,17,25H,14,16,18,28H2,(H,30,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156787 (CHEMBL3793404) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(Cl)cc1Cl Show InChI InChI=1S/C18H15Cl2N3O/c19-13-2-4-15(17(20)8-13)16(9-21)18(24)23-14-3-1-12-10-22-6-5-11(12)7-14/h1-8,10,16H,9,21H2,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156685 (CHEMBL3792412) Show SMILES Cc1cc(C)cc(c1)C(=O)OCc1ccc(cc1)C(CN)C(=O)Nc1ccc2cnccc2c1 Show InChI InChI=1S/C28H27N3O3/c1-18-11-19(2)13-24(12-18)28(33)34-17-20-3-5-21(6-4-20)26(15-29)27(32)31-25-8-7-23-16-30-10-9-22(23)14-25/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156789 (CHEMBL3793505) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1cccc(Cl)c1 Show InChI InChI=1S/C18H16ClN3O/c19-15-3-1-2-13(8-15)17(10-20)18(23)22-16-5-4-14-11-21-7-6-12(14)9-16/h1-9,11,17H,10,20H2,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156793 (CHEMBL3792921) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(F)cc1 Show InChI InChI=1S/C18H16FN3O/c19-15-4-1-12(2-5-15)17(10-20)18(23)22-16-6-3-14-11-21-8-7-13(14)9-16/h1-9,11,17H,10,20H2,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156733 (CHEMBL3793296) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1cccc2ccccc12 Show InChI InChI=1S/C22H19N3O/c23-13-21(20-7-3-5-15-4-1-2-6-19(15)20)22(26)25-18-9-8-17-14-24-11-10-16(17)12-18/h1-12,14,21H,13,23H2,(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156794 (CHEMBL3792666) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1cccc(F)c1 Show InChI InChI=1S/C18H16FN3O/c19-15-3-1-2-13(8-15)17(10-20)18(23)22-16-5-4-14-11-21-7-6-12(14)9-16/h1-9,11,17H,10,20H2,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156691 (CHEMBL3792435) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(OC(=O)CN)cc1 Show InChI InChI=1S/C20H20N4O3/c21-10-18(13-2-5-17(6-3-13)27-19(25)11-22)20(26)24-16-4-1-15-12-23-8-7-14(15)9-16/h1-9,12,18H,10-11,21-22H2,(H,24,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156795 (CHEMBL3794270) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccccc1F Show InChI InChI=1S/C18H16FN3O/c19-17-4-2-1-3-15(17)16(10-20)18(23)22-14-6-5-13-11-21-8-7-12(13)9-14/h1-9,11,16H,10,20H2,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156780 (CHEMBL3794298) Show SMILES Cc1cc(ccc1O)C(CN)C(=O)Nc1ccc2cnccc2c1 Show InChI InChI=1S/C19H19N3O2/c1-12-8-14(3-5-18(12)23)17(10-20)19(24)22-16-4-2-15-11-21-7-6-13(15)9-16/h2-9,11,17,23H,10,20H2,1H3,(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156786 (CHEMBL3793489) Show SMILES Cc1ccccc1C(CN)C(=O)Nc1ccc2cnccc2c1 Show InChI InChI=1S/C19H19N3O/c1-13-4-2-3-5-17(13)18(11-20)19(23)22-16-7-6-15-12-21-9-8-14(15)10-16/h2-10,12,18H,11,20H2,1H3,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156791 (CHEMBL3793969) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(F)c(F)c1 Show InChI InChI=1S/C18H15F2N3O/c19-16-4-2-12(8-17(16)20)15(9-21)18(24)23-14-3-1-13-10-22-6-5-11(13)7-14/h1-8,10,15H,9,21H2,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156777 (CHEMBL3793516) Show SMILES COc1ccc(cc1)C(CN)C(=O)Nc1ccc2cnccc2c1 Show InChI InChI=1S/C19H19N3O2/c1-24-17-6-3-13(4-7-17)18(11-20)19(23)22-16-5-2-15-12-21-9-8-14(15)10-16/h2-10,12,18H,11,20H2,1H3,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156783 (CHEMBL3792734) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1cccc(O)c1 Show InChI InChI=1S/C18H17N3O2/c19-10-17(13-2-1-3-16(22)9-13)18(23)21-15-5-4-14-11-20-7-6-12(14)8-15/h1-9,11,17,22H,10,19H2,(H,21,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156790 (CHEMBL3792549) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccccc1Cl Show InChI InChI=1S/C18H16ClN3O/c19-17-4-2-1-3-15(17)16(10-20)18(23)22-14-6-5-13-11-21-8-7-12(13)9-14/h1-9,11,16H,10,20H2,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50148578 (CHEMBL3770730) Show SMILES NC(C(=O)Nc1ccc2cnccc2c1)c1ccccc1 Show InChI InChI=1S/C17H15N3O/c18-16(12-4-2-1-3-5-12)17(21)20-15-7-6-14-11-19-9-8-13(14)10-15/h1-11,16H,18H2,(H,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156797 (CHEMBL3793538) Show SMILES NCCC(C(=O)Nc1ccc2cnccc2c1)c1ccccc1 Show InChI InChI=1S/C19H19N3O/c20-10-8-18(14-4-2-1-3-5-14)19(23)22-17-7-6-16-13-21-11-9-15(16)12-17/h1-7,9,11-13,18H,8,10,20H2,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156684 (CHEMBL3793688) Show SMILES CCCCC(=O)OCc1ccc(cc1)C(CN)C(=O)Nc1ccc2cnccc2c1 Show InChI InChI=1S/C24H27N3O3/c1-2-3-4-23(28)30-16-17-5-7-18(8-6-17)22(14-25)24(29)27-21-10-9-20-15-26-12-11-19(20)13-21/h5-13,15,22H,2-4,14,16,25H2,1H3,(H,27,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156688 (CHEMBL3792969) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(COC(=O)c2ccccc2)cc1 Show InChI InChI=1S/C26H23N3O3/c27-15-24(25(30)29-23-11-10-22-16-28-13-12-21(22)14-23)19-8-6-18(7-9-19)17-32-26(31)20-4-2-1-3-5-20/h1-14,16,24H,15,17,27H2,(H,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156734 (CHEMBL3793235) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C19H16F3N3O/c20-19(21,22)15-4-1-12(2-5-15)17(10-23)18(26)25-16-6-3-14-11-24-8-7-13(14)9-16/h1-9,11,17H,10,23H2,(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156711 (CHEMBL3792599) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(OC(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C26H23N3O3/c27-16-24(26(31)29-22-9-6-21-17-28-13-12-20(21)15-22)19-7-10-23(11-8-19)32-25(30)14-18-4-2-1-3-5-18/h1-13,15,17,24H,14,16,27H2,(H,29,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156776 (CHEMBL3792593) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(OCc2ccccc2)cc1 Show InChI InChI=1S/C25H23N3O2/c26-15-24(25(29)28-22-9-6-21-16-27-13-12-20(21)14-22)19-7-10-23(11-8-19)30-17-18-4-2-1-3-5-18/h1-14,16,24H,15,17,26H2,(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156778 (CHEMBL3793153) Show SMILES COc1cccc(c1)C(CN)C(=O)Nc1ccc2cnccc2c1 Show InChI InChI=1S/C19H19N3O2/c1-24-17-4-2-3-14(10-17)18(11-20)19(23)22-16-6-5-15-12-21-8-7-13(15)9-16/h2-10,12,18H,11,20H2,1H3,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156792 (CHEMBL3792581) Show SMILES NCC(C(=O)Nc1ccc2c(O)nccc2c1)c1ccc(F)cc1 Show InChI InChI=1S/C18H16FN3O2/c19-13-3-1-11(2-4-13)16(10-20)18(24)22-14-5-6-15-12(9-14)7-8-21-17(15)23/h1-9,16H,10,20H2,(H,21,23)(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156796 (CHEMBL3792781) Show SMILES NCC(C(=O)Nc1ccc2c(O)nccc2c1)c1ccccc1 Show InChI InChI=1S/C18H17N3O2/c19-11-16(12-4-2-1-3-5-12)18(23)21-14-6-7-15-13(10-14)8-9-20-17(15)22/h1-10,16H,11,19H2,(H,20,22)(H,21,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50319005 ((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...) Show SMILES C[C@@H](N)c1ccc(cc1)C(=O)Nc1ccnc2[nH]ccc12 |r| Show InChI InChI=1S/C16H16N4O/c1-10(17)11-2-4-12(5-3-11)16(21)20-14-7-9-19-15-13(14)6-8-18-15/h2-10H,17H2,1H3,(H2,18,19,20,21)/t10-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156735 (CHEMBL3793203) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C19H16F3N3O/c20-19(21,22)15-3-1-2-13(8-15)17(10-23)18(26)25-16-5-4-14-11-24-7-6-12(14)9-16/h1-9,11,17H,10,23H2,(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156775 (CHEMBL3792689) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1cccc(CO)c1 Show InChI InChI=1S/C19H19N3O2/c20-10-18(15-3-1-2-13(8-15)12-23)19(24)22-17-5-4-16-11-21-7-6-14(16)9-17/h1-9,11,18,23H,10,12,20H2,(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156690 (CHEMBL3794444) Show SMILES CC(C)C(=O)OCc1ccc(cc1)C(CN)C(=O)Nc1ccc2cnccc2c1 Show InChI InChI=1S/C23H25N3O3/c1-15(2)23(28)29-14-16-3-5-17(6-4-16)21(12-24)22(27)26-20-8-7-19-13-25-10-9-18(19)11-20/h3-11,13,15,21H,12,14,24H2,1-2H3,(H,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156785 (CHEMBL3794198) Show SMILES Cc1cccc(c1)C(CN)C(=O)Nc1ccc2cnccc2c1 Show InChI InChI=1S/C19H19N3O/c1-13-3-2-4-15(9-13)18(11-20)19(23)22-17-6-5-16-12-21-8-7-14(16)10-17/h2-10,12,18H,11,20H2,1H3,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156686 (CHEMBL3794389 | US11485707, Example 23) Show SMILES Cc1ccc(C(=O)OCc2ccc(cc2)C(CN)C(=O)Nc2ccc3cnccc3c2)c(C)c1 Show InChI InChI=1S/C28H27N3O3/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM50473665 (CHEMBL70751) Show SMILES CSc1ccc(Cl)cc1NCC1=NCCN1 |t:12| Show InChI InChI=1S/C11H14ClN3S/c1-16-10-3-2-8(12)6-9(10)15-7-11-13-4-5-14-11/h2-3,6,15H,4-5,7H2,1H3,(H,13,14)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	4.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research Laboratories Curated by ChEMBL					Assay Description Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes				J Med Chem 45: 2229-39 (2002) Article DOI: 10.1021/jm000542r BindingDB Entry DOI: 10.7270/Q2NG4TCQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156692 (CHEMBL3792612) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(OC(=O)c2cccnc2)cc1 Show InChI InChI=1S/C24H20N4O3/c25-13-22(23(29)28-20-6-3-18-14-27-11-9-17(18)12-20)16-4-7-21(8-5-16)31-24(30)19-2-1-10-26-15-19/h1-12,14-15,22H,13,25H2,(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM50473678 (CHEMBL306792) Show SMILES CSc1cc(F)ccc1NCC1=NCCN1 |t:12| Show InChI InChI=1S/C11H14FN3S/c1-16-10-6-8(12)2-3-9(10)15-7-11-13-4-5-14-11/h2-3,6,15H,4-5,7H2,1H3,(H,13,14)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research Laboratories Curated by ChEMBL					Assay Description Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes				J Med Chem 45: 2229-39 (2002) Article DOI: 10.1021/jm000542r BindingDB Entry DOI: 10.7270/Q2NG4TCQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156781 (CHEMBL3794254) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(O)c(O)c1 Show InChI InChI=1S/C18H17N3O3/c19-9-15(12-2-4-16(22)17(23)8-12)18(24)21-14-3-1-13-10-20-6-5-11(13)7-14/h1-8,10,15,22-23H,9,19H2,(H,21,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM50473672 (CHEMBL72768) Show SMILES CSc1ccc(F)cc1NCC1=NCCN1 |t:12| Show InChI InChI=1S/C11H14FN3S/c1-16-10-3-2-8(12)6-9(10)15-7-11-13-4-5-14-11/h2-3,6,15H,4-5,7H2,1H3,(H,13,14)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	6.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research Laboratories Curated by ChEMBL					Assay Description Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes				J Med Chem 45: 2229-39 (2002) Article DOI: 10.1021/jm000542r BindingDB Entry DOI: 10.7270/Q2NG4TCQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156729 (CHEMBL3794435) Show SMILES NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(OC(=O)c2ccccc2)cc1 Show InChI InChI=1S/C25H21N3O3/c26-15-23(24(29)28-21-9-6-20-16-27-13-12-19(20)14-21)17-7-10-22(11-8-17)31-25(30)18-4-2-1-3-5-18/h1-14,16,23H,15,26H2,(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156779 (CHEMBL3793368) Show SMILES COc1cc(ccc1O)C(CN)C(=O)Nc1ccc2cnccc2c1 Show InChI InChI=1S/C19H19N3O3/c1-25-18-9-13(3-5-17(18)23)16(10-20)19(24)22-15-4-2-14-11-21-7-6-12(14)8-15/h2-9,11,16,23H,10,20H2,1H3,(H,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM50421580 (CHEMBL117248) Show SMILES CSc1ccccc1NCC1=NCCN1 |t:11| Show InChI InChI=1S/C11H15N3S/c1-15-10-5-3-2-4-9(10)14-8-11-12-6-7-13-11/h2-5,14H,6-8H2,1H3,(H,12,13)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research Laboratories Curated by ChEMBL					Assay Description Affinity to human Alpha-1D adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes				J Med Chem 45: 2229-39 (2002) Article DOI: 10.1021/jm000542r BindingDB Entry DOI: 10.7270/Q2NG4TCQ
					More data for this Ligand-Target Pair
Alpha-1B adrenergic receptor (Homo sapiens (Human))	BDBM50473678 (CHEMBL306792) Show SMILES CSc1cc(F)ccc1NCC1=NCCN1 |t:12| Show InChI InChI=1S/C11H14FN3S/c1-16-10-6-8(12)2-3-9(10)15-7-11-13-4-5-14-11/h2-3,6,15H,4-5,7H2,1H3,(H,13,14)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research Laboratories Curated by ChEMBL					Assay Description Affinity to human Alpha-1B adrenergic receptor determined by radioligand binding techniques from rat-1 fibroblasts membranes				J Med Chem 45: 2229-39 (2002) Article DOI: 10.1021/jm000542r BindingDB Entry DOI: 10.7270/Q2NG4TCQ
					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Homo sapiens (Human))	BDBM30712 (6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimet...) Show SMILES Cc1cc(c(O)c(C)c1CC1=NCCN1)C(C)(C)C |t:11| Show InChI InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research Laboratories Curated by ChEMBL					Assay Description Affinity to human Alpha-2A adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells				J Med Chem 45: 2229-39 (2002) Article DOI: 10.1021/jm000542r BindingDB Entry DOI: 10.7270/Q2NG4TCQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50156798 (CHEMBL3793245) Show SMILES NC[C@H](C(=O)Nc1ccc2cnccc2c1)c1ccccc1 |r| Show InChI InChI=1S/C18H17N3O/c19-11-17(13-4-2-1-3-5-13)18(22)21-16-7-6-15-12-20-9-8-14(15)10-16/h1-10,12,17H,11,19H2,(H,21,22)/t17-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Aerie Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of ROCK2 (unknown origin) using RSK2 peptide (KKRNRTLTK) as substrate after 180 mins by luminescent kinase assay				Bioorg Med Chem Lett 26: 2475-80 (2016) Article DOI: 10.1016/j.bmcl.2016.03.104 BindingDB Entry DOI: 10.7270/Q2VD71CH
					More data for this Ligand-Target Pair

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