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Compile Data Set for Download or QSAR

Found 111 hits with Last Name = 'struzynski' and Initial = 'c'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50313558
PNG
((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Show SMILES CN1CCN(CC1)c1cc(C)c2nc([nH]c2c1)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O |r|
Show InChI InChI=1S/C26H29ClN6O2/c1-16-12-19(33-10-8-32(2)9-11-33)14-21-24(16)31-25(30-21)23-20(6-7-28-26(23)35)29-15-22(34)17-4-3-5-18(27)13-17/h3-7,12-14,22,34H,8-11,15H2,1-2H3,(H,30,31)(H2,28,29,35)/t22-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50313564
PNG
(3-(6-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCC(CC1)N1C[C@@H]2C[C@H]1CO2 |r|
Show InChI InChI=1S/C31H35ClN6O3/c1-18-11-22(37-9-6-21(7-10-37)38-16-24-13-23(38)17-41-24)14-26-29(18)36-30(35-26)28-25(5-8-33-31(28)40)34-15-27(39)19-3-2-4-20(32)12-19/h2-5,8,11-12,14,21,23-24,27,39H,6-7,9-10,13,15-17H2,1H3,(H,35,36)(H2,33,34,40)/t23-,24-,27+/m0/s1
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n/an/a 29n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50313557
PNG
((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCNCC1 |r|
Show InChI InChI=1S/C25H27ClN6O2/c1-15-11-18(32-9-7-27-8-10-32)13-20-23(15)31-24(30-20)22-19(5-6-28-25(22)34)29-14-21(33)16-3-2-4-17(26)12-16/h2-6,11-13,21,27,33H,7-10,14H2,1H3,(H,30,31)(H2,28,29,34)/t21-/m1/s1
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n/an/a 32n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50313559
PNG
((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCN(CCF)CC1 |r|
Show InChI InChI=1S/C27H30ClFN6O2/c1-17-13-20(35-11-9-34(8-6-29)10-12-35)15-22-25(17)33-26(32-22)24-21(5-7-30-27(24)37)31-16-23(36)18-3-2-4-19(28)14-18/h2-5,7,13-15,23,36H,6,8-12,16H2,1H3,(H,32,33)(H2,30,31,37)/t23-/m1/s1
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n/an/a 32n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234509
PNG
(4-(2-(5-chloro-1-methyl-1H-imidazol-4-yl)ethylamin...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2ncn(C)c2Cl)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C23H26ClN7O2/c1-14-11-15(31-7-9-33-10-8-31)12-18-20(14)29-22(28-18)19-16(3-6-26-23(19)32)25-5-4-17-21(24)30(2)13-27-17/h3,6,11-13H,4-5,7-10H2,1-2H3,(H,28,29)(H2,25,26,32)
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n/an/a 38n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234509
PNG
(4-(2-(5-chloro-1-methyl-1H-imidazol-4-yl)ethylamin...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2ncn(C)c2Cl)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C23H26ClN7O2/c1-14-11-15(31-7-9-33-10-8-31)12-18-20(14)29-22(28-18)19-16(3-6-26-23(19)32)25-5-4-17-21(24)30(2)13-27-17/h3,6,11-13H,4-5,7-10H2,1-2H3,(H,28,29)(H2,25,26,32)
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n/an/a 38n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50313561
PNG
(3-(6-((S)-3-aminopyrrolidin-1-yl)-4-methyl-1H-benz...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CC[C@H](N)C1 |r|
Show InChI InChI=1S/C25H27ClN6O2/c1-14-9-18(32-8-6-17(27)13-32)11-20-23(14)31-24(30-20)22-19(5-7-28-25(22)34)29-12-21(33)15-3-2-4-16(26)10-15/h2-5,7,9-11,17,21,33H,6,8,12-13,27H2,1H3,(H,30,31)(H2,28,29,34)/t17-,21+/m0/s1
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n/an/a 42n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50252293
PNG
((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCC(CC1)N1CCOCC1 |r|
Show InChI InChI=1S/C30H35ClN6O3/c1-19-15-23(36-9-6-22(7-10-36)37-11-13-40-14-12-37)17-25-28(19)35-29(34-25)27-24(5-8-32-30(27)39)33-18-26(38)20-3-2-4-21(31)16-20/h2-5,8,15-17,22,26,38H,6-7,9-14,18H2,1H3,(H,34,35)(H2,32,33,39)/t26-/m1/s1
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n/an/a 45n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50252236
PNG
((S)-N-(1-(2-(4-(2-(3-chlorophenyl)-2-hydroxyethyla...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCC(CC1)NC(=O)C1CC1 |r|
Show InChI InChI=1S/C30H33ClN6O3/c1-17-13-22(37-11-8-21(9-12-37)34-29(39)18-5-6-18)15-24-27(17)36-28(35-24)26-23(7-10-32-30(26)40)33-16-25(38)19-3-2-4-20(31)14-19/h2-4,7,10,13-15,18,21,25,38H,5-6,8-9,11-12,16H2,1H3,(H,34,39)(H,35,36)(H2,32,33,40)/t25-/m1/s1
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n/an/a 50n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234523
PNG
(4-(2-(5-chloro-1,2-dimethyl-1H-imidazol-4-yl)ethyl...)
Show SMILES Cc1nc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c(Cl)n1C
Show InChI InChI=1S/C24H28ClN7O2/c1-14-12-16(32-8-10-34-11-9-32)13-19-21(14)30-23(29-19)20-17(4-7-27-24(20)33)26-6-5-18-22(25)31(3)15(2)28-18/h4,7,12-13H,5-6,8-11H2,1-3H3,(H,29,30)(H2,26,27,33)
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n/an/a 66n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234524
PNG
(CHEMBL256908 | ethyl 1-(2-(3-(4-methyl-6-morpholin...)
Show SMILES CCOC(=O)c1cnn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1
Show InChI InChI=1S/C25H29N7O4/c1-3-36-25(34)17-14-28-32(15-17)7-6-26-19-4-5-27-24(33)21(19)23-29-20-13-18(12-16(2)22(20)30-23)31-8-10-35-11-9-31/h4-5,12-15H,3,6-11H2,1-2H3,(H,29,30)(H2,26,27,33)
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n/an/a 68n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234524
PNG
(CHEMBL256908 | ethyl 1-(2-(3-(4-methyl-6-morpholin...)
Show SMILES CCOC(=O)c1cnn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1
Show InChI InChI=1S/C25H29N7O4/c1-3-36-25(34)17-14-28-32(15-17)7-6-26-19-4-5-27-24(33)21(19)23-29-20-13-18(12-16(2)22(20)30-23)31-8-10-35-11-9-31/h4-5,12-15H,3,6-11H2,1-2H3,(H,29,30)(H2,26,27,33)
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n/an/a 68n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50313560
PNG
(3-(6-((R)-3-aminopyrrolidin-1-yl)-4-methyl-1H-benz...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CC[C@@H](N)C1 |r|
Show InChI InChI=1S/C25H27ClN6O2/c1-14-9-18(32-8-6-17(27)13-32)11-20-23(14)31-24(30-20)22-19(5-7-28-25(22)34)29-12-21(33)15-3-2-4-16(26)10-15/h2-5,7,9-11,17,21,33H,6,8,12-13,27H2,1H3,(H,30,31)(H2,28,29,34)/t17-,21-/m1/s1
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n/an/a 71n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234518
PNG
(4-(2-(5-bromo-1-methyl-1H-imidazol-4-yl)ethylamino...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2ncn(C)c2Br)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C23H26BrN7O2/c1-14-11-15(31-7-9-33-10-8-31)12-18-20(14)29-22(28-18)19-16(3-6-26-23(19)32)25-5-4-17-21(24)30(2)13-27-17/h3,6,11-13H,4-5,7-10H2,1-2H3,(H,28,29)(H2,25,26,32)
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n/an/a 75n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234518
PNG
(4-(2-(5-bromo-1-methyl-1H-imidazol-4-yl)ethylamino...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2ncn(C)c2Br)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C23H26BrN7O2/c1-14-11-15(31-7-9-33-10-8-31)12-18-20(14)29-22(28-18)19-16(3-6-26-23(19)32)25-5-4-17-21(24)30(2)13-27-17/h3,6,11-13H,4-5,7-10H2,1-2H3,(H,28,29)(H2,25,26,32)
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n/an/a 75n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50252193
PNG
(4-((S)-2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCC2(CC1)OCCO2 |r|
Show InChI InChI=1S/C28H30ClN5O4/c1-17-13-20(34-9-6-28(7-10-34)37-11-12-38-28)15-22-25(17)33-26(32-22)24-21(5-8-30-27(24)36)31-16-23(35)18-3-2-4-19(29)14-18/h2-5,8,13-15,23,35H,6-7,9-12,16H2,1H3,(H,32,33)(H2,30,31,36)/t23-/m1/s1
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n/an/a 75n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234525
PNG
(4-(2-(5-chloro-1-(2-fluoroethyl)-1H-imidazol-4-yl)...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2ncn(CCF)c2Cl)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C24H27ClFN7O2/c1-15-12-16(32-8-10-35-11-9-32)13-19-21(15)31-23(30-19)20-17(2-6-28-24(20)34)27-5-3-18-22(25)33(7-4-26)14-29-18/h2,6,12-14H,3-5,7-11H2,1H3,(H,30,31)(H2,27,28,34)
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n/an/a 82n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234506
PNG
(4-(2-(4-bromo-1H-pyrazol-1-yl)ethylamino)-3-(4-met...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cc(Br)cn2)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C22H24BrN7O2/c1-14-10-16(29-6-8-32-9-7-29)11-18-20(14)28-21(27-18)19-17(2-3-25-22(19)31)24-4-5-30-13-15(23)12-26-30/h2-3,10-13H,4-9H2,1H3,(H,27,28)(H2,24,25,31)
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n/an/a 82n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50252301
PNG
((S)-methyl 4-(1-(2-(4-(2-(3-chlorophenyl)-2-hydrox...)
Show SMILES COC(=O)N1CCN(CC1)C1CCN(CC1)c1cc(C)c2nc([nH]c2c1)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O |r|
Show InChI InChI=1S/C32H38ClN7O4/c1-20-16-24(38-10-7-23(8-11-38)39-12-14-40(15-13-39)32(43)44-2)18-26-29(20)37-30(36-26)28-25(6-9-34-31(28)42)35-19-27(41)21-4-3-5-22(33)17-21/h3-6,9,16-18,23,27,41H,7-8,10-15,19H2,1-2H3,(H,36,37)(H2,34,35,42)/t27-/m1/s1
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n/an/a 82n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234505
PNG
(4-(2-(5-chloro-1-ethyl-1H-imidazol-4-yl)ethylamino...)
Show SMILES CCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1Cl
Show InChI InChI=1S/C24H28ClN7O2/c1-3-31-14-28-18(22(31)25)5-6-26-17-4-7-27-24(33)20(17)23-29-19-13-16(12-15(2)21(19)30-23)32-8-10-34-11-9-32/h4,7,12-14H,3,5-6,8-11H2,1-2H3,(H,29,30)(H2,26,27,33)
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n/an/a 83n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234505
PNG
(4-(2-(5-chloro-1-ethyl-1H-imidazol-4-yl)ethylamino...)
Show SMILES CCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1Cl
Show InChI InChI=1S/C24H28ClN7O2/c1-3-31-14-28-18(22(31)25)5-6-26-17-4-7-27-24(33)20(17)23-29-19-13-16(12-15(2)21(19)30-23)32-8-10-34-11-9-32/h4,7,12-14H,3,5-6,8-11H2,1-2H3,(H,29,30)(H2,26,27,33)
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n/an/a 83n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234522
PNG
(CHEMBL256909 | methyl 1-(2-(3-(4-methyl-6-morpholi...)
Show SMILES COC(=O)c1cnn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1
Show InChI InChI=1S/C24H27N7O4/c1-15-11-17(30-7-9-35-10-8-30)12-19-21(15)29-22(28-19)20-18(3-4-26-23(20)32)25-5-6-31-14-16(13-27-31)24(33)34-2/h3-4,11-14H,5-10H2,1-2H3,(H,28,29)(H2,25,26,32)
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n/an/a 91n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234522
PNG
(CHEMBL256909 | methyl 1-(2-(3-(4-methyl-6-morpholi...)
Show SMILES COC(=O)c1cnn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1
Show InChI InChI=1S/C24H27N7O4/c1-15-11-17(30-7-9-35-10-8-30)12-19-21(15)29-22(28-19)20-18(3-4-26-23(20)32)25-5-6-31-14-16(13-27-31)24(33)34-2/h3-4,11-14H,5-10H2,1-2H3,(H,28,29)(H2,25,26,32)
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n/an/a 91n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234512
PNG
(4-(2-(4-bromo-3-(hydroxymethyl)-1H-pyrazol-1-yl)et...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cc(Br)c(CO)n2)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C23H26BrN7O3/c1-14-10-15(30-6-8-34-9-7-30)11-18-21(14)28-22(27-18)20-17(2-3-26-23(20)33)25-4-5-31-12-16(24)19(13-32)29-31/h2-3,10-12,32H,4-9,13H2,1H3,(H,27,28)(H2,25,26,33)
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n/an/a 96n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234510
PNG
(4-(2-(4-chloro-3-methyl-1H-pyrazol-1-yl)ethylamino...)
Show SMILES Cc1nn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)cc1Cl
Show InChI InChI=1S/C23H26ClN7O2/c1-14-11-16(30-7-9-33-10-8-30)12-19-21(14)28-22(27-19)20-18(3-4-26-23(20)32)25-5-6-31-13-17(24)15(2)29-31/h3-4,11-13H,5-10H2,1-2H3,(H,27,28)(H2,25,26,32)
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n/an/a 96n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM27879
PNG
(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1 |r|
Show InChI InChI=1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM27879
PNG
(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1 |r|
Show InChI InChI=1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234521
PNG
(4-(2-(4-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-me...)
Show SMILES Cc1cnn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1
Show InChI InChI=1S/C23H27N7O2/c1-15-13-26-30(14-15)6-5-24-18-3-4-25-23(31)20(18)22-27-19-12-17(11-16(2)21(19)28-22)29-7-9-32-10-8-29/h3-4,11-14H,5-10H2,1-2H3,(H,27,28)(H2,24,25,31)
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM27879
PNG
(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1 |r|
Show InChI InChI=1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R expressed in SAL cells

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234521
PNG
(4-(2-(4-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-me...)
Show SMILES Cc1cnn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1
Show InChI InChI=1S/C23H27N7O2/c1-15-13-26-30(14-15)6-5-24-18-3-4-25-23(31)20(18)22-27-19-12-17(11-16(2)21(19)28-22)29-7-9-32-10-8-29/h3-4,11-14H,5-10H2,1-2H3,(H,27,28)(H2,24,25,31)
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234527
PNG
(4-(2-(4-bromo-3-methyl-1H-pyrazol-1-yl)ethylamino)...)
Show SMILES Cc1nn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)cc1Br
Show InChI InChI=1S/C23H26BrN7O2/c1-14-11-16(30-7-9-33-10-8-30)12-19-21(14)28-22(27-19)20-18(3-4-26-23(20)32)25-5-6-31-13-17(24)15(2)29-31/h3-4,11-13H,5-10H2,1-2H3,(H,27,28)(H2,25,26,32)
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234513
PNG
(4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(4-me...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cc(Cl)cn2)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C22H24ClN7O2/c1-14-10-16(29-6-8-32-9-7-29)11-18-20(14)28-21(27-18)19-17(2-3-25-22(19)31)24-4-5-30-13-15(23)12-26-30/h2-3,10-13H,4-9H2,1H3,(H,27,28)(H2,24,25,31)
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n/an/a 120n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234513
PNG
(4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(4-me...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cc(Cl)cn2)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C22H24ClN7O2/c1-14-10-16(29-6-8-32-9-7-29)11-18-20(14)28-21(27-18)19-17(2-3-25-22(19)31)24-4-5-30-13-15(23)12-26-30/h2-3,10-13H,4-9H2,1H3,(H,27,28)(H2,24,25,31)
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n/an/a 120n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234506
PNG
(4-(2-(4-bromo-1H-pyrazol-1-yl)ethylamino)-3-(4-met...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cc(Br)cn2)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C22H24BrN7O2/c1-14-10-16(29-6-8-32-9-7-29)11-18-20(14)28-21(27-18)19-17(2-3-25-22(19)31)24-4-5-30-13-15(23)12-26-30/h2-3,10-13H,4-9H2,1H3,(H,27,28)(H2,24,25,31)
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n/an/a 144n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R expressed in SAL cells

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234519
PNG
(4-(2-(2,5-dichloro-1-methyl-1H-imidazol-4-yl)ethyl...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2nc(Cl)n(C)c2Cl)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C23H25Cl2N7O2/c1-13-11-14(32-7-9-34-10-8-32)12-17-19(13)30-21(28-17)18-15(3-6-27-22(18)33)26-5-4-16-20(24)31(2)23(25)29-16/h3,6,11-12H,4-5,7-10H2,1-2H3,(H,28,30)(H2,26,27,33)
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n/an/a 160n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234519
PNG
(4-(2-(2,5-dichloro-1-methyl-1H-imidazol-4-yl)ethyl...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2nc(Cl)n(C)c2Cl)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C23H25Cl2N7O2/c1-13-11-14(32-7-9-34-10-8-32)12-17-19(13)30-21(28-17)18-15(3-6-27-22(18)33)26-5-4-16-20(24)31(2)23(25)29-16/h3,6,11-12H,4-5,7-10H2,1-2H3,(H,28,30)(H2,26,27,33)
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n/an/a 160n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234529
PNG
(4-(2-(5-bromo-1-ethyl-1H-imidazol-4-yl)ethylamino)...)
Show SMILES CCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1Br
Show InChI InChI=1S/C24H28BrN7O2/c1-3-31-14-28-18(22(31)25)5-6-26-17-4-7-27-24(33)20(17)23-29-19-13-16(12-15(2)21(19)30-23)32-8-10-34-11-9-32/h4,7,12-14H,3,5-6,8-11H2,1-2H3,(H,29,30)(H2,26,27,33)
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n/an/a 172n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234503
PNG
(4-(2-(1-methyl-1H-imidazol-4-yl)ethylamino)-3-(4-m...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2cn(C)cn2)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C23H27N7O2/c1-15-11-17(30-7-9-32-10-8-30)12-19-21(15)28-22(27-19)20-18(4-6-25-23(20)31)24-5-3-16-13-29(2)14-26-16/h4,6,11-14H,3,5,7-10H2,1-2H3,(H,27,28)(H2,24,25,31)
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n/an/a 190n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234503
PNG
(4-(2-(1-methyl-1H-imidazol-4-yl)ethylamino)-3-(4-m...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2cn(C)cn2)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C23H27N7O2/c1-15-11-17(30-7-9-32-10-8-30)12-19-21(15)28-22(27-19)20-18(4-6-25-23(20)31)24-5-3-16-13-29(2)14-26-16/h4,6,11-14H,3,5,7-10H2,1-2H3,(H,27,28)(H2,24,25,31)
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n/an/a 190n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234527
PNG
(4-(2-(4-bromo-3-methyl-1H-pyrazol-1-yl)ethylamino)...)
Show SMILES Cc1nn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)cc1Br
Show InChI InChI=1S/C23H26BrN7O2/c1-14-11-16(30-7-9-33-10-8-30)12-19-21(14)28-22(27-19)20-18(3-4-26-23(20)32)25-5-6-31-13-17(24)15(2)29-31/h3-4,11-13H,5-10H2,1-2H3,(H,27,28)(H2,25,26,32)
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n/an/a 197n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R expressed in SAL cells

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234528
PNG
(4-(2-(1-ethyl-5-ethynyl-1H-imidazol-4-yl)ethylamin...)
Show SMILES CCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1C#C
Show InChI InChI=1S/C26H29N7O2/c1-4-22-19(29-16-32(22)5-2)6-8-27-20-7-9-28-26(34)23(20)25-30-21-15-18(14-17(3)24(21)31-25)33-10-12-35-13-11-33/h1,7,9,14-16H,5-6,8,10-13H2,2-3H3,(H,30,31)(H2,27,28,34)
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n/an/a 243n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234523
PNG
(4-(2-(5-chloro-1,2-dimethyl-1H-imidazol-4-yl)ethyl...)
Show SMILES Cc1nc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c(Cl)n1C
Show InChI InChI=1S/C24H28ClN7O2/c1-14-12-16(32-8-10-34-11-9-32)13-19-21(14)30-23(29-19)20-17(4-7-27-24(20)33)26-6-5-18-22(25)31(3)15(2)28-18/h4,7,12-13H,5-6,8-11H2,1-3H3,(H,29,30)(H2,26,27,33)
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n/an/a 266n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R expressed in SAL cells

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234508
PNG
(4-(2-(5-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-me...)
Show SMILES Cc1ccnn1CCNc1cc[nH]c(=O)c1-c1nc2c(C)cc(cc2[nH]1)N1CCOCC1
Show InChI InChI=1S/C23H27N7O2/c1-15-13-17(29-9-11-32-12-10-29)14-19-21(15)28-22(27-19)20-18(4-5-25-23(20)31)24-7-8-30-16(2)3-6-26-30/h3-6,13-14H,7-12H2,1-2H3,(H,27,28)(H2,24,25,31)
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n/an/a 270n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234529
PNG
(4-(2-(5-bromo-1-ethyl-1H-imidazol-4-yl)ethylamino)...)
Show SMILES CCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1Br
Show InChI InChI=1S/C24H28BrN7O2/c1-3-31-14-28-18(22(31)25)5-6-26-17-4-7-27-24(33)20(17)23-29-19-13-16(12-15(2)21(19)30-23)32-8-10-34-11-9-32/h4,7,12-14H,3,5-6,8-11H2,1-2H3,(H,29,30)(H2,26,27,33)
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n/an/a 284n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R expressed in SAL cells

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234501
PNG
(4-(2-(5-chloro-1-(2-methoxyethyl)-1H-imidazol-4-yl...)
Show SMILES COCCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1Cl
Show InChI InChI=1S/C25H30ClN7O3/c1-16-13-17(32-8-11-36-12-9-32)14-20-22(16)31-24(30-20)21-18(3-6-28-25(21)34)27-5-4-19-23(26)33(15-29-19)7-10-35-2/h3,6,13-15H,4-5,7-12H2,1-2H3,(H,30,31)(H2,27,28,34)
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n/an/a 290n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234502
PNG
(4-(2-(3-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-me...)
Show SMILES Cc1ccn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)n1
Show InChI InChI=1S/C23H27N7O2/c1-15-13-17(29-9-11-32-12-10-29)14-19-21(15)27-22(26-19)20-18(3-5-25-23(20)31)24-6-8-30-7-4-16(2)28-30/h3-5,7,13-14H,6,8-12H2,1-2H3,(H,26,27)(H2,24,25,31)
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n/an/a 290n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234501
PNG
(4-(2-(5-chloro-1-(2-methoxyethyl)-1H-imidazol-4-yl...)
Show SMILES COCCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1Cl
Show InChI InChI=1S/C25H30ClN7O3/c1-16-13-17(32-8-11-36-12-9-32)14-20-22(16)31-24(30-20)21-18(3-6-28-25(21)34)27-5-4-19-23(26)33(15-29-19)7-10-35-2/h3,6,13-15H,4-5,7-12H2,1-2H3,(H,30,31)(H2,27,28,34)
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n/an/a 290n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant IGF-1R tyrosine kinase expressed in baculovirus system assessed as [33gamma]ATP phosphorylation of poly(Glu/Tyr) subs...

Bioorg Med Chem Lett 20: 1744-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.087
BindingDB Entry DOI: 10.7270/Q2MW2H95
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234510
PNG
(4-(2-(4-chloro-3-methyl-1H-pyrazol-1-yl)ethylamino...)
Show SMILES Cc1nn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)cc1Cl
Show InChI InChI=1S/C23H26ClN7O2/c1-14-11-16(30-7-9-33-10-8-30)12-19-21(14)28-22(27-19)20-18(3-4-26-23(20)32)25-5-6-31-13-17(24)15(2)29-31/h3-4,11-13H,5-10H2,1-2H3,(H,27,28)(H2,25,26,32)
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n/an/a 292n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R expressed in SAL cells

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234519
PNG
(4-(2-(2,5-dichloro-1-methyl-1H-imidazol-4-yl)ethyl...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2nc(Cl)n(C)c2Cl)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C23H25Cl2N7O2/c1-13-11-14(32-7-9-34-10-8-32)12-17-19(13)30-21(28-17)18-15(3-6-27-22(18)33)26-5-4-16-20(24)31(2)23(25)29-16/h3,6,11-12H,4-5,7-10H2,1-2H3,(H,28,30)(H2,26,27,33)
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n/an/a 306n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R expressed in SAL cells

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50234526
PNG
(4-(2-(1H-pyrazol-1-yl)ethylamino)-3-(4-methyl-6-mo...)
Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cccn2)cc[nH]c1=O)N1CCOCC1
Show InChI InChI=1S/C22H25N7O2/c1-15-13-16(28-9-11-31-12-10-28)14-18-20(15)27-21(26-18)19-17(3-5-24-22(19)30)23-6-8-29-7-2-4-25-29/h2-5,7,13-14H,6,8-12H2,1H3,(H,26,27)(H2,23,24,30)
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n/an/a 330n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of IGF1R

Bioorg Med Chem Lett 18: 1702-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M
More data for this
Ligand-Target Pair
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