Compile Data Set for Download or QSAR

Found 261 hits with Last Name = 'suzuki' and Initial = 'o'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14774 (3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...) Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.490	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins				Bioorg Med Chem 21: 7025-37 (2013) Article DOI: 10.1016/j.bmc.2013.09.013 BindingDB Entry DOI: 10.7270/Q2DZ0C84
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14774 (3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...) Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.490	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis				Bioorg Med Chem Lett 23: 3325-8 (2013) Article DOI: 10.1016/j.bmcl.2013.03.104 BindingDB Entry DOI: 10.7270/Q2QF8WSQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495787 (CHEMBL3114956) Show SMILES COc1ccc(cc1Cl)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)c(F)c2)n1 Show InChI InChI=1S/C22H19ClFN3O5S/c1-32-18-7-5-13(9-15(18)23)21-26-17-3-2-8-33(30,31)20(17)22(27-21)25-14-6-4-12(10-19(28)29)16(24)11-14/h4-7,9,11H,2-3,8,10H2,1H3,(H,28,29)(H,25,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50493949 (CHEMBL2442479) Show SMILES CC(=C)c1ncc(C(N)=O)c(Nc2ccc(CC(=O)NCC(C)(C)C)cc2)n1 Show InChI InChI=1S/C21H27N5O2/c1-13(2)19-23-11-16(18(22)28)20(26-19)25-15-8-6-14(7-9-15)10-17(27)24-12-21(3,4)5/h6-9,11H,1,10,12H2,2-5H3,(H2,22,28)(H,24,27)(H,23,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins				Bioorg Med Chem 21: 7025-37 (2013) Article DOI: 10.1016/j.bmc.2013.09.013 BindingDB Entry DOI: 10.7270/Q2DZ0C84
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495791 (CHEMBL3114958) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2cc3ccccc3s2)cc1F Show InChI InChI=1S/C23H18FN3O4S2/c24-16-12-15(8-7-13(16)11-20(28)29)25-23-21-17(5-3-9-33(21,30)31)26-22(27-23)19-10-14-4-1-2-6-18(14)32-19/h1-2,4,6-8,10,12H,3,5,9,11H2,(H,28,29)(H,25,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495777 (CHEMBL3114948) Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)c(F)c2)n1 Show InChI InChI=1S/C22H19F2N3O5S/c1-32-18-7-5-13(9-16(18)24)21-26-17-3-2-8-33(30,31)20(17)22(27-21)25-14-6-4-12(10-19(28)29)15(23)11-14/h4-7,9,11H,2-3,8,10H2,1H3,(H,28,29)(H,25,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50491736 (CHEMBL2385759) Show SMILES CC(C)(C)CNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C26H30N4O3S/c1-26(2,3)17-27-22(31)16-18-11-13-20(14-12-18)28-25-23-21(10-7-15-34(23,32)33)29-24(30-25)19-8-5-4-6-9-19/h4-6,8-9,11-14H,7,10,15-17H2,1-3H3,(H,27,31)(H,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis				Bioorg Med Chem Lett 23: 3325-8 (2013) Article DOI: 10.1016/j.bmcl.2013.03.104 BindingDB Entry DOI: 10.7270/Q2QF8WSQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495793 (CHEMBL3114950) Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2cc(F)c(CC(O)=O)c(F)c2)n1 Show InChI InChI=1S/C22H18F3N3O5S/c1-33-18-5-4-11(7-16(18)25)21-27-17-3-2-6-34(31,32)20(17)22(28-21)26-12-8-14(23)13(10-19(29)30)15(24)9-12/h4-5,7-9H,2-3,6,10H2,1H3,(H,29,30)(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495778 (CHEMBL3114957) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccc3ccccc3c2)cc1F Show InChI InChI=1S/C25H20FN3O4S/c26-20-14-19(10-9-17(20)13-22(30)31)27-25-23-21(6-3-11-34(23,32)33)28-24(29-25)18-8-7-15-4-1-2-5-16(15)12-18/h1-2,4-5,7-10,12,14H,3,6,11,13H2,(H,30,31)(H,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50491737 (CHEMBL2385757) Show SMILES CC(C)CNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C25H28N4O3S/c1-17(2)16-26-22(30)15-18-10-12-20(13-11-18)27-25-23-21(9-6-14-33(23,31)32)28-24(29-25)19-7-4-3-5-8-19/h3-5,7-8,10-13,17H,6,9,14-16H2,1-2H3,(H,26,30)(H,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis				Bioorg Med Chem Lett 23: 3325-8 (2013) Article DOI: 10.1016/j.bmcl.2013.03.104 BindingDB Entry DOI: 10.7270/Q2QF8WSQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50493958 (CHEMBL2442473) Show SMILES NC(=O)c1cnc(nc1Nc1ccc(CC(=O)NO)cc1)-c1ccccc1 Show InChI InChI=1S/C19H17N5O3/c20-17(26)15-11-21-18(13-4-2-1-3-5-13)23-19(15)22-14-8-6-12(7-9-14)10-16(25)24-27/h1-9,11,27H,10H2,(H2,20,26)(H,24,25)(H,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins				Bioorg Med Chem 21: 7025-37 (2013) Article DOI: 10.1016/j.bmc.2013.09.013 BindingDB Entry DOI: 10.7270/Q2DZ0C84
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50493947 (CHEMBL2442465) Show SMILES CC(C)CNC(=O)Cc1ccc(Nc2nc(nc3CCNC(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C25H27N5O2/c1-16(2)15-27-21(31)14-17-8-10-19(11-9-17)28-24-22-20(12-13-26-25(22)32)29-23(30-24)18-6-4-3-5-7-18/h3-11,16H,12-15H2,1-2H3,(H,26,32)(H,27,31)(H,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins				Bioorg Med Chem 21: 7025-37 (2013) Article DOI: 10.1016/j.bmc.2013.09.013 BindingDB Entry DOI: 10.7270/Q2DZ0C84
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495788 (CHEMBL3114954) Show SMILES COc1ccc(cc1)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)c(F)c2)n1 Show InChI InChI=1S/C22H20FN3O5S/c1-31-16-8-5-13(6-9-16)21-25-18-3-2-10-32(29,30)20(18)22(26-21)24-15-7-4-14(11-19(27)28)17(23)12-15/h4-9,12H,2-3,10-11H2,1H3,(H,27,28)(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50491759 (CHEMBL2385755 | US11401286, Example 270) Show SMILES CCCNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C24H26N4O3S/c1-2-14-25-21(29)16-17-10-12-19(13-11-17)26-24-22-20(9-6-15-32(22,30)31)27-23(28-24)18-7-4-3-5-8-18/h3-5,7-8,10-13H,2,6,9,14-16H2,1H3,(H,25,29)(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis				Bioorg Med Chem Lett 23: 3325-8 (2013) Article DOI: 10.1016/j.bmcl.2013.03.104 BindingDB Entry DOI: 10.7270/Q2QF8WSQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50493961 (CHEMBL2442478) Show SMILES CC(C)(C)CNC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)-c2ccc3[nH]ccc3c2)cc1 Show InChI InChI=1S/C26H28N6O2/c1-26(2,3)15-30-22(33)12-16-4-7-19(8-5-16)31-25-20(23(27)34)14-29-24(32-25)18-6-9-21-17(13-18)10-11-28-21/h4-11,13-14,28H,12,15H2,1-3H3,(H2,27,34)(H,30,33)(H,29,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins				Bioorg Med Chem 21: 7025-37 (2013) Article DOI: 10.1016/j.bmc.2013.09.013 BindingDB Entry DOI: 10.7270/Q2DZ0C84
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495755 (CHEMBL3114955) Show SMILES COc1ccc(c(F)c1F)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)c(F)c2)n1 Show InChI InChI=1S/C22H18F3N3O5S/c1-33-16-7-6-13(18(24)19(16)25)21-27-15-3-2-8-34(31,32)20(15)22(28-21)26-12-5-4-11(9-17(29)30)14(23)10-12/h4-7,10H,2-3,8-9H2,1H3,(H,29,30)(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50493946 (CHEMBL2442472) Show SMILES CC(C)(C)CNC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)-c2ccccc2)cc1 Show InChI InChI=1S/C24H27N5O2/c1-24(2,3)15-27-20(30)13-16-9-11-18(12-10-16)28-23-19(21(25)31)14-26-22(29-23)17-7-5-4-6-8-17/h4-12,14H,13,15H2,1-3H3,(H2,25,31)(H,27,30)(H,26,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins				Bioorg Med Chem 21: 7025-37 (2013) Article DOI: 10.1016/j.bmc.2013.09.013 BindingDB Entry DOI: 10.7270/Q2DZ0C84
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495762 (CHEMBL3114945) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2cc3ccccc3s2)cc1 Show InChI InChI=1S/C23H19N3O4S2/c27-20(28)12-14-7-9-16(10-8-14)24-23-21-17(5-3-11-32(21,29)30)25-22(26-23)19-13-15-4-1-2-6-18(15)31-19/h1-2,4,6-10,13H,3,5,11-12H2,(H,27,28)(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495779 (CHEMBL3114953) Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2cc(F)c(CC(O)=O)cc2Cl)n1 Show InChI InChI=1S/C22H18ClF2N3O5S/c1-33-18-5-4-11(8-15(18)25)21-26-16-3-2-6-34(31,32)20(16)22(28-21)27-17-10-14(24)12(7-13(17)23)9-19(29)30/h4-5,7-8,10H,2-3,6,9H2,1H3,(H,29,30)(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495781 (CHEMBL3114947) Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1 Show InChI InChI=1S/C22H20FN3O5S/c1-31-18-9-6-14(12-16(18)23)21-25-17-3-2-10-32(29,30)20(17)22(26-21)24-15-7-4-13(5-8-15)11-19(27)28/h4-9,12H,2-3,10-11H2,1H3,(H,27,28)(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495789 (CHEMBL3114936) Show SMILES CC(=O)c1ccc(cc1)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1 Show InChI InChI=1S/C23H21N3O5S/c1-14(27)16-6-8-17(9-7-16)22-25-19-3-2-12-32(30,31)21(19)23(26-22)24-18-10-4-15(5-11-18)13-20(28)29/h4-11H,2-3,12-13H2,1H3,(H,28,29)(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50493962 (CHEMBL2442470) Show SMILES CC(C)CNC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)-c2ccccc2)cc1 Show InChI InChI=1S/C23H25N5O2/c1-15(2)13-25-20(29)12-16-8-10-18(11-9-16)27-23-19(21(24)30)14-26-22(28-23)17-6-4-3-5-7-17/h3-11,14-15H,12-13H2,1-2H3,(H2,24,30)(H,25,29)(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins				Bioorg Med Chem 21: 7025-37 (2013) Article DOI: 10.1016/j.bmc.2013.09.013 BindingDB Entry DOI: 10.7270/Q2DZ0C84
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50493950 (CHEMBL2442477) Show SMILES CC(C)(C)CNC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)-c2ccoc2)cc1 Show InChI InChI=1S/C22H25N5O3/c1-22(2,3)13-25-18(28)10-14-4-6-16(7-5-14)26-21-17(19(23)29)11-24-20(27-21)15-8-9-30-12-15/h4-9,11-12H,10,13H2,1-3H3,(H2,23,29)(H,25,28)(H,24,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins				Bioorg Med Chem 21: 7025-37 (2013) Article DOI: 10.1016/j.bmc.2013.09.013 BindingDB Entry DOI: 10.7270/Q2DZ0C84
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50491753 (CHEMBL2385758) Show SMILES CC(C)(C)NC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C25H28N4O3S/c1-25(2,3)29-21(30)16-17-11-13-19(14-12-17)26-24-22-20(10-7-15-33(22,31)32)27-23(28-24)18-8-5-4-6-9-18/h4-6,8-9,11-14H,7,10,15-16H2,1-3H3,(H,29,30)(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis				Bioorg Med Chem Lett 23: 3325-8 (2013) Article DOI: 10.1016/j.bmcl.2013.03.104 BindingDB Entry DOI: 10.7270/Q2QF8WSQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495771 (CHEMBL3112613) Show SMILES COc1ccc(cc1)-c1nc2CCCSc2c(Nc2ccc(CC(O)=O)cc2)n1 Show InChI InChI=1S/C22H21N3O3S/c1-28-17-10-6-15(7-11-17)21-24-18-3-2-12-29-20(18)22(25-21)23-16-8-4-14(5-9-16)13-19(26)27/h4-11H,2-3,12-13H2,1H3,(H,26,27)(H,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50493948 (CHEMBL2442462) Show SMILES CC(C)(C)CNC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)N2CCCC2)cc1 Show InChI InChI=1S/C22H30N6O2/c1-22(2,3)14-25-18(29)12-15-6-8-16(9-7-15)26-20-17(19(23)30)13-24-21(27-20)28-10-4-5-11-28/h6-9,13H,4-5,10-12,14H2,1-3H3,(H2,23,30)(H,25,29)(H,24,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins				Bioorg Med Chem 21: 7025-37 (2013) Article DOI: 10.1016/j.bmc.2013.09.013 BindingDB Entry DOI: 10.7270/Q2DZ0C84
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495774 (CHEMBL3114940) Show SMILES COc1ccc(cc1Cl)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1 Show InChI InChI=1S/C22H20ClN3O5S/c1-31-18-9-6-14(12-16(18)23)21-25-17-3-2-10-32(29,30)20(17)22(26-21)24-15-7-4-13(5-8-15)11-19(27)28/h4-9,12H,2-3,10-11H2,1H3,(H,27,28)(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495763 (CHEMBL3114944) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccc3c(F)cccc3c2)cc1 Show InChI InChI=1S/C25H20FN3O4S/c26-20-4-1-3-16-14-17(8-11-19(16)20)24-28-21-5-2-12-34(32,33)23(21)25(29-24)27-18-9-6-15(7-10-18)13-22(30)31/h1,3-4,6-11,14H,2,5,12-13H2,(H,30,31)(H,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495761 (CHEMBL3114949) Show SMILES COc1ccc(cc1F)-c1nc2CCCS(=O)(=O)c2c(Nc2cc(F)c(CC(O)=O)cc2F)n1 Show InChI InChI=1S/C22H18F3N3O5S/c1-33-18-5-4-11(7-15(18)25)21-26-16-3-2-6-34(31,32)20(16)22(28-21)27-17-10-13(23)12(8-14(17)24)9-19(29)30/h4-5,7-8,10H,2-3,6,9H2,1H3,(H,29,30)(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50491738 (CHEMBL2385753 | US11401286, Example 269) Show SMILES NC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C21H20N4O3S/c22-18(26)13-14-8-10-16(11-9-14)23-21-19-17(7-4-12-29(19,27)28)24-20(25-21)15-5-2-1-3-6-15/h1-3,5-6,8-11H,4,7,12-13H2,(H2,22,26)(H,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis				Bioorg Med Chem Lett 23: 3325-8 (2013) Article DOI: 10.1016/j.bmcl.2013.03.104 BindingDB Entry DOI: 10.7270/Q2QF8WSQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50493953 (CHEMBL2442469) Show SMILES NC(=O)c1cnc(nc1Nc1ccc(CC(=O)NCC2CC2)cc1)-c1ccccc1 Show InChI InChI=1S/C23H23N5O2/c24-21(30)19-14-26-22(17-4-2-1-3-5-17)28-23(19)27-18-10-8-15(9-11-18)12-20(29)25-13-16-6-7-16/h1-5,8-11,14,16H,6-7,12-13H2,(H2,24,30)(H,25,29)(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins				Bioorg Med Chem 21: 7025-37 (2013) Article DOI: 10.1016/j.bmc.2013.09.013 BindingDB Entry DOI: 10.7270/Q2DZ0C84
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50493957 (CHEMBL2442461) Show SMILES CN(C)c1ncc(C(N)=O)c(Nc2ccc(CC(=O)NCC(C)(C)C)cc2)n1 Show InChI InChI=1S/C20H28N6O2/c1-20(2,3)12-23-16(27)10-13-6-8-14(9-7-13)24-18-15(17(21)28)11-22-19(25-18)26(4)5/h6-9,11H,10,12H2,1-5H3,(H2,21,28)(H,23,27)(H,22,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins				Bioorg Med Chem 21: 7025-37 (2013) Article DOI: 10.1016/j.bmc.2013.09.013 BindingDB Entry DOI: 10.7270/Q2DZ0C84
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495760 (CHEMBL3114941) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C25H21N3O4S/c29-22(30)14-16-7-11-20(12-8-16)26-25-23-21(6-3-13-33(23,31)32)27-24(28-25)19-10-9-17-4-1-2-5-18(17)15-19/h1-2,4-5,7-12,15H,3,6,13-14H2,(H,29,30)(H,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495782 (CHEMBL3114946) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2cc3ccccc3o2)cc1 Show InChI InChI=1S/C23H19N3O5S/c27-20(28)12-14-7-9-16(10-8-14)24-23-21-17(5-3-11-32(21,29)30)25-22(26-23)19-13-15-4-1-2-6-18(15)31-19/h1-2,4,6-10,13H,3,5,11-12H2,(H,27,28)(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50491754 (CHEMBL2385756) Show SMILES CCCCNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C25H28N4O3S/c1-2-3-15-26-22(30)17-18-11-13-20(14-12-18)27-25-23-21(10-7-16-33(23,31)32)28-24(29-25)19-8-5-4-6-9-19/h4-6,8-9,11-14H,2-3,7,10,15-17H2,1H3,(H,26,30)(H,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis				Bioorg Med Chem Lett 23: 3325-8 (2013) Article DOI: 10.1016/j.bmcl.2013.03.104 BindingDB Entry DOI: 10.7270/Q2QF8WSQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50491740 (CHEMBL2385749) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C21H19N3O4S/c25-18(26)13-14-8-10-16(11-9-14)22-21-19-17(7-4-12-29(19,27)28)23-20(24-21)15-5-2-1-3-6-15/h1-3,5-6,8-11H,4,7,12-13H2,(H,25,26)(H,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis				Bioorg Med Chem Lett 23: 3325-8 (2013) Article DOI: 10.1016/j.bmcl.2013.03.104 BindingDB Entry DOI: 10.7270/Q2QF8WSQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50491751 (CHEMBL2385754) Show SMILES CNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C22H22N4O3S/c1-23-19(27)14-15-9-11-17(12-10-15)24-22-20-18(8-5-13-30(20,28)29)25-21(26-22)16-6-3-2-4-7-16/h2-4,6-7,9-12H,5,8,13-14H2,1H3,(H,23,27)(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis				Bioorg Med Chem Lett 23: 3325-8 (2013) Article DOI: 10.1016/j.bmcl.2013.03.104 BindingDB Entry DOI: 10.7270/Q2QF8WSQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50491739 (CHEMBL2385750) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CS(=O)(=O)CCc23)-c2ccccc2)cc1 Show InChI InChI=1S/C21H19N3O4S/c25-19(26)12-14-6-8-16(9-7-14)22-21-17-10-11-29(27,28)13-18(17)23-20(24-21)15-4-2-1-3-5-15/h1-9H,10-13H2,(H,25,26)(H,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis				Bioorg Med Chem Lett 23: 3325-8 (2013) Article DOI: 10.1016/j.bmcl.2013.03.104 BindingDB Entry DOI: 10.7270/Q2QF8WSQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50491746 (CHEMBL2385559) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CSCc23)-c2ccccc2)cc1 Show InChI InChI=1S/C20H17N3O2S/c24-18(25)10-13-6-8-15(9-7-13)21-20-16-11-26-12-17(16)22-19(23-20)14-4-2-1-3-5-14/h1-9H,10-12H2,(H,24,25)(H,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis				Bioorg Med Chem Lett 23: 3325-8 (2013) Article DOI: 10.1016/j.bmcl.2013.03.104 BindingDB Entry DOI: 10.7270/Q2QF8WSQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50493966 (CHEMBL2442475) Show SMILES CC(C)(C)CNC(=O)Cc1ccc(Nc2nc(ncc2C(N)=O)-c2cccnc2)cc1 Show InChI InChI=1S/C23H26N6O2/c1-23(2,3)14-27-19(30)11-15-6-8-17(9-7-15)28-22-18(20(24)31)13-26-21(29-22)16-5-4-10-25-12-16/h4-10,12-13H,11,14H2,1-3H3,(H2,24,31)(H,27,30)(H,26,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 30 mins				Bioorg Med Chem 21: 7025-37 (2013) Article DOI: 10.1016/j.bmc.2013.09.013 BindingDB Entry DOI: 10.7270/Q2DZ0C84
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50491761 (CHEMBL2385573) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCSc23)-c2ccccc2)cc1 Show InChI InChI=1S/C21H19N3O2S/c25-18(26)13-14-8-10-16(11-9-14)22-21-19-17(7-4-12-27-19)23-20(24-21)15-5-2-1-3-6-15/h1-3,5-6,8-11H,4,7,12-13H2,(H,25,26)(H,22,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis				Bioorg Med Chem Lett 23: 3325-8 (2013) Article DOI: 10.1016/j.bmcl.2013.03.104 BindingDB Entry DOI: 10.7270/Q2QF8WSQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495772 (CHEMBL3114926) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCSc23)-c2ccc(cc2)C#N)cc1 Show InChI InChI=1S/C22H18N4O2S/c23-13-15-3-7-16(8-4-15)21-25-18-2-1-11-29-20(18)22(26-21)24-17-9-5-14(6-10-17)12-19(27)28/h3-10H,1-2,11-12H2,(H,27,28)(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495764 (CHEMBL3114943) Show SMILES COc1cccc2cc(ccc12)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1 Show InChI InChI=1S/C26H23N3O5S/c1-34-22-6-2-4-17-15-18(9-12-20(17)22)25-28-21-5-3-13-35(32,33)24(21)26(29-25)27-19-10-7-16(8-11-19)14-23(30)31/h2,4,6-12,15H,3,5,13-14H2,1H3,(H,30,31)(H,27,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50491735 (CHEMBL2385761) Show SMILES CN(C)C(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C23H24N4O3S/c1-27(2)20(28)15-16-10-12-18(13-11-16)24-23-21-19(9-6-14-31(21,29)30)25-22(26-23)17-7-4-3-5-8-17/h3-5,7-8,10-13H,6,9,14-15H2,1-2H3,(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis				Bioorg Med Chem Lett 23: 3325-8 (2013) Article DOI: 10.1016/j.bmcl.2013.03.104 BindingDB Entry DOI: 10.7270/Q2QF8WSQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495769 (CHEMBL3114929) Show SMILES CC(=O)c1ccc(cc1)-c1nc2CCCSc2c(Nc2ccc(CC(O)=O)cc2)n1 Show InChI InChI=1S/C23H21N3O3S/c1-14(27)16-6-8-17(9-7-16)22-25-19-3-2-12-30-21(19)23(26-22)24-18-10-4-15(5-11-18)13-20(28)29/h4-11H,2-3,12-13H2,1H3,(H,28,29)(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495786 (CHEMBL3114928) Show SMILES CN(C)c1ccc(cc1)-c1nc2CCCSc2c(Nc2ccc(CC(O)=O)cc2)n1 Show InChI InChI=1S/C23H24N4O2S/c1-27(2)18-11-7-16(8-12-18)22-25-19-4-3-13-30-21(19)23(26-22)24-17-9-5-15(6-10-17)14-20(28)29/h5-12H,3-4,13-14H2,1-2H3,(H,28,29)(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495766 (CHEMBL3114935) Show SMILES CN(C)c1ccc(cc1)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1 Show InChI InChI=1S/C23H24N4O4S/c1-27(2)18-11-7-16(8-12-18)22-25-19-4-3-13-32(30,31)21(19)23(26-22)24-17-9-5-15(6-10-17)14-20(28)29/h5-12H,3-4,13-14H2,1-2H3,(H,28,29)(H,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495783 (CHEMBL3114942) Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccc(cc2)-c2ccccc2)cc1 Show InChI InChI=1S/C27H23N3O4S/c31-24(32)17-18-8-14-22(15-9-18)28-27-25-23(7-4-16-35(25,33)34)29-26(30-27)21-12-10-20(11-13-21)19-5-2-1-3-6-19/h1-3,5-6,8-15H,4,7,16-17H2,(H,31,32)(H,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50491750 (CHEMBL2385760) Show SMILES O=C(Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1)Nc1ccccc1 Show InChI InChI=1S/C27H24N4O3S/c32-24(28-21-10-5-2-6-11-21)18-19-13-15-22(16-14-19)29-27-25-23(12-7-17-35(25,33)34)30-26(31-27)20-8-3-1-4-9-20/h1-6,8-11,13-16H,7,12,17-18H2,(H,28,32)(H,29,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis				Bioorg Med Chem Lett 23: 3325-8 (2013) Article DOI: 10.1016/j.bmcl.2013.03.104 BindingDB Entry DOI: 10.7270/Q2QF8WSQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50495767 (CHEMBL3114934) Show SMILES COc1ccc(cc1)-c1nc2CCCS(=O)(=O)c2c(Nc2ccc(CC(O)=O)cc2)n1 Show InChI InChI=1S/C22H21N3O5S/c1-30-17-10-6-15(7-11-17)21-24-18-3-2-12-31(28,29)20(18)22(25-21)23-16-8-4-14(5-9-16)13-19(26)27/h4-11H,2-3,12-13H2,1H3,(H,26,27)(H,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Kyushu University Curated by ChEMBL					Assay Description Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 mins				Bioorg Med Chem Lett 24: 893-9 (2014) Article DOI: 10.1016/j.bmcl.2013.12.076 BindingDB Entry DOI: 10.7270/Q2GX4FHW
					More data for this Ligand-Target Pair

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