Found 76 hits with Last Name = 'werbovetz' and Initial = 'k' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50369323
(MECAMYLAMINE)Show InChI InChI=1S/C11H21N/c1-10(2)8-5-6-9(7-8)11(10,3)12-4/h8-9,12H,5-7H2,1-4H3/t8-,9+,11+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
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MCE KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve... |
Bioorg Med Chem 21: 4730-43 (2013)
Article DOI: 10.1016/j.bmc.2013.03.082 BindingDB Entry DOI: 10.7270/Q2V12673 |
More data for this Ligand-Target Pair | |
Tubulin alpha-1A chain
(Sus scrofa (Pig)) | BDBM50035218
(CHEMBL61 | PODOFILOX | Podophyllinic acid lactone ...)Show SMILES COc1cc(cc(OC)c1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12 |r| Show InChI InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
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CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tubulin beta chain
(Sus scrofa) | BDBM50035218
(CHEMBL61 | PODOFILOX | Podophyllinic acid lactone ...)Show SMILES COc1cc(cc(OC)c1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12 |r| Show InChI InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 1.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly |
Bioorg Med Chem Lett 15: 5382-5 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.001 BindingDB Entry DOI: 10.7270/Q2Z322D9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tubulin beta chain
(Sus scrofa) | BDBM50475544
(CHEMBL372120)Show SMILES COc1ccc2\C(=C/c3cc(OC)c(OC)c(OC)c3)C(=O)Nc2c1 Show InChI InChI=1S/C19H19NO5/c1-22-12-5-6-13-14(19(21)20-15(13)10-12)7-11-8-16(23-2)18(25-4)17(9-11)24-3/h5-10H,1-4H3,(H,20,21)/b14-7+ | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
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PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly |
Bioorg Med Chem Lett 15: 5382-5 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.001 BindingDB Entry DOI: 10.7270/Q2Z322D9 |
More data for this Ligand-Target Pair | |
Tubulin alpha-1A chain
(Sus scrofa (Pig)) | BDBM81747
(Chembridge No 9067250, Class 1, 8)Show InChI InChI=1S/C15H14FNO5S/c1-21-14-8-7-10(9-12(14)16)23(19,20)17-13-6-4-3-5-11(13)15(18)22-2/h3-9,17H,1-2H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
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PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50437522
(CHEMBL2407120)Show InChI InChI=1S/C16H16N2O2/c1-3-11-20-14-9-7-13(8-10-14)16(19)18-15-6-4-5-12(2)17-15/h3-10H,1,11H2,2H3,(H,17,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve... |
Bioorg Med Chem 21: 4730-43 (2013)
Article DOI: 10.1016/j.bmc.2013.03.082 BindingDB Entry DOI: 10.7270/Q2V12673 |
More data for this Ligand-Target Pair | |
Tubulin alpha chain
(Leishmania tarentolae (Sauroleishmania tarentolae)) | BDBM81744
(Oryzalin Analogue, 3)Show SMILES CCCN(CCC)c1c(cc(cc1N(=O)=O)S(=O)(=O)Nc1ccccc1)N(=O)=O Show InChI InChI=1S/C18H22N4O6S/c1-3-10-20(11-4-2)18-16(21(23)24)12-15(13-17(18)22(25)26)29(27,28)19-14-8-6-5-7-9-14/h5-9,12-13,19H,3-4,10-11H2,1-2H3 | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin alpha chain
(Leishmania tarentolae (Sauroleishmania tarentolae)) | BDBM81745
(Oryzalin Analogue, 4)Show SMILES CCCN(CCC)c1c(cc(cc1C#N)S(=O)(=O)Nc1ccccc1)C#N Show InChI InChI=1S/C20H22N4O2S/c1-3-10-24(11-4-2)20-16(14-21)12-19(13-17(20)15-22)27(25,26)23-18-8-6-5-7-9-18/h5-9,12-13,23H,3-4,10-11H2,1-2H3 | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50437521
(CHEMBL2407121)Show InChI InChI=1S/C16H18N2O2/c1-3-11-20-14-9-7-13(8-10-14)16(19)18-15-6-4-5-12(2)17-15/h4-10H,3,11H2,1-2H3,(H,17,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve... |
Bioorg Med Chem 21: 4730-43 (2013)
Article DOI: 10.1016/j.bmc.2013.03.082 BindingDB Entry DOI: 10.7270/Q2V12673 |
More data for this Ligand-Target Pair | |
Tubulin beta chain
(Sus scrofa) | BDBM50475546
(CHEMBL382519)Show InChI InChI=1S/C16H13NO3/c1-20-12-5-6-13-14(16(19)17-15(13)9-12)8-10-3-2-4-11(18)7-10/h2-9,18H,1H3,(H,17,19)/b14-8+ | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly |
Bioorg Med Chem Lett 15: 5382-5 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.001 BindingDB Entry DOI: 10.7270/Q2Z322D9 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50366799
(TUBOCURARINE | TUBOCURARINE CHLORIDE)Show SMILES COc1cc2CC[N+](C)(C)[C@@H]3Cc4ccc(O)c(Oc5cc6[C@H](Cc7ccc(Oc(c1O)c23)cc7)N(C)CCc6cc5OC)c4 |r| Show InChI InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41)/p+1/t28-,29+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve... |
Bioorg Med Chem 21: 4730-43 (2013)
Article DOI: 10.1016/j.bmc.2013.03.082 BindingDB Entry DOI: 10.7270/Q2V12673 |
More data for this Ligand-Target Pair | |
Tubulin alpha chain
(Leishmania tarentolae (Sauroleishmania tarentolae)) | BDBM81746
(Chembridge No 7992831, 5)Show InChI InChI=1S/C12H10INO/c1-3-4-5-10-11(13)6-9(8-14)7-12(10)15-2/h1,6-7H,4-5H2,2H3 | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50437513
(CHEMBL2407128)Show InChI InChI=1S/C18H21N3O2/c1-3-12-19-16-6-5-7-17(20-16)21-18(22)14-8-10-15(11-9-14)23-13-4-2/h4-11H,2-3,12-13H2,1H3,(H2,19,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve... |
Bioorg Med Chem 21: 4730-43 (2013)
Article DOI: 10.1016/j.bmc.2013.03.082 BindingDB Entry DOI: 10.7270/Q2V12673 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50437534
(CHEMBL2407134)Show InChI InChI=1S/C18H23N3O2/c1-3-12-19-16-6-5-7-17(20-16)21-18(22)14-8-10-15(11-9-14)23-13-4-2/h5-11H,3-4,12-13H2,1-2H3,(H2,19,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.54E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve... |
Bioorg Med Chem 21: 4730-43 (2013)
Article DOI: 10.1016/j.bmc.2013.03.082 BindingDB Entry DOI: 10.7270/Q2V12673 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50437518
(CHEMBL152025)Show InChI InChI=1S/C16H18N2O2/c1-4-20-14-7-5-13(6-8-14)16(19)18-15-10-11(2)9-12(3)17-15/h5-10H,4H2,1-3H3,(H,17,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.71E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve... |
Bioorg Med Chem 21: 4730-43 (2013)
Article DOI: 10.1016/j.bmc.2013.03.082 BindingDB Entry DOI: 10.7270/Q2V12673 |
More data for this Ligand-Target Pair | |
Tubulin beta chain
(Sus scrofa) | BDBM50475541
(CHEMBL196754)Show InChI InChI=1S/C16H13NO3/c1-20-12-6-7-13-14(16(19)17-15(13)9-12)8-10-2-4-11(18)5-3-10/h2-9,18H,1H3,(H,17,19)/b14-8+ | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly |
Bioorg Med Chem Lett 15: 5382-5 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.001 BindingDB Entry DOI: 10.7270/Q2Z322D9 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50437517
(CHEMBL2407124)Show InChI InChI=1S/C15H14N2O2/c1-2-11-19-13-8-6-12(7-9-13)15(18)17-14-5-3-4-10-16-14/h2-10H,1,11H2,(H,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.93E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve... |
Bioorg Med Chem 21: 4730-43 (2013)
Article DOI: 10.1016/j.bmc.2013.03.082 BindingDB Entry DOI: 10.7270/Q2V12673 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50437519
(CHEMBL2407123)Show InChI InChI=1S/C16H14N2O2/c1-3-11-20-14-9-7-13(8-10-14)16(19)18-15-6-4-5-12(2)17-15/h1,4-10H,11H2,2H3,(H,17,18,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve... |
Bioorg Med Chem 21: 4730-43 (2013)
Article DOI: 10.1016/j.bmc.2013.03.082 BindingDB Entry DOI: 10.7270/Q2V12673 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50437520
(CHEMBL2407122)Show InChI InChI=1S/C17H18N2O2/c1-12(2)11-21-15-9-7-14(8-10-15)17(20)19-16-6-4-5-13(3)18-16/h4-10H,1,11H2,2-3H3,(H,18,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.96E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve... |
Bioorg Med Chem 21: 4730-43 (2013)
Article DOI: 10.1016/j.bmc.2013.03.082 BindingDB Entry DOI: 10.7270/Q2V12673 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50437514
(CHEMBL2407127)Show InChI InChI=1S/C17H18N2O2/c1-3-12-21-15-10-8-13(9-11-15)17(20)19-16-7-5-6-14(4-2)18-16/h3,5-11H,1,4,12H2,2H3,(H,18,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve... |
Bioorg Med Chem 21: 4730-43 (2013)
Article DOI: 10.1016/j.bmc.2013.03.082 BindingDB Entry DOI: 10.7270/Q2V12673 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50437512
(CHEMBL2407129)Show InChI InChI=1S/C19H23N3O2/c1-3-5-13-20-17-7-6-8-18(21-17)22-19(23)15-9-11-16(12-10-15)24-14-4-2/h4,6-12H,2-3,5,13-14H2,1H3,(H2,20,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve... |
Bioorg Med Chem 21: 4730-43 (2013)
Article DOI: 10.1016/j.bmc.2013.03.082 BindingDB Entry DOI: 10.7270/Q2V12673 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50437536
(CHEMBL2407132)Show InChI InChI=1S/C14H15N3O2/c1-2-9-19-12-5-3-11(4-6-12)14(18)17-13-10-15-7-8-16-13/h3-8,10H,2,9H2,1H3,(H,16,17,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve... |
Bioorg Med Chem 21: 4730-43 (2013)
Article DOI: 10.1016/j.bmc.2013.03.082 BindingDB Entry DOI: 10.7270/Q2V12673 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50437535
(CHEMBL2407133)Show InChI InChI=1S/C17H20N2O2/c1-3-12-21-15-10-8-13(9-11-15)17(20)19-16-7-5-6-14(4-2)18-16/h5-11H,3-4,12H2,1-2H3,(H,18,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.76E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve... |
Bioorg Med Chem 21: 4730-43 (2013)
Article DOI: 10.1016/j.bmc.2013.03.082 BindingDB Entry DOI: 10.7270/Q2V12673 |
More data for this Ligand-Target Pair | |
Tubulin alpha-1A chain
(Sus scrofa (Pig)) | BDBM81746
(Chembridge No 7992831, 5)Show InChI InChI=1S/C12H10INO/c1-3-4-5-10-11(13)6-9(8-14)7-12(10)15-2/h1,6-7H,4-5H2,2H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin alpha-1A chain
(Sus scrofa (Pig)) | BDBM81744
(Oryzalin Analogue, 3)Show SMILES CCCN(CCC)c1c(cc(cc1N(=O)=O)S(=O)(=O)Nc1ccccc1)N(=O)=O Show InChI InChI=1S/C18H22N4O6S/c1-3-10-20(11-4-2)18-16(21(23)24)12-15(13-17(18)22(25)26)29(27,28)19-14-8-6-5-7-9-14/h5-9,12-13,19H,3-4,10-11H2,1-2H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin alpha-1A chain
(Sus scrofa (Pig)) | BDBM81743
(Oryzalin, 1)Show SMILES CCCN(CCC)c1c(cc(cc1N(=O)=O)S(N)(=O)=O)N(=O)=O Show InChI InChI=1S/C12H18N4O6S/c1-3-5-14(6-4-2)12-10(15(17)18)7-9(23(13,21)22)8-11(12)16(19)20/h7-8H,3-6H2,1-2H3,(H2,13,21,22) | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin beta chain
(Sus scrofa) | BDBM50475545
(CHEMBL381416)Show InChI InChI=1S/C15H11NO3/c17-10-3-1-9(2-4-10)7-13-12-6-5-11(18)8-14(12)16-15(13)19/h1-8,17-18H,(H,16,19)/b13-7+ | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly |
Bioorg Med Chem Lett 15: 5382-5 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.001 BindingDB Entry DOI: 10.7270/Q2Z322D9 |
More data for this Ligand-Target Pair | |
Tubulin beta chain
(Sus scrofa) | BDBM50131995
((E)-3-(4-hydroxybenzylidene)indolin-2-one | 3-(4-H...)Show InChI InChI=1S/C15H11NO2/c17-11-7-5-10(6-8-11)9-13-12-3-1-2-4-14(12)16-15(13)18/h1-9,17H,(H,16,18)/b13-9+ | PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly |
Bioorg Med Chem Lett 15: 5382-5 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.001 BindingDB Entry DOI: 10.7270/Q2Z322D9 |
More data for this Ligand-Target Pair | |
Tubulin alpha chain
(Leishmania tarentolae (Sauroleishmania tarentolae)) | BDBM81743
(Oryzalin, 1)Show SMILES CCCN(CCC)c1c(cc(cc1N(=O)=O)S(N)(=O)=O)N(=O)=O Show InChI InChI=1S/C12H18N4O6S/c1-3-5-14(6-4-2)12-10(15(17)18)7-9(23(13,21)22)8-11(12)16(19)20/h7-8H,3-6H2,1-2H3,(H2,13,21,22) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin beta chain
(Sus scrofa) | BDBM50476974
(CHEMBL55225 | sulfamidas35)Show SMILES CCCCN(CCCC)c1c(cc(cc1[N+]([O-])=O)S(=O)(=O)Nc1ccccc1)[N+]([O-])=O Show InChI InChI=1S/C20H26N4O6S/c1-3-5-12-22(13-6-4-2)20-18(23(25)26)14-17(15-19(20)24(27)28)31(29,30)21-16-10-8-7-9-11-16/h7-11,14-15,21H,3-6,12-13H2,1-2H3 | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibition of porcine tubulin assembly |
Bioorg Med Chem 15: 6071-9 (2007)
Article DOI: 10.1016/j.bmc.2007.06.042 BindingDB Entry DOI: 10.7270/Q2K93B99 |
More data for this Ligand-Target Pair | |
Tubulin beta chain
(Sus scrofa) | BDBM50475542
(CHEMBL378162)Show InChI InChI=1S/C15H11NO3/c17-10-3-1-2-9(6-10)7-13-12-5-4-11(18)8-14(12)16-15(13)19/h1-8,17-18H,(H,16,19)/b13-7+ | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly |
Bioorg Med Chem Lett 15: 5382-5 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.001 BindingDB Entry DOI: 10.7270/Q2Z322D9 |
More data for this Ligand-Target Pair | |
Tubulin beta chain
(Sus scrofa) | BDBM4810
((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)Show InChI InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8- | PDB
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly |
Bioorg Med Chem Lett 15: 5382-5 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.001 BindingDB Entry DOI: 10.7270/Q2Z322D9 |
More data for this Ligand-Target Pair | |
Tubulin beta chain
(Sus scrofa) | BDBM50475543
(CHEMBL382323)Show InChI InChI=1S/C15H11NO2/c17-11-5-3-4-10(8-11)9-13-12-6-1-2-7-14(12)16-15(13)18/h1-9,17H,(H,16,18)/b13-9+ | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly |
Bioorg Med Chem Lett 15: 5382-5 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.001 BindingDB Entry DOI: 10.7270/Q2Z322D9 |
More data for this Ligand-Target Pair | |
Tubulin beta chain
(Sus scrofa) | BDBM50476972
(CHEMBL393396)Show SMILES CCCCN(CCCC)c1c(Cl)cc(cc1Cl)S(=O)(=O)Nc1ccccc1 Show InChI InChI=1S/C20H26Cl2N2O2S/c1-3-5-12-24(13-6-4-2)20-18(21)14-17(15-19(20)22)27(25,26)23-16-10-8-7-9-11-16/h7-11,14-15,23H,3-6,12-13H2,1-2H3 | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibition of porcine tubulin assembly |
Bioorg Med Chem 15: 6071-9 (2007)
Article DOI: 10.1016/j.bmc.2007.06.042 BindingDB Entry DOI: 10.7270/Q2K93B99 |
More data for this Ligand-Target Pair | |
Tubulin beta chain
(Sus scrofa) | BDBM50476975
(CHEMBL236160)Show SMILES CCCCN(CCCC)c1c(N)cc(cc1N)S(=O)(=O)Nc1ccccc1 Show InChI InChI=1S/C20H30N4O2S/c1-3-5-12-24(13-6-4-2)20-18(21)14-17(15-19(20)22)27(25,26)23-16-10-8-7-9-11-16/h7-11,14-15,23H,3-6,12-13,21-22H2,1-2H3 | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibition of porcine tubulin assembly |
Bioorg Med Chem 15: 6071-9 (2007)
Article DOI: 10.1016/j.bmc.2007.06.042 BindingDB Entry DOI: 10.7270/Q2K93B99 |
More data for this Ligand-Target Pair | |
Tubulin alpha-1A chain
(Sus scrofa (Pig)) | BDBM81745
(Oryzalin Analogue, 4)Show SMILES CCCN(CCC)c1c(cc(cc1C#N)S(=O)(=O)Nc1ccccc1)C#N Show InChI InChI=1S/C20H22N4O2S/c1-3-10-24(11-4-2)20-16(14-21)12-19(13-17(20)15-22)27(25,26)23-18-8-6-5-7-9-18/h5-9,12-13,23H,3-4,10-11H2,1-2H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin beta chain
(Sus scrofa) | BDBM50476973
(CHEMBL393580)Show SMILES CCCCN(CCCC)c1c(cc(cc1C#N)S(=O)(=O)Nc1ccccc1)C#N Show InChI InChI=1S/C22H26N4O2S/c1-3-5-12-26(13-6-4-2)22-18(16-23)14-21(15-19(22)17-24)29(27,28)25-20-10-8-7-9-11-20/h7-11,14-15,25H,3-6,12-13H2,1-2H3 | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Inhibition of porcine tubulin assembly |
Bioorg Med Chem 15: 6071-9 (2007)
Article DOI: 10.1016/j.bmc.2007.06.042 BindingDB Entry DOI: 10.7270/Q2K93B99 |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human)) | BDBM50437533
(CHEMBL2407135)Show InChI InChI=1S/C19H25N3O2/c1-3-5-13-20-17-7-6-8-18(21-17)22-19(23)15-9-11-16(12-10-15)24-14-4-2/h6-12H,3-5,13-14H2,1-2H3,(H2,20,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
Curated by ChEMBL
| Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve... |
Bioorg Med Chem 21: 4730-43 (2013)
Article DOI: 10.1016/j.bmc.2013.03.082 BindingDB Entry DOI: 10.7270/Q2V12673 |
More data for this Ligand-Target Pair | |
Tubulin alpha chain
(Leishmania tarentolae (Sauroleishmania tarentolae)) | BDBM81747
(Chembridge No 9067250, Class 1, 8)Show InChI InChI=1S/C15H14FNO5S/c1-21-14-8-7-10(9-12(14)16)23(19,20)17-13-6-4-3-5-11(13)15(18)22-2/h3-9,17H,1-2H3 | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin alpha chain
(Leishmania tarentolae (Sauroleishmania tarentolae)) | BDBM81748
(Chembridge No 7946770, Class 1, 9)Show SMILES CCOc1cccc(c1)C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCCC1 Show InChI InChI=1S/C19H22N2O4S/c1-2-25-17-7-5-6-15(14-17)19(22)20-16-8-10-18(11-9-16)26(23,24)21-12-3-4-13-21/h5-11,14H,2-4,12-13H2,1H3,(H,20,22) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin alpha chain
(Leishmania tarentolae (Sauroleishmania tarentolae)) | BDBM81753
(Chembridge No 9035165, Class 2, 13)Show SMILES O=C(N1CCN(CC1)c1oc(nc1C#N)-c1ccccc1)c1cccs1 Show InChI InChI=1S/C19H16N4O2S/c20-13-15-19(25-17(21-15)14-5-2-1-3-6-14)23-10-8-22(9-11-23)18(24)16-7-4-12-26-16/h1-7,12H,8-11H2 | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin alpha-1A chain
(Sus scrofa (Pig)) | BDBM81752
(Chembridge No 9035650, Class 2, 12)Show SMILES COc1ccc(cc1)C(=O)N1CCN(CC1)c1oc(nc1C#N)-c1ccccc1 Show InChI InChI=1S/C22H20N4O3/c1-28-18-9-7-17(8-10-18)21(27)25-11-13-26(14-12-25)22-19(15-23)24-20(29-22)16-5-3-2-4-6-16/h2-10H,11-14H2,1H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin alpha-1A chain
(Sus scrofa (Pig)) | BDBM81753
(Chembridge No 9035165, Class 2, 13)Show SMILES O=C(N1CCN(CC1)c1oc(nc1C#N)-c1ccccc1)c1cccs1 Show InChI InChI=1S/C19H16N4O2S/c20-13-15-19(25-17(21-15)14-5-2-1-3-6-14)23-10-8-22(9-11-23)18(24)16-7-4-12-26-16/h1-7,12H,8-11H2 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin alpha-1A chain
(Sus scrofa (Pig)) | BDBM81751
(Chembridge No 9041709, Class 2, 11)Show SMILES O=C(N1CCN(CC1)c1oc(nc1C#N)-c1ccccc1)c1ccccc1 Show InChI InChI=1S/C21H18N4O2/c22-15-18-21(27-19(23-18)16-7-3-1-4-8-16)25-13-11-24(12-14-25)20(26)17-9-5-2-6-10-17/h1-10H,11-14H2 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin alpha chain
(Leishmania tarentolae (Sauroleishmania tarentolae)) | BDBM81749
(Chembridge No 7960631, Class 1, 10)Show InChI InChI=1S/C18H22N2O3S2/c1-4-20(5-2)25(22,23)15-12-10-14(11-13-15)19-18(21)16-8-6-7-9-17(16)24-3/h6-13H,4-5H2,1-3H3,(H,19,21) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin alpha chain
(Leishmania tarentolae (Sauroleishmania tarentolae)) | BDBM81752
(Chembridge No 9035650, Class 2, 12)Show SMILES COc1ccc(cc1)C(=O)N1CCN(CC1)c1oc(nc1C#N)-c1ccccc1 Show InChI InChI=1S/C22H20N4O3/c1-28-18-9-7-17(8-10-18)21(27)25-11-13-26(14-12-25)22-19(15-23)24-20(29-22)16-5-3-2-4-6-16/h2-10H,11-14H2,1H3 | PDB
UniProtKB/TrEMBL
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PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin alpha-1A chain
(Sus scrofa (Pig)) | BDBM81748
(Chembridge No 7946770, Class 1, 9)Show SMILES CCOc1cccc(c1)C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCCC1 Show InChI InChI=1S/C19H22N2O4S/c1-2-25-17-7-5-6-15(14-17)19(22)20-16-8-10-18(11-9-16)26(23,24)21-12-3-4-13-21/h5-11,14H,2-4,12-13H2,1H3,(H,20,22) | PDB MMDB
UniProtKB/SwissProt
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PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin alpha chain
(Leishmania tarentolae (Sauroleishmania tarentolae)) | BDBM81751
(Chembridge No 9041709, Class 2, 11)Show SMILES O=C(N1CCN(CC1)c1oc(nc1C#N)-c1ccccc1)c1ccccc1 Show InChI InChI=1S/C21H18N4O2/c22-15-18-21(27-19(23-18)16-7-3-1-4-8-16)25-13-11-24(12-14-25)20(26)17-9-5-2-6-10-17/h1-10H,11-14H2 | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin alpha-1A chain
(Sus scrofa (Pig)) | BDBM81749
(Chembridge No 7960631, Class 1, 10)Show InChI InChI=1S/C18H22N2O3S2/c1-4-20(5-2)25(22,23)15-12-10-14(11-13-15)19-18(21)16-8-6-7-9-17(16)24-3/h6-13H,4-5H2,1-3H3,(H,19,21) | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
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PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |
Tubulin alpha chain
(Leishmania tarentolae (Sauroleishmania tarentolae)) | BDBM81750
(Chembridge No 9063043, Class 1, 17)Show InChI InChI=1S/C18H19NO3/c1-13(2)12-22-15-10-8-14(9-11-15)18(20)19-16-6-4-5-7-17(16)21-3/h4-11H,1,12H2,2-3H3,(H,19,20) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Ohio State University
| Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin. |
Chem Biol Drug Des 72: 513-24 (2008)
Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV |
More data for this Ligand-Target Pair | |