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Compile Data Set for Download or QSAR

Found 54 hits with Last Name = 'wong' and Initial = 'vd'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352371
PNG
(CHEMBL1823342)
Show SMILES CCN(CC)C(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1
Show InChI InChI=1S/C34H36FN5O2/c1-3-38(4-2)34(42)32(25-11-6-5-7-12-25)40-21-19-39(20-22-40)31-17-16-27(23-30(31)35)37-33(41)29-15-9-8-14-28(29)26-13-10-18-36-24-26/h5-18,23-24,32H,3-4,19-22H2,1-2H3,(H,37,41)
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n/an/a 6n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50437018
PNG
(CHEMBL2403023)
Show SMILES CCN(CC)C(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1
Show InChI InChI=1S/C35H37FN4O2/c1-3-39(4-2)35(42)33(25-11-6-5-7-12-25)26-18-21-40(22-19-26)32-17-16-28(23-31(32)36)38-34(41)30-15-9-8-14-29(30)27-13-10-20-37-24-27/h5-17,20,23-24,26,33H,3-4,18-19,21-22H2,1-2H3,(H,38,41)
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n/an/a 7n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit


(Homo sapiens (Human))		BDBM50437018
PNG
(CHEMBL2403023)
Show SMILES CCN(CC)C(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1
Show InChI InChI=1S/C35H37FN4O2/c1-3-39(4-2)35(42)33(25-11-6-5-7-12-25)26-18-21-40(22-19-26)32-17-16-28(23-31(32)36)38-34(41)30-15-9-8-14-29(30)27-13-10-20-37-24-27/h5-17,20,23-24,26,33H,3-4,18-19,21-22H2,1-2H3,(H,38,41)
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n/an/a 7n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of MTP (unknown origin)-mediated triglyceride transfer from donor to acceptor vesicles preincubated for 5 mins followed by enzyme addition...

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352392
PNG
(CHEMBL1823577)
Show SMILES CCN(CC)C(=O)[C@H](N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1 |r|
Show InChI InChI=1S/C34H36FN5O2/c1-3-38(4-2)34(42)32(25-11-6-5-7-12-25)40-21-19-39(20-22-40)31-17-16-27(23-30(31)35)37-33(41)29-15-9-8-14-28(29)26-13-10-18-36-24-26/h5-18,23-24,32H,3-4,19-22H2,1-2H3,(H,37,41)/t32-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352389
PNG
(CHEMBL1823360)
Show SMILES CCN(CC)C(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1F)c1ccccc1
Show InChI InChI=1S/C35H37FN4O2/c1-3-38(4-2)35(42)33(27-15-9-6-10-16-27)40-23-21-39(22-24-40)32-20-19-28(25-31(32)36)37-34(41)30-18-12-11-17-29(30)26-13-7-5-8-14-26/h5-20,25,33H,3-4,21-24H2,1-2H3,(H,37,41)
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n/an/a 10n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352383
PNG
(CHEMBL1823354)
Show SMILES CCNC(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1C#N)c1ccccc1
Show InChI InChI=1S/C34H33N5O2/c1-2-36-34(41)32(26-13-7-4-8-14-26)39-21-19-38(20-22-39)31-18-17-28(23-27(31)24-35)37-33(40)30-16-10-9-15-29(30)25-11-5-3-6-12-25/h3-18,23,32H,2,19-22H2,1H3,(H,36,41)(H,37,40)
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n/an/a 11n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50437017
PNG
(CHEMBL2402905)
Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1F)c1ccccc1
Show InChI InChI=1S/C34H34FN3O2/c1-2-36-34(40)32(25-13-7-4-8-14-25)26-19-21-38(22-20-26)31-18-17-27(23-30(31)35)37-33(39)29-16-10-9-15-28(29)24-11-5-3-6-12-24/h3-18,23,26,32H,2,19-22H2,1H3,(H,36,40)(H,37,39)
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n/an/a 12n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50437008
PNG
(CHEMBL2403028)
Show SMILES CCN(CC)C(=O)C(C1CCN(CC1)c1ccc(NC(=O)Nc2c(C)noc2C)cc1F)c1ccccc1
Show InChI InChI=1S/C29H36FN5O3/c1-5-34(6-2)28(36)26(21-10-8-7-9-11-21)22-14-16-35(17-15-22)25-13-12-23(18-24(25)30)31-29(37)32-27-19(3)33-38-20(27)4/h7-13,18,22,26H,5-6,14-17H2,1-4H3,(H2,31,32,37)
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n/an/a 12n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit


(Homo sapiens (Human))		BDBM50437017
PNG
(CHEMBL2402905)
Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1F)c1ccccc1
Show InChI InChI=1S/C34H34FN3O2/c1-2-36-34(40)32(25-13-7-4-8-14-25)26-19-21-38(22-20-26)31-18-17-27(23-30(31)35)37-33(39)29-16-10-9-15-28(29)24-11-5-3-6-12-24/h3-18,23,26,32H,2,19-22H2,1H3,(H,36,40)(H,37,39)
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n/an/a 13n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of MTP (unknown origin)-mediated triglyceride transfer from donor to acceptor vesicles preincubated for 5 mins followed by enzyme addition...

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352393
PNG
(CHEMBL1823578)
Show SMILES CCN(CC)C(=O)[C@@H](N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1 |r|
Show InChI InChI=1S/C34H36FN5O2/c1-3-38(4-2)34(42)32(25-11-6-5-7-12-25)40-21-19-39(20-22-40)31-17-16-27(23-30(31)35)37-33(41)29-15-9-8-14-28(29)26-13-10-18-36-24-26/h5-18,23-24,32H,3-4,19-22H2,1-2H3,(H,37,41)/t32-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50437009
PNG
(CHEMBL2403027)
Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)Nc2c(C)noc2C)cc1F)c1ccccc1
Show InChI InChI=1S/C27H32FN5O3/c1-4-29-26(34)24(19-8-6-5-7-9-19)20-12-14-33(15-13-20)23-11-10-21(16-22(23)28)30-27(35)31-25-17(2)32-36-18(25)3/h5-11,16,20,24H,4,12-15H2,1-3H3,(H,29,34)(H2,30,31,35)
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n/an/a 15n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50437014
PNG
(CHEMBL2402906)
Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1
Show InChI InChI=1S/C33H33FN4O2/c1-2-36-33(40)31(23-9-4-3-5-10-23)24-16-19-38(20-17-24)30-15-14-26(21-29(30)34)37-32(39)28-13-7-6-12-27(28)25-11-8-18-35-22-25/h3-15,18,21-22,24,31H,2,16-17,19-20H2,1H3,(H,36,40)(H,37,39)
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n/an/a 24n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352376
PNG
(CHEMBL1823347)
Show SMILES COC(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1C#N)c1ccccc1
Show InChI InChI=1S/C33H30N4O3/c1-40-33(39)31(25-12-6-3-7-13-25)37-20-18-36(19-21-37)30-17-16-27(22-26(30)23-34)35-32(38)29-15-9-8-14-28(29)24-10-4-2-5-11-24/h2-17,22,31H,18-21H2,1H3,(H,35,38)
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n/an/a 25n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352370
PNG
(CHEMBL1823341)
Show SMILES COc1cccnc1C(=O)N1CCN(CC1)c1ccc(NC(C)(C)c2ccccc2)cc1Cl
Show InChI InChI=1S/C26H29ClN4O2/c1-26(2,19-8-5-4-6-9-19)29-20-11-12-22(21(27)18-20)30-14-16-31(17-15-30)25(32)24-23(33-3)10-7-13-28-24/h4-13,18,29H,14-17H2,1-3H3
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n/an/a 25n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit


(Homo sapiens (Human))		BDBM50437016
PNG
(CHEMBL2402907)
Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccsc2)cc1F)c1ccccc1
Show InChI InChI=1S/C32H32FN3O2S/c1-2-34-32(38)30(22-8-4-3-5-9-22)23-14-17-36(18-15-23)29-13-12-25(20-28(29)33)35-31(37)27-11-7-6-10-26(27)24-16-19-39-21-24/h3-13,16,19-21,23,30H,2,14-15,17-18H2,1H3,(H,34,38)(H,35,37)
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n/an/a 25n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of MTP (unknown origin)-mediated triglyceride transfer from donor to acceptor vesicles preincubated for 5 mins followed by enzyme addition...

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50437011
PNG
(CHEMBL2403025)
Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)Nc2ccccc2-c2ccccc2)cc1F)c1ccccc1
Show InChI InChI=1S/C34H35FN4O2/c1-2-36-33(40)32(25-13-7-4-8-14-25)26-19-21-39(22-20-26)31-18-17-27(23-29(31)35)37-34(41)38-30-16-10-9-15-28(30)24-11-5-3-6-12-24/h3-18,23,26,32H,2,19-22H2,1H3,(H,36,40)(H2,37,38,41)
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n/an/a 27n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352385
PNG
(CHEMBL1823356)
Show SMILES CCNC(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1C#N)c1ccccc1
Show InChI InChI=1S/C33H32N6O2/c1-2-36-33(41)31(24-9-4-3-5-10-24)39-19-17-38(18-20-39)30-15-14-27(21-26(30)22-34)37-32(40)29-13-7-6-12-28(29)25-11-8-16-35-23-25/h3-16,21,23,31H,2,17-20H2,1H3,(H,36,41)(H,37,40)
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n/an/a 30n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit


(Homo sapiens (Human))		BDBM50437007
PNG
(CHEMBL2403029)
Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(cc1F)C(=O)Nc1ccccc1-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C34H34FN3O2/c1-2-36-34(40)32(25-13-7-4-8-14-25)26-19-21-38(22-20-26)31-18-17-27(23-29(31)35)33(39)37-30-16-10-9-15-28(30)24-11-5-3-6-12-24/h3-18,23,26,32H,2,19-22H2,1H3,(H,36,40)(H,37,39)
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n/an/a 33n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of MTP (unknown origin)-mediated triglyceride transfer from donor to acceptor vesicles preincubated for 5 mins followed by enzyme addition...

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352382
PNG
(CHEMBL1823353)
Show SMILES CCNC(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1F)c1ccccc1
Show InChI InChI=1S/C33H33FN4O2/c1-2-35-33(40)31(25-13-7-4-8-14-25)38-21-19-37(20-22-38)30-18-17-26(23-29(30)34)36-32(39)28-16-10-9-15-27(28)24-11-5-3-6-12-24/h3-18,23,31H,2,19-22H2,1H3,(H,35,40)(H,36,39)
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n/an/a 35n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50437010
PNG
(CHEMBL2403024)
Show SMILES CCN(CC)C(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2c(C)noc2C)cc1F)c1ccccc1
Show InChI InChI=1S/C29H35FN4O3/c1-5-33(6-2)29(36)27(21-10-8-7-9-11-21)22-14-16-34(17-15-22)25-13-12-23(18-24(25)30)31-28(35)26-19(3)32-37-20(26)4/h7-13,18,22,27H,5-6,14-17H2,1-4H3,(H,31,35)
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n/an/a 37n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352388
PNG
(CHEMBL1823359)
Show SMILES CCN(CC)C(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1C#N)c1ccccc1
Show InChI InChI=1S/C36H37N5O2/c1-3-39(4-2)36(43)34(28-15-9-6-10-16-28)41-23-21-40(22-24-41)33-20-19-30(25-29(33)26-37)38-35(42)32-18-12-11-17-31(32)27-13-7-5-8-14-27/h5-20,25,34H,3-4,21-24H2,1-2H3,(H,38,42)
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n/an/a 37n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352388
PNG
(CHEMBL1823359)
Show SMILES CCN(CC)C(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1C#N)c1ccccc1
Show InChI InChI=1S/C36H37N5O2/c1-3-39(4-2)36(43)34(28-15-9-6-10-16-28)41-23-21-40(22-24-41)33-20-19-30(25-29(33)26-37)38-35(42)32-18-12-11-17-31(32)27-13-7-5-8-14-27/h5-20,25,34H,3-4,21-24H2,1-2H3,(H,38,42)
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n/an/a 37n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352373
PNG
(CHEMBL1823344)
Show SMILES COC(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccncc2)cc1F)c1ccccc1
Show InChI InChI=1S/C31H29FN4O3/c1-39-31(38)29(23-7-3-2-4-8-23)36-19-17-35(18-20-36)28-12-11-24(21-27(28)32)34-30(37)26-10-6-5-9-25(26)22-13-15-33-16-14-22/h2-16,21,29H,17-20H2,1H3,(H,34,37)
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n/an/a 37n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352379
PNG
(CHEMBL1823350)
Show SMILES COC(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1
Show InChI InChI=1S/C31H29FN4O3/c1-39-31(38)29(22-8-3-2-4-9-22)36-18-16-35(17-19-36)28-14-13-24(20-27(28)32)34-30(37)26-12-6-5-11-25(26)23-10-7-15-33-21-23/h2-15,20-21,29H,16-19H2,1H3,(H,34,37)
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n/an/a 40n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352384
PNG
(CHEMBL1823355)
Show SMILES CCNC(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1
Show InChI InChI=1S/C32H32FN5O2/c1-2-35-32(40)30(23-9-4-3-5-10-23)38-19-17-37(18-20-38)29-15-14-25(21-28(29)33)36-31(39)27-13-7-6-12-26(27)24-11-8-16-34-22-24/h3-16,21-22,30H,2,17-20H2,1H3,(H,35,40)(H,36,39)
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n/an/a 42n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50437007
PNG
(CHEMBL2403029)
Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(cc1F)C(=O)Nc1ccccc1-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C34H34FN3O2/c1-2-36-34(40)32(25-13-7-4-8-14-25)26-19-21-38(22-20-26)31-18-17-27(23-29(31)35)33(39)37-30-16-10-9-15-28(30)24-11-5-3-6-12-24/h3-18,23,26,32H,2,19-22H2,1H3,(H,36,40)(H,37,39)
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n/an/a 45n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352391
PNG
(CHEMBL1823576)
Show SMILES CCC(CC)C(=O)Nc1ccc(N2CCN(CC2)C(C(=O)N(CC)CC)c2ccccc2)c(F)c1
Show InChI InChI=1S/C28H39FN4O2/c1-5-21(6-2)27(34)30-23-14-15-25(24(29)20-23)32-16-18-33(19-17-32)26(22-12-10-9-11-13-22)28(35)31(7-3)8-4/h9-15,20-21,26H,5-8,16-19H2,1-4H3,(H,30,34)
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n/an/a 50n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352375
PNG
(CHEMBL1823346)
Show SMILES COC(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1F)c1ccccc1
Show InChI InChI=1S/C32H30FN3O3/c1-39-32(38)30(24-12-6-3-7-13-24)36-20-18-35(19-21-36)29-17-16-25(22-28(29)33)34-31(37)27-15-9-8-14-26(27)23-10-4-2-5-11-23/h2-17,22,30H,18-21H2,1H3,(H,34,37)
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n/an/a 52n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50437016
PNG
(CHEMBL2402907)
Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccsc2)cc1F)c1ccccc1
Show InChI InChI=1S/C32H32FN3O2S/c1-2-34-32(38)30(22-8-4-3-5-9-22)23-14-17-36(18-15-23)29-13-12-25(20-28(29)33)35-31(37)27-11-7-6-10-26(27)24-16-19-39-21-24/h3-13,16,19-21,23,30H,2,14-15,17-18H2,1H3,(H,34,38)(H,35,37)
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n/an/a 70n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50140506
PNG
((E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cy...)
Show SMILES CC(=O)N1CCc2ccc(cc12)N(C1CCN(CCC2CCCC2)CC1)C(=O)\C=C\c1cccc(c1)C#N
Show InChI InChI=1S/C32H38N4O2/c1-24(37)35-20-14-28-10-11-30(22-31(28)35)36(32(38)12-9-26-7-4-8-27(21-26)23-33)29-15-18-34(19-16-29)17-13-25-5-2-3-6-25/h4,7-12,21-22,25,29H,2-3,5-6,13-20H2,1H3/b12-9+
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n/an/a 100n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352377
PNG
(CHEMBL1823348)
Show SMILES COC(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1C)c1ccccc1
Show InChI InChI=1S/C33H33N3O3/c1-24-23-27(34-32(37)29-16-10-9-15-28(29)25-11-5-3-6-12-25)17-18-30(24)35-19-21-36(22-20-35)31(33(38)39-2)26-13-7-4-8-14-26/h3-18,23,31H,19-22H2,1-2H3,(H,34,37)
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n/an/a 100n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352387
PNG
(CHEMBL1823358)
Show SMILES CCNC(=O)C(N1CCN(CC1)c1ccc(NC(=O)C(CC)CC)cc1C#N)c1ccccc1
Show InChI InChI=1S/C27H35N5O2/c1-4-20(5-2)26(33)30-23-12-13-24(22(18-23)19-28)31-14-16-32(17-15-31)25(27(34)29-6-3)21-10-8-7-9-11-21/h7-13,18,20,25H,4-6,14-17H2,1-3H3,(H,29,34)(H,30,33)
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n/an/a 150n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50437015
PNG
(CHEMBL2403026)
Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)Nc2c(C)cccc2C)cc1F)c1ccccc1
Show InChI InChI=1S/C30H35FN4O2/c1-4-32-29(36)27(22-11-6-5-7-12-22)23-15-17-35(18-16-23)26-14-13-24(19-25(26)31)33-30(37)34-28-20(2)9-8-10-21(28)3/h5-14,19,23,27H,4,15-18H2,1-3H3,(H,32,36)(H2,33,34,37)
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n/an/a 162n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352381
PNG
(CHEMBL1823352)
Show SMILES CCC(CC)C(=O)Nc1ccc(N2CCN(CC2)C(C(=O)OC)c2ccccc2)c(F)c1
Show InChI InChI=1S/C25H32FN3O3/c1-4-18(5-2)24(30)27-20-11-12-22(21(26)17-20)28-13-15-29(16-14-28)23(25(31)32-3)19-9-7-6-8-10-19/h6-12,17-18,23H,4-5,13-16H2,1-3H3,(H,27,30)
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n/an/a 165n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM42539
PNG
(4-(Hydroxy-diphenyl-methyl)-piperidine-1-carbothio...)
Show SMILES CCOc1ccc(NC(=S)N2CCC(CC2)C(O)(c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C27H30N2O2S/c1-2-31-25-15-13-24(14-16-25)28-26(32)29-19-17-23(18-20-29)27(30,21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-16,23,30H,2,17-20H2,1H3,(H,28,32)
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n/an/a 200n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352390
PNG
(CHEMBL1823575)
Show SMILES CCC(CC)C(=O)Nc1ccc(N2CCN(CC2)C(C(=O)N(CC)CC)c2ccccc2)c(c1)C#N
Show InChI InChI=1S/C29H39N5O2/c1-5-22(6-2)28(35)31-25-14-15-26(24(20-25)21-30)33-16-18-34(19-17-33)27(23-12-10-9-11-13-23)29(36)32(7-3)8-4/h9-15,20,22,27H,5-8,16-19H2,1-4H3,(H,31,35)
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n/an/a 200n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352390
PNG
(CHEMBL1823575)
Show SMILES CCC(CC)C(=O)Nc1ccc(N2CCN(CC2)C(C(=O)N(CC)CC)c2ccccc2)c(c1)C#N
Show InChI InChI=1S/C29H39N5O2/c1-5-22(6-2)28(35)31-25-14-15-26(24(20-25)21-30)33-16-18-34(19-17-33)27(23-12-10-9-11-13-23)29(36)32(7-3)8-4/h9-15,20,22,27H,5-8,16-19H2,1-4H3,(H,31,35)
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n/an/a 200n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit


(Homo sapiens (Human))		BDBM50437014
PNG
(CHEMBL2402906)
Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1
Show InChI InChI=1S/C33H33FN4O2/c1-2-36-33(40)31(23-9-4-3-5-10-23)24-16-19-38(20-17-24)30-15-14-26(21-29(30)34)37-32(39)28-13-7-6-12-27(28)25-11-8-18-35-22-25/h3-15,18,21-22,24,31H,2,16-17,19-20H2,1H3,(H,36,40)(H,37,39)
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n/an/a 210n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of MTP (unknown origin)-mediated triglyceride transfer from donor to acceptor vesicles preincubated for 5 mins followed by enzyme addition...

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352378
PNG
(CHEMBL1823349)
Show SMILES COC(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1)c1ccccc1
Show InChI InChI=1S/C31H30N4O3/c1-38-31(37)29(23-8-3-2-4-9-23)35-20-18-34(19-21-35)26-15-13-25(14-16-26)33-30(36)28-12-6-5-11-27(28)24-10-7-17-32-22-24/h2-17,22,29H,18-21H2,1H3,(H,33,36)
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n/an/a 220n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352372
PNG
(CHEMBL1823343)
Show SMILES COC(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccncc2)cc1)c1ccccc1
Show InChI InChI=1S/C31H30N4O3/c1-38-31(37)29(24-7-3-2-4-8-24)35-21-19-34(20-22-35)26-13-11-25(12-14-26)33-30(36)28-10-6-5-9-27(28)23-15-17-32-18-16-23/h2-18,29H,19-22H2,1H3,(H,33,36)
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n/an/a 240n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352386
PNG
(CHEMBL1823357)
Show SMILES CCNC(=O)C(N1CCN(CC1)c1ccc(NC(=O)C(CC)CC)cc1F)c1ccccc1
Show InChI InChI=1S/C26H35FN4O2/c1-4-19(5-2)25(32)29-21-12-13-23(22(27)18-21)30-14-16-31(17-15-30)24(26(33)28-6-3)20-10-8-7-9-11-20/h7-13,18-19,24H,4-6,14-17H2,1-3H3,(H,28,33)(H,29,32)
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PubMed
n/an/a 370n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50135642
PNG
(Benzo[b]thiophene-2-carboxylic acid (2-benzylsulfa...)
Show SMILES CN(C)CCCN(C(=O)c1cc2ccccc2s1)c1ccccc1SCc1ccccc1
Show InChI InChI=1S/C27H28N2OS2/c1-28(2)17-10-18-29(27(30)26-19-22-13-6-8-15-24(22)32-26)23-14-7-9-16-25(23)31-20-21-11-4-3-5-12-21/h3-9,11-16,19H,10,17-18,20H2,1-2H3
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n/an/a 450n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50437013
PNG
(CHEMBL2402909)
Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2c(C)noc2C)cc1F)c1ccccc1
Show InChI InChI=1S/C27H31FN4O3/c1-4-29-26(33)25(19-8-6-5-7-9-19)20-12-14-32(15-13-20)23-11-10-21(16-22(23)28)30-27(34)24-17(2)31-35-18(24)3/h5-11,16,20,25H,4,12-15H2,1-3H3,(H,29,33)(H,30,34)
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n/an/a 476n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352380
PNG
(CHEMBL1823351)
Show SMILES CCC(CC)C(=O)Nc1ccc(cc1)N1CCN(CC1)C(C(=O)OC)c1ccccc1
Show InChI InChI=1S/C25H33N3O3/c1-4-19(5-2)24(29)26-21-11-13-22(14-12-21)27-15-17-28(18-16-27)23(25(30)31-3)20-9-7-6-8-10-20/h6-14,19,23H,4-5,15-18H2,1-3H3,(H,26,29)
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PubMed
n/an/a 530n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50352374
PNG
(CHEMBL1823345)
Show SMILES COC(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2ccccc2)cc1)c1ccccc1
Show InChI InChI=1S/C32H31N3O3/c1-38-32(37)30(25-12-6-3-7-13-25)35-22-20-34(21-23-35)27-18-16-26(17-19-27)33-31(36)29-15-9-8-14-28(29)24-10-4-2-5-11-24/h2-19,30H,20-23H2,1H3,(H,33,36)
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n/an/a 530n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting

Bioorg Med Chem Lett 21: 5552-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.136
BindingDB Entry DOI: 10.7270/Q2R49R5K
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(Homo sapiens (Human))		BDBM50437012
PNG
(CHEMBL2402908)
Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2ccccc2Br)cc1F)c1ccccc1
Show InChI InChI=1S/C28H29BrFN3O2/c1-2-31-28(35)26(19-8-4-3-5-9-19)20-14-16-33(17-15-20)25-13-12-21(18-24(25)30)32-27(34)22-10-6-7-11-23(22)29/h3-13,18,20,26H,2,14-17H2,1H3,(H,31,35)(H,32,34)
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n/an/a 665n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from NPY-Y2 receptor in human KAN-TS cell membranes after 1 hr by scintillation counting analysis

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit


(Homo sapiens (Human))		BDBM50352371
PNG
(CHEMBL1823342)
Show SMILES CCN(CC)C(=O)C(N1CCN(CC1)c1ccc(NC(=O)c2ccccc2-c2cccnc2)cc1F)c1ccccc1
Show InChI InChI=1S/C34H36FN5O2/c1-3-38(4-2)34(42)32(25-11-6-5-7-12-25)40-21-19-39(20-22-40)31-17-16-27(23-30(31)35)37-33(41)29-15-9-8-14-28(29)26-13-10-18-36-24-26/h5-18,23-24,32H,3-4,19-22H2,1-2H3,(H,37,41)
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n/an/a 710n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of MTP (unknown origin)

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit


(Homo sapiens (Human))		BDBM50437011
PNG
(CHEMBL2403025)
Show SMILES CCNC(=O)C(C1CCN(CC1)c1ccc(NC(=O)Nc2ccccc2-c2ccccc2)cc1F)c1ccccc1
Show InChI InChI=1S/C34H35FN4O2/c1-2-36-33(40)32(25-13-7-4-8-14-25)26-19-21-39(22-20-26)31-18-17-27(23-29(31)35)37-34(41)38-30-16-10-9-15-28(30)24-11-5-3-6-12-24/h3-18,23,26,32H,2,19-22H2,1H3,(H,36,40)(H2,37,38,41)
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n/an/a 7.40E+3n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of MTP (unknown origin)-mediated triglyceride transfer from donor to acceptor vesicles preincubated for 5 mins followed by enzyme addition...

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit


(Homo sapiens (Human))		BDBM50437010
PNG
(CHEMBL2403024)
Show SMILES CCN(CC)C(=O)C(C1CCN(CC1)c1ccc(NC(=O)c2c(C)noc2C)cc1F)c1ccccc1
Show InChI InChI=1S/C29H35FN4O3/c1-5-33(6-2)29(36)27(21-10-8-7-9-11-21)22-14-16-34(17-15-22)25-13-12-23(18-24(25)30)31-28(35)26-19(3)32-37-20(26)4/h7-13,18,22,27H,5-6,14-17H2,1-4H3,(H,31,35)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of MTP (unknown origin)-mediated triglyceride transfer from donor to acceptor vesicles preincubated for 5 mins followed by enzyme addition...

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
Microsomal triglyceride transfer protein large subunit


(Homo sapiens (Human))		BDBM50437008
PNG
(CHEMBL2403028)
Show SMILES CCN(CC)C(=O)C(C1CCN(CC1)c1ccc(NC(=O)Nc2c(C)noc2C)cc1F)c1ccccc1
Show InChI InChI=1S/C29H36FN5O3/c1-5-34(6-2)28(36)26(21-10-8-7-9-11-21)22-14-16-35(17-15-22)25-13-12-23(18-24(25)30)31-29(37)32-27-19(3)33-38-20(27)4/h7-13,18,22,26H,5-6,14-17H2,1-4H3,(H2,31,32,37)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Research& Development LLC

Curated by ChEMBL


Assay Description
Inhibition of MTP (unknown origin)-mediated triglyceride transfer from donor to acceptor vesicles preincubated for 5 mins followed by enzyme addition...

Bioorg Med Chem Lett 23: 4141-4 (2013)


Article DOI: 10.1016/j.bmcl.2013.05.038
BindingDB Entry DOI: 10.7270/Q29C6ZV8
More data for this
Ligand-Target Pair
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