Found 158 hits with Last Name = 'zoeckler' and Initial = 'm' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cytochrome P450 1A2
(Homo sapiens (Human)) | BDBM50201124
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H21ClN6O2/c1-14-9-17(31-8-7-26-13-31)11-19-22(14)30-23(29-19)21-18(5-6-27-24(21)33)28-12-20(32)15-3-2-4-16(25)10-15/h2-11,13,20,32H,12H2,1H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | <18 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co
Curated by ChEMBL
| Assay Description Concentration required to inhibit Cytochrome P450 1A2 in vitro by 50% |
J Med Chem 48: 5639-43 (2005)
Article DOI: 10.1021/jm050392q BindingDB Entry DOI: 10.7270/Q2MW2GPP |
More data for this Ligand-Target Pair | |
Cytochrome P450 2C9
(Homo sapiens (Human)) | BDBM50201124
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H21ClN6O2/c1-14-9-17(31-8-7-26-13-31)11-19-22(14)30-23(29-19)21-18(5-6-27-24(21)33)28-12-20(32)15-3-2-4-16(25)10-15/h2-11,13,20,32H,12H2,1H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | <18 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co
Curated by ChEMBL
| Assay Description Concentration required to inhibit Cytochrome P450 2C9 in vitro by 50% |
J Med Chem 48: 5639-43 (2005)
Article DOI: 10.1021/jm050392q BindingDB Entry DOI: 10.7270/Q2MW2GPP |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50201124
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H21ClN6O2/c1-14-9-17(31-8-7-26-13-31)11-19-22(14)30-23(29-19)21-18(5-6-27-24(21)33)28-12-20(32)15-3-2-4-16(25)10-15/h2-11,13,20,32H,12H2,1H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | <18 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co
Curated by ChEMBL
| Assay Description Concentration required to inhibit cytochrome P450 isozyme CYP3A4-BzRes in vitro by 50% |
J Med Chem 48: 5639-43 (2005)
Article DOI: 10.1021/jm050392q BindingDB Entry DOI: 10.7270/Q2MW2GPP |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50201124
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H21ClN6O2/c1-14-9-17(31-8-7-26-13-31)11-19-22(14)30-23(29-19)21-18(5-6-27-24(21)33)28-12-20(32)15-3-2-4-16(25)10-15/h2-11,13,20,32H,12H2,1H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | <18 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co
Curated by ChEMBL
| Assay Description Concentration required to inhibit cytochrome P450 isozyme CYP3A4-BFC in vitro by 50% |
J Med Chem 48: 5639-43 (2005)
Article DOI: 10.1021/jm050392q BindingDB Entry DOI: 10.7270/Q2MW2GPP |
More data for this Ligand-Target Pair | |
Cytochrome P450 2C19
(Homo sapiens (Human)) | BDBM50201124
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H21ClN6O2/c1-14-9-17(31-8-7-26-13-31)11-19-22(14)30-23(29-19)21-18(5-6-27-24(21)33)28-12-20(32)15-3-2-4-16(25)10-15/h2-11,13,20,32H,12H2,1H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co
Curated by ChEMBL
| Assay Description Concentration required to inhibit cytochrome P450 isozyme CYP2C19 in vitro by 50% |
J Med Chem 48: 5639-43 (2005)
Article DOI: 10.1021/jm050392q BindingDB Entry DOI: 10.7270/Q2MW2GPP |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50209387
(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(6-(4...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O)C1=NC(C)(C)CN1 |t:32| Show InChI InChI=1S/C26H27ClN6O2/c1-14-9-16(23-30-13-26(2,3)33-23)11-19-22(14)32-24(31-19)21-18(7-8-28-25(21)35)29-12-20(34)15-5-4-6-17(27)10-15/h4-11,20,34H,12-13H2,1-3H3,(H,30,33)(H,31,32)(H2,28,29,35) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human IGF1R expressed in recombinant insect cells |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Cytochrome P450 1A2
(Homo sapiens (Human)) | BDBM50209380
((S)-3-(6-bromo-4-methyl-1H-benzo[d]imidazol-2-yl)-...)Show SMILES Cc1cc(Br)cc2[nH]c(nc12)-c1c(N[C@H](CO)Cc2ccccc2)cc[nH]c1=O Show InChI InChI=1S/C22H21BrN4O2/c1-13-9-15(23)11-18-20(13)27-21(26-18)19-17(7-8-24-22(19)29)25-16(12-28)10-14-5-3-2-4-6-14/h2-9,11,16,28H,10,12H2,1H3,(H,26,27)(H2,24,25,29)/t16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of CYP1A2 in microsomes |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50209385
(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(4-me...)Show SMILES CC1CNC(=N1)c1cc(C)c2nc([nH]c2c1)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O |c:4| Show InChI InChI=1S/C25H25ClN6O2/c1-13-8-16(23-29-11-14(2)30-23)10-19-22(13)32-24(31-19)21-18(6-7-27-25(21)34)28-12-20(33)15-4-3-5-17(26)9-15/h3-10,14,20,33H,11-12H2,1-2H3,(H,29,30)(H,31,32)(H2,27,28,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human IGF1R expressed in recombinant insect cells |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50206136
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(N[C@H](CO)Cc2ccccc2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C25H24N6O2/c1-16-11-19(31-10-9-26-15-31)13-21-23(16)30-24(29-21)22-20(7-8-27-25(22)33)28-18(14-32)12-17-5-3-2-4-6-17/h2-11,13,15,18,32H,12,14H2,1H3,(H,29,30)(H2,27,28,33)/t18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 in microsomes |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50209389
(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(4-me...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O)C1=NCCCN1 |t:32| Show InChI InChI=1S/C25H25ClN6O2/c1-14-10-16(23-27-7-3-8-28-23)12-19-22(14)32-24(31-19)21-18(6-9-29-25(21)34)30-13-20(33)15-4-2-5-17(26)11-15/h2,4-6,9-12,20,33H,3,7-8,13H2,1H3,(H,27,28)(H,31,32)(H2,29,30,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human IGF1R expressed in recombinant insect cells |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM27879
(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1 |r| Show InChI InChI=1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against IR kinase with ATP concentration at 1/2Km |
J Med Chem 48: 5639-43 (2005)
Article DOI: 10.1021/jm050392q BindingDB Entry DOI: 10.7270/Q2MW2GPP |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50206120
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCc2ccccn2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C22H19N7O/c1-14-10-16(29-9-8-23-13-29)11-18-20(14)28-21(27-18)19-17(5-7-25-22(19)30)26-12-15-4-2-3-6-24-15/h2-11,13H,12H2,1H3,(H,27,28)(H2,25,26,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 in microsomes |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50209392
(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(4-me...)Show SMILES CN1CCN=C1c1cc(C)c2nc([nH]c2c1)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O |c:4| Show InChI InChI=1S/C25H25ClN6O2/c1-14-10-16(24-27-8-9-32(24)2)12-19-22(14)31-23(30-19)21-18(6-7-28-25(21)34)29-13-20(33)15-4-3-5-17(26)11-15/h3-7,10-12,20,33H,8-9,13H2,1-2H3,(H,30,31)(H2,28,29,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human IGF1R expressed in recombinant insect cells |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM27879
(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1 |r| Show InChI InChI=1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against IGF-1R kinase |
J Med Chem 48: 5639-43 (2005)
Article DOI: 10.1021/jm050392q BindingDB Entry DOI: 10.7270/Q2MW2GPP |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM27879
(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1 |r| Show InChI InChI=1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against IGF-1R Sal kinase with ATP concentration at 1/2Km |
J Med Chem 48: 5639-43 (2005)
Article DOI: 10.1021/jm050392q BindingDB Entry DOI: 10.7270/Q2MW2GPP |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50209391
(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(4-me...)Show SMILES Cc1c[nH]c(n1)-c1cc(C)c2[nH]c(nc2c1)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O Show InChI InChI=1S/C25H23ClN6O2/c1-13-8-16(23-29-11-14(2)30-23)10-19-22(13)32-24(31-19)21-18(6-7-27-25(21)34)28-12-20(33)15-4-3-5-17(26)9-15/h3-11,20,33H,12H2,1-2H3,(H,29,30)(H,31,32)(H2,27,28,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human IGF1R expressed in recombinant insect cells |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201135
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H21ClN6O2/c1-14-9-17(31-8-7-26-13-31)11-19-22(14)30-23(29-19)21-18(5-6-27-24(21)33)28-12-20(32)15-3-2-4-16(25)10-15/h2-11,13,20,32H,12H2,1H3,(H,29,30)(H2,27,28,33)/t20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201144
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(Br)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H21BrN6O2/c1-14-9-17(31-8-7-26-13-31)11-19-22(14)30-23(29-19)21-18(5-6-27-24(21)33)28-12-20(32)15-3-2-4-16(25)10-15/h2-11,13,20,32H,12H2,1H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201132
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES COc1ccc(cc1Cl)C(O)CNc1cc[nH]c(=O)c1-c1nc2cc(cc(C)c2[nH]1)-n1ccnc1 Show InChI InChI=1S/C25H23ClN6O3/c1-14-9-16(32-8-7-27-13-32)11-19-23(14)31-24(30-19)22-18(5-6-28-25(22)34)29-12-20(33)15-3-4-21(35-2)17(26)10-15/h3-11,13,20,33H,12H2,1-2H3,(H,30,31)(H2,28,29,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Focal adhesion kinase 1
(Homo sapiens (Human)) | BDBM27879
(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1 |r| Show InChI InChI=1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against FAK with ATP concentration at 1/2Km |
J Med Chem 48: 5639-43 (2005)
Article DOI: 10.1021/jm050392q BindingDB Entry DOI: 10.7270/Q2MW2GPP |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201138
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2ccc(F)c(Cl)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H20ClFN6O2/c1-13-8-15(32-7-6-27-12-32)10-19-22(13)31-23(30-19)21-18(4-5-28-24(21)34)29-11-20(33)14-2-3-17(26)16(25)9-14/h2-10,12,20,33H,11H2,1H3,(H,30,31)(H2,28,29,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50209382
(2-(4-{[2-(3-chlorophenyl)-2-hydroxyethyl]amino}-2-...)Show SMILES CNC(=N)c1cc(C)c2nc([nH]c2c1)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O Show InChI InChI=1S/C23H23ClN6O2/c1-12-8-14(21(25)26-2)10-17-20(12)30-22(29-17)19-16(6-7-27-23(19)32)28-11-18(31)13-4-3-5-15(24)9-13/h3-10,18,31H,11H2,1-2H3,(H2,25,26)(H,29,30)(H2,27,28,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human IGF1R expressed in recombinant insect cells |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50209386
(2-(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-2-ox...)Show SMILES CNC(=O)c1cc(C)c2nc([nH]c2c1)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O Show InChI InChI=1S/C23H22ClN5O3/c1-12-8-14(22(31)25-2)10-17-20(12)29-21(28-17)19-16(6-7-26-23(19)32)27-11-18(30)13-4-3-5-15(24)9-13/h3-10,18,30H,11H2,1-2H3,(H,25,31)(H,28,29)(H2,26,27,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human IGF1R expressed in recombinant insect cells |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201124
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H21ClN6O2/c1-14-9-17(31-8-7-26-13-31)11-19-22(14)30-23(29-19)21-18(5-6-27-24(21)33)28-12-20(32)15-3-2-4-16(25)10-15/h2-11,13,20,32H,12H2,1H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201124
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H21ClN6O2/c1-14-9-17(31-8-7-26-13-31)11-19-22(14)30-23(29-19)21-18(5-6-27-24(21)33)28-12-20(32)15-3-2-4-16(25)10-15/h2-11,13,20,32H,12H2,1H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human IGF1R expressed in recombinant insect cells |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201124
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H21ClN6O2/c1-14-9-17(31-8-7-26-13-31)11-19-22(14)30-23(29-19)21-18(5-6-27-24(21)33)28-12-20(32)15-3-2-4-16(25)10-15/h2-11,13,20,32H,12H2,1H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against IGF-1R kinase |
J Med Chem 48: 5639-43 (2005)
Article DOI: 10.1021/jm050392q BindingDB Entry DOI: 10.7270/Q2MW2GPP |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50209394
(2-(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-2-ox...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O)C(N)=O Show InChI InChI=1S/C22H20ClN5O3/c1-11-7-13(20(24)30)9-16-19(11)28-21(27-16)18-15(5-6-25-22(18)31)26-10-17(29)12-3-2-4-14(23)8-12/h2-9,17,29H,10H2,1H3,(H2,24,30)(H,27,28)(H2,25,26,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human IGF1R expressed in recombinant insect cells |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM27879
(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1 |r| Show InChI InChI=1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 182 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against MEK with ATP concentration at 1/2Km |
J Med Chem 48: 5639-43 (2005)
Article DOI: 10.1021/jm050392q BindingDB Entry DOI: 10.7270/Q2MW2GPP |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201133
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(O)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H22N6O3/c1-14-9-16(30-8-7-25-13-30)11-19-22(14)29-23(28-19)21-18(5-6-26-24(21)33)27-12-20(32)15-3-2-4-17(31)10-15/h2-11,13,20,31-32H,12H2,1H3,(H,28,29)(H2,26,27,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201135
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H21ClN6O2/c1-14-9-17(31-8-7-26-13-31)11-19-22(14)30-23(29-19)21-18(5-6-27-24(21)33)28-12-20(32)15-3-2-4-16(25)10-15/h2-11,13,20,32H,12H2,1H3,(H,29,30)(H2,27,28,33)/t20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R expressed in Sal cells |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201126
(3-(2-(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(c2)C#N)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C25H21N7O2/c1-15-9-18(32-8-7-27-14-32)11-20-23(15)31-24(30-20)22-19(5-6-28-25(22)34)29-13-21(33)17-4-2-3-16(10-17)12-26/h2-11,14,21,33H,13H2,1H3,(H,30,31)(H2,28,29,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201129
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cc(Cl)cc(Cl)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H20Cl2N6O2/c1-13-6-17(32-5-4-27-12-32)10-19-22(13)31-23(30-19)21-18(2-3-28-24(21)34)29-11-20(33)14-7-15(25)9-16(26)8-14/h2-10,12,20,33H,11H2,1H3,(H,30,31)(H2,28,29,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50209393
(2-(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-2-ox...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O)C(=O)NC1CC1 Show InChI InChI=1S/C25H24ClN5O3/c1-13-9-15(24(33)29-17-5-6-17)11-19-22(13)31-23(30-19)21-18(7-8-27-25(21)34)28-12-20(32)14-3-2-4-16(26)10-14/h2-4,7-11,17,20,32H,5-6,12H2,1H3,(H,29,33)(H,30,31)(H2,27,28,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human IGF1R expressed in recombinant insect cells |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201128
(CHEMBL388206 | N-(3-(2-(3-(6-(1H-imidazol-1-yl)-4-...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(NS(C)(=O)=O)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C25H25N7O4S/c1-15-10-18(32-9-8-26-14-32)12-20-23(15)30-24(29-20)22-19(6-7-27-25(22)34)28-13-21(33)16-4-3-5-17(11-16)31-37(2,35)36/h3-12,14,21,31,33H,13H2,1-2H3,(H,29,30)(H2,27,28,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201143
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cccc(c1)C(O)CNc1cc[nH]c(=O)c1-c1nc2cc(cc(C)c2[nH]1)-n1ccnc1 Show InChI InChI=1S/C25H24N6O2/c1-15-4-3-5-17(10-15)21(32)13-28-19-6-7-27-25(33)22(19)24-29-20-12-18(31-9-8-26-14-31)11-16(2)23(20)30-24/h3-12,14,21,32H,13H2,1-2H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM27879
(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1 |r| Show InChI InChI=1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid PDB UniChem
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Similars
| Article PubMed
| n/a | n/a | 341 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against LCK with ATP concentration at 1/2Km |
J Med Chem 48: 5639-43 (2005)
Article DOI: 10.1021/jm050392q BindingDB Entry DOI: 10.7270/Q2MW2GPP |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201123
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1ccc(cc1)C(O)CNc1cc[nH]c(=O)c1-c1nc2cc(cc(C)c2[nH]1)-n1ccnc1 Show InChI InChI=1S/C25H24N6O2/c1-15-3-5-17(6-4-15)21(32)13-28-19-7-8-27-25(33)22(19)24-29-20-12-18(31-10-9-26-14-31)11-16(2)23(20)30-24/h3-12,14,21,32H,13H2,1-2H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50209391
(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(4-me...)Show SMILES Cc1c[nH]c(n1)-c1cc(C)c2[nH]c(nc2c1)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O Show InChI InChI=1S/C25H23ClN6O2/c1-13-8-16(23-29-11-14(2)30-23)10-19-22(13)32-24(31-19)21-18(6-7-27-25(21)34)28-12-20(33)15-4-3-5-17(26)9-15/h3-11,20,33H,12H2,1-2H3,(H,29,30)(H,31,32)(H2,27,28,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 in microsomes |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201124
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H21ClN6O2/c1-14-9-17(31-8-7-26-13-31)11-19-22(14)30-23(29-19)21-18(5-6-27-24(21)33)28-12-20(32)15-3-2-4-16(25)10-15/h2-11,13,20,32H,12H2,1H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R expressed in Sal cells |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Cytochrome P450 1A2
(Homo sapiens (Human)) | BDBM50209378
(4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(4-me...)Show SMILES Cc1cccc2[nH]c(nc12)-c1c(NCC(O)c2cccc(Cl)c2)cc[nH]c1=O Show InChI InChI=1S/C21H19ClN4O2/c1-12-4-2-7-16-19(12)26-20(25-16)18-15(8-9-23-21(18)28)24-11-17(27)13-5-3-6-14(22)10-13/h2-10,17,27H,11H2,1H3,(H,25,26)(H2,23,24,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of CYP1A2 in microsomes |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50206120
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCc2ccccn2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C22H19N7O/c1-14-10-16(29-9-8-23-13-29)11-18-20(14)28-21(27-18)19-17(5-7-25-22(19)30)26-12-15-4-2-3-6-24-15/h2-11,13H,12H2,1H3,(H,27,28)(H2,25,26,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human IGF1R expressed in recombinant insect cells |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201143
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cccc(c1)C(O)CNc1cc[nH]c(=O)c1-c1nc2cc(cc(C)c2[nH]1)-n1ccnc1 Show InChI InChI=1S/C25H24N6O2/c1-15-4-3-5-17(10-15)21(32)13-28-19-6-7-27-25(33)22(19)24-29-20-12-18(31-9-8-26-14-31)11-16(2)23(20)30-24/h3-12,14,21,32H,13H2,1-2H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R expressed in Sal cells |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201130
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NC[C@H](O)c2cccc(Cl)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H21ClN6O2/c1-14-9-17(31-8-7-26-13-31)11-19-22(14)30-23(29-19)21-18(5-6-27-24(21)33)28-12-20(32)15-3-2-4-16(25)10-15/h2-11,13,20,32H,12H2,1H3,(H,29,30)(H2,27,28,33)/t20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R expressed in Sal cells |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201120
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2ccc(Cl)c(Cl)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H20Cl2N6O2/c1-13-8-15(32-7-6-27-12-32)10-19-22(13)31-23(30-19)21-18(4-5-28-24(21)34)29-11-20(33)14-2-3-16(25)17(26)9-14/h2-10,12,20,33H,11H2,1H3,(H,30,31)(H2,28,29,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201134
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(F)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H21FN6O2/c1-14-9-17(31-8-7-26-13-31)11-19-22(14)30-23(29-19)21-18(5-6-27-24(21)33)28-12-20(32)15-3-2-4-16(25)10-15/h2-11,13,20,32H,12H2,1H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R expressed in Sal cells |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM27879
(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1 |r| Show InChI InChI=1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co
Curated by ChEMBL
| Assay Description Concentration required to inhibit cytochrome P450 isozyme CYP3A4-BFC in vitro by 50% |
J Med Chem 48: 5639-43 (2005)
Article DOI: 10.1021/jm050392q BindingDB Entry DOI: 10.7270/Q2MW2GPP |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201137
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES COc1ccc(cc1)C(O)CNc1cc[nH]c(=O)c1-c1nc2cc(cc(C)c2[nH]1)-n1ccnc1 Show InChI InChI=1S/C25H24N6O3/c1-15-11-17(31-10-9-26-14-31)12-20-23(15)30-24(29-20)22-19(7-8-27-25(22)33)28-13-21(32)16-3-5-18(34-2)6-4-16/h3-12,14,21,32H,13H2,1-2H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201134
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(F)c2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C24H21FN6O2/c1-14-9-17(31-8-7-26-13-31)11-19-22(14)30-23(29-19)21-18(5-6-27-24(21)33)28-12-20(32)15-3-2-4-16(25)10-15/h2-11,13,20,32H,12H2,1H3,(H,29,30)(H2,27,28,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50206136
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(N[C@H](CO)Cc2ccccc2)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C25H24N6O2/c1-16-11-19(31-10-9-26-15-31)13-21-23(16)30-24(29-21)22-20(7-8-27-25(22)33)28-18(14-32)12-17-5-3-2-4-6-17/h2-11,13,15,18,32H,12,14H2,1H3,(H,29,30)(H2,27,28,33)/t18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human IGF1R expressed in recombinant insect cells |
Bioorg Med Chem Lett 17: 3072-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.048 BindingDB Entry DOI: 10.7270/Q2F76C71 |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50201125
(3-(6-(1H-imidazol-1-yl)-4-methyl-1H-benzo[d]imidaz...)Show SMILES Cc1cc(cc2nc([nH]c12)-c1c(NCC(O)c2cccc(c2)C(F)(F)F)cc[nH]c1=O)-n1ccnc1 Show InChI InChI=1S/C25H21F3N6O2/c1-14-9-17(34-8-7-29-13-34)11-19-22(14)33-23(32-19)21-18(5-6-30-24(21)36)31-12-20(35)15-3-2-4-16(10-15)25(26,27)28/h2-11,13,20,35H,12H2,1H3,(H,32,33)(H2,30,31,36) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of IGF1R |
Bioorg Med Chem Lett 17: 974-7 (2007)
Article DOI: 10.1016/j.bmcl.2006.11.041 BindingDB Entry DOI: 10.7270/Q25T3K4D |
More data for this Ligand-Target Pair | |