SMILES String Search

Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 327.1
BDBM7266

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 66 hits in this display
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Ninein (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by PDSP K_i Database									Biochem J 371: 199-204 (2003) Article DOI: 10.1042/BJ20021535 BindingDB Entry DOI: 10.7270/Q2KH0KV9
University of Dundee Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	470	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by PDSP K_i Database									Biochem J 371: 199-204 (2003) Article DOI: 10.1042/BJ20021535 BindingDB Entry DOI: 10.7270/Q2KH0KV9
University of Dundee Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	670	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by PDSP K_i Database									Biochem J 371: 199-204 (2003) Article DOI: 10.1042/BJ20021535 BindingDB Entry DOI: 10.7270/Q2KH0KV9
University of Dundee Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells				Citation and Details
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 3 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells				Citation and Details
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universit£t Braunschweig Curated by ChEMBL					Assay Description Inhibition of GSK3-beta expressed in insect Sf9 cells				Eur J Med Chem 45: 335-42 (2010) Article DOI: 10.1016/j.ejmech.2009.10.018 BindingDB Entry DOI: 10.7270/Q26W9C1V
Technische Universit£t Braunschweig Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Rattus norvegicus (rat))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity in rat uterus by uterotonic assay				Citation and Details
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Rattus norvegicus (rat))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	30
CNRS					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...				Eur J Biochem 267: 5983-94 (2000) Article DOI: 10.1046/j.1432-1327.2000.01673.x BindingDB Entry DOI: 10.7270/Q2CR5RJS
CNRS					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GSK3beta (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112949 BindingDB Entry DOI: 10.7270/Q22V2KVV
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
The Rockefeller University Curated by ChEMBL					Assay Description Inhibition of GSK3-beta				Trends Pharmacol Sci 25: 471-80 (2004) Article DOI: 10.1016/j.tips.2004.07.006 BindingDB Entry DOI: 10.7270/Q2VX0HG5
The Rockefeller University Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Northwestern University Curated by ChEMBL					Assay Description Inhibition of GSK3beta (unknown origin) expressed in sf9 cells after 30 mins by scintillation counting analysis in presence of [gamma-32P]ATP				Bioorg Med Chem Lett 24: 1532-7 (2014) Article DOI: 10.1016/j.bmcl.2014.01.078 BindingDB Entry DOI: 10.7270/Q2S46W05
Northwestern University Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Rattus norvegicus (rat))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	7.5	30
Technische Universitat Braunschweig					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				Bioorg Med Chem Lett 14: 413-6 (2004) Article DOI: 10.1016/j.bmcl.2003.10.062 BindingDB Entry DOI: 10.7270/Q2BR8QDD
Technische Universitat Braunschweig					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK9/cyclin T expressed in insect cells assessed as incorporation of [gamma-33P]-ATP in to pRB fragment (773 to 928) ...				Bioorg Med Chem Lett 20: 4940-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.024 BindingDB Entry DOI: 10.7270/Q21836T2
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of GSK3beta (unknown origin)				J Med Chem 60: 8482-8514 (2017) Article DOI: 10.1021/acs.jmedchem.7b00922 BindingDB Entry DOI: 10.7270/Q25T3NW3
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of GSK3-beta				Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL					Assay Description Inhibition of Cyclin-dependent kinase 1-cyclin B from M phase starfish (Marthasterias glacialis) oocytes				J Med Chem 46: 876-9 (2003) Article DOI: 10.1021/jm021090g BindingDB Entry DOI: 10.7270/Q2X067TX
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Universität Hamburg Curated by ChEMBL					Assay Description Inhibition of Cyclin-dependent kinase 1-cyclin B from Starfish oocytes				Bioorg Med Chem Lett 10: 567-9 (2000) BindingDB Entry DOI: 10.7270/Q2Z60N98
Universität Hamburg Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universit£t Braunschweig Curated by ChEMBL					Assay Description Inhibition of CDK1/cyclin B expressed in M phase starfish oocyte				Eur J Med Chem 45: 335-42 (2010) Article DOI: 10.1016/j.ejmech.2009.10.018 BindingDB Entry DOI: 10.7270/Q26W9C1V
Technische Universit£t Braunschweig Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
University of Jordan Curated by ChEMBL					Assay Description Inhibition of human GST-CDK1/cyclin B1 expressed in baculovirus using [gamma-33P]ATP after 45 mins by liquid scintillation counting				Eur J Med Chem 45: 4316-30 (2010) Article DOI: 10.1016/j.ejmech.2010.06.034 BindingDB Entry DOI: 10.7270/Q2W66KZM
University of Jordan Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Inhibition of CDK1/cyclin B				Bioorg Med Chem Lett 20: 4940-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.024 BindingDB Entry DOI: 10.7270/Q21836T2
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Universität Hamburg Curated by ChEMBL					Assay Description In vitro inhibitory activity against cyclin-dependent kinase 1-cyclin B (Cyclin-Dependent Kinase) harvested from starfish oocytes.				J Med Chem 42: 2909-19 (1999) Article DOI: 10.1021/jm9900570 BindingDB Entry DOI: 10.7270/Q21C1W2R
Universität Hamburg Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Babasaheb Bhimrao Ambedkar University Curated by ChEMBL					Assay Description Inhibition of GST-tagged CDK1/cyclin B (unknown origin) expressed in Escherichia coli				Eur J Med Chem 142: 244-265 (2017) Article DOI: 10.1016/j.ejmech.2017.07.042 BindingDB Entry DOI: 10.7270/Q2571FQR
Babasaheb Bhimrao Ambedkar University Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mus musculus (mouse))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	MMDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Activity at human B2 receptor transfected in CHO cells assessed as ability to antagonize BK-induced inositol-phosphate accumulation				Citation and Details
TBA					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
The Rockefeller University Curated by ChEMBL					Assay Description Inhibition of CDK1/cyclinB				Trends Pharmacol Sci 25: 471-80 (2004) Article DOI: 10.1016/j.tips.2004.07.006 BindingDB Entry DOI: 10.7270/Q2VX0HG5
The Rockefeller University Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Marthasterias glacialis (starfish))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	7.2	30
Technische Universitat Braunschweig					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				Bioorg Med Chem Lett 14: 413-6 (2004) Article DOI: 10.1016/j.bmcl.2003.10.062 BindingDB Entry DOI: 10.7270/Q2BR8QDD
Technische Universitat Braunschweig					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Marthasterias glacialis (starfish))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	7.2	30
CNRS					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...				Eur J Biochem 267: 5983-94 (2000) Article DOI: 10.1046/j.1432-1327.2000.01673.x BindingDB Entry DOI: 10.7270/Q2CR5RJS
CNRS					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of Lck				Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mus musculus (mouse))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	MMDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Activity at human B2 receptor transfected in CHO cells assessed as ability to antagonize BK-induced inositol-phosphate accumulation				Citation and Details
TBA					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	780	n/a	n/a	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK2/cyclin A assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation c...				Bioorg Med Chem Lett 20: 4940-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.024 BindingDB Entry DOI: 10.7270/Q21836T2
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Nuclear receptor subfamily 0 group B member 1 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	>834	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay									PubChem Bioassay (2013) BindingDB Entry DOI: 10.7270/Q23777B0
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL					Assay Description Inhibition of Cyclin-dependent kinase 5 (CDK5)				J Med Chem 46: 876-9 (2003) Article DOI: 10.1021/jm021090g BindingDB Entry DOI: 10.7270/Q2X067TX
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universit£t Braunschweig Curated by ChEMBL					Assay Description Inhibition of recombinant CDK5/p25 expressed in Escherichia coli				J Med Chem 51: 2196-207 (2008) Article DOI: 10.1021/jm701582f BindingDB Entry DOI: 10.7270/Q2SF2X22
Technische Universit£t Braunschweig Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	7.2	30
Technische Universitat Braunschweig					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...				Bioorg Med Chem Lett 14: 413-6 (2004) Article DOI: 10.1016/j.bmcl.2003.10.062 BindingDB Entry DOI: 10.7270/Q2BR8QDD
Technische Universitat Braunschweig					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	30
CNRS					Assay Description Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...				Eur J Biochem 267: 5983-94 (2000) Article DOI: 10.1046/j.1432-1327.2000.01673.x BindingDB Entry DOI: 10.7270/Q2CR5RJS
CNRS					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mus musculus (mouse))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	MMDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at rat UT receptor				Citation and Details
TBA					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK5/p25 assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation counti...				Bioorg Med Chem Lett 20: 4940-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.024 BindingDB Entry DOI: 10.7270/Q21836T2
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00335 BindingDB Entry DOI: 10.7270/Q2RF601N
TBA					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mus musculus (mouse))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	MMDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity in rat uterus by uterotonic assay				Citation and Details
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells				Citation and Details
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of ERK2				Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Casein kinase I isoform alpha (Sus scrofa)	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Inhibition of porcine brain CK1 assessed as incorporation of [gamma-33P]-ATP into RRKHAAIGpSAYSITA substrate after 30 mins by scintillation counting				Bioorg Med Chem Lett 20: 4940-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.024 BindingDB Entry DOI: 10.7270/Q21836T2
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Inhibition of CLK1				Bioorg Med Chem Lett 20: 4940-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.024 BindingDB Entry DOI: 10.7270/Q21836T2
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (RAT)	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli assessed as assessed as incorporation of [gamma-33P]-ATP into myelin bas...				Bioorg Med Chem Lett 20: 4940-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.024 BindingDB Entry DOI: 10.7270/Q21836T2
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase 3 (Plasmodium falciparum (isolate 3D7))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum GSK3				Bioorg Med Chem Lett 20: 4940-4 (2010) Article DOI: 10.1016/j.bmcl.2010.06.024 BindingDB Entry DOI: 10.7270/Q21836T2
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1 (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity in rat uterus by uterotonic assay				Citation and Details
TBA					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at NOP receptor in Albino guinea pig ileum assessed as effect on electrically stimulated contractions				Citation and Details
TBA					More data for this Ligand-Target Pair
MO15-related protein kinase Pfmrk (Plasmodium falciparum)	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Walter Reed Army Institute of Research Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum cyclin-dependent kinase				J Med Chem 47: 5418-26 (2004) Article DOI: 10.1021/jm040108f BindingDB Entry DOI: 10.7270/Q2BZ66TW
Walter Reed Army Institute of Research Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity in phenoxybenzamine-treated rat by Pressor assay				Citation and Details
TBA					More data for this Ligand-Target Pair
MO15-related protein kinase Pfmrk (Plasmodium falciparum)	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Research Curated by ChEMBL					Assay Description Inhibitory activity against Plasmodium falciparum cyclin dependent protein kinase, Pfmrk				J Med Chem 46: 3877-82 (2003) Article DOI: 10.1021/jm0300983 BindingDB Entry DOI: 10.7270/Q2028S9W
Institute of Research Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM7266 (14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of c-Src				Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair

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