Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 324.4 BDBM24231

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 2 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM24231 (2-[4-(piperidin-1-ylmethyl)phenoxy]-1,3-benzothiaz...) Show SMILES C(N1CCCCC1)c1ccc(Oc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C19H20N2OS/c1-4-12-21(13-5-1)14-15-8-10-16(11-9-15)22-19-20-17-6-2-3-7-18(17)23-19/h2-3,6-11H,1,4-5,12-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	25
Johnson & Johnson Pharmaceutical					Assay Description Recombinant human LTA4H was incubated with various concentrations of test compound for 10 min at room temperature in assay buffer, and the substrate,...				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM24231 (2-[4-(piperidin-1-ylmethyl)phenoxy]-1,3-benzothiaz...) Show SMILES C(N1CCCCC1)c1ccc(Oc2nc3ccccc3s2)cc1 Show InChI InChI=1S/C19H20N2OS/c1-4-12-21(13-5-1)14-15-8-10-16(11-9-15)22-19-20-17-6-2-3-7-18(17)23-19/h2-3,6-11H,1,4-5,12-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description Compounds were assessed for their ability to displace [3H]astemizole using membranes from HEK-293 cells expressing the hERG K+ channel.				J Med Chem 51: 4150-69 (2008) Article DOI: 10.1021/jm701575k BindingDB Entry DOI: 10.7270/Q2GB22CX
					More data for this Ligand-Target Pair