Found 8 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Calmodulin-domain protein kinase 1, putative
(Cryptosporidium parvum (strain Iowa II)) | BDBM340882
(3-isopropyl-1-(quinolin-3-yl)imidazo[1,5- a]pyrazi...)Show InChI InChI=1S/C18H17N5/c1-11(2)18-22-15(16-17(19)20-7-8-23(16)18)13-9-12-5-3-4-6-14(12)21-10-13/h3-11H,1-2H3,(H2,19,20) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
(Cryptosporidium parvum (strain Iowa II)) | BDBM340882
(3-isopropyl-1-(quinolin-3-yl)imidazo[1,5- a]pyrazi...)Show InChI InChI=1S/C18H17N5/c1-11(2)18-22-15(16-17(19)20-7-8-23(16)18)13-9-12-5-3-4-6-14(12)21-10-13/h3-11H,1-2H3,(H2,19,20) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM340882
(3-isopropyl-1-(quinolin-3-yl)imidazo[1,5- a]pyrazi...)Show InChI InChI=1S/C18H17N5/c1-11(2)18-22-15(16-17(19)20-7-8-23(16)18)13-9-12-5-3-4-6-14(12)21-10-13/h3-11H,1-2H3,(H2,19,20) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |
cGMP-dependent protein kinase
() | BDBM340882
(3-isopropyl-1-(quinolin-3-yl)imidazo[1,5- a]pyrazi...)Show InChI InChI=1S/C18H17N5/c1-11(2)18-22-15(16-17(19)20-7-8-23(16)18)13-9-12-5-3-4-6-14(12)21-10-13/h3-11H,1-2H3,(H2,19,20) | UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340882
(3-isopropyl-1-(quinolin-3-yl)imidazo[1,5- a]pyrazi...)Show InChI InChI=1S/C18H17N5/c1-11(2)18-22-15(16-17(19)20-7-8-23(16)18)13-9-12-5-3-4-6-14(12)21-10-13/h3-11H,1-2H3,(H2,19,20) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340882
(3-isopropyl-1-(quinolin-3-yl)imidazo[1,5- a]pyrazi...)Show InChI InChI=1S/C18H17N5/c1-11(2)18-22-15(16-17(19)20-7-8-23(16)18)13-9-12-5-3-4-6-14(12)21-10-13/h3-11H,1-2H3,(H2,19,20) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM340882
(3-isopropyl-1-(quinolin-3-yl)imidazo[1,5- a]pyrazi...)Show InChI InChI=1S/C18H17N5/c1-11(2)18-22-15(16-17(19)20-7-8-23(16)18)13-9-12-5-3-4-6-14(12)21-10-13/h3-11H,1-2H3,(H2,19,20) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 686 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM340882
(3-isopropyl-1-(quinolin-3-yl)imidazo[1,5- a]pyrazi...)Show InChI InChI=1S/C18H17N5/c1-11(2)18-22-15(16-17(19)20-7-8-23(16)18)13-9-12-5-3-4-6-14(12)21-10-13/h3-11H,1-2H3,(H2,19,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |