Found 8 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cGMP-dependent protein kinase
() | BDBM340925
(3-(6-(3-chloro-4-(2,2,2- trifluorethyl)benzyloxy)n...)Show SMILES CC(C)n1nc(-c2ccc3cc(OCc4ccc(CC(F)(F)F)c(Cl)c4)ccc3c2)c2c(N)ncnc12 Show InChI InChI=1S/C27H23ClF3N5O/c1-15(2)36-26-23(25(32)33-14-34-26)24(35-36)19-6-5-18-11-21(8-7-17(18)10-19)37-13-16-3-4-20(22(28)9-16)12-27(29,30)31/h3-11,14-15H,12-13H2,1-2H3,(H2,32,33,34) | UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 15.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340925
(3-(6-(3-chloro-4-(2,2,2- trifluorethyl)benzyloxy)n...)Show SMILES CC(C)n1nc(-c2ccc3cc(OCc4ccc(CC(F)(F)F)c(Cl)c4)ccc3c2)c2c(N)ncnc12 Show InChI InChI=1S/C27H23ClF3N5O/c1-15(2)36-26-23(25(32)33-14-34-26)24(35-36)19-6-5-18-11-21(8-7-17(18)10-19)37-13-16-3-4-20(22(28)9-16)12-27(29,30)31/h3-11,14-15H,12-13H2,1-2H3,(H2,32,33,34) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 15.9 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1
(Toxoplasma gondii) | BDBM340925
(3-(6-(3-chloro-4-(2,2,2- trifluorethyl)benzyloxy)n...)Show SMILES CC(C)n1nc(-c2ccc3cc(OCc4ccc(CC(F)(F)F)c(Cl)c4)ccc3c2)c2c(N)ncnc12 Show InChI InChI=1S/C27H23ClF3N5O/c1-15(2)36-26-23(25(32)33-14-34-26)24(35-36)19-6-5-18-11-21(8-7-17(18)10-19)37-13-16-3-4-20(22(28)9-16)12-27(29,30)31/h3-11,14-15H,12-13H2,1-2H3,(H2,32,33,34) | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 15.9 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
(Cryptosporidium parvum (strain Iowa II)) | BDBM340925
(3-(6-(3-chloro-4-(2,2,2- trifluorethyl)benzyloxy)n...)Show SMILES CC(C)n1nc(-c2ccc3cc(OCc4ccc(CC(F)(F)F)c(Cl)c4)ccc3c2)c2c(N)ncnc12 Show InChI InChI=1S/C27H23ClF3N5O/c1-15(2)36-26-23(25(32)33-14-34-26)24(35-36)19-6-5-18-11-21(8-7-17(18)10-19)37-13-16-3-4-20(22(28)9-16)12-27(29,30)31/h3-11,14-15H,12-13H2,1-2H3,(H2,32,33,34) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 262 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2K077GQ |
More data for this Ligand-Target Pair | |
Calcium-dependent protein kinase 1
(Cryptosporidium parvum) | BDBM340925
(3-(6-(3-chloro-4-(2,2,2- trifluorethyl)benzyloxy)n...)Show SMILES CC(C)n1nc(-c2ccc3cc(OCc4ccc(CC(F)(F)F)c(Cl)c4)ccc3c2)c2c(N)ncnc12 Show InChI InChI=1S/C27H23ClF3N5O/c1-15(2)36-26-23(25(32)33-14-34-26)24(35-36)19-6-5-18-11-21(8-7-17(18)10-19)37-13-16-3-4-20(22(28)9-16)12-27(29,30)31/h3-11,14-15H,12-13H2,1-2H3,(H2,32,33,34) | UniProtKB/TrEMBL
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 262 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Washington Through its Center for Commercialization
US Patent
| Assay Description Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha... |
US Patent US9765037 (2017)
BindingDB Entry DOI: 10.7270/Q2B56MVC |
More data for this Ligand-Target Pair | |
Calmodulin-domain protein kinase 1, putative
(Cryptosporidium parvum (strain Iowa II)) | BDBM340925
(3-(6-(3-chloro-4-(2,2,2- trifluorethyl)benzyloxy)n...)Show SMILES CC(C)n1nc(-c2ccc3cc(OCc4ccc(CC(F)(F)F)c(Cl)c4)ccc3c2)c2c(N)ncnc12 Show InChI InChI=1S/C27H23ClF3N5O/c1-15(2)36-26-23(25(32)33-14-34-26)24(35-36)19-6-5-18-11-21(8-7-17(18)10-19)37-13-16-3-4-20(22(28)9-16)12-27(29,30)31/h3-11,14-15H,12-13H2,1-2H3,(H2,32,33,34) | PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 262 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM340925
(3-(6-(3-chloro-4-(2,2,2- trifluorethyl)benzyloxy)n...)Show SMILES CC(C)n1nc(-c2ccc3cc(OCc4ccc(CC(F)(F)F)c(Cl)c4)ccc3c2)c2c(N)ncnc12 Show InChI InChI=1S/C27H23ClF3N5O/c1-15(2)36-26-23(25(32)33-14-34-26)24(35-36)19-6-5-18-11-21(8-7-17(18)10-19)37-13-16-3-4-20(22(28)9-16)12-27(29,30)31/h3-11,14-15H,12-13H2,1-2H3,(H2,32,33,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM340925
(3-(6-(3-chloro-4-(2,2,2- trifluorethyl)benzyloxy)n...)Show SMILES CC(C)n1nc(-c2ccc3cc(OCc4ccc(CC(F)(F)F)c(Cl)c4)ccc3c2)c2c(N)ncnc12 Show InChI InChI=1S/C27H23ClF3N5O/c1-15(2)36-26-23(25(32)33-14-34-26)24(35-36)19-6-5-18-11-21(8-7-17(18)10-19)37-13-16-3-4-20(22(28)9-16)12-27(29,30)31/h3-11,14-15H,12-13H2,1-2H3,(H2,32,33,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR CO
US Patent
| Assay Description Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti... |
US Patent US10544104 (2020)
BindingDB Entry DOI: 10.7270/Q2D79DSF |
More data for this Ligand-Target Pair | |