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Target
Sequence
Name
&
Ki
IC50
Kd
EC50
Rate constants
ΔG°
ΔH°
-TΔS°
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Ki
IC50
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Marvin 2D Structure
The following exact ligands are found in BindingDB
Wt: 240.2
BDBM50567047
Purchase
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
33
hits in this display
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/a
n/a
76
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Displacement of Kinase tracer 236 from biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 1.5 hrs by TR-FRET...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
3D Structure (crystal)
Dual specificity protein kinase CLK4
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
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MCE
PC cid
PC sid
PDB
UniChem
n/a
n/a
219
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
GoogleScholar
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MCE
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/a
n/a
220
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of full length GST-tagged human DYRK1A phosphorylation expressed in baculovirus expression system in presence of [gamma-33P]ATP by radiome...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
3D Structure (crystal)
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
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PC cid
PC sid
PDB
UniChem
n/a
n/a
236
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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MCE
PC cid
PC sid
PDB
UniChem
n/a
n/a
319
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
Reactome pathway
KEGG
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MCE
PC cid
PC sid
PDB
UniChem
PDB
n/a
n/a
464
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
3D Structure (crystal)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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MCE
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/a
n/a
590
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of human DYRK1A-mediated tau phosphorylation expressed in HEK293 cells incubated for 2 hrs by ELISA
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
3D Structure (crystal)
Dual specificity protein kinase CLK2
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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MCE
PC cid
PC sid
PDB
UniChem
n/a
n/a
1.33E+3
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK3
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
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MCE
PC cid
PC sid
PDB
UniChem
n/a
n/a
2.97E+3
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
NCI pathway
KEGG
UniProtKB/SwissProt
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MCE
PC cid
PC sid
PDB
UniChem
n/a
n/a
3.27E+3
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 3
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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MCE
PC cid
PC sid
PDB
UniChem
n/a
n/a
4.45E+3
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 4
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
KEGG
UniProtKB/SwissProt
antibodypedia
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MCE
PC cid
PC sid
PDB
UniChem
n/a
n/a
9.59E+3
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
MMDB
KEGG
UniProtKB/SwissProt
DrugBank
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MCE
PC cid
PC sid
PDB
UniChem
n/a
n/a
9.67E+3
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
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MCE
PC cid
PC sid
PDB
UniChem
n/a
n/a
>1.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform epsilon
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
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MCE
PC cid
PC sid
PDB
UniChem
n/a
n/a
>1.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
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MCE
PC cid
PC sid
PDB
UniChem
PDB
n/a
n/a
n/a
0.240
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
3D Structure (crystal)
Dual specificity protein kinase CLK1
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
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MCE
PC cid
PC sid
PDB
UniChem
n/a
n/a
n/a
5.40
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase WNK2
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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Purchase
MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/a
n/a
n/a
1.00E+4
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to wild-type human partial length WNK2 (V47 to D482 residues) expressed in mammalian expression system measured after 1 hr by compet...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
STE20/SPS1-related proline-alanine-rich protein kinase
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/a
n/a
n/a
1.00E+4
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to wild-type human partial length STK39 (P43 to I357 residues) expressed in mammalian expression system measured after 1 hr by compe...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/a
n/a
n/a
1.80E+3
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to wild-type human partial length JAK3 JH1 catalytic domain (I781 to S1124 residues) expressed in mammalian expression system measur...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1B
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
UniProtKB/SwissProt
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/a
n/a
n/a
1.00E+4
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to wild-type human partial length CAMK1B (W9 to A311 residues) expressed in mammalian expression system measured after 1 hr by compe...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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Purchase
MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/a
n/a
n/a
1.80E+3
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to wild-type human partial length MKNK2 (G63 to S388 residues) expressed in mammalian expression system measured after 1 hr by compe...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
Homeodomain-interacting protein kinase 2
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
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MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/a
n/a
n/a
1.20E+3
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to wild-type human partial length HIPK2 (M153 to S564 residues) expressed in mammalian expression system measured after 1 hr by comp...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/a
n/a
n/a
360
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to wild-type human full length DYRK2 (M1 to S528 residues) expressed in mammalian expression system measured after 1 hr by competiti...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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Purchase
MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/a
n/a
n/a
220
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to wild-type human partial length CLK2 (D144 to R498 residues) expressed in bacterial expression system measured after 1 hr by compe...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
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Purchase
MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/a
n/a
n/a
70
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to wild-type human full length CLK1 (M1 to I484 residues) expressed in bacterial expression system measured after 1 hr by competitiv...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK4
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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Purchase
MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/a
n/a
n/a
61
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to wild-type human partial length CLK4 (R135 to K481 residues) expressed in bacterial expression system measured after 1 hr by compe...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/a
n/a
n/a
56
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to wild-type human full length DYRK1B (M1 to S629 residues) expressed in bacterial expression system measured after 1 hr by competit...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
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MCE
PC cid
PC sid
PDB
UniChem
Article
PubMed
n/a
n/a
n/a
15
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to wild-type human partial length HASPIN (I452 to K798 residues) expressed in mammalian expression system measured after 1 hr by com...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/a
n/a
n/a
3
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to wild-type human partial length DYRK1A (H129 to S509 residues) expressed in mammalian expression system measured after 1 hr by com...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
3D Structure (crystal)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/a
n/a
n/a
85
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant measured up to 5 ...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
3D Structure (crystal)
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
PDB
UniChem
n/a
n/a
n/a
>1.00E+4
n/a
n/a
n/a
n/a
n/a
TBA
Citation and Details
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
BDBM50567047
(CHEMBL4848254)
Show SMILES
CN(C)c1nccc(n1)-c1cnn2ncccc12
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
MCE
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/a
n/a
n/a
n/a
n/a
0.240
n/a
n/a
n/a
TBA
Assay Description
Binding affinity to biotinylated DYRK1A (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation rate constant measured up ...
Citation and Details
Article DOI:
10.1021/acs.jmedchem.1c01115
BindingDB Entry DOI:
10.7270/Q2BV7MDT
More data for this
Ligand-Target Pair
3D Structure (crystal)